JP6745728B2 - ニコチン塩、共結晶、及び塩共結晶複合体 - Google Patents

ニコチン塩、共結晶、及び塩共結晶複合体 Download PDF

Info

Publication number
JP6745728B2
JP6745728B2 JP2016569810A JP2016569810A JP6745728B2 JP 6745728 B2 JP6745728 B2 JP 6745728B2 JP 2016569810 A JP2016569810 A JP 2016569810A JP 2016569810 A JP2016569810 A JP 2016569810A JP 6745728 B2 JP6745728 B2 JP 6745728B2
Authority
JP
Japan
Prior art keywords
nicotine
salt
acid
salts
crystals
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2016569810A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017523133A (ja
Inventor
ダル，ギャリー・エム
カー，アンドルー
シャープ，エマ
Original Assignee
アール・ジエイ・レイノルズ・タバコ・カンパニー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アール・ジエイ・レイノルズ・タバコ・カンパニー filed Critical アール・ジエイ・レイノルズ・タバコ・カンパニー
Publication of JP2017523133A publication Critical patent/JP2017523133A/ja
Application granted granted Critical
Publication of JP6745728B2 publication Critical patent/JP6745728B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B13/00—Tobacco for pipes, for cigars, e.g. cigar inserts, or for cigarettes; Chewing tobacco; Snuff
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
    • A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
    • A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
    • A24B15/36—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances containing a heterocyclic ring
    • A24B15/38—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances containing a heterocyclic ring having only nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/105—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic
    • C07C65/11—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic with carboxyl groups on a condensed ring system containing two rings
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/10—Devices using liquid inhalable precursors
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/20—Devices using solid inhalable precursors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
    • A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
    • A61M11/042—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters electrical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/06—Inhaling appliances shaped like cigars, cigarettes or pipes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8206—Internal energy supply devices battery-operated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Toxicology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Dermatology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacture Of Tobacco Products (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2016569810A 2014-05-27 2015-05-26 ニコチン塩、共結晶、及び塩共結晶複合体 Active JP6745728B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462003295P 2014-05-27 2014-05-27
US62/003,295 2014-05-27
PCT/US2015/032416 WO2015183801A1 (en) 2014-05-27 2015-05-26 Nicotine salts, co-crystals, and salt co-crystal complexes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020070760A Division JP7168609B2 (ja) 2014-05-27 2020-04-10 ニコチン塩、共結晶、及び塩共結晶複合体

Publications (2)

Publication Number Publication Date
JP2017523133A JP2017523133A (ja) 2017-08-17
JP6745728B2 true JP6745728B2 (ja) 2020-08-26

Family

ID=53284639

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2016569810A Active JP6745728B2 (ja) 2014-05-27 2015-05-26 ニコチン塩、共結晶、及び塩共結晶複合体
JP2020070760A Active JP7168609B2 (ja) 2014-05-27 2020-04-10 ニコチン塩、共結晶、及び塩共結晶複合体
JP2022112935A Pending JP2022160452A (ja) 2014-05-27 2022-07-14 ニコチン塩、共結晶、及び塩共結晶複合体
JP2024107228A Pending JP2024156667A (ja) 2014-05-27 2024-07-03 ニコチン塩、共結晶、及び塩共結晶複合体

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2020070760A Active JP7168609B2 (ja) 2014-05-27 2020-04-10 ニコチン塩、共結晶、及び塩共結晶複合体
JP2022112935A Pending JP2022160452A (ja) 2014-05-27 2022-07-14 ニコチン塩、共結晶、及び塩共結晶複合体
JP2024107228A Pending JP2024156667A (ja) 2014-05-27 2024-07-03 ニコチン塩、共結晶、及び塩共結晶複合体

Country Status (6)

Country Link
US (5) US9738622B2 (enExample)
EP (3) EP3871515B1 (enExample)
JP (4) JP6745728B2 (enExample)
CN (3) CN113816940A (enExample)
PL (1) PL3871515T3 (enExample)
WO (1) WO2015183801A1 (enExample)

Families Citing this family (134)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160345631A1 (en) 2005-07-19 2016-12-01 James Monsees Portable devices for generating an inhalable vapor
US10039321B2 (en) 2013-11-12 2018-08-07 Vmr Products Llc Vaporizer
US10076139B2 (en) 2013-12-23 2018-09-18 Juul Labs, Inc. Vaporizer apparatus
GB2560652B8 (en) 2013-12-23 2018-12-19 Juul Labs Uk Holdco Ltd Vaporization device systems and methods
US20160366947A1 (en) 2013-12-23 2016-12-22 James Monsees Vaporizer apparatus
USD842536S1 (en) 2016-07-28 2019-03-05 Juul Labs, Inc. Vaporizer cartridge
US10159282B2 (en) 2013-12-23 2018-12-25 Juul Labs, Inc. Cartridge for use with a vaporizer device
US10058129B2 (en) 2013-12-23 2018-08-28 Juul Labs, Inc. Vaporization device systems and methods
USD825102S1 (en) 2016-07-28 2018-08-07 Juul Labs, Inc. Vaporizer device with cartridge
US10508096B2 (en) 2014-05-27 2019-12-17 R.J. Reynolds Tobacco Company Nicotine salts, co-crystals, and salt co-crystal complexes
CN113816940A (zh) 2014-05-27 2021-12-21 R.J.雷诺兹烟草公司 烟碱盐、共晶体和盐共晶体络合物
US9896429B2 (en) 2014-05-27 2018-02-20 R.J. Reynolds Tobacco Company Nicotine salts, co-crystals, and salt co-crystal complexes
EP3226704B1 (en) 2014-12-05 2021-01-20 Juul Labs, Inc. Calibrated dose control
US11224594B2 (en) * 2015-09-16 2022-01-18 Philip Morris Products S.A. Nicotine formulations and methods of making and using the same
CN114656446A (zh) * 2015-11-25 2022-06-24 R.J.雷诺兹烟草公司 烟碱盐、共晶体和盐共晶体配合物
EP3419443A4 (en) 2016-02-11 2019-11-20 Juul Labs, Inc. SAFE MOUNTING OF CARTRIDGES FOR EVAPORATOR DEVICES
FR3047641B1 (fr) * 2016-02-12 2021-10-29 Laboratoires Ceres Formulation comprenant un support d'aerosolisation et de la nicotine r
US10405582B2 (en) 2016-03-10 2019-09-10 Pax Labs, Inc. Vaporization device with lip sensing
US10329068B2 (en) 2016-05-23 2019-06-25 R.J. Reynolds Tobacco Company Flavoring mechanism for a tobacco related material
JP6839181B2 (ja) * 2016-05-27 2021-03-03 日本たばこ産業株式会社 非燃焼型加熱喫煙物品用のたばこ充填物
CA3025623C (en) 2016-05-27 2020-11-17 Japan Tobacco Inc. Tobacco filling for non-combustion-type heating smoking article
ES2936094T3 (es) 2016-06-13 2023-03-14 Syneurx Int Taiwan Corp Cocristales de benzoato de sodio y usos de los mismos
USD849996S1 (en) 2016-06-16 2019-05-28 Pax Labs, Inc. Vaporizer cartridge
USD836541S1 (en) 2016-06-23 2018-12-25 Pax Labs, Inc. Charging device
USD851830S1 (en) 2016-06-23 2019-06-18 Pax Labs, Inc. Combined vaporizer tamp and pick tool
US10080387B2 (en) 2016-09-23 2018-09-25 Rai Strategic Holdings, Inc. Aerosol delivery device with replaceable wick and heater assembly
PL3562330T3 (pl) 2016-12-30 2025-03-31 Philip Morris Products S.A. Sposób wytwarzania arkusza zawierającego nikotynę
GB201706778D0 (en) * 2017-04-28 2017-06-14 British American Tobacco Investments Ltd Method
US10779576B2 (en) 2017-05-24 2020-09-22 VMR Products, LLC Flavor disk
EP3644771A4 (en) * 2017-06-26 2021-11-17 Nude Nicotine, Inc. NICOTINE SALT AND METHOD FOR MANUFACTURING AND USING THEREOF
US10575562B2 (en) 2017-06-30 2020-03-03 Rai Strategic Holdings, Inc. Smoking article for identifying an attribute of an aerosol-generating element for adaptive power output and an associated method
WO2019049049A1 (en) * 2017-09-05 2019-03-14 R. J. Reynolds Tobacco Company SALTS, CO-CRYSTALS, AND CO-CRYSTAL COMPLEXES OF NICOTINE SALTS
USD887632S1 (en) 2017-09-14 2020-06-16 Pax Labs, Inc. Vaporizer cartridge
US10667554B2 (en) 2017-09-18 2020-06-02 Rai Strategic Holdings, Inc. Smoking articles
US20200268026A1 (en) * 2017-10-06 2020-08-27 Cargill, Incorporated Steviol glycoside solubility enhancers
WO2019071182A1 (en) 2017-10-06 2019-04-11 Cargill, Incorporated STEVIOL GLYCOSIDE SOLUBILITY AMPLIFIERS
US12114688B2 (en) 2017-10-24 2024-10-15 Rai Strategic Holdings, Inc. Method for formulating aerosol precursor for aerosol delivery device
GB2569365A (en) * 2017-12-15 2019-06-19 Nerudia Ltd A substitute smoking consumable
US12349725B2 (en) 2017-12-15 2025-07-08 Imperial Tobacco Limited Substitute smoking consumable
GB2569367A (en) * 2017-12-15 2019-06-19 Nerudia Ltd A substitute smoking consumable
GB2569363A (en) * 2017-12-15 2019-06-19 Nerudia Ltd A substitute smoking consumable
GB2569368A (en) * 2017-12-15 2019-06-19 Nerudia Ltd A substitute smoking consumable
CN108285441A (zh) * 2018-01-03 2018-07-17 云南中烟工业有限责任公司 一种尼古丁-扁桃酸盐复合物晶体、其制备方法及包含其的烟草制品
CN108329296A (zh) * 2018-01-03 2018-07-27 云南中烟工业有限责任公司 一种尼古丁-酒石酸盐复合物晶体、其制备方法及包含其的烟草制品
CN108323792B (zh) * 2018-01-03 2021-05-07 云南中烟工业有限责任公司 一种尼古丁-龙胆酸盐复合物晶体、其制备方法及包含其的烟草制品
CN108323791B (zh) * 2018-01-03 2021-02-12 云南中烟工业有限责任公司 一种尼古丁-氧化锌复合物、其制备方法及包含其的烟草制品
US11388924B2 (en) * 2018-02-02 2022-07-19 10150703 Canada Inc. Nicotine ion pair formulation neutralized with CO2 and process therefor
JP6371928B1 (ja) * 2018-02-23 2018-08-08 株式会社 東亜産業 電子タバコ用充填物およびそれを用いた電子タバコカートリッジ
US11191298B2 (en) 2018-06-22 2021-12-07 Rai Strategic Holdings, Inc. Aerosol source member having combined susceptor and aerosol precursor material
US11723399B2 (en) 2018-07-13 2023-08-15 R.J. Reynolds Tobacco Company Smoking article with detachable cartridge
US10897925B2 (en) 2018-07-27 2021-01-26 Joseph Pandolfino Articles and formulations for smoking products and vaporizers
CN108774211A (zh) * 2018-08-24 2018-11-09 云南中烟工业有限责任公司 一种尼古丁共晶、其制备方法及用途
US11413409B2 (en) 2018-09-12 2022-08-16 Juul Labs, Inc. Vaporizer including positive temperature coefficient of resistivity (PTCR) heating element
US20200093181A1 (en) 2018-09-20 2020-03-26 Rai Strategic Holdings, Inc. Flavorants
US11247005B2 (en) 2018-09-26 2022-02-15 Rai Strategic Holdings, Inc. Aerosol delivery device with conductive inserts
CN109288115A (zh) * 2018-10-16 2019-02-01 云南拓宝科技有限公司 一种无溶剂法制备的烟碱盐及其制备方法
GB201817861D0 (en) * 2018-11-01 2018-12-19 Nicoventures Trading Ltd Gel and crystalline powder
US20200154785A1 (en) 2018-11-20 2020-05-21 R.J. Reynolds Tobacco Company Overwrap material containing aerosol former for aerosol source member
US20200237018A1 (en) 2019-01-29 2020-07-30 Rai Strategic Holdings, Inc. Susceptor arrangement for induction-heated aerosol delivery device
EP3714876A1 (de) * 2019-03-29 2020-09-30 VitaSalts AG Verdampfungszusammensetzungen zum inhalieren
EP3714873A1 (de) * 2019-03-29 2020-09-30 VitaSalts AG Basisflüssigkeit für verdampfungszusammensetzungen zum inhalieren
CA3135185A1 (en) 2019-04-06 2020-10-15 Cargill, Incorporated Sensory modifiers
WO2021126313A1 (en) * 2019-07-15 2021-06-24 The Research Foundation For The State University Of New York Nicotine materials, methods of making same, and uses thereof
US12075819B2 (en) 2019-07-18 2024-09-03 R.J. Reynolds Tobacco Company Aerosol delivery device with consumable cartridge
US11330838B2 (en) 2019-07-19 2022-05-17 R. J. Reynolds Tobacco Company Holder for aerosol delivery device with detachable cartridge
US11395510B2 (en) 2019-07-19 2022-07-26 R.J. Reynolds Tobacco Company Aerosol delivery device with rotatable enclosure for cartridge
US12082607B2 (en) 2019-07-19 2024-09-10 R.J. Reynolds Tobacco Company Aerosol delivery device with clamshell holder for cartridge
US20210015177A1 (en) 2019-07-19 2021-01-21 R.J. Reynolds Tobacco Company Aerosol delivery device with separable heat source and substrate
US12232542B2 (en) 2019-07-19 2025-02-25 R.J. Reynolds Tobacco Company Aerosol delivery device with sliding sleeve
CN110447948A (zh) * 2019-08-20 2019-11-15 深圳多客技术有限公司 电子烟液、其制备方法及制备尼古丁盐、电子烟的新型酸
CN110483479A (zh) * 2019-09-05 2019-11-22 深圳市真味生物科技有限公司 高稳定性尼古丁盐、其制备方法及电子烟油
US12213510B2 (en) * 2019-09-11 2025-02-04 Nicoventures Trading Limited Pouched products with enhanced flavor stability
US20220071984A1 (en) * 2019-09-11 2022-03-10 Nicoventures Trading Limited Oral product with nicotine and ion pairing agent
MX2022002859A (es) 2019-09-12 2022-11-03 Cabbacis Llc Articulos y formulaciones para vaporizadores y productos para fumar.
CN110590741A (zh) * 2019-10-10 2019-12-20 云南中烟工业有限责任公司 一种烟碱-苹果酸复合晶体及其制备方法与应用
CN111084410A (zh) * 2019-11-22 2020-05-01 云南中烟工业有限责任公司 一种尼古丁-草酸盐复合物晶体的制备方法及应用
CN111072629A (zh) * 2019-11-22 2020-04-28 云南中烟工业有限责任公司 一种尼古丁-草酸盐复合物晶体及其应用
US12491250B2 (en) 2019-12-09 2025-12-09 Nicoventures Trading Limited Oral composition with nanocrystalline cellulose
JP2023505352A (ja) 2019-12-09 2023-02-08 ニコベンチャーズ トレーディング リミテッド 方法
WO2021116895A2 (en) 2019-12-09 2021-06-17 Nicoventures Trading Limited Stimulus-responsive pouch
PH12022551258A1 (en) 2019-12-09 2023-11-20 Nicoventures Trading Ltd Nanoemulsion for oral use
WO2021116823A1 (en) 2019-12-09 2021-06-17 Nicoventures Trading Limited Oral product
WO2021116824A1 (en) 2019-12-09 2021-06-17 Nicoventures Trading Limited Oral product comprising a cannabinoid
WO2021116825A1 (en) 2019-12-09 2021-06-17 Nicoventures Trading Limited Oral product
US20210204593A1 (en) 2020-01-02 2021-07-08 R.J. Reynolds Tobacco Company Smoking article with downstream flavor addition
US11607511B2 (en) 2020-01-08 2023-03-21 Nicoventures Trading Limited Inductively-heated substrate tablet for aerosol delivery device
US11457665B2 (en) 2020-01-16 2022-10-04 Nicoventures Trading Limited Susceptor arrangement for an inductively-heated aerosol delivery device
US11589616B2 (en) 2020-04-29 2023-02-28 R.J. Reynolds Tobacco Company Aerosol delivery device with sliding and axially rotating locking mechanism
US11439185B2 (en) 2020-04-29 2022-09-13 R. J. Reynolds Tobacco Company Aerosol delivery device with sliding and transversely rotating locking mechanism
CN111393410B (zh) * 2020-04-30 2023-09-01 云南中烟工业有限责任公司 一种尼古丁-3,5-二羟基苯甲酸盐的制备方法及其在电子烟中的应用
CN111528516A (zh) * 2020-04-30 2020-08-14 云南中烟工业有限责任公司 一种尼古丁-3,5-二羟基苯甲酸盐复合物晶体及其在无烟气烟草制品中的应用
CN111528515A (zh) * 2020-04-30 2020-08-14 云南中烟工业有限责任公司 一种含尼古丁-3,5-二羟基苯甲酸盐的烟草再造烟叶及其应用
US20210345667A1 (en) 2020-05-08 2021-11-11 R. J. Reynolds Tobacco Company Aerosol delivery device
US11533946B2 (en) 2020-06-22 2022-12-27 R. J. Reynolds Tobacco Co. Systems and methods for determining a characteristic of a smoking article
US20220000178A1 (en) 2020-07-01 2022-01-06 Nicoventures Trading Limited 3d-printed substrate for aerosol delivery device
GB202013489D0 (en) 2020-08-27 2020-10-14 Nicoventures Holdings Ltd Consumable
GB202013491D0 (en) 2020-08-27 2020-10-14 Nicoventures Holdings Ltd Oral Product
KR20230068413A (ko) 2020-09-11 2023-05-17 니코벤처스 트레이딩 리미티드 알지네이트-기반 기재
DE102020133733B4 (de) * 2020-12-16 2022-07-07 Hauni Maschinenbau Gmbh Verfahren zur Einstellung des Nikotingehalts in einem E-Zigaretten-Aerosol
CN112979614B (zh) * 2021-02-09 2022-09-13 西北大学 尼古丁—邻苯二甲酸复合晶体、所述复合晶体的制备方法及应用
JP7087136B2 (ja) * 2021-02-10 2022-06-20 日本たばこ産業株式会社 非燃焼型加熱喫煙物品用のたばこ充填物
US12433340B2 (en) 2021-04-02 2025-10-07 R. J. Reynolds Tobacco Company Aerosol delivery device consumable unit
US12426633B2 (en) 2021-04-02 2025-09-30 R. J. Reynolds Tobacco Company Aerosol delivery device with integrated inductive heater
US11825872B2 (en) 2021-04-02 2023-11-28 R.J. Reynolds Tobacco Company Aerosol delivery device with protective sleeve
US12426634B2 (en) 2021-04-02 2025-09-30 R. J. Reynolds Tobacco Company Aerosol delivery device with integrated lighter
US20220313614A1 (en) * 2021-04-06 2022-10-06 Altria Client Services Llc Encapsulated nicotine granules and methods of preparation thereof
CN113087698B (zh) * 2021-04-13 2023-02-24 西北大学 一种尼古丁苯甲酸盐固体的制备方法及抗真菌应用
EP4326097A1 (en) * 2021-04-22 2024-02-28 Nicoventures Trading Limited Oral compositions and methods of manufacture
US20220354785A1 (en) * 2021-04-22 2022-11-10 Nicoventures Trading Limited Oral lozenge products
CN113208149B (zh) * 2021-05-24 2022-11-11 中烟施伟策（云南）再造烟叶有限公司 一种适用于造纸法再造烟叶保香提质的方法
KR20240043140A (ko) 2021-07-15 2024-04-02 레이 스트라티직 홀딩스, 인크. 무화기없는 소모품을 갖는 불연성 에어로졸 공급 시스템
US12426637B2 (en) 2021-08-17 2025-09-30 Rai Strategic Holdings, Inc. Inductively heated aerosol delivery device consumable
CN113861163B (zh) * 2021-10-27 2023-06-23 深圳市真味生物科技有限公司 一种便于运输和储存的尼古丁盐的制备方法
CN113861164B (zh) * 2021-10-29 2022-09-20 迪嘉药业集团有限公司 一种烟碱的结晶制备方法
WO2023084498A1 (en) 2021-11-15 2023-05-19 Nicoventures Trading Limited Oral products with nicotine-polymer complex
US12279648B2 (en) 2021-12-20 2025-04-22 Rai Strategic Holdings, Inc. Aerosol delivery device with improved sealing arrangement
CN114343229B (zh) * 2022-01-24 2023-03-10 深圳市真味生物科技有限公司 一种新型尼古丁盐的制备方法
US20230303572A1 (en) * 2022-03-08 2023-09-28 Mind Medicine, Inc. 18-mc salt forms
CN114868955B (zh) * 2022-05-09 2023-08-18 东莞市吉纯生物技术有限公司 一种尼古丁盐制备方法、尼古丁盐以及气溶胶制品
CN114957208A (zh) * 2022-05-22 2022-08-30 南京科技职业学院 一种尼古丁有机盐及其制备方法
US12329199B2 (en) 2022-08-30 2025-06-17 R.J. Reynolds Tobaco Company Aerosol delivery device with improved mouthpieces
US20240065337A1 (en) 2022-08-30 2024-02-29 R.J. Reynolds Tobacco Company Aerosol delivery device with actuatable ignitor contacts and dual-purpose slider actuator
US12357024B2 (en) 2022-08-30 2025-07-15 R. J. Reynolds Tobacco Company Aerosol delivery device with static ignitor contacts
US20240065322A1 (en) 2022-08-30 2024-02-29 R.J. Reynolds Tobacco Company Aerosol delivery device with alternative consumable loading and ejection configurations
CN115413809B (zh) * 2022-09-30 2023-10-27 深圳梵活生命科学股份有限公司 一种击喉感强的尼古丁盐的制备方法及其应用
CN115594661A (zh) * 2022-10-08 2023-01-13 深圳正和生物科技有限公司（Cn） 二酒石酸尼古丁盐及其制备方法、烟油和反应釜
US20240196972A1 (en) 2022-12-14 2024-06-20 R.J. Reynolds Tobacco Company Aerosol delivery device with deflectable or collapsible housing
US12471639B2 (en) 2022-12-14 2025-11-18 R.J. Reynolds Tobacco Company Aerosol delivery device with improved cartridge loading
US20240196971A1 (en) 2022-12-14 2024-06-20 R.J. Reynolds Tobacco Company Aerosol delivery device with automatic consumable loading and ejecting
CN116268538A (zh) * 2023-04-11 2023-06-23 东莞市吉纯生物技术有限公司 一种固体苹果酸尼古丁盐的制备方法
CN117383998A (zh) * 2023-09-28 2024-01-12 天津理工大学 一种共晶的制备方法
EP4659595A1 (en) 2024-06-06 2025-12-10 Nicoventures Trading Limited Nicotine-polymer complex comprising multiple nicotine forms
EP4659596A1 (en) 2024-06-06 2025-12-10 Nicoventures Trading Limited Oral products with low free-base nicotine content
EP4659594A1 (en) 2024-06-06 2025-12-10 Nicoventures Trading Limited Oral products containing modified nicotine-polymer complex

Family Cites Families (162)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1376586A (en) 1918-04-06 1921-05-03 Schwartz Francis Tobacco-tablet
US2033909A (en) 1934-12-19 1936-03-17 Niacet Chemicals Corp Manufacture of calcium levulinate
US2822306A (en) 1955-07-01 1958-02-04 Plate Gmbh Dr Aromatic and pleasant tasting de-nicotinized tobacco and method of producing same
US4153063A (en) 1970-09-02 1979-05-08 Studiengesellschaft Kohle Mbh Process for the extraction of nicotine from tobacco
US3696917A (en) 1970-09-10 1972-10-10 Elaine G Levi Tobacco pouch closure
DE3112479A1 (de) 1981-03-26 1982-11-25 Josef Dipl.-Chem. Dr.Rer.Nat. 1000 Berlin Klosa Nikotinsaeureamid-orotat
DE3210669A1 (de) 1982-03-23 1983-09-29 Hrvoje Dr. Zagreb Krnjević Pharmazeutisches mittel zur behandlung von hautkrankheiten, schleimhauterkrankungen und nagelwuchsstoerungen
US4528993A (en) 1982-08-20 1985-07-16 R. J. Reynolds Tobacco Company Process for producing moist snuff
US4513756A (en) 1983-04-28 1985-04-30 The Pinkerton Tobacco Company Process of making tobacco pellets
US5092352A (en) 1983-12-14 1992-03-03 American Brands, Inc. Chewing tobacco product
US4793365A (en) 1984-09-14 1988-12-27 R. J. Reynolds Tobacco Company Smoking article
US4624269A (en) 1984-09-17 1986-11-25 The Pinkerton Tobacco Company Chewable tobacco based product
GB8615676D0 (en) 1986-06-26 1986-07-30 Stoppers Co Ltd Nicotine containing lozenge
US4830028A (en) 1987-02-10 1989-05-16 R. J. Reynolds Tobacco Company Salts provided from nicotine and organic acid as cigarette additives
US4987907A (en) 1988-06-29 1991-01-29 Helme Tobacco Company Chewing tobacco composition and process for producing same
US4967771A (en) 1988-12-07 1990-11-06 R. J. Reynolds Tobacco Company Process for extracting tobacco
US5101839A (en) 1990-08-15 1992-04-07 R. J. Reynolds Tobacco Company Cigarette and smokable filler material therefor
US5525351A (en) 1989-11-07 1996-06-11 Dam; Anders Nicotine containing stimulant unit
US4991599A (en) 1989-12-20 1991-02-12 Tibbetts Hubert M Fiberless tobacco product for smoking and chewing
US5031646A (en) 1990-01-16 1991-07-16 R. J. Reynolds Tobacco Company Cigarette
US5159944A (en) 1990-05-24 1992-11-03 R. J. Reynolds Tobacco Company Cigarette
US5110605A (en) 1990-08-21 1992-05-05 Oramed, Inc. Calcium polycarbophil-alginate controlled release composition and method
US5220930A (en) 1992-02-26 1993-06-22 R. J. Reynolds Tobacco Company Cigarette with wrapper having additive package
US5387416A (en) 1993-07-23 1995-02-07 R. J. Reynolds Tobacco Company Tobacco composition
US5549906A (en) 1993-07-26 1996-08-27 Pharmacia Ab Nicotine lozenge and therapeutic method for smoking cessation
SE9803986D0 (sv) 1998-11-23 1998-11-23 Pharmacia & Upjohn Ab New compositions
US7374779B2 (en) 1999-02-26 2008-05-20 Lipocine, Inc. Pharmaceutical formulations and systems for improved absorption and multistage release of active agents
US6248760B1 (en) 1999-04-14 2001-06-19 Paul C Wilhelmsen Tablet giving rapid release of nicotine for transmucosal administration
US20010016593A1 (en) 1999-04-14 2001-08-23 Wilhelmsen Paul C. Element giving rapid release of nicotine for transmucosal administration
GB9911037D0 (en) 1999-05-13 1999-07-14 Micap Limited Nicotine delivery service
SK9742002A3 (en) 2000-01-07 2003-02-04 Transform Pharmaceuticals Inc High-throughput formation, identification, and analysis of diverse solid-forms
EP2295619B1 (en) 2001-01-26 2014-04-23 MEMC Electronic Materials, Inc. Process for producing Low Defect Density Silicon Having a Vacancy-Dominated Core Substantially Free of Oxidation Induced Stacking Faults
US6668839B2 (en) 2001-05-01 2003-12-30 Jonnie R. Williams Smokeless tobacco product
US20040020503A1 (en) 2001-05-01 2004-02-05 Williams Jonnie R. Smokeless tobacco product
JP4017526B2 (ja) 2001-05-01 2007-12-05 リージェント コート テクノロジーズ エルエルシー 無煙タバコ製品
US7237559B2 (en) 2001-08-14 2007-07-03 R.J. Reynolds Tobacco Company Wrapping materials for smoking articles
US7032601B2 (en) 2001-09-28 2006-04-25 U.S. Smokeless Tobacco Company Encapsulated materials
US6953040B2 (en) 2001-09-28 2005-10-11 U.S. Smokeless Tobacco Company Tobacco mint plant material product
US6779530B2 (en) 2002-01-23 2004-08-24 Schweitzer-Mauduit International, Inc. Smoking articles with reduced ignition proclivity characteristics
US7927613B2 (en) 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
JP4906233B2 (ja) 2002-03-01 2012-03-28 ユニバーシティー オブ サウス フロリダ 少なくとも１種の有効薬剤成分を含有する多構成要素固相
US20040101543A1 (en) 2002-03-22 2004-05-27 John Liu Nicotine-containing oral dosage form
SE0201669D0 (sv) * 2002-06-03 2002-06-03 Pharmacia Ab New formulation and use thereof
US7234471B2 (en) 2003-10-09 2007-06-26 R. J. Reynolds Tobacco Company Cigarette and wrapping materials therefor
ATE359075T1 (de) 2002-12-20 2007-05-15 Niconovum Ab Chemisch und physikalisch stabiles teilchenförmiges material enthaltend nikotin und microcrystalline cellulose
JP5069905B2 (ja) 2003-01-21 2012-11-07 アプテュイト （ウエスト ラファイエット）、エルエルシー 新規な共結晶化
SE0301244D0 (sv) 2003-04-29 2003-04-29 Swedish Match North Europe Ab Smokeless tobacco product user package
PL1663168T3 (pl) 2003-09-08 2009-07-31 Mcneil Ab Preparaty nikotyny i ich zastosowanie
US20050066986A1 (en) 2003-09-30 2005-03-31 Nestor Timothy Brian Smokable rod for a cigarette
US7901512B2 (en) 2003-11-03 2011-03-08 U.S. Smokeless Tobacco Company Flavored smokeless tobacco and methods of making
US8627828B2 (en) 2003-11-07 2014-01-14 U.S. Smokeless Tobacco Company Llc Tobacco compositions
US7694686B2 (en) 2003-12-22 2010-04-13 U.S. Smokeless Tobacco Company Conditioning process for tobacco and/or snuff compositions
US7008742B2 (en) 2003-12-24 2006-03-07 Eastman Kodak Company Heat-induced formation of co-crystalline composition containing titanyl phthalocyanine and titanyl fluorophthalocyanine
EP1740930A4 (en) 2004-03-12 2010-09-15 Aptuit Kansas City Llc SEARCH FOR FORMATS BY ULTRASOUND CRYSTALLIZATION AND COKRISTALLIZATION USING ULTRASOUND
US20060018840A1 (en) 2004-06-28 2006-01-26 Nektar Therapeutics Aerosolizable formulation comprising nicotine
EP1765309B1 (en) 2004-07-02 2009-08-05 Radi Medical Biodegradable AB Smokeless toabacco product
US7650891B1 (en) 2004-09-03 2010-01-26 Rosswil Llc Ltd. Tobacco precursor product
UA88792C2 (ru) 2004-11-10 2009-11-25 Таргасепт, Інк. Гидроксибензоатные соли метаникотиновых соединений
US7565818B2 (en) 2005-06-01 2009-07-28 R.J. Reynolds Tobacco Company Apparatus and methods for manufacturing cigarettes
US20070056600A1 (en) 2005-09-14 2007-03-15 R. J. Reynolds Tobacco Company Filtered smoking article
US7861728B2 (en) 2006-02-10 2011-01-04 R.J. Reynolds Tobacco Company Smokeless tobacco composition having an outer and inner pouch
US20070062549A1 (en) 2005-09-22 2007-03-22 Holton Darrell E Jr Smokeless tobacco composition
WO2007067727A2 (en) 2005-12-08 2007-06-14 Ssci, Inc. Metronidazole cocrystals and imipramine cocrystals
US7819124B2 (en) 2006-01-31 2010-10-26 U.S. Smokeless Tobacco Company Tobacco articles and methods
US7810507B2 (en) 2006-02-10 2010-10-12 R. J. Reynolds Tobacco Company Smokeless tobacco composition
CA2646942C (en) 2006-03-16 2014-07-29 Niconovum Ab Improved snuff composition
AU2007224586A1 (en) 2006-03-16 2007-09-20 Niconovum Ab Stable lozenge compositions providing rapid release of nicotine
US20070246055A1 (en) 2006-04-21 2007-10-25 Oglesby Robert L Smoking articles and wrapping materials therefor
SE529886C2 (sv) 2006-04-28 2007-12-18 Swedish Match North Europe Ab En ny metod för framställning av en fuktsnuskomposition som inte innehåller tobak
US8642016B2 (en) 2006-07-21 2014-02-04 Jsrnti, Llc Medicinal delivery system, and related methods
US20080173317A1 (en) 2006-08-01 2008-07-24 John Howard Robinson Smokeless tobacco
US20080029116A1 (en) 2006-08-01 2008-02-07 John Howard Robinson Smokeless tobacco
US7726320B2 (en) 2006-10-18 2010-06-01 R. J. Reynolds Tobacco Company Tobacco-containing smoking article
GB0702402D0 (en) 2007-02-08 2007-03-21 Thar Pharmaceuticals Inc Method of creating crystalline substances
CN101686731B (zh) 2007-02-23 2013-05-08 美国无烟烟草有限责任公司 新型烟草组合物及制备方法
US20110033928A1 (en) 2007-03-09 2011-02-10 The Regents Of The University Of Michigan Methods and compositions for growth of cells and embryonic tissue on a synthetic polymer matrix
GB0706044D0 (en) 2007-03-28 2007-05-09 Syngenta Ltd C0-Crystals
US9004074B2 (en) 2007-06-05 2015-04-14 Al-Farabi Kazakh National University Method for extraction of nicotine from tobacco raw material
US20100204204A1 (en) 2007-06-06 2010-08-12 University Of South Florida Nutraceutical co-crystal compositions
WO2009004488A2 (en) 2007-06-08 2009-01-08 Philip Morris Products S.A. Capsule clusters for oral consumption
US7946295B2 (en) 2007-07-23 2011-05-24 R. J. Reynolds Tobacco Company Smokeless tobacco composition
US20090081291A1 (en) 2007-09-26 2009-03-26 Gin Jerry B Sustained Release Dosage Forms For Delivery of Agents to an Oral Cavity of a User
US8336557B2 (en) 2007-11-28 2012-12-25 Philip Morris Usa Inc. Smokeless compressed tobacco product for oral consumption
US7935817B2 (en) 2008-03-31 2011-05-03 Apotex Pharmachem Inc. Salt form and cocrystals of adefovir dipivoxil and processes for preparation thereof
CA2721031A1 (en) 2008-04-08 2009-10-15 Novelix Pharmaceuticals, Inc. Novel (pyrroloquinoxalinyl) pyrazinecarbohydrazide-oxalic acid co-crystal for treatment of cancer and other diseases
US8197592B2 (en) 2008-04-25 2012-06-12 Sun Chemical Corp. Crystal forms of quinacridones made from 2,9-dimethoxyquinacridone and 2,9-dichloroquinacridone
DE102008028071A1 (de) 2008-06-12 2009-12-17 Bayer Schering Pharma Aktiengesellschaft Neue Cokristall-Verbindung von Rivaroxaban und Malonsäure
EP2304834A4 (en) 2008-07-18 2014-03-19 Flexel Llc THIN, FLEXIBLE AND RECHARGEABLE ELECTROCHEMICAL ENERGY CELL AND METHOD FOR THE PRODUCTION THEREOF
MX2011002312A (es) 2008-09-03 2011-04-26 Vertex Pharma Co-cristales y formulaciones farmaceuticas que comprenden los mismos.
NZ591710A (en) 2008-10-14 2012-11-30 Mcneil Ab Controlled release oral dosage form comprising at least one portion that is rapidly disintegrating and at least one portion that is slowly disintegrating
US9155772B2 (en) 2008-12-08 2015-10-13 Philip Morris Usa Inc. Soft, chewable and orally dissolvable and/or disintegrable products
CN102369009B (zh) 2009-03-30 2014-04-30 泰博特克药品公司 依曲韦林和烟酰胺的共晶体
US8173625B2 (en) 2009-05-08 2012-05-08 Theaprin Pharmaceuticals Inc. Intravenous formulation with water-soluble cocrystals of acetylsalicylic acid and theanine
US11246334B2 (en) 2009-05-11 2022-02-15 Altria Client Services Llc Method and device for flavoring smokeless tobacco
US20120258170A1 (en) 2009-05-20 2012-10-11 Nutracryst Therapeutics Private Limited Pharmaceutical co-crystals of quercetin
AR077692A1 (es) 2009-08-06 2011-09-14 Vitae Pharmaceuticals Inc Sales de 2-((r)-(3-clorofenil) ((r)-1-((s) -2-(metilamino)-3-((r)-tetrahidro-2h-piran-3-il) propilcarbamoil) piperidin -3-il) metoxi) etilcarbamato de metilo
US9254002B2 (en) 2009-08-17 2016-02-09 Chong Corporation Tobacco solution for vaporized inhalation
CN102770434A (zh) 2009-12-03 2012-11-07 阿斯利康(瑞典)有限公司 三唑并[4,5-d]嘧啶血小板聚集抑制剂的共晶体
US20110139164A1 (en) 2009-12-15 2011-06-16 R. J. Reynolds Tobacco Company Tobacco Product And Method For Manufacture
US8955523B2 (en) 2010-01-15 2015-02-17 R.J. Reynolds Tobacco Company Tobacco-derived components and materials
US8399712B2 (en) 2010-02-03 2013-03-19 Laurus Labs Private Limited Pterostilbene cocrystals
US20120028930A1 (en) 2010-02-26 2012-02-02 Bionevia Pharmaceuticals Inc. Flupirtine salts and polymorphs
WO2011112922A2 (en) 2010-03-11 2011-09-15 Vertex Pharmaceuticals Incorporated Co-crystals and pharmaceutical formulations comprising the same
WO2011131526A1 (de) 2010-04-19 2011-10-27 Basf Se Verfahren zur herstellung wasserabsorbierender polymerpartikel
US9402415B2 (en) 2010-04-21 2016-08-02 R. J. Reynolds Tobacco Company Tobacco seed-derived components and materials
WO2011158110A2 (en) 2010-04-28 2011-12-22 Nuformix Limited Cilostazol cocrystals and compositions
US20110268809A1 (en) 2010-04-28 2011-11-03 Paul Andrew Brinkley Nicotine-Containing Pharmaceutical Compositions
US20110274628A1 (en) * 2010-05-07 2011-11-10 Borschke August J Nicotine-containing pharmaceutical compositions
EP3650439B1 (en) 2010-07-23 2021-02-24 Grünenthal GmbH Salts or co-crystals of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol
US9155321B2 (en) 2010-08-11 2015-10-13 R.J. Reynolds Tobacco Company Meltable smokeless tobacco composition
US11116237B2 (en) 2010-08-11 2021-09-14 R.J. Reynolds Tobacco Company Meltable smokeless tobacco composition
US9675102B2 (en) 2010-09-07 2017-06-13 R. J. Reynolds Tobacco Company Smokeless tobacco product comprising effervescent composition
US20120199145A1 (en) 2010-11-18 2012-08-09 R.J. Reynolds Tobacco Company Method for treating an extracted tobacco pulp and tobacco products made therefrom
US9775376B2 (en) 2010-12-01 2017-10-03 R.J. Reynolds Tobacco Company Smokeless tobacco pastille and moulding process for forming smokeless tobacco products
US9204667B2 (en) 2010-12-01 2015-12-08 R.J. Reynolds Tobacco Company Smokeless tobacco pastille and injection molding process for forming smokeless tobacco products
US20120152265A1 (en) 2010-12-17 2012-06-21 R.J. Reynolds Tobacco Company Tobacco-Derived Syrup Composition
US9107453B2 (en) 2011-01-28 2015-08-18 R.J. Reynolds Tobacco Company Tobacco-derived casing composition
US8893725B2 (en) 2011-01-28 2014-11-25 R. J. Reynolds Tobacco Company Polymeric materials derived from tobacco
US20120211016A1 (en) 2011-02-18 2012-08-23 Byrd Jr Medwick Vaughan Plastic from tobacco biomass
CN102349699B (zh) 2011-07-04 2013-07-03 郑俊祥 一种电子烟液的制备方法
US9084439B2 (en) 2011-09-22 2015-07-21 R.J. Reynolds Tobacco Company Translucent smokeless tobacco product
US9474303B2 (en) 2011-09-22 2016-10-25 R.J. Reynolds Tobacco Company Translucent smokeless tobacco product
US9629392B2 (en) 2011-09-22 2017-04-25 R.J. Reynolds Tobacco Company Translucent smokeless tobacco product
US20130078307A1 (en) 2011-09-22 2013-03-28 Niconovum Usa, Inc. Nicotine-containing pharmaceutical composition
US9854839B2 (en) * 2012-01-31 2018-01-02 Altria Client Services Llc Electronic vaping device and method
US12285025B2 (en) 2012-02-10 2025-04-29 R.J. Reynolds Tobacco Company Multi-layer smokeless tobacco composition
US20130255702A1 (en) 2012-03-28 2013-10-03 R.J. Reynolds Tobacco Company Smoking article incorporating a conductive substrate
US20130269719A1 (en) 2012-04-11 2013-10-17 R.J. Reynolds Tobacco Company Method for treating plants with probiotics
US9044035B2 (en) * 2012-04-17 2015-06-02 R.J. Reynolds Tobacco Company Remelted ingestible products
US10004259B2 (en) * 2012-06-28 2018-06-26 Rai Strategic Holdings, Inc. Reservoir and heater system for controllable delivery of multiple aerosolizable materials in an electronic smoking article
MX357741B (es) * 2012-07-06 2018-07-23 Laboratorios Senosiain S A De C V Star Nuevas formas sólidas de inhibidores de fosfodiesterasa tipo 5.
US9485953B2 (en) 2012-07-19 2016-11-08 R.J. Reynolds Tobacco Company Method for treating tobacco plants with enzymes
US20140060552A1 (en) * 2012-08-28 2014-03-06 Ploom, Inc. Methods and devices for delivery and monitoring of tobacco, nicotine, or other substances
GB201215273D0 (en) 2012-08-28 2012-10-10 Kind Consumer Ltd Nicotine composition
US8881737B2 (en) 2012-09-04 2014-11-11 R.J. Reynolds Tobacco Company Electronic smoking article comprising one or more microheaters
US8910639B2 (en) 2012-09-05 2014-12-16 R. J. Reynolds Tobacco Company Single-use connector and cartridge for a smoking article and related method
US20140088044A1 (en) * 2012-09-21 2014-03-27 Basil Rigas Product comprising a nicotine-containing material and an anti-cancer agent
US10117460B2 (en) 2012-10-08 2018-11-06 Rai Strategic Holdings, Inc. Electronic smoking article and associated method
US9854841B2 (en) 2012-10-08 2018-01-02 Rai Strategic Holdings, Inc. Electronic smoking article and associated method
US9210738B2 (en) 2012-12-07 2015-12-08 R.J. Reynolds Tobacco Company Apparatus and method for winding a substantially continuous heating element about a substantially continuous wick
US8999405B1 (en) 2013-01-25 2015-04-07 Stephen E. Bachman Smokeless tobacco substitute
US8910640B2 (en) 2013-01-30 2014-12-16 R.J. Reynolds Tobacco Company Wick suitable for use in an electronic smoking article
US20140261487A1 (en) 2013-03-14 2014-09-18 R. J. Reynolds Tobacco Company Electronic smoking article with improved storage and transport of aerosol precursor compositions
US9220302B2 (en) 2013-03-15 2015-12-29 R.J. Reynolds Tobacco Company Cartridge for an aerosol delivery device and method for assembling a cartridge for a smoking article
US9609893B2 (en) 2013-03-15 2017-04-04 Rai Strategic Holdings, Inc. Cartridge and control body of an aerosol delivery device including anti-rotation mechanism and related method
RU2659887C2 (ru) 2013-05-06 2018-07-04 Джуул Лэбз, Инк. Составы на основе солей никотина для аэрозольных устройств и способы их применения
ES2821907T3 (es) 2013-07-11 2021-04-28 Alexza Pharmaceuticals Inc Sal de nicotina con ácido metasalicílico
US11229239B2 (en) 2013-07-19 2022-01-25 Rai Strategic Holdings, Inc. Electronic smoking article with haptic feedback
CN105530825A (zh) * 2013-07-19 2016-04-27 奥驰亚客户服务有限责任公司 电子吸烟器具的液体气溶胶制剂
US10251422B2 (en) 2013-07-22 2019-04-09 Altria Client Services Llc Electronic smoking article
US10172387B2 (en) 2013-08-28 2019-01-08 Rai Strategic Holdings, Inc. Carbon conductive substrate for electronic smoking article
KR102428028B1 (ko) 2014-04-28 2022-08-03 필립모리스 프로덕츠 에스.에이. 향미를 가진 니코틴 분말 흡입기
CN113816940A (zh) 2014-05-27 2021-12-21 R.J.雷诺兹烟草公司 烟碱盐、共晶体和盐共晶体络合物
US10508096B2 (en) 2014-05-27 2019-12-17 R.J. Reynolds Tobacco Company Nicotine salts, co-crystals, and salt co-crystal complexes
US9896429B2 (en) 2014-05-27 2018-02-20 R.J. Reynolds Tobacco Company Nicotine salts, co-crystals, and salt co-crystal complexes
GB2535427A (en) 2014-11-07 2016-08-24 Nicoventures Holdings Ltd Solution
GB2532062A (en) 2014-11-07 2016-05-11 Nicoventures Holdings Ltd Container
GB201516729D0 (en) 2015-09-22 2015-11-04 The Technology Partnership Plc Liquid nicotine formulation
GB2542838B (en) 2015-10-01 2022-01-12 Nicoventures Trading Ltd Aerosol provision system
KR102471453B1 (ko) * 2015-11-24 2022-11-28 아아르. 제이. 레날드즈 토바코 캄파니 전기적으로-급전되는 에어로졸 송달 시스템
CN114656446A (zh) 2015-11-25 2022-06-24 R.J.雷诺兹烟草公司 烟碱盐、共晶体和盐共晶体配合物
PL3562328T3 (pl) * 2016-12-30 2025-04-28 Philip Morris Products S.A. Arkusz zawierający nikotynę i środek wiążący

Also Published As

Publication number Publication date
US20150344456A1 (en) 2015-12-03
US9738622B2 (en) 2017-08-22
JP7168609B2 (ja) 2022-11-09
EP3148982A1 (en) 2017-04-05
PL3871515T3 (pl) 2025-06-16
EP4603486A3 (en) 2025-10-15
US20210395219A1 (en) 2021-12-23
JP2022160452A (ja) 2022-10-19
EP3871515A1 (en) 2021-09-01
WO2015183801A1 (en) 2015-12-03
JP2020128376A (ja) 2020-08-27
US11136305B2 (en) 2021-10-05
EP4603486A2 (en) 2025-08-20
JP2024156667A (ja) 2024-11-06
EP3871515B1 (en) 2025-04-16
CN113816940A (zh) 2021-12-21
CN113754634A (zh) 2021-12-07
US20250163019A1 (en) 2025-05-22
US20170334881A1 (en) 2017-11-23
US12454517B2 (en) 2025-10-28
US20200148664A1 (en) 2020-05-14
US10556880B2 (en) 2020-02-11
CN106536501A (zh) 2017-03-22
JP2017523133A (ja) 2017-08-17

Similar Documents

Publication Publication Date Title
JP7168609B2 (ja) ニコチン塩、共結晶、及び塩共結晶複合体
US12077518B2 (en) Nicotine salts, co-crystals, and salt co-crystal complexes
US12180179B2 (en) Nicotine salts, co-crystals, and salt co-crystal complexes
EP3379952B1 (en) Nicotine salts, co-crystals, and salt co-crystal complexes
EP3681865B1 (en) Nicotine salts, co-crystals, and salt co-crystal complexes
US20220248744A1 (en) Nicotine materials, methods of making same, and uses thereof

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20180525

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20190212

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20190207

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20190507

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190807

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20191210

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200410

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20200527

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20200707

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20200804

R150 Certificate of patent or registration of utility model

Ref document number: 6745728

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250