GB2596010B - Use of caseinolytic protease P function as a biomarker of drug response to imipridone-like agents - Google Patents

Use of caseinolytic protease P function as a biomarker of drug response to imipridone-like agents Download PDF

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Publication number
GB2596010B
GB2596010B GB2113038.0A GB202113038A GB2596010B GB 2596010 B GB2596010 B GB 2596010B GB 202113038 A GB202113038 A GB 202113038A GB 2596010 B GB2596010 B GB 2596010B
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United Kingdom
Prior art keywords
imipridone
biomarker
agents
function
drug response
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
GB2113038.0A
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GB2596010A (en
GB202113038D0 (en
Inventor
Iwanowicz Edwin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Madera Therapeutics LLC
Original Assignee
Madera Therapeutics LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Madera Therapeutics LLC filed Critical Madera Therapeutics LLC
Priority claimed from PCT/US2020/019944 external-priority patent/WO2020176654A1/en
Publication of GB202113038D0 publication Critical patent/GB202113038D0/en
Publication of GB2596010A publication Critical patent/GB2596010A/en
Application granted granted Critical
Publication of GB2596010B publication Critical patent/GB2596010B/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB2113038.0A 2019-02-11 2020-02-26 Use of caseinolytic protease P function as a biomarker of drug response to imipridone-like agents Active GB2596010B (en)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US201962975088P 2019-02-11 2019-02-11
US201962811432P 2019-02-27 2019-02-27
US201962819204P 2019-03-15 2019-03-15
US201962825667P 2019-03-28 2019-03-28
US201962840254P 2019-04-29 2019-04-29
US201962871694P 2019-07-08 2019-07-08
US201962885055P 2019-08-09 2019-08-09
US201962901142P 2019-09-16 2019-09-16
US201962931043P 2019-11-05 2019-11-05
PCT/US2020/019944 WO2020176654A1 (en) 2019-02-27 2020-02-26 Use of caseinolytic protease p function as a biomarker of drug response to imipridone-like agents

Publications (3)

Publication Number Publication Date
GB202113038D0 GB202113038D0 (en) 2021-10-27
GB2596010A GB2596010A (en) 2021-12-15
GB2596010B true GB2596010B (en) 2023-03-01

Family

ID=78149387

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2113038.0A Active GB2596010B (en) 2019-02-11 2020-02-26 Use of caseinolytic protease P function as a biomarker of drug response to imipridone-like agents

Country Status (1)

Country Link
GB (1) GB2596010B (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100113487A1 (en) * 2007-04-20 2010-05-06 Craig D Boyle Pyrimidinone derivatives and methods of use thereof
WO2015153468A1 (en) * 2014-03-31 2015-10-08 The Scripps Research Institute Pharmacophore for trail induction
WO2016184437A1 (en) * 2015-05-15 2016-11-24 南京盖特医药技术有限公司 Imidazo-pyrimidone compounds, and preparation method and application thereof
WO2018031987A1 (en) * 2016-08-12 2018-02-15 Nanjing Gator Meditech Company, Ltd. Protein kinase regulators
WO2018031990A1 (en) * 2016-08-12 2018-02-15 Nanjing Gator Meditech Company, Ltd. Protein kinase regulators

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100113487A1 (en) * 2007-04-20 2010-05-06 Craig D Boyle Pyrimidinone derivatives and methods of use thereof
WO2015153468A1 (en) * 2014-03-31 2015-10-08 The Scripps Research Institute Pharmacophore for trail induction
WO2016184437A1 (en) * 2015-05-15 2016-11-24 南京盖特医药技术有限公司 Imidazo-pyrimidone compounds, and preparation method and application thereof
WO2018031987A1 (en) * 2016-08-12 2018-02-15 Nanjing Gator Meditech Company, Ltd. Protein kinase regulators
WO2018031990A1 (en) * 2016-08-12 2018-02-15 Nanjing Gator Meditech Company, Ltd. Protein kinase regulators

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PUBCHEM, Substance Record for SID 90314507, Available Data: 22 February 2010 [retrived on 13 May 2020]. Retrieved from the Internet: <URL: https://pubchem.ncbi.nlm.nih.gov/substance/90314507/version/1>. entire document *

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Publication number Publication date
GB2596010A (en) 2021-12-15
GB202113038D0 (en) 2021-10-27

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