KR20180043810A - Ntrk에 관련된 장애 치료용으로 유용한 화합물 및 조성물 - Google Patents

Ntrk에 관련된 장애 치료용으로 유용한 화합물 및 조성물 Download PDF

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Publication number
KR20180043810A
KR20180043810A KR1020187008146A KR20187008146A KR20180043810A KR 20180043810 A KR20180043810 A KR 20180043810A KR 1020187008146 A KR1020187008146 A KR 1020187008146A KR 20187008146 A KR20187008146 A KR 20187008146A KR 20180043810 A KR20180043810 A KR 20180043810A
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South Korea
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mmol
ring
mixture
compound
cycloalkyl
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Korean (ko)
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스티븐 마크 웬글로스키
나타샤 브르즈만스
챈드라세카 브이. 미두투루
네일 비풀코
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블루프린트 메디신즈 코포레이션
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Publication of KR20180043810A publication Critical patent/KR20180043810A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020187008146A 2015-08-26 2016-08-25 Ntrk에 관련된 장애 치료용으로 유용한 화합물 및 조성물 Withdrawn KR20180043810A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562210264P 2015-08-26 2015-08-26
US62/210,264 2015-08-26
PCT/US2016/048698 WO2017035354A1 (en) 2015-08-26 2016-08-25 Compounds and compositions useful for treating disorders related to ntrk

Publications (1)

Publication Number Publication Date
KR20180043810A true KR20180043810A (ko) 2018-04-30

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KR1020187008146A Withdrawn KR20180043810A (ko) 2015-08-26 2016-08-25 Ntrk에 관련된 장애 치료용으로 유용한 화합물 및 조성물

Country Status (17)

Country Link
US (2) US10017512B2 (https=)
EP (1) EP3341374A1 (https=)
JP (1) JP6877407B2 (https=)
KR (1) KR20180043810A (https=)
CN (1) CN108137607B (https=)
AR (1) AR105836A1 (https=)
AU (1) AU2016311426B2 (https=)
BR (1) BR112018003588A2 (https=)
CA (1) CA2995997A1 (https=)
HK (1) HK1255330A1 (https=)
IL (1) IL257702A (https=)
MX (1) MX2018002407A (https=)
PH (1) PH12018500397A1 (https=)
RU (1) RU2744974C2 (https=)
TW (1) TW201713665A (https=)
WO (1) WO2017035354A1 (https=)
ZA (1) ZA201801881B (https=)

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BR112018003588A2 (pt) 2015-08-26 2018-09-25 Blueprint Medicines Corp compostos e composições úteis para tratamento de distúrbios relacionados ao ntrk
SI3371171T1 (sl) 2015-11-02 2024-03-29 Blueprint Medicines Corporation Inhibitorji ret
SG10201912607SA (en) 2015-11-19 2020-02-27 Blueprint Medicines Corp Compounds and compositions useful for treating disorders related to ntrk
US10183928B2 (en) 2016-03-17 2019-01-22 Blueprint Medicines Corporation Inhibitors of RET
CN109311889B (zh) 2016-04-15 2021-11-16 缆图药品公司 激活素受体样激酶抑制剂
US10227329B2 (en) 2016-07-22 2019-03-12 Blueprint Medicines Corporation Compounds useful for treating disorders related to RET
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Also Published As

Publication number Publication date
JP2018528200A (ja) 2018-09-27
JP6877407B2 (ja) 2021-05-26
US20170066773A1 (en) 2017-03-09
WO2017035354A1 (en) 2017-03-02
AR105836A1 (es) 2017-11-15
US10017512B2 (en) 2018-07-10
HK1255330A1 (zh) 2019-08-16
RU2018110379A (ru) 2019-09-27
RU2018110379A3 (https=) 2019-12-26
AU2016311426B2 (en) 2021-05-20
EP3341374A1 (en) 2018-07-04
IL257702A (en) 2018-04-30
ZA201801881B (en) 2019-05-29
BR112018003588A2 (pt) 2018-09-25
PH12018500397A1 (en) 2018-08-29
MX2018002407A (es) 2018-11-29
CN108137607B (zh) 2021-04-06
US20190169194A1 (en) 2019-06-06
US11046697B2 (en) 2021-06-29
CA2995997A1 (en) 2017-03-02
CN108137607A (zh) 2018-06-08
TW201713665A (zh) 2017-04-16
RU2744974C2 (ru) 2021-03-17
AU2016311426A1 (en) 2018-04-05

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PA0105 International application

Patent event date: 20180322

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid