MX2016002720A - Metodo para mejorar la estabilidad del anticuerpo. - Google Patents
Metodo para mejorar la estabilidad del anticuerpo.Info
- Publication number
- MX2016002720A MX2016002720A MX2016002720A MX2016002720A MX2016002720A MX 2016002720 A MX2016002720 A MX 2016002720A MX 2016002720 A MX2016002720 A MX 2016002720A MX 2016002720 A MX2016002720 A MX 2016002720A MX 2016002720 A MX2016002720 A MX 2016002720A
- Authority
- MX
- Mexico
- Prior art keywords
- asp
- antibody
- asn
- residue
- atom
- Prior art date
Links
- 125000001433 C-terminal amino-acid group Chemical group 0.000 abstract 2
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 210000004899 c-terminal region Anatomy 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1002—Coronaviridae
- C07K16/1003—Severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2 or Covid-19]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
- G16B15/20—Protein or domain folding
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
- G16C99/00—Subject matter not provided for in other groups of this subclass
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Theoretical Computer Science (AREA)
- Bioinformatics & Computational Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Evolutionary Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Computing Systems (AREA)
- Genetics & Genomics (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
La presente invención se relaciona con un método para seleccionar o deseleccionar un anticuerpo que comprende: a) determinar para cada residuo de Asp y Asn en una región de anticuerpo Fv, la flexibilidad conformacional del átomo Ca usando un montaje de modelo de homología, b) determinar para cada residuo de Asp y Asn en una región de anticuerpo Fv, el tamaño del residuo de aminoácido C-terminal al residuo de Asp o Asn, y c) seleccionar un anticuerpo en el que el átomo Ca es conformacionalmente inflexible y/o el residuo de Asp o Asn tiene un residuo de aminoácido C-terminal grande, o deseleccionar un anticuerpo en el que el átomo Ca tiene una flexibilidad conformacional moderada a alta y/o el Asp y Asn tiene un residuo de aminoácido C-terminal pequeño.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13183389 | 2013-09-06 | ||
EP13184174 | 2013-09-12 | ||
PCT/EP2014/068649 WO2015032776A1 (en) | 2013-09-06 | 2014-09-03 | Method for improving antibody stability |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2016002720A true MX2016002720A (es) | 2016-06-08 |
Family
ID=51485608
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016002720A MX2016002720A (es) | 2013-09-06 | 2014-09-03 | Metodo para mejorar la estabilidad del anticuerpo. |
Country Status (11)
Country | Link |
---|---|
US (2) | US10418126B2 (es) |
EP (2) | EP3761033A3 (es) |
JP (1) | JP6580570B2 (es) |
KR (1) | KR20160052562A (es) |
CN (1) | CN105518461B (es) |
CA (1) | CA2918191A1 (es) |
DK (1) | DK3042205T3 (es) |
HK (1) | HK1223684A1 (es) |
MX (1) | MX2016002720A (es) |
RU (1) | RU2711719C2 (es) |
WO (1) | WO2015032776A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10093978B2 (en) | 2013-08-12 | 2018-10-09 | Genentech, Inc. | Compositions for detecting complement factor H (CFH) and complement factor I (CFI) polymorphisms |
CR20160561A (es) * | 2014-05-01 | 2017-05-03 | Genentech Inc | Variantes del anticuerpo anti-factor d y sus usos |
US10407510B2 (en) | 2015-10-30 | 2019-09-10 | Genentech, Inc. | Anti-factor D antibodies and conjugates |
US10654932B2 (en) | 2015-10-30 | 2020-05-19 | Genentech, Inc. | Anti-factor D antibody variant conjugates and uses thereof |
CN114207728A (zh) * | 2019-08-02 | 2022-03-18 | 杰南技术公司 | 通过基于物理的模拟预测聚合物中的侧链降解 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US100736A (en) * | 1870-03-15 | dundeedale | ||
RU2134724C1 (ru) * | 1992-08-24 | 1999-08-20 | Ниссин Сокухин Кабусики Кайся | Гуманизированное антитело и способ его получения, полинуклеотид (варианты), гибридомная клеточная линия (варианты) |
AU2005287557B2 (en) * | 2004-09-21 | 2011-10-13 | Biontech Ag | Use of microproteins as tryptase inhibitors |
JP5374359B2 (ja) * | 2006-03-17 | 2013-12-25 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 安定化されたポリペプチド化合物 |
EP3202786A3 (en) * | 2007-03-12 | 2017-10-11 | ESBATech, an Alcon Biomedical Research Unit LLC | Sequence based engineering and optimization of single chain antibodies |
JP5745720B2 (ja) * | 2008-06-25 | 2015-07-08 | エスバテック − ア ノバルティスカンパニー エルエルシー | イムノバインダーの溶解性の最適化 |
JP5990102B2 (ja) * | 2009-09-29 | 2016-09-07 | ユニフェルシテイト ヘント | ホスホ−6−マンノースへのマンノース−1−ホスホ−6−マンノース結合の加水分解 |
WO2015140126A1 (en) * | 2014-03-21 | 2015-09-24 | F. Hoffmann-La Roche Ag | In vitro prediction of in vivo half-life of antibodies |
WO2015144932A1 (en) * | 2014-03-28 | 2015-10-01 | Novozymes A/S | Enzyme variants and polynucleotides encoding same |
BR112016027884B1 (pt) * | 2014-05-30 | 2023-05-02 | Novozymes A/S | Variante de uma xilanase da família 11 de gh genitora, polinucleotídeo, construção de ácido nucleico, vetor de expressão, célula hospedeira, e, métodos de produção de uma variante de xilanase da família 11 de gh e de degradação de um material contendo xilana |
-
2014
- 2014-09-03 MX MX2016002720A patent/MX2016002720A/es unknown
- 2014-09-03 WO PCT/EP2014/068649 patent/WO2015032776A1/en active Application Filing
- 2014-09-03 KR KR1020167005951A patent/KR20160052562A/ko not_active Application Discontinuation
- 2014-09-03 CA CA2918191A patent/CA2918191A1/en not_active Abandoned
- 2014-09-03 CN CN201480048544.3A patent/CN105518461B/zh not_active Expired - Fee Related
- 2014-09-03 JP JP2016539511A patent/JP6580570B2/ja not_active Expired - Fee Related
- 2014-09-03 EP EP19217274.0A patent/EP3761033A3/en not_active Withdrawn
- 2014-09-03 EP EP14758893.3A patent/EP3042205B1/en active Active
- 2014-09-03 RU RU2016111352A patent/RU2711719C2/ru not_active IP Right Cessation
- 2014-09-03 DK DK14758893.3T patent/DK3042205T3/da active
-
2016
- 2016-03-04 US US15/061,130 patent/US10418126B2/en not_active Expired - Fee Related
- 2016-10-17 HK HK16111972.1A patent/HK1223684A1/zh not_active IP Right Cessation
-
2019
- 2019-08-02 US US16/530,375 patent/US20200066372A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20200066372A1 (en) | 2020-02-27 |
EP3761033A3 (en) | 2021-01-20 |
RU2711719C2 (ru) | 2020-01-21 |
US20160275238A1 (en) | 2016-09-22 |
KR20160052562A (ko) | 2016-05-12 |
EP3042205A1 (en) | 2016-07-13 |
CN105518461A (zh) | 2016-04-20 |
CN105518461B (zh) | 2018-04-13 |
RU2016111352A3 (es) | 2018-05-23 |
EP3042205B1 (en) | 2019-12-25 |
WO2015032776A1 (en) | 2015-03-12 |
JP6580570B2 (ja) | 2019-09-25 |
DK3042205T3 (da) | 2020-03-02 |
US10418126B2 (en) | 2019-09-17 |
RU2016111352A (ru) | 2017-10-11 |
EP3761033A2 (en) | 2021-01-06 |
CA2918191A1 (en) | 2015-03-12 |
HK1223684A1 (zh) | 2017-08-04 |
JP2016530288A (ja) | 2016-09-29 |
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