CA2991311C - OXYSTEROLS AND THEIR METHODS OF USE - Google Patents
OXYSTEROLS AND THEIR METHODS OF USEInfo
- Publication number
- CA2991311C CA2991311C CA2991311A CA2991311A CA2991311C CA 2991311 C CA2991311 C CA 2991311C CA 2991311 A CA2991311 A CA 2991311A CA 2991311 A CA2991311 A CA 2991311A CA 2991311 C CA2991311 C CA 2991311C
- Authority
- CA
- Canada
- Prior art keywords
- compound
- independently
- substituted
- unsubstituted
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562189065P | 2015-07-06 | 2015-07-06 | |
| US62/189,065 | 2015-07-06 | ||
| PCT/US2016/041160 WO2017007832A1 (en) | 2015-07-06 | 2016-07-06 | Oxysterols and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2991311A1 CA2991311A1 (en) | 2017-01-12 |
| CA2991311C true CA2991311C (en) | 2025-05-06 |
Family
ID=57686058
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2991311A Active CA2991311C (en) | 2015-07-06 | 2016-07-06 | OXYSTEROLS AND THEIR METHODS OF USE |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US10696712B2 (enExample) |
| EP (2) | EP4316591A3 (enExample) |
| JP (3) | JP6882996B2 (enExample) |
| AU (2) | AU2016289965B2 (enExample) |
| CA (1) | CA2991311C (enExample) |
| HK (1) | HK1255500A1 (enExample) |
| MA (1) | MA42409A (enExample) |
| WO (1) | WO2017007832A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI2753632T3 (fi) | 2011-09-08 | 2023-08-02 | Sage Therapeutics Inc | Neuroaktiivisia steroideja, koostumuksia ja niiden käyttöjä |
| RS67266B1 (sr) | 2013-03-13 | 2025-10-31 | Sage Therapeutics Inc | Neuroaktivni steroidi i postupci za njihovu upotrebu |
| ES2970222T3 (es) | 2014-06-18 | 2024-05-27 | Sage Therapeutics Inc | Oxiesteroles y procedimientos de uso de los mismos |
| EP3204011A4 (en) * | 2014-10-07 | 2018-06-20 | Sage Therapeutics, Inc. | Neuroactive compounds and methods of use thereof |
| MA42409A (fr) | 2015-07-06 | 2018-05-16 | Sage Therapeutics Inc | Oxystérols et leurs procédés d'utilisation |
| FI3828194T3 (fi) | 2015-07-06 | 2025-07-17 | Sage Therapeutics Inc | Oxysteroleita ja menetelmiä niiden käyttämiseksi |
| MX390271B (es) | 2015-07-06 | 2025-03-20 | Sage Therapeutics Inc | Oxiesteroles y metodos de uso de los mismos |
| US20190330259A1 (en) | 2016-04-01 | 2019-10-31 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| WO2017193046A1 (en) | 2016-05-06 | 2017-11-09 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| LT3481846T (lt) | 2016-07-07 | 2021-08-25 | Sage Therapeutics, Inc. | 11-pakeistieji 24-hidroksisteroliai, skirti naudoti gydant su nmda susijusias būkles |
| JP7149266B2 (ja) | 2016-09-30 | 2022-10-06 | セージ セラピューティクス， インコーポレイテッド | Ｃ７置換オキシステロールおよびｎｍｄａモジュレーターとしての方法 |
| MA46566A (fr) | 2016-10-18 | 2019-08-28 | Sage Therapeutics Inc | Oxystérols et leurs procédés d'utilisation |
| IL293231B2 (en) | 2016-10-18 | 2025-10-01 | Sage Therapeutics Inc | Oxysterols and methods of use thereof |
| US10857163B1 (en) | 2019-09-30 | 2020-12-08 | Athenen Therapeutics, Inc. | Compositions that preferentially potentiate subtypes of GABAA receptors and methods of use thereof |
| CN110628737B (zh) * | 2019-10-14 | 2022-06-07 | 南京农业大学 | 一个调控黄瓜矮化性状相关基因及其应用 |
| EP4333856A1 (en) * | 2021-05-04 | 2024-03-13 | Sage Therapeutics, Inc. | Neuroactive steroid for the treatment of mild cognitive impairment associated with parkinson's disease |
| AU2022291395A1 (en) | 2021-06-11 | 2024-01-04 | Sage Therapeutics, Inc. | Neuroactive steroid for the treatment of alzheimer's disease |
| WO2023114224A1 (en) | 2021-12-13 | 2023-06-22 | Sage Therapeutics, Inc. | Combination of muscarinic receptor positive modulators and nmda positive allosteric modulators |
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| US2594323A (en) | 1948-07-22 | 1952-04-29 | Upjohn Co | 24-substituted delta 5-cholene-3, 24-diols |
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| US3079385A (en) | 1961-01-24 | 1963-02-26 | Roussel Uclaf | Novel process of preparation of polyhydroxylated pregnanes |
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| JPS5840960B2 (ja) * | 1976-12-28 | 1983-09-08 | 帝人株式会社 | ヒドロキシコレステロ−ル立体異性体間の相互変換法 |
| US4183852A (en) * | 1977-07-18 | 1980-01-15 | Kaiser Emil T | Process for preparing 25-hydroxycholesterol |
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| US4174345A (en) * | 1978-08-01 | 1979-11-13 | Kaiser Emil T | Synthesis of steroids |
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| JPS5735597A (en) * | 1980-08-13 | 1982-02-26 | Teijin Ltd | 25,26-epoxy-3beta,24-dihydroxycholest-5-ene or its hydroxyl- protected derivative and their preparation |
| JPS61254599A (ja) * | 1985-05-07 | 1986-11-12 | Sumitomo Pharmaceut Co Ltd | コレステロ−ルのフツ素誘導体 |
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| IL110309A0 (en) | 1993-07-15 | 1994-10-21 | Univ Kentucky Res Found | A method of protecting against neuron loss |
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| PL185622B1 (pl) | 1995-06-23 | 2003-06-30 | Novo Nordisk As | Zastosowanie związku steroidowego i sposób regulacji mejozy w komórce rozrodczej ssaka |
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| FI2753632T3 (fi) * | 2011-09-08 | 2023-08-02 | Sage Therapeutics Inc | Neuroaktiivisia steroideja, koostumuksia ja niiden käyttöjä |
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| RS67266B1 (sr) | 2013-03-13 | 2025-10-31 | Sage Therapeutics Inc | Neuroaktivni steroidi i postupci za njihovu upotrebu |
| RU2021111681A (ru) | 2013-03-13 | 2021-05-11 | Сейдж Терапьютикс, Инк. | Нейроактивные стероиды, композиции и их применение |
| ES2970222T3 (es) | 2014-06-18 | 2024-05-27 | Sage Therapeutics Inc | Oxiesteroles y procedimientos de uso de los mismos |
| WO2016007762A1 (en) | 2014-07-09 | 2016-01-14 | Duke University | Compositions and methods for the repair of myelin |
| US10016095B2 (en) * | 2014-10-03 | 2018-07-10 | Progressive International Corporation | Salad spinner |
| EP3204011A4 (en) * | 2014-10-07 | 2018-06-20 | Sage Therapeutics, Inc. | Neuroactive compounds and methods of use thereof |
| MX390271B (es) * | 2015-07-06 | 2025-03-20 | Sage Therapeutics Inc | Oxiesteroles y metodos de uso de los mismos |
| MA42409A (fr) | 2015-07-06 | 2018-05-16 | Sage Therapeutics Inc | Oxystérols et leurs procédés d'utilisation |
| FI3828194T3 (fi) | 2015-07-06 | 2025-07-17 | Sage Therapeutics Inc | Oxysteroleita ja menetelmiä niiden käyttämiseksi |
| GB2557875A (en) | 2015-09-02 | 2018-07-04 | Univ Swansea | Diagnostic methods and kits |
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-
2016
- 2016-07-06 MA MA042409A patent/MA42409A/fr unknown
- 2016-07-06 WO PCT/US2016/041160 patent/WO2017007832A1/en not_active Ceased
- 2016-07-06 AU AU2016289965A patent/AU2016289965B2/en active Active
- 2016-07-06 US US15/742,422 patent/US10696712B2/en active Active
- 2016-07-06 HK HK18114684.2A patent/HK1255500A1/zh unknown
- 2016-07-06 EP EP23199636.4A patent/EP4316591A3/en active Pending
- 2016-07-06 JP JP2017568208A patent/JP6882996B2/ja active Active
- 2016-07-06 CA CA2991311A patent/CA2991311C/en active Active
- 2016-07-06 EP EP16821920.2A patent/EP3319610A4/en not_active Withdrawn
-
2020
- 2020-05-20 US US16/879,460 patent/US20210101925A1/en not_active Abandoned
-
2021
- 2021-01-07 JP JP2021001453A patent/JP7410062B2/ja active Active
- 2021-08-20 AU AU2021218227A patent/AU2021218227B2/en active Active
-
2022
- 2022-05-20 US US17/749,976 patent/US20230047157A1/en not_active Abandoned
- 2022-07-01 JP JP2022107293A patent/JP7478190B2/ja active Active
-
2024
- 2024-06-18 US US18/746,388 patent/US20250154192A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2016289965A1 (en) | 2018-01-18 |
| AU2021218227B2 (en) | 2023-08-03 |
| EP4316591A2 (en) | 2024-02-07 |
| JP7478190B2 (ja) | 2024-05-02 |
| CA2991311A1 (en) | 2017-01-12 |
| US10696712B2 (en) | 2020-06-30 |
| US20250154192A1 (en) | 2025-05-15 |
| US20230047157A1 (en) | 2023-02-16 |
| EP4316591A3 (en) | 2024-04-24 |
| NZ738582A (en) | 2024-10-25 |
| AU2021218227A1 (en) | 2021-09-09 |
| HK1255500A1 (zh) | 2019-08-16 |
| JP2021063118A (ja) | 2021-04-22 |
| US20210101925A1 (en) | 2021-04-08 |
| EP3319610A4 (en) | 2019-03-06 |
| JP7410062B2 (ja) | 2024-01-09 |
| MA42409A (fr) | 2018-05-16 |
| JP2022130668A (ja) | 2022-09-06 |
| JP6882996B2 (ja) | 2021-06-02 |
| WO2017007832A1 (en) | 2017-01-12 |
| JP2018519329A (ja) | 2018-07-19 |
| US20180201643A1 (en) | 2018-07-19 |
| EP3319610A1 (en) | 2018-05-16 |
| AU2016289965B2 (en) | 2021-09-09 |
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