JP6877407B2 - Ｎｔｒｋ関連障害の治療に有用な化合物および組成物 - Google Patents

Ｎｔｒｋ関連障害の治療に有用な化合物および組成物 Download PDF

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JP6877407B2
JP6877407B2 JP2018510406A JP2018510406A JP6877407B2 JP 6877407 B2 JP6877407 B2 JP 6877407B2 JP 2018510406 A JP2018510406 A JP 2018510406A JP 2018510406 A JP2018510406 A JP 2018510406A JP 6877407 B2 JP6877407 B2 JP 6877407B2
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JP2018528200A5 (https=
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スティーブン マーク ウェングロウスキー，
スティーブン マーク ウェングロウスキー，
ナターシャ ブルージマンス，
ナターシャ ブルージマンス，
チャンドラセカール ブイ． ミドゥトゥル，
チャンドラセカール ブイ． ミドゥトゥル，
ニール ジュニア ビフルコ，
ニール ジュニア ビフルコ，
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ブループリント メディシンズ コーポレイション
ブループリント メディシンズ コーポレイション
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2018510406A 2015-08-26 2016-08-25 Ｎｔｒｋ関連障害の治療に有用な化合物および組成物 Expired - Fee Related JP6877407B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562210264P 2015-08-26 2015-08-26
US62/210,264 2015-08-26
PCT/US2016/048698 WO2017035354A1 (en) 2015-08-26 2016-08-25 Compounds and compositions useful for treating disorders related to ntrk

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JP2018528200A JP2018528200A (ja) 2018-09-27
JP2018528200A5 JP2018528200A5 (https=) 2019-09-12
JP6877407B2 true JP6877407B2 (ja) 2021-05-26

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US (2) US10017512B2 (https=)
EP (1) EP3341374A1 (https=)
JP (1) JP6877407B2 (https=)
KR (1) KR20180043810A (https=)
CN (1) CN108137607B (https=)
AR (1) AR105836A1 (https=)
AU (1) AU2016311426B2 (https=)
BR (1) BR112018003588A2 (https=)
CA (1) CA2995997A1 (https=)
HK (1) HK1255330A1 (https=)
IL (1) IL257702A (https=)
MX (1) MX2018002407A (https=)
PH (1) PH12018500397A1 (https=)
RU (1) RU2744974C2 (https=)
TW (1) TW201713665A (https=)
WO (1) WO2017035354A1 (https=)
ZA (1) ZA201801881B (https=)

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Also Published As

Publication number Publication date
KR20180043810A (ko) 2018-04-30
PH12018500397A1 (en) 2018-08-29
AU2016311426A1 (en) 2018-04-05
US10017512B2 (en) 2018-07-10
RU2744974C2 (ru) 2021-03-17
ZA201801881B (en) 2019-05-29
WO2017035354A1 (en) 2017-03-02
CA2995997A1 (en) 2017-03-02
US20170066773A1 (en) 2017-03-09
AU2016311426B2 (en) 2021-05-20
RU2018110379A3 (https=) 2019-12-26
US20190169194A1 (en) 2019-06-06
AR105836A1 (es) 2017-11-15
TW201713665A (zh) 2017-04-16
CN108137607A (zh) 2018-06-08
MX2018002407A (es) 2018-11-29
HK1255330A1 (zh) 2019-08-16
EP3341374A1 (en) 2018-07-04
IL257702A (en) 2018-04-30
BR112018003588A2 (pt) 2018-09-25
US11046697B2 (en) 2021-06-29
RU2018110379A (ru) 2019-09-27
JP2018528200A (ja) 2018-09-27
CN108137607B (zh) 2021-04-06

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