EA035959B1 - Последовательность модифицированного эндолизина kz144 - Google Patents
Последовательность модифицированного эндолизина kz144 Download PDFInfo
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- EA035959B1 EA035959B1 EA201691004A EA201691004A EA035959B1 EA 035959 B1 EA035959 B1 EA 035959B1 EA 201691004 A EA201691004 A EA 201691004A EA 201691004 A EA201691004 A EA 201691004A EA 035959 B1 EA035959 B1 EA 035959B1
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01017—Lysozyme (3.2.1.17)
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2013/073869 WO2015070911A1 (en) | 2013-11-14 | 2013-11-14 | Modified kz144 endolysin sequence |
| PCT/EP2014/074671 WO2015071436A1 (en) | 2013-11-14 | 2014-11-14 | Modified kz144 endolysin sequence |
Publications (2)
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| EA201691004A1 EA201691004A1 (ru) | 2017-01-30 |
| EA035959B1 true EA035959B1 (ru) | 2020-09-07 |
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| EA201691004A EA035959B1 (ru) | 2013-11-14 | 2014-11-14 | Последовательность модифицированного эндолизина kz144 |
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| US (1) | US10184120B2 (enExample) |
| JP (1) | JP6745720B2 (enExample) |
| KR (1) | KR102302044B1 (enExample) |
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| WO (2) | WO2015070911A1 (enExample) |
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| MX2018003101A (es) | 2015-09-17 | 2018-12-17 | Contrafect Corp | Activo de polipeptidos de lisina contra bacterias gram-negativas. |
| CA3022334A1 (en) * | 2016-04-28 | 2017-11-02 | Lysando Ag | Antimicrobial agents against salmonella bacteria |
| WO2017203471A1 (en) * | 2016-05-27 | 2017-11-30 | Sasinapas Co., Ltd. | Endolysin variant |
| WO2018100408A1 (en) * | 2016-11-30 | 2018-06-07 | Sasinapas Co.,Ltd. | Modified peptides |
| CN110651044A (zh) * | 2017-04-03 | 2020-01-03 | 萨西那帕斯有限公司 | 工程化的革兰氏阴性细胞内溶素 |
| JP7515409B2 (ja) * | 2018-05-30 | 2024-07-12 | ライサンド アーゲー | 新規抗微生物融合タンパク質 |
| CN111304181B (zh) * | 2020-02-17 | 2021-11-23 | 华东理工大学 | 一种基因工程改造后的副溶血性弧菌噬菌体裂解酶及其制备方法和应用 |
| KR20250044545A (ko) | 2023-09-23 | 2025-04-01 | 조배근 | 사료급이기 청소기 |
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| WO2010149792A2 (en) * | 2009-06-26 | 2010-12-29 | Katholieke Universiteit Leuven, K.U. Leuven R&D | Antimicrobial agents |
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| CA1289092C (en) * | 1987-01-15 | 1991-09-17 | Robert A. Hallewell | Thermostable human cu/zn superoxide dismutase muteins |
| EP0285123A3 (en) | 1987-04-03 | 1989-02-01 | Stabra AG | A method for complete mutagenesis of nucleic acids |
| ZA936811B (en) * | 1992-10-28 | 1995-03-15 | Upjohn Co | Somatotropin modifications |
| JPH08127540A (ja) * | 1994-09-09 | 1996-05-21 | Takeda Chem Ind Ltd | 抗潰瘍医薬 |
| CN101952424A (zh) * | 2007-08-22 | 2011-01-19 | 海格罗斯投资有限责任公司 | 用于人类和动物葡萄球菌感染的新蛋白 |
| GB0815484D0 (en) | 2008-08-26 | 2008-10-01 | Univ Leuven Kath | Antibacterial agents |
| KR101701890B1 (ko) | 2009-06-26 | 2017-02-02 | 뤼산도 아게 | 항균제 |
| EP2470648B1 (en) * | 2009-08-24 | 2019-04-10 | Katholieke Universiteit Leuven K.U. Leuven R&D | New endolysin obpgplys |
| SG184836A1 (en) * | 2010-04-27 | 2012-11-29 | Lysando Ag | Method of reducing biofilms |
| GB201018518D0 (en) * | 2010-11-03 | 2010-12-15 | Univ Leuven Kath | Novel endolysin |
| EP2468856A1 (en) | 2010-12-23 | 2012-06-27 | Lysando Aktiengesellschaft | Antimicrobial Agents |
| KR20130142837A (ko) * | 2012-06-20 | 2013-12-30 | 한국외국어대학교 연구산학협력단 | 슈도모나스 에루기노사의 박테리오파아지 및 그 용도 |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2010149792A2 (en) * | 2009-06-26 | 2010-12-29 | Katholieke Universiteit Leuven, K.U. Leuven R&D | Antimicrobial agents |
Non-Patent Citations (4)
| Title |
|---|
| A. FOKINE, K. A. MIROSHNIKOV, M. M. SHNEIDER, V. V. MESYANZHINOV, M. G. ROSSMANN: "Structure of the Bacteriophage �KZ Lytic Transglycosylase gp144", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 283, no. 11, 14 March 2008 (2008-03-14), pages 7242 - 7250, XP055130395, ISSN: 00219258, DOI: 10.1074/jbc.M709398200 * |
| BRIERS, Y. ; SCHMELCHER, M. ; LOESSNER, M.J. ; HENDRIX, J. ; ENGELBORGHS, Y. ; VOLCKAERT, G. ; LAVIGNE, R.: "The high-affinity peptidoglycan binding domain of Pseudomonas phage endolysin KZ144", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM, NL, vol. 383, no. 2, 29 May 2009 (2009-05-29), AMSTERDAM, NL, pages 187 - 191, XP026057388, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2009.03.161 * |
| LOPEZ, R. GARCIA, E. GARCIA, P.: "Enzymes for anti-infective therapy: phage lysins", DRUG DISCOVERY TODAY: THERAPEUTIC STRATEGIES, ELSEVIER, AMSTERDAM, NL, vol. 1, no. 4, 1 December 2004 (2004-12-01), AMSTERDAM, NL, pages 469 - 474, XP004694307, ISSN: 1740-6773, DOI: 10.1016/j.ddstr.2004.09.002 * |
| YVES BRIERS, GUIDO BRIERS, ANNELEEN VOLCKAERT, STIJN CORNELISSEN, CHRIS LAGAERT, KIRSTEN MICHIELS, ROB HERTVELDT, LAVIGNE: "Muralytic activity and modular structure of the endolysins of Pseudomonas aeruginosa bacteriophages ?KZ and EL", MOLECULAR MICROBIOLOGY, BLACKWELL SCIENCE, vol. 65, no. 5, 1 September 2007 (2007-09-01), pages 1334 - 1344, XP055119325, ISSN: 0950382X, DOI: 10.1111/j.1365-2958.2007.05870.x * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015070911A1 (en) | 2015-05-21 |
| BR112016011091B1 (pt) | 2024-02-06 |
| CA2929686A1 (en) | 2015-05-21 |
| BR112016011091A2 (pt) | 2017-12-05 |
| US10184120B2 (en) | 2019-01-22 |
| WO2015071436A1 (en) | 2015-05-21 |
| CN105793419B (zh) | 2021-06-01 |
| CA2929686C (en) | 2023-08-08 |
| JP6745720B2 (ja) | 2020-08-26 |
| KR20160085342A (ko) | 2016-07-15 |
| US20160281074A1 (en) | 2016-09-29 |
| MX374403B (es) | 2025-03-06 |
| KR102302044B1 (ko) | 2021-09-15 |
| NZ719338A (en) | 2022-03-25 |
| MX2016006277A (es) | 2017-01-05 |
| EA201691004A1 (ru) | 2017-01-30 |
| JP2016537979A (ja) | 2016-12-08 |
| CN105793419A (zh) | 2016-07-20 |
| AU2014350104B2 (en) | 2020-03-05 |
| AU2014350104A1 (en) | 2016-05-12 |
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