JP6744855B2 - 抗体のｉｎ ｖｉｖｏでの半減期のｉｎ ｖｉｔｒｏでの予測 - Google Patents

抗体のｉｎ ｖｉｖｏでの半減期のｉｎ ｖｉｔｒｏでの予測 Download PDF

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Publication number
JP6744855B2
JP6744855B2 JP2017500408A JP2017500408A JP6744855B2 JP 6744855 B2 JP6744855 B2 JP 6744855B2 JP 2017500408 A JP2017500408 A JP 2017500408A JP 2017500408 A JP2017500408 A JP 2017500408A JP 6744855 B2 JP6744855 B2 JP 6744855B2
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antibody
fcrn
retention time
region
life
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JP2017517745A5 (cg-RX-API-DMAC7.html
JP2017517745A (ja
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エムリッヒ，トーマス
ケッテンベルガー，フーベルト
シュロットハウアー，ティルマン
ショック，アンゲラ
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/16—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
    • B01D15/166—Fluid composition conditioning, e.g. gradient
    • B01D15/168—Fluid composition conditioning, e.g. gradient pH gradient or chromatofocusing, i.e. separation according to the isoelectric point pI
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
JP2017500408A 2014-03-21 2015-03-17 抗体のｉｎ ｖｉｖｏでの半減期のｉｎ ｖｉｔｒｏでの予測 Active JP6744855B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP14161103.8 2014-03-21
EP14161103 2014-03-21
EP14165987 2014-04-25
EP14165987.0 2014-04-25
PCT/EP2015/055482 WO2015140126A1 (en) 2014-03-21 2015-03-17 In vitro prediction of in vivo half-life of antibodies

Related Child Applications (1)

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JP2020129979A Division JP7032490B2 (ja) 2014-03-21 2020-07-31 抗体のｉｎ ｖｉｖｏでの半減期のｉｎ ｖｉｔｒｏでの予測

Publications (3)

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JP2017517745A JP2017517745A (ja) 2017-06-29
JP2017517745A5 JP2017517745A5 (cg-RX-API-DMAC7.html) 2018-04-12
JP6744855B2 true JP6744855B2 (ja) 2020-08-19

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JP2017500408A Active JP6744855B2 (ja) 2014-03-21 2015-03-17 抗体のｉｎ ｖｉｖｏでの半減期のｉｎ ｖｉｔｒｏでの予測
JP2020129979A Active JP7032490B2 (ja) 2014-03-21 2020-07-31 抗体のｉｎ ｖｉｖｏでの半減期のｉｎ ｖｉｔｒｏでの予測

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US (2) US20170227547A1 (cg-RX-API-DMAC7.html)
EP (1) EP3119490B1 (cg-RX-API-DMAC7.html)
JP (2) JP6744855B2 (cg-RX-API-DMAC7.html)
KR (1) KR20160134687A (cg-RX-API-DMAC7.html)
CN (1) CN106103478B (cg-RX-API-DMAC7.html)
BR (1) BR112016023417A2 (cg-RX-API-DMAC7.html)
CA (1) CA2938722A1 (cg-RX-API-DMAC7.html)
MX (1) MX377315B (cg-RX-API-DMAC7.html)
RU (1) RU2688349C2 (cg-RX-API-DMAC7.html)
WO (1) WO2015140126A1 (cg-RX-API-DMAC7.html)

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HRP20191766T1 (hr) 2014-11-06 2019-12-27 F. Hoffmann - La Roche Ag Varijante fc regije s modificiranim vezanjem na neonatalni fc receptor (fcrn) i postupci primjene
CN106957365B (zh) * 2016-01-11 2021-03-16 上海交通大学 一种单克隆抗体FnAb8及其应用
CN106957364B (zh) * 2016-01-11 2021-03-16 上海交通大学 一种单克隆抗体FnAb12及其应用
WO2018197533A1 (en) 2017-04-28 2018-11-01 F. Hoffmann-La Roche Ag Antibody selection method
CA3051549A1 (en) 2018-08-09 2020-02-09 Regeneron Pharmaceuticals, Inc. Methods for assessing binding affinity of an antibody variant to the neonatal fc receptor
CN112955468B (zh) 2018-10-01 2024-08-09 豪夫迈·罗氏有限公司 包含抗fap克隆212的双特异性抗原结合分子
JP2022511396A (ja) 2018-10-01 2022-01-31 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Ｃｄ４０への三価結合を伴う二重特異性抗原結合分子
CN112955240B (zh) * 2018-10-25 2022-09-16 豪夫迈·罗氏有限公司 抗体FcRn结合的修饰
CN113227134A (zh) * 2018-12-05 2021-08-06 株式会社梅花治疗 抗体的Fc区变体
CN113227789B (zh) * 2018-12-30 2024-12-24 豪夫迈·罗氏有限公司 基于pH梯度SPR的结合测定
AR121706A1 (es) 2020-04-01 2022-06-29 Hoffmann La Roche Moléculas de unión a antígeno biespecíficas dirigidas a ox40 y fap
EP4133269A1 (en) * 2020-04-08 2023-02-15 F. Hoffmann-La Roche AG Large molecule unspecific clearance assay
JP7322857B2 (ja) * 2020-11-02 2023-08-08 株式会社三洋物産 遊技機
JP7322858B2 (ja) * 2020-11-02 2023-08-08 株式会社三洋物産 遊技機
CN113308476B (zh) * 2021-05-12 2022-06-28 广东药康生物科技有限公司 一种FcRn基因人源化动物模型的构建方法
JPWO2022244838A1 (cg-RX-API-DMAC7.html) * 2021-05-19 2022-11-24
WO2025090910A2 (en) * 2023-10-25 2025-05-01 Multiverse Pharma Inc. Antigen binding molecules targeting il-12 and il-23
US20250332526A1 (en) * 2024-04-26 2025-10-30 Waters Technologies Corporation Direct affinity to size-exclusion chromatography methods and systems thereof

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JP7032490B2 (ja) 2022-03-08
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