KR20160134687A - 항체의 생체내 반감기의 시험관내 예측방법 - Google Patents

항체의 생체내 반감기의 시험관내 예측방법 Download PDF

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KR20160134687A
KR20160134687A KR1020167025760A KR20167025760A KR20160134687A KR 20160134687 A KR20160134687 A KR 20160134687A KR 1020167025760 A KR1020167025760 A KR 1020167025760A KR 20167025760 A KR20167025760 A KR 20167025760A KR 20160134687 A KR20160134687 A KR 20160134687A
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antibody
fcrn
residence time
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val
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Korean (ko)
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토마스 엠리치
후버트 케텐버거
틸만 슐로타우어
안젤라 쇼흐
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에프. 호프만-라 로슈 아게
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Publication of KR20160134687A publication Critical patent/KR20160134687A/ko
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854Immunoglobulins
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/10Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/16Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
    • B01D15/166Fluid composition conditioning, e.g. gradient
    • B01D15/168Fluid composition conditioning, e.g. gradient pH gradient or chromatofocusing, i.e. separation according to the isoelectric point pI
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804Affinity chromatography
    • B01D15/3809Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
KR1020167025760A 2014-03-21 2015-03-17 항체의 생체내 반감기의 시험관내 예측방법 Ceased KR20160134687A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP14161103 2014-03-21
EP14161103.8 2014-03-21
EP14165987 2014-04-25
EP14165987.0 2014-04-25
PCT/EP2015/055482 WO2015140126A1 (en) 2014-03-21 2015-03-17 In vitro prediction of in vivo half-life of antibodies

Publications (1)

Publication Number Publication Date
KR20160134687A true KR20160134687A (ko) 2016-11-23

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020167025760A Ceased KR20160134687A (ko) 2014-03-21 2015-03-17 항체의 생체내 반감기의 시험관내 예측방법

Country Status (10)

Country Link
US (2) US20170227547A1 (cg-RX-API-DMAC7.html)
EP (1) EP3119490B1 (cg-RX-API-DMAC7.html)
JP (2) JP6744855B2 (cg-RX-API-DMAC7.html)
KR (1) KR20160134687A (cg-RX-API-DMAC7.html)
CN (1) CN106103478B (cg-RX-API-DMAC7.html)
BR (1) BR112016023417A2 (cg-RX-API-DMAC7.html)
CA (1) CA2938722A1 (cg-RX-API-DMAC7.html)
MX (1) MX377315B (cg-RX-API-DMAC7.html)
RU (1) RU2688349C2 (cg-RX-API-DMAC7.html)
WO (1) WO2015140126A1 (cg-RX-API-DMAC7.html)

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CN104125852B9 (zh) 2012-02-15 2017-05-17 弗·哈夫曼-拉罗切有限公司 基于Fc‑受体的亲和色谱
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CN106103478B (zh) 2014-03-21 2020-04-03 豪夫迈·罗氏有限公司 抗体体内半寿期的体外预测
EP3215528B1 (en) 2014-11-06 2019-08-07 F.Hoffmann-La Roche Ag Fc-region variants with modified fcrn-binding and methods of use
CN106957365B (zh) * 2016-01-11 2021-03-16 上海交通大学 一种单克隆抗体FnAb8及其应用
CN106957364B (zh) * 2016-01-11 2021-03-16 上海交通大学 一种单克隆抗体FnAb12及其应用
WO2018197533A1 (en) 2017-04-28 2018-11-01 F. Hoffmann-La Roche Ag Antibody selection method
EP3608674A1 (en) * 2018-08-09 2020-02-12 Regeneron Pharmaceuticals, Inc. Methods for assessing binding affinity of an antibody variant to the neonatal fc receptor
US11242396B2 (en) 2018-10-01 2022-02-08 Hoffmann-La Roche Inc. Bispecific antigen binding molecules comprising anti-FAP clone 212
EP3861025A1 (en) 2018-10-01 2021-08-11 F. Hoffmann-La Roche AG Bispecific antigen binding molecules with trivalent binding to cd40
JP2022512798A (ja) 2018-10-25 2022-02-07 エフ.ホフマン-ラ ロシュ アーゲー 抗体FcRn結合の改変
JP7536294B2 (ja) * 2018-12-05 2024-08-20 株式会社バイカ・セラピュティクス 抗体のFc領域改変体
JP7241888B2 (ja) 2018-12-30 2023-03-17 エフ. ホフマン-ラ ロシュ アーゲー pH勾配SPRに基づく結合アッセイ
AR121706A1 (es) 2020-04-01 2022-06-29 Hoffmann La Roche Moléculas de unión a antígeno biespecíficas dirigidas a ox40 y fap
CN115380217B (zh) * 2020-04-08 2025-12-05 豪夫迈·罗氏有限公司 大分子非特异性清除测定
JP7322857B2 (ja) * 2020-11-02 2023-08-08 株式会社三洋物産 遊技機
JP7322858B2 (ja) * 2020-11-02 2023-08-08 株式会社三洋物産 遊技機
CN113308476B (zh) * 2021-05-12 2022-06-28 广东药康生物科技有限公司 一种FcRn基因人源化动物模型的构建方法
US20250076283A1 (en) * 2021-05-19 2025-03-06 Chugai Seiyaku Kabushiki Kaisha Method for predicting in vivo pharmacokinetics of molecule
TW202535933A (zh) * 2023-10-25 2025-09-16 美商多重宇宙製藥公司 靶向il-12及il-23之抗原結合分子
US20250332526A1 (en) * 2024-04-26 2025-10-30 Waters Technologies Corporation Direct affinity to size-exclusion chromatography methods and systems thereof

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WO2015140126A1 (en) 2015-09-24
CN106103478A (zh) 2016-11-09
US20170227547A1 (en) 2017-08-10
CN106103478B (zh) 2020-04-03
RU2016137932A (ru) 2018-04-23
JP2020183967A (ja) 2020-11-12
MX2016011982A (es) 2016-12-09
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US12461109B2 (en) 2025-11-04
US20210190795A1 (en) 2021-06-24
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