EA035959B1 - Последовательность модифицированного эндолизина kz144 - Google Patents

Последовательность модифицированного эндолизина kz144 Download PDF

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Publication number
EA035959B1
EA035959B1 EA201691004A EA201691004A EA035959B1 EA 035959 B1 EA035959 B1 EA 035959B1 EA 201691004 A EA201691004 A EA 201691004A EA 201691004 A EA201691004 A EA 201691004A EA 035959 B1 EA035959 B1 EA 035959B1
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EA
Eurasian Patent Office
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leu
lys
thr
ala
gly
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EA201691004A
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English (en)
Russian (ru)
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EA201691004A1 (ru
Inventor
Стефан Миллер
Рейнхард Стернер
Хейке Стуер
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Лисандо Аг
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Application filed by Лисандо Аг filed Critical Лисандо Аг
Publication of EA201691004A1 publication Critical patent/EA201691004A1/ru
Publication of EA035959B1 publication Critical patent/EA035959B1/ru

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/24Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2462Lysozyme (3.2.1.17)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/47Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/503Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01017Lysozyme (3.2.1.17)
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
EA201691004A 2013-11-14 2014-11-14 Последовательность модифицированного эндолизина kz144 EA035959B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2013/073869 WO2015070911A1 (en) 2013-11-14 2013-11-14 Modified kz144 endolysin sequence
PCT/EP2014/074671 WO2015071436A1 (en) 2013-11-14 2014-11-14 Modified kz144 endolysin sequence

Publications (2)

Publication Number Publication Date
EA201691004A1 EA201691004A1 (ru) 2017-01-30
EA035959B1 true EA035959B1 (ru) 2020-09-07

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA201691004A EA035959B1 (ru) 2013-11-14 2014-11-14 Последовательность модифицированного эндолизина kz144

Country Status (10)

Country Link
US (1) US10184120B2 (enExample)
JP (1) JP6745720B2 (enExample)
KR (1) KR102302044B1 (enExample)
CN (1) CN105793419B (enExample)
AU (1) AU2014350104B2 (enExample)
BR (1) BR112016011091B1 (enExample)
CA (1) CA2929686C (enExample)
EA (1) EA035959B1 (enExample)
MX (1) MX374403B (enExample)
WO (2) WO2015070911A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2018003101A (es) 2015-09-17 2018-12-17 Contrafect Corp Activo de polipeptidos de lisina contra bacterias gram-negativas.
CA3022334A1 (en) * 2016-04-28 2017-11-02 Lysando Ag Antimicrobial agents against salmonella bacteria
WO2017203471A1 (en) * 2016-05-27 2017-11-30 Sasinapas Co., Ltd. Endolysin variant
WO2018100408A1 (en) * 2016-11-30 2018-06-07 Sasinapas Co.,Ltd. Modified peptides
CN110651044A (zh) * 2017-04-03 2020-01-03 萨西那帕斯有限公司 工程化的革兰氏阴性细胞内溶素
JP7515409B2 (ja) * 2018-05-30 2024-07-12 ライサンド アーゲー 新規抗微生物融合タンパク質
CN111304181B (zh) * 2020-02-17 2021-11-23 华东理工大学 一种基因工程改造后的副溶血性弧菌噬菌体裂解酶及其制备方法和应用
KR20250044545A (ko) 2023-09-23 2025-04-01 조배근 사료급이기 청소기

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010149792A2 (en) * 2009-06-26 2010-12-29 Katholieke Universiteit Leuven, K.U. Leuven R&D Antimicrobial agents

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1289092C (en) * 1987-01-15 1991-09-17 Robert A. Hallewell Thermostable human cu/zn superoxide dismutase muteins
EP0285123A3 (en) 1987-04-03 1989-02-01 Stabra AG A method for complete mutagenesis of nucleic acids
ZA936811B (en) * 1992-10-28 1995-03-15 Upjohn Co Somatotropin modifications
JPH08127540A (ja) * 1994-09-09 1996-05-21 Takeda Chem Ind Ltd 抗潰瘍医薬
CN101952424A (zh) * 2007-08-22 2011-01-19 海格罗斯投资有限责任公司 用于人类和动物葡萄球菌感染的新蛋白
GB0815484D0 (en) 2008-08-26 2008-10-01 Univ Leuven Kath Antibacterial agents
KR101701890B1 (ko) 2009-06-26 2017-02-02 뤼산도 아게 항균제
EP2470648B1 (en) * 2009-08-24 2019-04-10 Katholieke Universiteit Leuven K.U. Leuven R&D New endolysin obpgplys
SG184836A1 (en) * 2010-04-27 2012-11-29 Lysando Ag Method of reducing biofilms
GB201018518D0 (en) * 2010-11-03 2010-12-15 Univ Leuven Kath Novel endolysin
EP2468856A1 (en) 2010-12-23 2012-06-27 Lysando Aktiengesellschaft Antimicrobial Agents
KR20130142837A (ko) * 2012-06-20 2013-12-30 한국외국어대학교 연구산학협력단 슈도모나스 에루기노사의 박테리오파아지 및 그 용도

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010149792A2 (en) * 2009-06-26 2010-12-29 Katholieke Universiteit Leuven, K.U. Leuven R&D Antimicrobial agents

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
A. FOKINE, K. A. MIROSHNIKOV, M. M. SHNEIDER, V. V. MESYANZHINOV, M. G. ROSSMANN: "Structure of the Bacteriophage �KZ Lytic Transglycosylase gp144", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 283, no. 11, 14 March 2008 (2008-03-14), pages 7242 - 7250, XP055130395, ISSN: 00219258, DOI: 10.1074/jbc.M709398200 *
BRIERS, Y. ; SCHMELCHER, M. ; LOESSNER, M.J. ; HENDRIX, J. ; ENGELBORGHS, Y. ; VOLCKAERT, G. ; LAVIGNE, R.: "The high-affinity peptidoglycan binding domain of Pseudomonas phage endolysin KZ144", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM, NL, vol. 383, no. 2, 29 May 2009 (2009-05-29), AMSTERDAM, NL, pages 187 - 191, XP026057388, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2009.03.161 *
LOPEZ, R. GARCIA, E. GARCIA, P.: "Enzymes for anti-infective therapy: phage lysins", DRUG DISCOVERY TODAY: THERAPEUTIC STRATEGIES, ELSEVIER, AMSTERDAM, NL, vol. 1, no. 4, 1 December 2004 (2004-12-01), AMSTERDAM, NL, pages 469 - 474, XP004694307, ISSN: 1740-6773, DOI: 10.1016/j.ddstr.2004.09.002 *
YVES BRIERS, GUIDO BRIERS, ANNELEEN VOLCKAERT, STIJN CORNELISSEN, CHRIS LAGAERT, KIRSTEN MICHIELS, ROB HERTVELDT, LAVIGNE: "Muralytic activity and modular structure of the endolysins of Pseudomonas aeruginosa bacteriophages ?KZ and EL", MOLECULAR MICROBIOLOGY, BLACKWELL SCIENCE, vol. 65, no. 5, 1 September 2007 (2007-09-01), pages 1334 - 1344, XP055119325, ISSN: 0950382X, DOI: 10.1111/j.1365-2958.2007.05870.x *

Also Published As

Publication number Publication date
WO2015070911A1 (en) 2015-05-21
BR112016011091B1 (pt) 2024-02-06
CA2929686A1 (en) 2015-05-21
BR112016011091A2 (pt) 2017-12-05
US10184120B2 (en) 2019-01-22
WO2015071436A1 (en) 2015-05-21
CN105793419B (zh) 2021-06-01
CA2929686C (en) 2023-08-08
JP6745720B2 (ja) 2020-08-26
KR20160085342A (ko) 2016-07-15
US20160281074A1 (en) 2016-09-29
MX374403B (es) 2025-03-06
KR102302044B1 (ko) 2021-09-15
NZ719338A (en) 2022-03-25
MX2016006277A (es) 2017-01-05
EA201691004A1 (ru) 2017-01-30
JP2016537979A (ja) 2016-12-08
CN105793419A (zh) 2016-07-20
AU2014350104B2 (en) 2020-03-05
AU2014350104A1 (en) 2016-05-12

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