JP6873919B2 - オートタキシン阻害剤とその使用 - Google Patents

オートタキシン阻害剤とその使用 Download PDF

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JP6873919B2
JP6873919B2 JP2017560309A JP2017560309A JP6873919B2 JP 6873919 B2 JP6873919 B2 JP 6873919B2 JP 2017560309 A JP2017560309 A JP 2017560309A JP 2017560309 A JP2017560309 A JP 2017560309A JP 6873919 B2 JP6873919 B2 JP 6873919B2
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disease
autotaxin
cancer
fibrosis
compound
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JP2018515556A5 (https=
JP2018515556A (ja
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ベイン，グレッチェン
フランシス エバンズ，ジリアン
フランシス エバンズ，ジリアン
ハワード ハッチンソン，ジョン
ハワード ハッチンソン，ジョン
ロナーガン，デイビッド
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セイバー セラピューティクス エルエルシー
セイバー セラピューティクス エルエルシー
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • Veterinary Medicine (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
JP2017560309A 2015-05-27 2016-05-24 オートタキシン阻害剤とその使用 Active JP6873919B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021071253A JP7274521B2 (ja) 2015-05-27 2021-04-20 オートタキシン阻害剤とその使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562167216P 2015-05-27 2015-05-27
US62/167,216 2015-05-27
PCT/US2016/033933 WO2016191427A1 (en) 2015-05-27 2016-05-24 Autotaxin inhibitors and uses thereof

Related Child Applications (1)

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JP2021071253A Division JP7274521B2 (ja) 2015-05-27 2021-04-20 オートタキシン阻害剤とその使用

Publications (3)

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JP2018515556A JP2018515556A (ja) 2018-06-14
JP2018515556A5 JP2018515556A5 (https=) 2019-06-27
JP6873919B2 true JP6873919B2 (ja) 2021-05-19

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JP2021071253A Active JP7274521B2 (ja) 2015-05-27 2021-04-20 オートタキシン阻害剤とその使用

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US (2) US10632104B2 (https=)
EP (2) EP3302490B1 (https=)
JP (2) JP6873919B2 (https=)
KR (2) KR102663569B1 (https=)
CN (2) CN107921048A (https=)
AU (4) AU2016268250B2 (https=)
BR (1) BR122023011445B1 (https=)
CA (1) CA2986759C (https=)
EA (2) EA039684B1 (https=)
ES (1) ES2915267T3 (https=)
IL (2) IL280863B2 (https=)
MX (2) MX2017015225A (https=)
SG (1) SG10201911204WA (https=)
WO (1) WO2016191427A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3071561B1 (en) 2013-11-22 2021-03-24 Sabre Therapeutics LLC Autotaxin inhibitor compounds
CA2986759C (en) 2015-05-27 2025-06-17 Sabre Therapeutics Llc AUTOTAXIN INHIBITORS AND THEIR USES
CN107021915A (zh) * 2017-04-27 2017-08-08 李亚庆 一种治疗妇科炎症的化合物及制备方法和应用
WO2019036430A1 (en) * 2017-08-14 2019-02-21 Camp4 Therapeutics Corporation METHODS OF TREATING HEPATIC DISEASES
WO2019172651A1 (ko) 2018-03-06 2019-09-12 주식회사 엘지화학 편광판 및 이를 포함하는 화상 표시 장치
EA202190661A1 (ru) * 2018-09-18 2021-08-13 Метакрайн, Инк. Агонисты фарнезоидного х-рецептора для лечения заболевания
CN117018202A (zh) * 2019-07-08 2023-11-10 上海交通大学医学院附属瑞金医院 趋化因子受体ccr6抑制剂在预防银屑病复发中的新应用
KR20240126870A (ko) 2021-12-22 2024-08-21 캠프4 테라퓨틱스 코포레이션 조절 rna들을 표적으로 하는 안티센스 올리고뉴클레오티드를 사용한 유전자 전사의 조절
CN114767863B (zh) * 2022-04-29 2024-01-30 西北工业大学 一种enpp2基因或蛋白在调控结直肠癌细胞中的应用
JP2025516335A (ja) * 2022-05-03 2025-05-27 セイバー セラピューティクス エルエルシー オートタキシン阻害剤の多形形態
US20250281486A1 (en) * 2022-05-05 2025-09-11 The Trustees Of Indiana University Therapeutic strategies to manage facial contractures post injury
GR1010570B (el) 2022-12-22 2023-11-17 Uni-Pharma Κλεων Τσετης Φαρμακευτικα Εργαστηρια Α.Β.Ε.Ε., 4-(2-(4-((2,4-διοξοθειαζολιδιν-5-υλ)μεθυλ)φαινοξυ) παραγωγα με δραση αναστολης της αυτοταξινης
TW202502735A (zh) * 2023-03-02 2025-01-16 印度商吉德斯生命科學有限公司 新穎atx抑制劑
CN116159056A (zh) * 2023-03-09 2023-05-26 中南大学湘雅医院 一种氟非尼酮在制备非酒精性脂肪性肝炎药物中的应用
CN116239577A (zh) * 2023-03-27 2023-06-09 沈阳药科大学 一种制备Cudetaxestat的方法

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