JP2016537979A5 - - Google Patents

Info

Publication number

JP2016537979A5

JP2016537979A5 JP2016531660A JP2016531660A JP2016537979A5 JP 2016537979 A5 JP2016537979 A5 JP 2016537979A5 JP 2016531660 A JP2016531660 A JP 2016531660A JP 2016531660 A JP2016531660 A JP 2016531660A JP 2016537979 A5 JP2016537979 A5 JP 2016537979A5

Authority

JP

Japan

Prior art keywords

amino acid

seq

polypeptide

sequence

present

Prior art date

2014-11-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 108090000765 processed proteins & peptides Proteins 0.000 claims description 115
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 114
• 229920001184 polypeptide Polymers 0.000 claims description 105
• 235000001014 amino acid Nutrition 0.000 claims description 38
• 150000001413 amino acids Chemical class 0.000 claims description 38
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 32
• 230000001747 exhibiting effect Effects 0.000 claims description 14
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 5
• WTJDAUWOECZENF-OZWITMHCSA-N smap-29 Chemical compound NC(=O)[C@H](C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](N)CCCNC(N)=N)[C@@H](C)CC)C(C)C)CC1=CC=C(O)C=C1 WTJDAUWOECZENF-OZWITMHCSA-N 0.000 claims description 3
• 241000894006 Bacteria Species 0.000 claims description 2
• 241000589876 Campylobacter Species 0.000 claims description 2
• MSFSPUZXLOGKHJ-UHFFFAOYSA-N Muraminsaeure Natural products OC(=O)C(C)OC1C(N)C(O)OC(CO)C1O MSFSPUZXLOGKHJ-UHFFFAOYSA-N 0.000 claims description 2
• 108010013639 Peptidoglycan Proteins 0.000 claims description 2
• 241000589516 Pseudomonas Species 0.000 claims description 2
• 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims description 2
• 102000039446 nucleic acids Human genes 0.000 description 4
• 108020004707 nucleic acids Proteins 0.000 description 4
• 150000007523 nucleic acids Chemical class 0.000 description 4
• 108700042778 Antimicrobial Peptides Proteins 0.000 description 2
• 102000044503 Antimicrobial Peptides Human genes 0.000 description 2
• 125000000539 amino acid group Chemical group 0.000 description 2
• 125000002091 cationic group Chemical group 0.000 description 2
• 230000002209 hydrophobic effect Effects 0.000 description 2
• 108010078480 insect defensin A Proteins 0.000 description 2
• 239000000203 mixture Substances 0.000 description 2
• GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 description 1
• 101800002011 Amphipathic peptide Proteins 0.000 description 1
• 239000003085 diluting agent Substances 0.000 description 1
• 239000008194 pharmaceutical composition Substances 0.000 description 1
• 239000000546 pharmaceutical excipient Substances 0.000 description 1