JP6820840B2 - 流体処理システム用ガスフィルタの制御された真空脱ガス及び関連する方法 - Google Patents

流体処理システム用ガスフィルタの制御された真空脱ガス及び関連する方法 Download PDF

Info

Publication number
JP6820840B2
JP6820840B2 JP2017518967A JP2017518967A JP6820840B2 JP 6820840 B2 JP6820840 B2 JP 6820840B2 JP 2017518967 A JP2017518967 A JP 2017518967A JP 2017518967 A JP2017518967 A JP 2017518967A JP 6820840 B2 JP6820840 B2 JP 6820840B2
Authority
JP
Japan
Prior art keywords
gas
filter
container
filter assembly
compartment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2017518967A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017529869A (ja
JP2017529869A5 (enExample
Inventor
ディー.ジョーンズ ネフィ
ディー.ジョーンズ ネフィ
ディー.ブロー クリストファー
ディー.ブロー クリストファー
Original Assignee
ライフ テクノロジーズ コーポレイション
ライフ テクノロジーズ コーポレイション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ライフ テクノロジーズ コーポレイション, ライフ テクノロジーズ コーポレイション filed Critical ライフ テクノロジーズ コーポレイション
Publication of JP2017529869A publication Critical patent/JP2017529869A/ja
Publication of JP2017529869A5 publication Critical patent/JP2017529869A5/ja
Application granted granted Critical
Publication of JP6820840B2 publication Critical patent/JP6820840B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00Apparatus for enzymology or microbiology
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D19/00Degasification of liquids
    • B01D19/0005Degasification of liquids with one or more auxiliary substances
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D19/00Degasification of liquids
    • B01D19/0031Degasification of liquids by filtration
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D19/00Degasification of liquids
    • B01D19/0036Flash degasification
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D46/00Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
    • B01D46/0002Casings; Housings; Frame constructions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D46/00Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
    • B01D46/0002Casings; Housings; Frame constructions
    • B01D46/0016Folded frame or housing constructions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D46/00Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
    • B01D46/24Particle separators, e.g. dust precipitators, using rigid hollow filter bodies
    • B01D46/2403Particle separators, e.g. dust precipitators, using rigid hollow filter bodies characterised by the physical shape or structure of the filtering element
    • B01D46/2411Filter cartridges
    • B01D46/2414End caps including additional functions or special forms
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D46/00Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
    • B01D46/42Auxiliary equipment or operation thereof
    • B01D46/44Auxiliary equipment or operation thereof controlling filtration
    • B01D46/446Auxiliary equipment or operation thereof controlling filtration by pressure measuring
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D46/00Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
    • B01D46/42Auxiliary equipment or operation thereof
    • B01D46/44Auxiliary equipment or operation thereof controlling filtration
    • B01D46/448Auxiliary equipment or operation thereof controlling filtration by temperature measuring
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D46/00Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
    • B01D46/56Filters or filtering processes specially modified for separating dispersed particles from gases or vapours with multiple filtering elements, characterised by their mutual disposition
    • B01D46/58Filters or filtering processes specially modified for separating dispersed particles from gases or vapours with multiple filtering elements, characterised by their mutual disposition connected in parallel
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D5/00Condensation of vapours; Recovering volatile solvents by condensation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D53/00Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols
    • B01D53/26Drying gases or vapours
    • B01D53/265Drying gases or vapours by refrigeration (condensation)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00Apparatus for enzymology or microbiology
    • C12M1/02Apparatus for enzymology or microbiology with agitation means; with heat exchange means
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00Apparatus for enzymology or microbiology
    • C12M1/34Measuring or testing with condition measuring or sensing means, e.g. colony counters
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/02Form or structure of the vessel
    • C12M23/14Bags
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/26Constructional details, e.g. recesses, hinges flexible
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04Filters; Permeable or porous membranes or plates, e.g. dialysis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/06Nozzles; Sprayers; Spargers; Diffusers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/20Degassing; Venting; Bubble traps
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C12M41/14Incubators; Climatic chambers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/40Means for regulation, monitoring, measurement or control, e.g. flow regulation of pressure
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48Automatic or computerized control
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C12Q1/16Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor using radioactive material
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D2271/00Sealings for filters specially adapted for separating dispersed particles from gases or vapours
    • B01D2271/02Gaskets, sealings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Sustainable Development (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Computer Hardware Design (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Geometry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Filtering Of Dispersed Particles In Gases (AREA)
  • Degasification And Air Bubble Elimination (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
JP2017518967A 2014-10-07 2015-10-06 流体処理システム用ガスフィルタの制御された真空脱ガス及び関連する方法 Active JP6820840B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14/508,824 2014-10-07
US14/508,824 US9457306B2 (en) 2014-10-07 2014-10-07 Regulated vacuum off-gassing of gas filter for fluid processing system and related methods
PCT/US2015/054241 WO2016057512A1 (en) 2014-10-07 2015-10-06 Regulated vacuum off-gassing of gas filter for fluid processing system and related methods

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020171376A Division JP7123104B2 (ja) 2014-10-07 2020-10-09 流体処理システム用ガスフィルタの制御された真空脱ガス及び関連する方法

Publications (3)

Publication Number Publication Date
JP2017529869A JP2017529869A (ja) 2017-10-12
JP2017529869A5 JP2017529869A5 (enExample) 2018-07-12
JP6820840B2 true JP6820840B2 (ja) 2021-01-27

Family

ID=54337895

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2017518967A Active JP6820840B2 (ja) 2014-10-07 2015-10-06 流体処理システム用ガスフィルタの制御された真空脱ガス及び関連する方法
JP2020171376A Active JP7123104B2 (ja) 2014-10-07 2020-10-09 流体処理システム用ガスフィルタの制御された真空脱ガス及び関連する方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2020171376A Active JP7123104B2 (ja) 2014-10-07 2020-10-09 流体処理システム用ガスフィルタの制御された真空脱ガス及び関連する方法

Country Status (8)

Country Link
US (5) US9457306B2 (enExample)
EP (2) EP3800241A1 (enExample)
JP (2) JP6820840B2 (enExample)
KR (3) KR102558490B1 (enExample)
CN (1) CN106999798B (enExample)
BR (1) BR112017007286B1 (enExample)
RU (1) RU2720197C2 (enExample)
WO (1) WO2016057512A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8455242B2 (en) 2010-02-22 2013-06-04 Hyclone Laboratories, Inc. Mixing system with condenser
EP3466509B1 (en) 2014-03-21 2021-03-10 Life Technologies Corporation Condenser systems for fluid processing systems
CN106232219B (zh) 2014-03-21 2020-04-24 生命科技股份有限公司 用于流体处理系统的气体过滤器系统
US9457306B2 (en) * 2014-10-07 2016-10-04 Life Technologies Corporation Regulated vacuum off-gassing of gas filter for fluid processing system and related methods
CN112403668B (zh) 2015-12-29 2023-06-27 生命科技股份有限公司 具有部分分割分隔区的柔性生物处理容器
US10898845B2 (en) * 2017-07-31 2021-01-26 Fanca Technologies Pty Ltd. Mobile dust extraction device
WO2019209805A1 (en) 2018-04-27 2019-10-31 Baxter International Inc. Method of mixing a pharmaceutical solution and mixing system
CN108993050B (zh) * 2018-08-24 2024-01-23 深圳市贝腾科技有限公司 过滤装置
SG11202101947UA (en) * 2018-08-29 2021-03-30 Rapid Micro Biosystems Inc Use of clean and dry gas for particle removal and assembly therefor
GB201816897D0 (en) * 2018-10-17 2018-11-28 Ge Healthcare Bio Sciences Corp A Bioreactor System
AU2020204975A1 (en) 2019-01-04 2021-08-12 Oribiotech Ltd Cell processing container, cell processing system and methods of use thereof
AU2020104139A4 (en) * 2019-12-16 2021-03-04 Webster, Steven A separator for a fluid stream and method therein
CN111729419B (zh) * 2020-08-10 2020-12-29 诸城市人民医院 一种废气排放处理设备
CN112210504B (zh) * 2020-10-15 2021-05-18 新疆天润生物科技股份有限公司 一种马克思克鲁维酵母菌菌株的培养方法
DE102020214439B4 (de) * 2020-11-17 2023-03-16 Christof-Herbert Diener Vakuumvorrichtung mit einem Sintermetall-Taschenfilter und Verwendung eines Abgaspartikelfilters in einer Vakuumvorrichtung
CN113413688A (zh) * 2021-06-18 2021-09-21 威斯坦(厦门)实业有限公司 一种应用于小型3d打印机的双滤芯除尘系统及其控制方法
KR102494602B1 (ko) * 2022-08-24 2023-02-06 주식회사 우영씨앤티 대기오염방지시설의 정압자동보정장치

Family Cites Families (168)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE400829C (de) 1923-12-14 1924-08-19 Siemens & Halske Akt Ges Elektrische Stellvorrichtung fuer Eisenbahnsignale, Weichen o. dgl.
US3140716A (en) 1961-06-26 1964-07-14 Baxter Laboratories Inc Heat exchanger for blood
US3221724A (en) 1964-01-27 1965-12-07 Gen Motors Corp Vapor recovery system
US3212274A (en) 1964-07-28 1965-10-19 Eidus William Thermoelectric condenser
US3422887A (en) 1967-06-19 1969-01-21 Graham Mfg Co Inc Condenser for distillation column
DE1757388B1 (de) 1968-05-03 1971-10-28 Delbag Luftfilter Gmbh Filtervorrichtung zur Abscheidung gesundheitsschaedigender,vorzugsweise radioaktiver Schwebstoffe aus einem Gasstrom
US3867260A (en) 1969-05-23 1975-02-18 New Brunswick Scientific Co Mass transfer condenser, particularly for use with fermenting vessels
US3672959A (en) 1969-12-12 1972-06-27 Harold C Sweet Portable distillery
DE7602442U1 (de) 1976-01-27 1976-10-28 Delbag-Luftfilter Gmbh, 1000 Berlin Drosselbare, rohrfoermige bypass-messstrecke mit wartungsschutz und kontinuierlicher stroemungsgeschwindigkeitsabtastung an schuettgutanlagen der kerntechnik
US4182656A (en) * 1976-09-10 1980-01-08 Johnston Laboratories, Inc. Method for detecting the presence of biologically active agents utilizing 13 C-labeled substrates
SU839444A3 (ru) 1976-10-07 1981-06-15 Этаблиссман Вальвен (Фирма) Очиститель углекислого газаК РЕзЕРВуАРАМ дл бРОжЕНи
FR2405610A1 (fr) 1977-10-07 1979-05-04 Leboeuf Lola Dispositif a plaques chauffantes electriques pour appareil de transfusion du sang
US4194950A (en) 1977-11-09 1980-03-25 Zalles Robert I Liquid purifying apparatus
US4177816A (en) 1978-03-27 1979-12-11 Sci-Med Life Systems, Inc. Heat exchanger for blood
US4258784A (en) 1978-04-07 1981-03-31 The Boeing Company Heat exchange apparatus and method of utilizing the same
US4574876A (en) 1981-05-11 1986-03-11 Extracorporeal Medical Specialties, Inc. Container with tapered walls for heating or cooling fluids
US4731072A (en) 1981-05-11 1988-03-15 Mcneilab, Inc. Apparatus for heating or cooling fluids
DE3270115D1 (en) * 1981-08-18 1986-04-30 Drm, Dr. Muller Ag Method and apparatus for the cultivation of micro-organisms
JPS5942884A (ja) 1982-09-01 1984-03-09 Ajinomoto Co Inc 通気撹拌培養方法及びそれに用いる装置
US4573933A (en) 1983-06-20 1986-03-04 Cameron Robert W Floating search and rescue inflatable pyramid
US4668388A (en) 1983-11-25 1987-05-26 Texaco Inc. High rate sludge reactor
US4502876A (en) 1984-01-03 1985-03-05 Behnke Jr Albert R Cartridge for use in rebreathing apparatus
US4561498A (en) 1984-03-21 1985-12-31 Union Carbide Corporation Intercooler with three-section baffle
US4612086A (en) 1984-05-11 1986-09-16 Inquimet Sociedad Anonima Industrial Comercial Y Agraria Evaporators
JPS61149080A (ja) * 1984-12-25 1986-07-07 Iwashiya Seibutsu Kagaku:Kk スケ−ルアツプ用生物細胞培養装置
US4665690A (en) * 1985-01-14 1987-05-19 Mazda Motor Corporation Exhaust gas cleaning system for vehicle
EP0241736B1 (de) 1986-04-14 1991-06-12 BBC Brown Boveri AG Zündverfahren für einen Thyristorschalter
US4744414A (en) 1986-09-02 1988-05-17 Arco Chemical Company Plastic film plate-type heat exchanger
DE8714819U1 (de) 1987-11-06 1988-01-07 Pall Deutschland GmbH, 6072 Dreieich Kunststoffgehäuse
JPH01254205A (ja) * 1988-04-01 1989-10-11 Asahi Chem Ind Co Ltd ウイルス除去ユニツト
US5121857A (en) 1988-07-16 1992-06-16 Corrugated Products Limited Agitating and dispensing arrangement for bag-in-box containers
JP2502149B2 (ja) 1989-05-12 1996-05-29 日本碍子株式会社 バイオリアクタ―の温度保持方法
JP2903027B2 (ja) 1989-12-27 1999-06-07 コニカ株式会社 化学反応系の温度制御方法及び化学反応液処理装置
US5287918A (en) 1990-06-06 1994-02-22 Rolls-Royce Plc Heat exchangers
JPH04118015A (ja) 1990-09-10 1992-04-20 Fujitsu Ltd 簡易型クリーンルーム
JP3067789B2 (ja) 1990-09-14 2000-07-24 ティーディーケイ株式会社 射出成形装置
FI86961C (fi) 1990-12-14 1994-08-01 Aquamax Oy Vaermevaexlare
US5381510A (en) 1991-03-15 1995-01-10 In-Touch Products Co. In-line fluid heating apparatus with gradation of heat energy from inlet to outlet
US5245693A (en) 1991-03-15 1993-09-14 In-Touch Products Co. Parenteral fluid warmer apparatus and disposable cassette utilizing thin, flexible heat-exchange membrane
JP2550789Y2 (ja) 1991-04-16 1997-10-15 東京濾器株式会社 フレキシブルエアクリーナ
JPH05168463A (ja) * 1991-06-07 1993-07-02 Nippon Sanso Kk 光合成生物を用いた二酸化炭素固定化方法及び装置
US5243833A (en) 1991-11-08 1993-09-14 Instacool Inc. Of North America Device for thawing frozen transfusion material and method therefore
US5267956A (en) * 1992-02-05 1993-12-07 Alcon Surgical, Inc. Surgical cassette
US5271557A (en) * 1992-04-02 1993-12-21 Univar Corporation Methods and systems for gas treatment
US5350513A (en) 1992-07-02 1994-09-27 Calgon Carbon Corporation Flexible-walled absorber
GB9214379D0 (en) 1992-07-07 1992-08-19 Health Lab Service Board Process for culturing cells
US5372621A (en) 1993-06-14 1994-12-13 Emcon, Inc. Condensate trap for vapor extraction system
US5417729A (en) 1993-07-08 1995-05-23 Nfs Radiation Protection Systems Portable modular air cleaning system
US5443985A (en) 1993-07-22 1995-08-22 Alberta Research Council Cell culture bioreactor
US5411077A (en) 1994-04-11 1995-05-02 Minnesota Mining And Manufacturing Company Flexible thermal transfer apparatus for cooling electronic components
JPH0870845A (ja) * 1994-09-02 1996-03-19 Sigma Tec:Kk 培養システムに付設する排出ガスの循環方法とその装 置
FR2735702B1 (fr) 1995-06-22 1997-07-25 Inst Textile De France Dispositif de separation physico-chimique de constituants d'un fluide
JP3579505B2 (ja) 1995-06-23 2004-10-20 リンナイ株式会社 乾燥装置
US5632792A (en) * 1995-08-16 1997-05-27 Purolator Products Company Air induction filter hose assembly
US6003593A (en) 1995-10-31 1999-12-21 Denso International America, Inc. Automotive vehicle climate control system
US6165105A (en) 1996-09-27 2000-12-26 Boutellier; Urs Apparatus and method for training of the respiratory muscles
US5875282A (en) 1996-10-21 1999-02-23 Gaymar Industries, Inc. Medical apparatus for warming patient fluids
GB9702058D0 (en) 1997-01-31 1997-03-19 Smiths Industries Plc Fluid-treatment assemblies
US6083587A (en) 1997-09-22 2000-07-04 Baxter International Inc. Multilayered polymer structure for medical products
EP1052924B1 (en) 1998-01-09 2010-03-24 Royal Appliance Manufacturing Co. Upright vacuum cleaner with cyclonic airflow
US6133021A (en) 1998-02-09 2000-10-17 Kwangju Institute Of Science And Technology Bioreactor system and method for probing toxic materials
JPH11333239A (ja) 1998-05-25 1999-12-07 Sharp Corp 樹脂製熱交換器
US6673098B1 (en) 1998-08-24 2004-01-06 Radiant Medical, Inc. Disposable cassette for intravascular heat exchange catheter
GB9825812D0 (en) * 1998-11-25 1999-01-20 Univ Dundee Method and apparatus for removing particles
US6432698B1 (en) 1999-01-06 2002-08-13 Rutgers, The State University Disposable bioreactor for culturing microorganisms and cells
ATE227143T1 (de) 1999-03-09 2002-11-15 Augustine Medical Inc Vorrichtung zum erwärmen von iv-flüssigkeit mit detektion der anwesenheit und ausrichtung einer kassette
JP4526712B2 (ja) * 1999-04-23 2010-08-18 有限会社筑波バイオシステム 液体培地における担子菌の培養方法
AU782928B2 (en) 1999-05-06 2005-09-08 Universite Laval Scalable bioreactor culture process and system for the maturation of conifer somatic embryos
US6464666B1 (en) 1999-10-08 2002-10-15 Augustine Medical, Inc. Intravenous fluid warming cassette with stiffening member and integral handle
US6391093B1 (en) * 2000-01-24 2002-05-21 Delphi Technologies, Inc. Welding filtration system
EP1123739B1 (en) 2000-02-11 2006-11-29 STMicroelectronics S.r.l. Integrated device for microfluid thermoregulation, and manufacturing process thereof
JP2002003505A (ja) 2000-06-20 2002-01-09 Japan Polychem Corp α−オレフィン重合体の製造方法
US6409785B1 (en) 2000-08-07 2002-06-25 Bha Technologies, Inc. Cleanable HEPA filter media
US6743273B2 (en) 2000-09-05 2004-06-01 Donaldson Company, Inc. Polymer, polymer microfiber, polymer nanofiber and applications including filter structures
US20020131654A1 (en) 2001-03-19 2002-09-19 Smith Sidney T. Large volume flexible container
JP4679818B2 (ja) 2001-07-16 2011-05-11 アイダホ テクノロジー インコーポレーテッド 熱サイクルシステム及びその使用方法
US7722839B2 (en) 2001-10-11 2010-05-25 Cytotherm, L.P. Apparatus and method for thawing biological materials
US20030077466A1 (en) 2001-10-19 2003-04-24 Smith Sidney T. Multilayered polymer structure
US6619054B1 (en) 2002-05-06 2003-09-16 Hydrogenics Corporation Condenser for dehumidifying gas
US7232457B2 (en) 2002-08-08 2007-06-19 Arizant Healthcare Inc. Fluid warming cassette with a tensioning rod
US6837610B2 (en) 2002-09-27 2005-01-04 Ilc Dover Lpp Bioprocess container, bioprocess container mixing device and method of use thereof
US6673598B1 (en) 2002-10-29 2004-01-06 Synthecon, Inc. Disposable culture bag
GB2397303B (en) * 2003-01-17 2007-04-04 Smartmembrane Corp Gas separation membranes
JP2004271031A (ja) 2003-03-07 2004-09-30 Zojirushi Corp 熱交換器の製造方法および該熱交換器を用いた除湿機
US7394976B2 (en) 2003-03-25 2008-07-01 Arizant Healthcare Inc. Fluid warming cassette and system capable of operation under negative pressure
US6882797B2 (en) 2003-03-26 2005-04-19 Gaymar Industries, Inc. Multiple plate fluid warmer unit
US7011797B2 (en) 2003-06-30 2006-03-14 Allan P Bakke Apparatus for thawing frozen biological fluids utilizing heating plates and oscillatory motion to enhance heat transfer by mixing
CN2642387Y (zh) * 2003-09-30 2004-09-22 刘岗 一种气体净化装置
JP2007534335A (ja) 2004-04-27 2007-11-29 バクスター・インターナショナル・インコーポレイテッド 攪拌タンク反応器システム
DE102004026446B4 (de) 2004-05-29 2006-04-20 WWT Technischer Gerätebau GmbH Beutelwärmer für Flüssigkeitswärmebeutel
US7629167B2 (en) * 2004-06-04 2009-12-08 Xcellerex, Inc. Disposable bioreactor systems and methods
FR2873384B1 (fr) 2004-07-21 2006-10-20 Chr Hansen Sa Sa Procede d'ensemencement direct a partir de ferments concentres congeles et dispositif associe
JP3706626B1 (ja) * 2004-11-08 2005-10-12 学校法人 久留米大学 真空発生装置とそれを使用した医療用吸引システム
US20060196501A1 (en) 2005-03-02 2006-09-07 Hynetics Llc Systems and methods for mixing and sparging solutions and/or suspensions
US7682067B2 (en) 2005-04-22 2010-03-23 Hyclone Laboratories, Inc. Mixing systems and related mixers
US7879599B2 (en) 2005-04-22 2011-02-01 Hyclone Laboratories, Inc. Tube ports and related container systems
US8603805B2 (en) 2005-04-22 2013-12-10 Hyclone Laboratories, Inc. Gas spargers and related container systems
CN101228261A (zh) 2005-05-31 2008-07-23 纳诺罗吉克斯公司 利用来自工业设备的余热的制氢装置
US7478535B2 (en) 2005-06-09 2009-01-20 Turner Jr J Glenn System, and associated method, for recovering water from air
ITMI20051899A1 (it) 2005-10-10 2007-04-11 Cardionova S R L Dispositivo di scambio termico ad uso medicale
US20070199890A1 (en) 2006-02-27 2007-08-30 Agion Technologies, Inc. Antimicrobial activated carbon and use thereof
JP4732187B2 (ja) * 2006-02-27 2011-07-27 株式会社カネカ 自動培養装置
US7487688B2 (en) 2006-03-20 2009-02-10 Hyclone Laboratories, Inc. Sampling ports and related container systems
WO2007134170A2 (en) * 2006-05-10 2007-11-22 Delaware Capital Formation, Inc. Hydrocarbon vapor emission control
JP4146476B2 (ja) 2006-05-26 2008-09-10 シャープ株式会社 生物反応装置
DE202006009493U1 (de) 2006-06-14 2007-07-26 Monolith GmbH Bürosysteme Rollenschneidgerät zum Beschneiden von Blattgut
JP5145335B2 (ja) 2006-06-16 2013-02-13 エクセレレックス インク. 液体を収容するように形成された容器
JP5254226B2 (ja) * 2006-07-14 2013-08-07 エクセレレックス インク. 環境保護用収容システム
US7921577B2 (en) * 2006-09-12 2011-04-12 Victaulic Company Method and apparatus for drying sprinkler piping networks
US20100151558A1 (en) 2006-09-13 2010-06-17 Petroalgae, Llc Tubular Microbial Growth System
US7831318B2 (en) 2006-10-31 2010-11-09 Rockwell Automation Technologies, Inc. Model predictive control of fermentation temperature in biofuel production
US9637714B2 (en) 2006-12-28 2017-05-02 Colorado State University Research Foundation Diffuse light extended surface area water-supported photobioreactor
DE102007005205A1 (de) 2007-01-29 2008-07-31 Fp Sensor Systems Gmbh Messeinrichtung zur Bestimmung der Aktivität eines Fermentationsprozesses
WO2008101127A2 (en) 2007-02-15 2008-08-21 Broadley-James Corporation Bioreactor jacket
KR20160105534A (ko) * 2007-03-20 2016-09-06 도날드슨 컴파니, 인코포레이티드 에어로졸 세퍼레이터 어셈블리; 요소; 및 방법
US7896199B2 (en) 2007-05-01 2011-03-01 Daniel Steven Kaczmarek Portable liquid-dispensing bag
US9109193B2 (en) 2007-07-30 2015-08-18 Ge Healthcare Bio-Sciences Corp. Continuous perfusion bioreactor system
JP4860598B2 (ja) 2007-08-02 2012-01-25 株式会社 ちくま精機 樹脂製凝縮器および生ゴミ処理機
US7955841B2 (en) 2007-08-23 2011-06-07 Akonni Biosystems Temperature control device with a flexible temperature control surface
US20090081742A1 (en) 2007-09-24 2009-03-26 Dunlop Eric H High efficiency separations to recover oil from microalgae
US8297223B2 (en) * 2007-10-02 2012-10-30 Msp Corporation Method and apparatus for particle filtration and enhancing tool performance in film deposition
KR101401521B1 (ko) 2007-11-13 2014-06-03 삼성전자주식회사 진공청소기
US7832922B2 (en) 2007-11-30 2010-11-16 Levitronix Gmbh Mixing apparatus and container for such
JP5613060B2 (ja) 2008-01-18 2014-10-22 アベストン・グリフォード・リミテッド 光バイオリアクター
JP5148718B2 (ja) 2008-01-25 2013-02-20 エクセレレックス インク. 袋体の皴除去及び漏れ検知システム、及び液体収容のための電磁攪拌システム
US20080127832A1 (en) 2008-02-23 2008-06-05 Yuejie Zhang Transparent Foldable Dust Bag
US20090233334A1 (en) 2008-03-11 2009-09-17 Excellgene Sa Cell cultivation and production of recombinant proteins by means of an orbital shake bioreactor system with disposable bags at the 1,500 liter scale
US9340763B2 (en) 2008-03-25 2016-05-17 Ge Healthcare Bio-Sciences Corp. Temperature controlling surfaces and support structures
US20100229296A1 (en) 2008-04-19 2010-09-16 Chen Samuel Self Inflating Pool
US8381780B2 (en) 2008-05-22 2013-02-26 Xcellerex, Inc. Lift and support assemblies and methods for collapsible bag containers of vessels and bioreactors
DE102008025968B4 (de) 2008-05-30 2014-08-21 Sartorius Stedim Biotech Gmbh Bioreaktor mit Kondensator
DE102008027638A1 (de) 2008-06-06 2009-12-10 Sann, Heiner, Dr. Disposable Vorrichtung und Verfahren zur Abluftkühlung, Luftfeuchtereduzierung und Schaumreduzierung
US9675225B2 (en) 2008-07-04 2017-06-13 Emerson Electric Co. Filter cage for wet/dry vacuums
CN201276562Y (zh) 2008-10-22 2009-07-22 方民 一种尾气回用好氧生物发酵罐
DE102009003972B4 (de) 2009-01-07 2011-04-28 Sartorius Stedim Biotech Gmbh Abgassystem für Bioreaktoren
US8308944B2 (en) 2009-03-20 2012-11-13 Algal Scientific Corporation System and method for treating wastewater via phototactic heterotrophic microorganism growth
US9376656B2 (en) 2009-03-30 2016-06-28 Brad W. Bartilson Photobioreactor system and method for the growth of algae for biofuels and related products
CN201396935Y (zh) 2009-03-31 2010-02-03 北京天和瑞生物科技有限公司 一种加热系统
WO2011041508A1 (en) 2009-09-30 2011-04-07 Xcellerex, Inc. Disposable bioreactor condenser bag and filter heater
IN2012DN05207A (enExample) 2009-12-22 2015-10-23 Ge Healthcare Bio Sciences Ab
KR20120101173A (ko) * 2010-01-06 2012-09-12 어드밴스드 테크놀러지 머티리얼즈, 인코포레이티드 가스 제거 및 검출 기능을 갖는 액체 분배 시스템
US8641314B2 (en) 2010-02-01 2014-02-04 Hyclone Laboratories, Inc. Quick coupling for drive shaft
US8506198B2 (en) 2010-02-01 2013-08-13 Hyclone Laboratories, Inc. Self aligning coupling for mixing system
US8455242B2 (en) 2010-02-22 2013-06-04 Hyclone Laboratories, Inc. Mixing system with condenser
CA2791488C (en) 2010-03-08 2017-05-23 Arvind Accel Limited Three zone plastic heat exchange element
US8960486B2 (en) 2010-06-16 2015-02-24 Life Technologies Corporation Fluid mixing system with hangers
US8580113B2 (en) * 2010-08-31 2013-11-12 Zenon Technology Partnership Method for utilizing internally generated biogas for closed membrane system operation
US8608369B2 (en) 2011-01-07 2013-12-17 Hyclone Laboratories, Inc. Methods and systems for heating and mixing fluids
JP5751856B2 (ja) 2011-02-18 2015-07-22 株式会社日立製作所 生体細胞の培養容器、及び培養装置
US8480516B2 (en) 2011-02-23 2013-07-09 Nike, Inc. Methods for encouraging use of greenhouse gas reducing golf balls
US20110198066A1 (en) 2011-04-21 2011-08-18 Nathan Starbard Single use heat exchanger
US9005959B2 (en) 2011-05-01 2015-04-14 Therapeutic Proteins International, LLC Bioreactor exhaust
GB2491623A (en) 2011-06-09 2012-12-12 Alberto Martinez Albalat Multilayer fluid heat exchanger comprising plastic and metal layers
WO2012170878A2 (en) 2011-06-10 2012-12-13 Humacyte, Inc. Apparatuses for tissue and organ production and storage
US9284841B1 (en) 2011-07-14 2016-03-15 Julie C. Vickers Disposable heat exchanger assembly for sterile and aseptic biotechnology and pharmaceutical manufacturing applications
CN202786257U (zh) 2011-08-31 2013-03-13 通用电气健康护理生物科学股份公司 用于生物反应器的排气过滤装置
KR101152862B1 (ko) 2011-09-02 2012-06-12 이종실 음식물쓰레기 처리장치
US9469671B2 (en) * 2011-09-03 2016-10-18 Therapeutic Proteins International, LLC Closed bioreactor
CN106635740B (zh) 2011-09-30 2019-03-15 生命科技股份有限公司 具有膜喷洒器的容器
EP2766467A1 (en) 2011-10-10 2014-08-20 DASGIP Information and Process Technology GmbH Biotechnological apparatus comprising a bioreactor, exhaust gas temperature control device for a bioreactor and a method for treating an exhaust gas stream in a biotechnological apparatus
WO2013063129A1 (en) 2011-10-25 2013-05-02 Hyclone Laboratories, Inc. Fluid mixing systems with adjustable mixing element
GB2496141B (en) 2011-11-01 2017-04-26 Intersurgical Ag Improvements relating to breathing systems
US9656197B2 (en) 2012-11-12 2017-05-23 Pall Corporation Systems and methods for conditioning a filter assembly
KR101421637B1 (ko) * 2013-01-25 2014-07-22 (주)이루자 스퍼터용 불활성 가스 정제 장치
EP3466509B1 (en) 2014-03-21 2021-03-10 Life Technologies Corporation Condenser systems for fluid processing systems
CN106232219B (zh) 2014-03-21 2020-04-24 生命科技股份有限公司 用于流体处理系统的气体过滤器系统
US9346754B2 (en) * 2014-05-08 2016-05-24 Medicinova, Inc. Method of treating advanced non-alcoholic steatohepatitis
US9457306B2 (en) * 2014-10-07 2016-10-04 Life Technologies Corporation Regulated vacuum off-gassing of gas filter for fluid processing system and related methods

Also Published As

Publication number Publication date
US20180334648A1 (en) 2018-11-22
BR112017007286A2 (pt) 2017-12-26
KR102744045B1 (ko) 2024-12-19
US11685886B2 (en) 2023-06-27
US12188000B2 (en) 2025-01-07
US20160096131A1 (en) 2016-04-07
US10059916B2 (en) 2018-08-28
JP7123104B2 (ja) 2022-08-22
US9457306B2 (en) 2016-10-04
RU2017115935A (ru) 2018-11-13
RU2017115935A3 (enExample) 2019-08-12
EP3204485B1 (en) 2020-11-25
CN106999798A (zh) 2017-08-01
US10822582B2 (en) 2020-11-03
EP3204485A1 (en) 2017-08-16
KR20230005421A (ko) 2023-01-09
CN106999798B (zh) 2019-10-08
KR20230111269A (ko) 2023-07-25
EP3800241A1 (en) 2021-04-07
KR20170070102A (ko) 2017-06-21
RU2720197C2 (ru) 2020-04-27
KR102558490B1 (ko) 2023-07-21
WO2016057512A1 (en) 2016-04-14
BR112017007286B1 (pt) 2022-02-01
US20160362653A1 (en) 2016-12-15
US20230279328A1 (en) 2023-09-07
JP2017529869A (ja) 2017-10-12
JP2021010911A (ja) 2021-02-04
US20210040432A1 (en) 2021-02-11
KR102483219B1 (ko) 2023-01-02

Similar Documents

Publication Publication Date Title
JP6820840B2 (ja) 流体処理システム用ガスフィルタの制御された真空脱ガス及び関連する方法
US12076681B2 (en) Methods for gas filtration in fluid processing systems
US12285713B2 (en) Condenser bag for processing a fluid
HK40049404A (en) Regulated vacuum off-gassing of gas filter for fluid processing system and related methods

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180530

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20180530

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20190625

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190925

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20191029

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20200129

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200330

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20200609

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20201009

C60 Trial request (containing other claim documents, opposition documents)

Free format text: JAPANESE INTERMEDIATE CODE: C60

Effective date: 20201009

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20201019

C21 Notice of transfer of a case for reconsideration by examiners before appeal proceedings

Free format text: JAPANESE INTERMEDIATE CODE: C21

Effective date: 20201020

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20201208

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20210105

R150 Certificate of patent or registration of utility model

Ref document number: 6820840

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250