JP6824432B2 - 六酸化四砒素の結晶多形を含む乳癌予防または治療用薬学組成物及びその製造方法 - Google Patents
六酸化四砒素の結晶多形を含む乳癌予防または治療用薬学組成物及びその製造方法 Download PDFInfo
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- 230000009897 systematic effect Effects 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000002076 thermal analysis method Methods 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
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- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
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- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
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- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/36—Arsenic; Compounds thereof
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Description
また、本発明の薬学組成物は、乳癌転移を抑制する効果に優れることが確認された。
Claims (5)
- 有効成分として六酸化四砒素(As4O6)を含む乳癌予防または治療用薬学組成物であって、
前記六酸化四砒素は、以下の(i)乃至(iii)の特性
(i)格子定数:
a=b=c=11.0734Å
α=β=γ=90°
V=1357.82Å3
(ii)As−O結合長さ:1.786Å
(iii)O−As−O結合角:98.36゜
を有する六酸化四砒素の結晶多形aが99重量%以上である
ことを特徴とする乳癌予防または治療用薬学組成物。 - 請求項1に記載の乳癌予防または治療用薬学組成物の製造方法であって、
塩化ナトリウムを100〜800℃に加熱した後、冷却する第1工程;
塩化ナトリウムの上に三酸化二砒素(As2O3)を上げた後、密閉状態で100℃から1000℃まで加熱した後、冷却する第2工程;
昇華された砒素を捕集する濾過紙で結晶化された結晶を分離する第3工程;及び
前記第3工程で得た結晶を第2工程の三酸化二砒素の代わりに使用して第2工程及び第3工程を4〜10回繰り返して六酸化四砒素結晶を得る第4工程;
を通じて製造され、
前記第4工程で得られる六酸化四砒素は、前記結晶多形aが99重量%以上である
ことを特徴とする乳癌予防または治療用薬学組成物の製造方法。 - 前記六酸化四砒素は純度が99.9%以上である
請求項1に記載の乳癌予防または治療用薬学組成物。 - 前記結晶多形aはX−線粉末回折分光図で、光源波長が1.5406Åの時、回折角2θ=10〜50°で1°/minの速度(scan step 0.02°)で表示されたピークが13.84、27.88、32.32、35.3、39.84、42.38、46.34、48.6、及び49.34と示される
請求項1に記載の乳癌予防または治療用薬学組成物。 - 有効成分として六酸化四砒素(As4O6)を含む乳癌転移抑制用薬学組成物であって、
前記六酸化四砒素は、以下の(i)乃至(iii)の特性
(i)格子定数:
a=b=c=11.0734Å
α=β=γ=90°
V=1357.82Å3
(ii)As−O結合長さ:1.786Å
(iii)O−As−O結合角:98.36゜
を有する六酸化四砒素の結晶多形aが99重量%以上である
ことを特徴とする乳癌転移抑制用薬学組成物。
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KR10-2016-0155228 | 2016-11-21 | ||
KR1020160155228A KR101834366B1 (ko) | 2016-11-21 | 2016-11-21 | 육산화사비소의 결정다형을 포함하는 유방암 예방 또는 치료용 약학 조성물 및 이의 제조방법 |
PCT/KR2017/013148 WO2018093215A1 (ko) | 2016-11-21 | 2017-11-17 | 육산화사비소의 결정다형을 포함하는 유방암 예방 또는 치료용 약학 조성물 및 이의 제조방법 |
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CA2876689C (en) | 2012-06-13 | 2022-04-26 | Incyte Corporation | Substituted tricyclic compounds as fgfr inhibitors |
PT2986610T (pt) | 2013-04-19 | 2018-03-09 | Incyte Holdings Corp | Heterociclos bicíclicos como inibidores de fgfr |
MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
AU2016219822B2 (en) | 2015-02-20 | 2020-07-09 | Incyte Holdings Corporation | Bicyclic heterocycles as FGFR inhibitors |
KR101844049B1 (ko) | 2016-12-05 | 2018-03-30 | 주식회사 케마스 | 육산화사비소의 결정다형을 포함하는 간암 예방 또는 치료용 약학 조성물 |
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AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
BR112020022373A2 (pt) | 2018-05-04 | 2021-02-02 | Incyte Corporation | sais de um inibidor de fgfr |
PE20210920A1 (es) | 2018-05-04 | 2021-05-19 | Incyte Corp | Formas solidas de un inhibidor de fgfr y procesos para prepararlas |
US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
WO2021007269A1 (en) | 2019-07-09 | 2021-01-14 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
CR20220169A (es) | 2019-10-14 | 2022-10-27 | Incyte Corp | Heterociclos bicíclicos como inhibidores de fgfr |
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JP2023505258A (ja) | 2019-12-04 | 2023-02-08 | インサイト・コーポレイション | Fgfr阻害剤としての三環式複素環 |
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