CN106456643B - 用于trail诱导的药效团 - Google Patents

用于trail诱导的药效团 Download PDF

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Publication number
CN106456643B
CN106456643B CN201580021658.3A CN201580021658A CN106456643B CN 106456643 B CN106456643 B CN 106456643B CN 201580021658 A CN201580021658 A CN 201580021658A CN 106456643 B CN106456643 B CN 106456643B
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compound
cancer
trail
cell derived
compounds
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Chinese (zh)
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CN106456643A (zh
Inventor
基姆·D·扬达
尼古拉斯·T·雅各布
乔纳森·W·洛克纳
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Scripps Research Institute
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Scripps Research Institute
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201580021658.3A 2014-03-31 2015-03-30 用于trail诱导的药效团 Active CN106456643B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202010184181.3A CN111499636B (zh) 2014-03-31 2015-03-30 用于trail诱导的药效团

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461972689P 2014-03-31 2014-03-31
US61/972,689 2014-03-31
PCT/US2015/023362 WO2015153468A1 (en) 2014-03-31 2015-03-30 Pharmacophore for trail induction

Related Child Applications (1)

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CN202010184181.3A Division CN111499636B (zh) 2014-03-31 2015-03-30 用于trail诱导的药效团

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CN106456643A CN106456643A (zh) 2017-02-22
CN106456643B true CN106456643B (zh) 2020-04-17

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CN202010184181.3A Active CN111499636B (zh) 2014-03-31 2015-03-30 用于trail诱导的药效团

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US (5) US10239877B2 (OSRAM)
EP (3) EP4470617A3 (OSRAM)
JP (4) JP6756435B2 (OSRAM)
KR (2) KR102473930B1 (OSRAM)
CN (2) CN106456643B (OSRAM)
AU (4) AU2015241069B2 (OSRAM)
CA (2) CA3158795A1 (OSRAM)
CY (1) CY1123093T1 (OSRAM)
DK (2) DK3125898T3 (OSRAM)
ES (2) ES2999685T3 (OSRAM)
FI (1) FI3662910T3 (OSRAM)
HR (2) HRP20200478T1 (OSRAM)
HU (2) HUE049013T2 (OSRAM)
LT (2) LT3125898T (OSRAM)
PL (2) PL3662910T3 (OSRAM)
PT (2) PT3662910T (OSRAM)
RS (2) RS66254B1 (OSRAM)
SI (2) SI3662910T1 (OSRAM)
SM (2) SMT202400497T1 (OSRAM)
WO (1) WO2015153468A1 (OSRAM)

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US9688679B2 (en) 2013-03-13 2017-06-27 Oncoceutics, Inc. 7-benzyl-4-(methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-A]pyrido[3,4-E]pyrimidin-5 (1H)-one, salts thereof and methods of using the same in combination therapy
BR112015023256A2 (pt) 2013-03-13 2017-07-18 Oncoceutics Inc terapia de combinação com 7-benzil-10-(2-metil-benzil)-2,6,7,8,9,10-hexaidroimidazol[1,2-a]pirido[4,3-d]pirimidin-5(3h)-ona.
US9376437B2 (en) 2013-03-13 2016-06-28 Oncoceutics, Inc 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, salts thereof and methods of using the same in combination therapy
CN106163524B (zh) * 2013-11-15 2019-11-08 昂克希尔迪克斯有限公司 7-苄基-4-(2-甲基苄基)-2,4,6,7,8,9-六氢咪唑并[1,2-a]吡啶并[3,4-e]嘧啶-5(1H)-酮、其盐及应用方法
SMT202400497T1 (it) 2014-03-31 2025-01-14 Scripps Research Inst Farmacoforo per induzione di trail
IL295286B2 (en) * 2015-01-30 2024-10-01 Oncoceutics Inc 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo [1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, analogs thereof, and salts thereof and methods for their use in therapy
CN104860948B (zh) * 2015-05-15 2017-09-26 南京盖特医药技术有限公司 咪唑并嘧啶酮类化合物及其制备方法和应用
EP3408298B1 (en) * 2016-01-29 2024-11-20 Oncoceutics, Inc. G protein-coupled receptor (gpcr) modulation by imipridones
WO2018031987A1 (en) 2016-08-12 2018-02-15 Nanjing Gator Meditech Company, Ltd. Protein kinase regulators
US10172862B2 (en) 2017-01-30 2019-01-08 Oncoceutics, Inc. Imipridones for gliomas
GB2596010B (en) * 2019-02-11 2023-03-01 Madera Therapeutics Llc Use of caseinolytic protease P function as a biomarker of drug response to imipridone-like agents
WO2020176654A1 (en) 2019-02-27 2020-09-03 Madera Therapeutics, LLC Use of caseinolytic protease p function as a biomarker of drug response to imipridone-like agents
KR20230106583A (ko) 2020-08-06 2023-07-13 에오토보스 로란드 투도만예게템 신규한 이미프리돈 유도체의 합성 및 이들의 항암 활성에 대한 평가
CN115448921B (zh) * 2021-06-08 2023-08-01 四川大学 一类咪唑烷并嘧啶酮化合物及在治疗HsClpP介导的疾病中的用途
CN116751199B (zh) * 2023-06-02 2025-03-18 中国科学院基础医学与肿瘤研究所(筹) 一种线粒体蛋白酶靶向嵌合体、制备方法及用途

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CN102970868A (zh) * 2010-04-16 2013-03-13 柯瑞斯公司 具有k-ras突变的癌症的治疗

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US9376437B2 (en) 2013-03-13 2016-06-28 Oncoceutics, Inc 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, salts thereof and methods of using the same in combination therapy
BR112015023256A2 (pt) * 2013-03-13 2017-07-18 Oncoceutics Inc terapia de combinação com 7-benzil-10-(2-metil-benzil)-2,6,7,8,9,10-hexaidroimidazol[1,2-a]pirido[4,3-d]pirimidin-5(3h)-ona.
WO2015073072A1 (en) * 2013-11-15 2015-05-21 Oncoceutics, Inc. 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one
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SMT202400497T1 (it) * 2014-03-31 2025-01-14 Scripps Research Inst Farmacoforo per induzione di trail

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US10633385B2 (en) 2020-04-28
DK3662910T3 (en) 2024-11-04
RS60163B1 (sr) 2020-05-29
RS66254B1 (sr) 2024-12-31
AU2015241069B2 (en) 2020-10-15
AU2015241069A1 (en) 2016-10-20
SI3125898T1 (sl) 2020-07-31
DK3125898T3 (da) 2020-03-30
SMT202400497T1 (it) 2025-01-14
KR20220163533A (ko) 2022-12-09
LT3125898T (lt) 2020-04-10
CN111499636A (zh) 2020-08-07
JP6756435B2 (ja) 2020-09-16
SMT202000219T1 (it) 2020-05-08
JP2021119157A (ja) 2021-08-12
JP7186256B2 (ja) 2022-12-08
HUE069651T2 (hu) 2025-03-28
EP3125898A1 (en) 2017-02-08
PT3662910T (pt) 2024-11-27
EP3125898B1 (en) 2019-12-25
AU2024204977A1 (en) 2024-08-08
PL3662910T3 (pl) 2025-08-11
PL3125898T3 (pl) 2020-11-16
WO2015153468A1 (en) 2015-10-08
ES2999685T3 (en) 2025-02-26
EP3125898A4 (en) 2017-08-16
EP3662910B1 (en) 2024-09-18
KR20160138513A (ko) 2016-12-05
HRP20241680T1 (hr) 2025-02-28
EP3662910A1 (en) 2020-06-10
US20220002300A1 (en) 2022-01-06
FI3662910T3 (fi) 2024-10-31
JP2017511321A (ja) 2017-04-20
AU2022283729A1 (en) 2023-02-02
US11891392B2 (en) 2024-02-06
JP2023022184A (ja) 2023-02-14
CA3158795A1 (en) 2015-10-08
JP6873201B2 (ja) 2021-05-19
KR102473930B1 (ko) 2022-12-05
JP7688245B2 (ja) 2025-06-04
JP2020002170A (ja) 2020-01-09
LT3662910T (lt) 2024-12-27
HRP20200478T1 (hr) 2020-07-24
CY1123093T1 (el) 2021-10-29
CA2944452C (en) 2022-07-19
US10239877B2 (en) 2019-03-26
US20170107221A1 (en) 2017-04-20
SI3662910T1 (sl) 2025-05-30
HUE049013T2 (hu) 2020-08-28
KR102611067B1 (ko) 2023-12-06
ES2779979T3 (es) 2020-08-21
CN111499636B (zh) 2023-01-13
US20190284188A1 (en) 2019-09-19
CA2944452A1 (en) 2015-10-08
CN106456643A (zh) 2017-02-22
US20240190877A1 (en) 2024-06-13
EP4470617A2 (en) 2024-12-04
PT3125898T (pt) 2020-04-01
EP4470617A3 (en) 2025-02-26
US20200283440A1 (en) 2020-09-10
AU2020286314A1 (en) 2021-01-21

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Application publication date: 20170222

Assignee: CHINA RESOURCES SANJIU MEDICAL & PHARMACEUTICAL Co.,Ltd.

Assignor: ONCOCEUTICS, Inc.

Contract record no.: X2021990000006

Denomination of invention: Pharmacophores for trail induction

Granted publication date: 20200417

License type: Exclusive License

Record date: 20210105

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