JP6756435B2 - Ｔｒａｉｌ誘導のためのファーマコフォア - Google Patents

Ｔｒａｉｌ誘導のためのファーマコフォア Download PDF

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JP6756435B2
JP6756435B2 JP2016559887A JP2016559887A JP6756435B2 JP 6756435 B2 JP6756435 B2 JP 6756435B2 JP 2016559887 A JP2016559887 A JP 2016559887A JP 2016559887 A JP2016559887 A JP 2016559887A JP 6756435 B2 JP6756435 B2 JP 6756435B2
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compound
cancer
alkyl
cell
derived
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JP2017511321A (ja
JP2017511321A5 (OSRAM
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キム ディー． ヤンダ
キム ディー． ヤンダ
ニコラス ティー． ジェイコブ
ニコラス ティー． ジェイコブ
ジョナサン ダブリュ． ロックナー
ジョナサン ダブリュ． ロックナー
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ザ スクリプス リサーチ インスティテュート
ザ スクリプス リサーチ インスティテュート
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2016559887A 2014-03-31 2015-03-30 Ｔｒａｉｌ誘導のためのファーマコフォア Active JP6756435B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461972689P 2014-03-31 2014-03-31
US61/972,689 2014-03-31
PCT/US2015/023362 WO2015153468A1 (en) 2014-03-31 2015-03-30 Pharmacophore for trail induction

Related Child Applications (1)

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JP2019164086A Division JP6873201B2 (ja) 2014-03-31 2019-09-10 Ｔｒａｉｌ誘導のためのファーマコフォア

Publications (3)

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JP2017511321A JP2017511321A (ja) 2017-04-20
JP2017511321A5 JP2017511321A5 (OSRAM) 2018-05-10
JP6756435B2 true JP6756435B2 (ja) 2020-09-16

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JP2016559887A Active JP6756435B2 (ja) 2014-03-31 2015-03-30 Ｔｒａｉｌ誘導のためのファーマコフォア
JP2019164086A Active JP6873201B2 (ja) 2014-03-31 2019-09-10 Ｔｒａｉｌ誘導のためのファーマコフォア
JP2021071035A Active JP7186256B2 (ja) 2014-03-31 2021-04-20 Ｔｒａｉｌ誘導のためのファーマコフォア
JP2022188821A Active JP7688245B2 (ja) 2014-03-31 2022-11-28 Ｔｒａｉｌ誘導のためのファーマコフォア

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JP2019164086A Active JP6873201B2 (ja) 2014-03-31 2019-09-10 Ｔｒａｉｌ誘導のためのファーマコフォア
JP2021071035A Active JP7186256B2 (ja) 2014-03-31 2021-04-20 Ｔｒａｉｌ誘導のためのファーマコフォア
JP2022188821A Active JP7688245B2 (ja) 2014-03-31 2022-11-28 Ｔｒａｉｌ誘導のためのファーマコフォア

Country Status (20)

Country Link
US (5) US10239877B2 (OSRAM)
EP (3) EP3662910B1 (OSRAM)
JP (4) JP6756435B2 (OSRAM)
KR (2) KR102473930B1 (OSRAM)
CN (2) CN106456643B (OSRAM)
AU (4) AU2015241069B2 (OSRAM)
CA (2) CA3158795A1 (OSRAM)
CY (1) CY1123093T1 (OSRAM)
DK (2) DK3125898T3 (OSRAM)
ES (2) ES2779979T3 (OSRAM)
FI (1) FI3662910T3 (OSRAM)
HR (2) HRP20200478T1 (OSRAM)
HU (2) HUE049013T2 (OSRAM)
LT (2) LT3662910T (OSRAM)
PL (2) PL3125898T3 (OSRAM)
PT (2) PT3662910T (OSRAM)
RS (2) RS60163B1 (OSRAM)
SI (2) SI3125898T1 (OSRAM)
SM (2) SMT202000219T1 (OSRAM)
WO (1) WO2015153468A1 (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023022184A (ja) * 2014-03-31 2023-02-14 ザ スクリプス リサーチ インスティテュート Ｔｒａｉｌ誘導のためのファーマコフォア

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ES2734568T3 (es) 2013-03-13 2019-12-10 Oncoceutics Inc 7-Bencil-10-(2-metilbencil)-2,6,7,8,9,10-hexahidroimidazo[1,2-a]pirido[4,3-d]pirimidin-5(3H)-ona para su uso en el tratamiento de cáncer
US9688679B2 (en) 2013-03-13 2017-06-27 Oncoceutics, Inc. 7-benzyl-4-(methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-A]pyrido[3,4-E]pyrimidin-5 (1H)-one, salts thereof and methods of using the same in combination therapy
US9376437B2 (en) 2013-03-13 2016-06-28 Oncoceutics, Inc 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, salts thereof and methods of using the same in combination therapy
CN106163524B (zh) * 2013-11-15 2019-11-08 昂克希尔迪克斯有限公司 7-苄基-4-(2-甲基苄基)-2,4,6,7,8,9-六氢咪唑并[1,2-a]吡啶并[3,4-e]嘧啶-5(1H)-酮、其盐及应用方法
JP6802172B2 (ja) * 2015-01-30 2020-12-16 オンコシューティクス インコーポレイテッドＯｎｃｏｃｅｕｔｉｃｓ，Ｉｎｃ． ７−ベンジル−４−（２−メチルベンジル）−２，４，６，７，８，９−ヘキサヒドロイミダゾ［１，２−ａ］ピリド［３，４−ｅ］ピリミジン−５（１ｈ）−オン、その類似体、およびこれらの塩ならびに治療におけるこれらの使用方法
CN104860948B (zh) * 2015-05-15 2017-09-26 南京盖特医药技术有限公司 咪唑并嘧啶酮类化合物及其制备方法和应用
BR112018015590A2 (pt) * 2016-01-29 2019-10-01 Oncoceutics Inc modulação de receptor acoplado à proteína g (gpcr) por imipridonas
EP3496724B8 (en) 2016-08-12 2021-11-17 Madera Therapeutics, LLC Protein kinase regulators
US10172862B2 (en) 2017-01-30 2019-01-08 Oncoceutics, Inc. Imipridones for gliomas
GB2596010B (en) * 2019-02-11 2023-03-01 Madera Therapeutics Llc Use of caseinolytic protease P function as a biomarker of drug response to imipridone-like agents
WO2020176654A1 (en) 2019-02-27 2020-09-03 Madera Therapeutics, LLC Use of caseinolytic protease p function as a biomarker of drug response to imipridone-like agents
WO2022029459A1 (en) 2020-08-06 2022-02-10 Eötvös Loránd Tudományegyetem Synthesis of novel imipridone derivatives and their evaluation for their anticancer activity
CN115448921B (zh) * 2021-06-08 2023-08-01 四川大学 一类咪唑烷并嘧啶酮化合物及在治疗HsClpP介导的疾病中的用途
CN116751199B (zh) * 2023-06-02 2025-03-18 中国科学院基础医学与肿瘤研究所(筹) 一种线粒体蛋白酶靶向嵌合体、制备方法及用途

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BE786028A (fr) * 1971-07-08 1973-01-08 Boehringer Sohn Ingelheim 2,3-dihydro-oxo-imidazo(1,2-a)-pyrimidines, leurs sels d'addition avec des acides et procedes pour les fabriquer
DE2150062A1 (de) 1971-10-07 1973-04-12 Boehringer Sohn Ingelheim Imidazo- eckige klammer auf 1,2-a eckige klammer zu -pyrido- eckige klammer auf 4,3-d eckige klammer zu -pyrimidine, deren saeureadditionssalze und verfahren zu deren herstellung
JPS5374893A (en) 1976-12-15 1978-07-03 Fujitsu Ltd Driving method for semiconductor photosensitive device
JPS6132833U (ja) 1984-07-31 1986-02-27 日信工業株式会社 デイスクブレ−キ装置
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ES2665293T3 (es) * 2008-06-09 2018-04-25 Allergan, Inc. Compuesto para tratar estados con mediación alfa-adrenérgica
EP2557923A4 (en) 2010-04-16 2013-10-23 Curis Inc TREATMENT OF CANCER DISORDERS WITH K-RAS MUTATIONS
WO2012078448A1 (en) * 2010-12-06 2012-06-14 Schering Corporation Tricyclic heterocycles useful as dipeptidyl peptidase-iv inhibitors
AU2012228334B2 (en) * 2011-03-15 2017-03-23 Chiesi Farmaceutici S.P.A. Isoxazolidine derivatives
AU2012240246A1 (en) 2011-04-04 2013-05-09 Netherlands Cancer Institute Methods and compositions for predicting resistance to anticancer treatment with protein kinase inhibitors
RS65813B1 (sr) 2011-04-29 2024-08-30 Penn State Res Found Indukcija malog molekula trail genom u normalnim i tumorskim ćelijama kao antikancerska terapija
WO2015073072A1 (en) * 2013-11-15 2015-05-21 Oncoceutics, Inc. 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one
US9376437B2 (en) * 2013-03-13 2016-06-28 Oncoceutics, Inc 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, salts thereof and methods of using the same in combination therapy
ES2734568T3 (es) * 2013-03-13 2019-12-10 Oncoceutics Inc 7-Bencil-10-(2-metilbencil)-2,6,7,8,9,10-hexahidroimidazo[1,2-a]pirido[4,3-d]pirimidin-5(3H)-ona para su uso en el tratamiento de cáncer
US9688679B2 (en) 2013-03-13 2017-06-27 Oncoceutics, Inc. 7-benzyl-4-(methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-A]pyrido[3,4-E]pyrimidin-5 (1H)-one, salts thereof and methods of using the same in combination therapy
US9181237B2 (en) * 2013-10-04 2015-11-10 Mallinckrodt Llc Substituted berbines and their synthesis
EP3662910B1 (en) 2014-03-31 2024-09-18 The Scripps Research Institute Pharmacophore for trail induction

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023022184A (ja) * 2014-03-31 2023-02-14 ザ スクリプス リサーチ インスティテュート Ｔｒａｉｌ誘導のためのファーマコフォア
JP7688245B2 (ja) 2014-03-31 2025-06-04 ザ スクリプス リサーチ インスティテュート Ｔｒａｉｌ誘導のためのファーマコフォア

Also Published As

Publication number Publication date
ES2999685T3 (en) 2025-02-26
KR102611067B1 (ko) 2023-12-06
HUE049013T2 (hu) 2020-08-28
EP3662910A1 (en) 2020-06-10
EP3125898A1 (en) 2017-02-08
US20240190877A1 (en) 2024-06-13
US20220002300A1 (en) 2022-01-06
AU2020286314A1 (en) 2021-01-21
AU2015241069A1 (en) 2016-10-20
JP7186256B2 (ja) 2022-12-08
JP2023022184A (ja) 2023-02-14
WO2015153468A1 (en) 2015-10-08
EP3125898A4 (en) 2017-08-16
SI3125898T1 (sl) 2020-07-31
PT3125898T (pt) 2020-04-01
EP3662910B1 (en) 2024-09-18
RS66254B1 (sr) 2024-12-31
PL3125898T3 (pl) 2020-11-16
LT3662910T (lt) 2024-12-27
US10239877B2 (en) 2019-03-26
PL3662910T3 (pl) 2025-08-11
AU2024204977A1 (en) 2024-08-08
JP2017511321A (ja) 2017-04-20
CN106456643A (zh) 2017-02-22
CN106456643B (zh) 2020-04-17
EP3125898B1 (en) 2019-12-25
JP7688245B2 (ja) 2025-06-04
DK3125898T3 (da) 2020-03-30
CA2944452A1 (en) 2015-10-08
KR20160138513A (ko) 2016-12-05
US10633385B2 (en) 2020-04-28
CA2944452C (en) 2022-07-19
CY1123093T1 (el) 2021-10-29
EP4470617A3 (en) 2025-02-26
JP6873201B2 (ja) 2021-05-19
EP4470617A2 (en) 2024-12-04
HUE069651T2 (hu) 2025-03-28
LT3125898T (lt) 2020-04-10
JP2020002170A (ja) 2020-01-09
DK3662910T3 (en) 2024-11-04
HRP20241680T1 (hr) 2025-02-28
US11891392B2 (en) 2024-02-06
KR102473930B1 (ko) 2022-12-05
SMT202000219T1 (it) 2020-05-08
AU2022283729A1 (en) 2023-02-02
FI3662910T3 (fi) 2024-10-31
US20170107221A1 (en) 2017-04-20
KR20220163533A (ko) 2022-12-09
HRP20200478T1 (hr) 2020-07-24
PT3662910T (pt) 2024-11-27
SI3662910T1 (sl) 2025-05-30
CA3158795A1 (en) 2015-10-08
US20190284188A1 (en) 2019-09-19
JP2021119157A (ja) 2021-08-12
CN111499636A (zh) 2020-08-07
US20200283440A1 (en) 2020-09-10
RS60163B1 (sr) 2020-05-29
AU2015241069B2 (en) 2020-10-15
CN111499636B (zh) 2023-01-13
SMT202400497T1 (it) 2025-01-14
ES2779979T3 (es) 2020-08-21

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