JP6757255B2 - プログラム可能な核酸プローブを用いた高スループット及び高度多重化イメージング - Google Patents

プログラム可能な核酸プローブを用いた高スループット及び高度多重化イメージング Download PDF

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JP6757255B2
JP6757255B2 JP2016551812A JP2016551812A JP6757255B2 JP 6757255 B2 JP6757255 B2 JP 6757255B2 JP 2016551812 A JP2016551812 A JP 2016551812A JP 2016551812 A JP2016551812 A JP 2016551812A JP 6757255 B2 JP6757255 B2 JP 6757255B2
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nucleic acid
imager
chain
docking
labeled imager
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JP2017509872A (ja
JP2017509872A5 (ru
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イン，ペン
アガスティ，サリット
チェン，シ
ユングマン，ラルフ
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Harvard College
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804—Nucleic acid analysis using immunogens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
    • C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
    • C12Q2537/143—Multiplexing, i.e. use of multiple primers or probes in a single reaction, usually for simultaneously analyse of multiple analysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/179—Nucleic acid detection characterized by the use of physical, structural and functional properties the label being a nucleic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/601—Detection means characterised by use of a special device being a microscope, e.g. atomic force microscopy [AFM]
JP2016551812A 2014-03-11 2015-03-11 プログラム可能な核酸プローブを用いた高スループット及び高度多重化イメージング Active JP6757255B2 (ja)

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US201461951461P 2014-03-11 2014-03-11
US61/951,461 2014-03-11
PCT/US2015/020034 WO2015138653A1 (en) 2014-03-11 2015-03-11 High-throughput and highly multiplexed imaging with programmable nucleic acid probes

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JP2020144012A Division JP7264856B2 (ja) 2014-03-11 2020-08-28 プログラム可能な核酸プローブを用いた高スループット及び高度多重化イメージング

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JP2017509872A JP2017509872A (ja) 2017-04-06
JP2017509872A5 JP2017509872A5 (ru) 2018-04-19
JP6757255B2 true JP6757255B2 (ja) 2020-09-16

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JP2020144012A Active JP7264856B2 (ja) 2014-03-11 2020-08-28 プログラム可能な核酸プローブを用いた高スループット及び高度多重化イメージング
JP2023027120A Pending JP2023067901A (ja) 2014-03-11 2023-02-24 プログラム可能な核酸プローブを用いた高スループット及び高度多重化イメージング

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JP2023027120A Pending JP2023067901A (ja) 2014-03-11 2023-02-24 プログラム可能な核酸プローブを用いた高スループット及び高度多重化イメージング

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US (5) US10294510B2 (ru)
EP (4) EP4245859A3 (ru)
JP (3) JP6757255B2 (ru)
KR (2) KR102382892B1 (ru)
CN (2) CN110004208A (ru)
AU (2) AU2015229406C1 (ru)
BR (1) BR112016018314A2 (ru)
CA (1) CA2932943C (ru)
IL (1) IL246962B (ru)
RU (1) RU2662969C2 (ru)
WO (1) WO2015138653A1 (ru)

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JP2017509872A (ja) 2017-04-06
KR102313982B1 (ko) 2021-10-18
KR20210127799A (ko) 2021-10-22
WO2015138653A1 (en) 2015-09-17
BR112016018314A2 (pt) 2017-10-17
AU2015229406A1 (en) 2016-06-23
US20180216159A1 (en) 2018-08-02
EP4030166B1 (en) 2023-06-28
US20190323061A1 (en) 2019-10-24
JP2023067901A (ja) 2023-05-16
US20160319328A1 (en) 2016-11-03
AU2015229406B2 (en) 2020-07-09
EP3117214A4 (en) 2017-12-20
CA2932943A1 (en) 2015-09-17
CN110004208A (zh) 2019-07-12
JP2020193988A (ja) 2020-12-03
CA2932943C (en) 2023-09-26
KR102382892B1 (ko) 2022-04-08
CN105980855A (zh) 2016-09-28
EP3686599B1 (en) 2022-01-19
US10190151B2 (en) 2019-01-29
AU2020239730A1 (en) 2020-10-15
EP3117214A1 (en) 2017-01-18
US20230027974A1 (en) 2023-01-26
RU2016139490A (ru) 2018-04-11
KR20160130993A (ko) 2016-11-15
US9944972B2 (en) 2018-04-17
EP3117214B1 (en) 2020-05-06
IL246962B (en) 2020-10-29
CN105980855B (zh) 2019-04-09
RU2662969C2 (ru) 2018-07-31
US10294510B2 (en) 2019-05-21
IL246962A0 (en) 2016-09-29
EP3686599A1 (en) 2020-07-29
EP4245859A2 (en) 2023-09-20
JP7264856B2 (ja) 2023-04-25
AU2015229406C1 (en) 2021-01-07
US20170137864A1 (en) 2017-05-18
AU2020239730B2 (en) 2024-01-18
EP4030166A1 (en) 2022-07-20
EP4245859A3 (en) 2023-11-08

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