JP6851978B2 - ミトコンドリアプロファイリングによるアルボシジブ応答の予測 - Google Patents

ミトコンドリアプロファイリングによるアルボシジブ応答の予測 Download PDF

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JP6851978B2
JP6851978B2 JP2017554864A JP2017554864A JP6851978B2 JP 6851978 B2 JP6851978 B2 JP 6851978B2 JP 2017554864 A JP2017554864 A JP 2017554864A JP 2017554864 A JP2017554864 A JP 2017554864A JP 6851978 B2 JP6851978 B2 JP 6851978B2
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cancer
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patient
treatment
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JP2018516245A5 (enExample
JP2018516245A (ja
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スティーブン エル． ワーナー，
スティーブン エル． ワーナー，
デイビッド ジェイ． ベアス，
デイビッド ジェイ． ベアス，
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スミトモ ダイニッポン ファーマ オンコロジー， インコーポレイテッド
スミトモ ダイニッポン ファーマ オンコロジー， インコーポレイテッド
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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
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    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
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JP2017554864A 2015-04-20 2016-04-20 ミトコンドリアプロファイリングによるアルボシジブ応答の予測 Active JP6851978B2 (ja)

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US201562150138P 2015-04-20 2015-04-20
US62/150,138 2015-04-20
PCT/US2016/028443 WO2016172214A1 (en) 2015-04-20 2016-04-20 Predicting response to alvocidib by mitochondrial profiling

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JP2018516245A JP2018516245A (ja) 2018-06-21
JP2018516245A5 JP2018516245A5 (enExample) 2019-05-30
JP6851978B2 true JP6851978B2 (ja) 2021-03-31

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US (4) US9901574B2 (enExample)
EP (2) EP3611506B1 (enExample)
JP (1) JP6851978B2 (enExample)
KR (1) KR20180018507A (enExample)
CN (1) CN107995863A (enExample)
AU (1) AU2016252609B2 (enExample)
BR (1) BR112017022666A8 (enExample)
CA (1) CA2982928A1 (enExample)
HK (1) HK1251655A1 (enExample)
IL (1) IL255029B (enExample)
MX (1) MX2017013383A (enExample)
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WO (1) WO2016172214A1 (enExample)

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JP6851978B2 (ja) 2015-04-20 2021-03-31 スミトモ ダイニッポン ファーマ オンコロジー， インコーポレイテッド ミトコンドリアプロファイリングによるアルボシジブ応答の予測
JP6510075B2 (ja) 2015-05-18 2019-05-08 トレロ ファーマシューティカルズ， インコーポレイテッド バイオアベイラビリティが高いアルボシジブプロドラッグ
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WO2019055579A1 (en) 2017-09-12 2019-03-21 Tolero Pharmaceuticals, Inc. TREATMENT REGIME FOR CANCERS THAT ARE INSENSITIVE TO BCL-2 INHIBITORS USING THE MCL-1 ALVOCIDIB INHIBITOR
EP3737757A4 (en) 2018-01-12 2021-09-22 Children's Hospital Medical Center BFL 1 INHIBITION TREATMENT METHODS
US20190314357A1 (en) * 2018-04-13 2019-10-17 Tolero Pharmaceuticals, Inc. Cyclin-dependent kinase inhibitors in combination with anthracyclines for treatment of cancer
US20210277037A1 (en) * 2018-06-21 2021-09-09 Sumitomo Dainippon Pharma Oncology, Inc. Deuterated alvocidib and alvocidib prodrugs
TWI810397B (zh) * 2018-11-14 2023-08-01 瑞典商阿斯特捷利康公司 治療癌症之方法
US11034710B2 (en) 2018-12-04 2021-06-15 Sumitomo Dainippon Pharma Oncology, Inc. CDK9 inhibitors and polymorphs thereof for use as agents for treatment of cancer
US11793802B2 (en) 2019-03-20 2023-10-24 Sumitomo Pharma Oncology, Inc. Treatment of acute myeloid leukemia (AML) with venetoclax failure
TWI770503B (zh) * 2019-05-13 2022-07-11 大陸商蘇州亞盛藥業有限公司 用於預測bcl-2/bcl-xl抑制劑對癌症的功效的方法和組合物
US20220257581A1 (en) * 2019-07-08 2022-08-18 Sumitomo Dainippon Pharma Oncology, Inc. Treatment of Cancer
WO2021007316A1 (en) 2019-07-08 2021-01-14 Sumitomo Dainippon Pharma Oncology, Inc. Treatment of cancer
US12478607B2 (en) 2019-07-11 2025-11-25 Children's Hospital Medical Center Compounds useful for inhibiting BFL1 and their use in therapy
TWI885019B (zh) * 2019-11-27 2025-06-01 大陸商蘇州亞盛藥業有限公司 用於預測靶向細胞凋亡途徑的化合物的抗癌功效的方法和組合物
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