JP6745720B2 - 改変されたｋｚ１４４エンドリシン配列 - Google Patents

改変されたｋｚ１４４エンドリシン配列 Download PDF

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JP6745720B2
JP6745720B2 JP2016531660A JP2016531660A JP6745720B2 JP 6745720 B2 JP6745720 B2 JP 6745720B2 JP 2016531660 A JP2016531660 A JP 2016531660A JP 2016531660 A JP2016531660 A JP 2016531660A JP 6745720 B2 JP6745720 B2 JP 6745720B2
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amino acid
seq
polypeptide
sequence
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JP2016537979A (ja
JP2016537979A5 (enExample
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ステファン ミラー
ステファン ミラー
ラインハルト スターナー
ラインハルト スターナー
ハイク シュチュアー
ハイク シュチュアー
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ライサンド アクツィエンゲゼルシャフト
ライサンド アクツィエンゲゼルシャフト
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2462—Lysozyme (3.2.1.17)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01017—Lysozyme (3.2.1.17)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2016531660A 2013-11-14 2014-11-14 改変されたｋｚ１４４エンドリシン配列 Active JP6745720B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EPPCT/EP2013/073869 2013-11-14
PCT/EP2013/073869 WO2015070911A1 (en) 2013-11-14 2013-11-14 Modified kz144 endolysin sequence
PCT/EP2014/074671 WO2015071436A1 (en) 2013-11-14 2014-11-14 Modified kz144 endolysin sequence

Publications (3)

Publication Number Publication Date
JP2016537979A JP2016537979A (ja) 2016-12-08
JP2016537979A5 JP2016537979A5 (enExample) 2017-12-07
JP6745720B2 true JP6745720B2 (ja) 2020-08-26

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JP2016531660A Active JP6745720B2 (ja) 2013-11-14 2014-11-14 改変されたｋｚ１４４エンドリシン配列

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US (1) US10184120B2 (enExample)
JP (1) JP6745720B2 (enExample)
KR (1) KR102302044B1 (enExample)
CN (1) CN105793419B (enExample)
AU (1) AU2014350104B2 (enExample)
BR (1) BR112016011091B1 (enExample)
CA (1) CA2929686C (enExample)
EA (1) EA035959B1 (enExample)
MX (1) MX374403B (enExample)
WO (2) WO2015070911A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4151228A3 (en) 2015-09-17 2023-06-14 Contrafect Corporation Lysin polypeptides active against gram-negative bacteria
CN109072211B (zh) * 2016-04-28 2023-10-27 莱桑多股份公司 抗沙门氏菌的抗菌剂
EP3464583A1 (en) 2016-05-27 2019-04-10 Sasinapas Co., Ltd. Endolysin variant
WO2018100408A1 (en) * 2016-11-30 2018-06-07 Sasinapas Co.,Ltd. Modified peptides
US11208643B2 (en) * 2017-04-03 2021-12-28 Sasinapas Co., Ltd. Engineered gram-negative endolysins
EP3802620A1 (en) * 2018-05-30 2021-04-14 Lysando AG Novel antimicrobial fusion proteins
CN111304181B (zh) * 2020-02-17 2021-11-23 华东理工大学 一种基因工程改造后的副溶血性弧菌噬菌体裂解酶及其制备方法和应用
KR20250044545A (ko) 2023-09-23 2025-04-01 조배근 사료급이기 청소기

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1289092C (en) * 1987-01-15 1991-09-17 Robert A. Hallewell Thermostable human cu/zn superoxide dismutase muteins
EP0285123A3 (en) 1987-04-03 1989-02-01 Stabra AG A method for complete mutagenesis of nucleic acids
ZA936811B (en) * 1992-10-28 1995-03-15 Upjohn Co Somatotropin modifications
JPH08127540A (ja) * 1994-09-09 1996-05-21 Takeda Chem Ind Ltd 抗潰瘍医薬
JP2010536354A (ja) * 2007-08-22 2010-12-02 ヒグロス インベスト ゲーエムベーハー ヒトおよび動物のブドウ球菌（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ）感染症において使用するための新しいタンパク質
GB0815484D0 (en) * 2008-08-26 2008-10-01 Univ Leuven Kath Antibacterial agents
SG177370A1 (en) * 2009-06-26 2012-02-28 Univ Leuven Kath Antimicrobial agents
BRPI1015203B1 (pt) 2009-06-26 2021-06-01 Lysando Ag Proteína de fusão composta por uma endolisina e uma extensão de peptídeo anfifática, usos da mesma e composição farmacêutica que compreende a dita proteína
EP2470648B1 (en) * 2009-08-24 2019-04-10 Katholieke Universiteit Leuven K.U. Leuven R&D New endolysin obpgplys
MX340520B (es) * 2010-04-27 2016-07-12 Lysando Ag * Metodo de reduccion de biopeliculas.
GB201018518D0 (en) * 2010-11-03 2010-12-15 Univ Leuven Kath Novel endolysin
EP2468856A1 (en) 2010-12-23 2012-06-27 Lysando Aktiengesellschaft Antimicrobial Agents
KR20130142837A (ko) * 2012-06-20 2013-12-30 한국외국어대학교 연구산학협력단 슈도모나스 에루기노사의 박테리오파아지 및 그 용도

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Publication number Publication date
JP2016537979A (ja) 2016-12-08
AU2014350104B2 (en) 2020-03-05
EA035959B1 (ru) 2020-09-07
MX2016006277A (es) 2017-01-05
CN105793419A (zh) 2016-07-20
CA2929686C (en) 2023-08-08
NZ719338A (en) 2022-03-25
WO2015070911A1 (en) 2015-05-21
EA201691004A1 (ru) 2017-01-30
US10184120B2 (en) 2019-01-22
WO2015071436A1 (en) 2015-05-21
BR112016011091A2 (pt) 2017-12-05
CA2929686A1 (en) 2015-05-21
US20160281074A1 (en) 2016-09-29
CN105793419B (zh) 2021-06-01
AU2014350104A1 (en) 2016-05-12
KR20160085342A (ko) 2016-07-15
BR112016011091B1 (pt) 2024-02-06
MX374403B (es) 2025-03-06
KR102302044B1 (ko) 2021-09-15

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