JP6728055B2 - Ｉｌ−１５部分とポリマーとのコンジュゲート - Google Patents

Ｉｌ−１５部分とポリマーとのコンジュゲート Download PDF

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Publication number
JP6728055B2
JP6728055B2 JP2016559891A JP2016559891A JP6728055B2 JP 6728055 B2 JP6728055 B2 JP 6728055B2 JP 2016559891 A JP2016559891 A JP 2016559891A JP 2016559891 A JP2016559891 A JP 2016559891A JP 6728055 B2 JP6728055 B2 JP 6728055B2
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moiety
conjugate
water
polymer
daltons
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JP2017511322A (ja
JP2017511322A5 (enExample
Inventor
シャオフェン リウ，
シャオフェン リウ，
ピーター ベネディクト カーク，
ピーター ベネディクト カーク，
トーマス チャン，
トーマス チャン，
デボラ エイチ． チャリッチ，
デボラ エイチ． チャリッチ，
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ネクター セラピューティクス
ネクター セラピューティクス
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2086—IL-13 to IL-16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • C08G65/48—Polymers modified by chemical after-treatment

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Polymers & Plastics (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2016559891A 2014-04-03 2015-04-01 Ｉｌ−１５部分とポリマーとのコンジュゲート Active JP6728055B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461974914P 2014-04-03 2014-04-03
US61/974,914 2014-04-03
PCT/US2015/023871 WO2015153753A2 (en) 2014-04-03 2015-04-01 Conjugates of an il-15 moiety and a polymer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020074680A Division JP2020114875A (ja) 2014-04-03 2020-04-20 Ｉｌ−１５部分とポリマーとのコンジュゲート

Publications (3)

Publication Number Publication Date
JP2017511322A JP2017511322A (ja) 2017-04-20
JP2017511322A5 JP2017511322A5 (enExample) 2018-04-12
JP6728055B2 true JP6728055B2 (ja) 2020-07-22

Family

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Family Applications (2)

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JP2016559891A Active JP6728055B2 (ja) 2014-04-03 2015-04-01 Ｉｌ−１５部分とポリマーとのコンジュゲート
JP2020074680A Withdrawn JP2020114875A (ja) 2014-04-03 2020-04-20 Ｉｌ−１５部分とポリマーとのコンジュゲート

Family Applications After (1)

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JP2020074680A Withdrawn JP2020114875A (ja) 2014-04-03 2020-04-20 Ｉｌ−１５部分とポリマーとのコンジュゲート

Country Status (12)

Country Link
US (1) US20170035898A1 (enExample)
EP (2) EP3919071A1 (enExample)
JP (2) JP6728055B2 (enExample)
KR (1) KR102432169B1 (enExample)
CN (1) CN106456716A (enExample)
AU (3) AU2015240806B2 (enExample)
CA (1) CA2942571C (enExample)
ES (1) ES2876433T3 (enExample)
IL (1) IL248169A0 (enExample)
MA (1) MA39711A (enExample)
MX (2) MX388865B (enExample)
WO (1) WO2015153753A2 (enExample)

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EP3038642A4 (en) 2013-08-30 2017-01-18 Armo Biosciences, Inc. Methods of using interleukin-10 for treating diseases and disorders
EP3068425B1 (en) 2013-11-11 2021-01-27 Armo Biosciences, Inc. Methods of using interleukin-10 for treating diseases and disorders
CN106573072A (zh) 2014-06-02 2017-04-19 阿尔莫生物科技股份有限公司 降低血清胆固醇的方法
AU2015333827A1 (en) 2014-10-14 2017-04-20 Armo Biosciences, Inc. Interleukin-15 compositions and uses thereof
CN107106655A (zh) 2014-10-22 2017-08-29 阿尔莫生物科技股份有限公司 使用白细胞介素‑10治疗疾病和病症的方法
US10618970B2 (en) 2015-02-03 2020-04-14 Armo Biosciences, Inc. Method of treating cancer with IL-10 and antibodies that induce ADCC
HK1248137A1 (zh) 2015-05-28 2018-10-12 阿尔莫生物科技股份有限公司 用於治疗癌症的聚乙二醇化白细胞介素-10
WO2017035232A1 (en) 2015-08-25 2017-03-02 Armo Biosciences, Inc. Methods of using interleukin-10 for treating diseases and disorders
WO2017062832A1 (en) 2015-10-08 2017-04-13 Nektar Therapeutics Combination of an il-2rbeta-selective agonist and a long-acting il-15 agonist
KR20180089516A (ko) * 2015-12-21 2018-08-08 아르모 바이오사이언시스 인코포레이티드 인터류킨-15 조성물 및 이의 용도
CN109715196A (zh) 2016-06-13 2019-05-03 转矩医疗股份有限公司 用于促进免疫细胞功能的组合物和方法
CN119700941A (zh) * 2017-05-15 2025-03-28 尼克塔治疗公司 长效白细胞介素-15受体激动剂以及相关免疫治疗组合物和方法
CA3074826A1 (en) 2017-09-05 2019-03-14 Torque Therapeutics, Inc. Therapeutic protein compositions and methods of making and using the same
MY203509A (en) * 2018-02-26 2024-06-30 Synthorx Inc Il-15 conjugates and uses thereof
EP3876974A4 (en) * 2018-11-09 2022-11-23 Nektar Therapeutics LONG-ACTING INTERLEUKIN-15 RECEPTOR AGONIST IN COMBINATION WITH ANOTHER PHARMACOLOGICALLY ACTIVE AGENT
EP3958888A4 (en) * 2019-04-26 2023-07-12 Prolynx LLC SLOW-RELEASE CYTOKINE CONJUGATES
WO2020247388A2 (en) 2019-06-03 2020-12-10 Medikine, Inc. Il-2alpha receptor subunit binding compounds
EP4017540A1 (en) * 2019-08-23 2022-06-29 Synthorx, Inc. Il-15 conjugates and uses thereof
EP4313154A4 (en) * 2021-03-29 2025-05-07 AJ Sciences (Yixing) Co., Ltd Protein-macromolecule conjugates and methods of use thereof
KR20240024241A (ko) 2021-06-23 2024-02-23 싸이튠 파마 인터루킨 15 변이체
EP4370536A2 (en) * 2021-07-12 2024-05-22 Nektar Therapeutics Polymer engineered forms of interferon-gamma and methods of use
WO2023133595A2 (en) 2022-01-10 2023-07-13 Sana Biotechnology, Inc. Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses
WO2023193015A1 (en) 2022-04-01 2023-10-05 Sana Biotechnology, Inc. Cytokine receptor agonist and viral vector combination therapies
WO2025101551A1 (en) * 2023-11-06 2025-05-15 Regents Of The University Of Minnesota Prostate-specific membrane antigen (psma)-binding peptides and method of use

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Also Published As

Publication number Publication date
MX2016012908A (es) 2017-01-11
EP3139947B8 (en) 2021-06-30
CA2942571C (en) 2023-09-19
JP2020114875A (ja) 2020-07-30
US20170035898A1 (en) 2017-02-09
EP3139947B1 (en) 2021-05-26
EP3919071A1 (en) 2021-12-08
EP3139947A2 (en) 2017-03-15
KR102432169B1 (ko) 2022-08-11
AU2015240806B2 (en) 2019-09-19
MA39711A (fr) 2015-10-08
AU2021258008A1 (en) 2021-11-25
AU2019283778A1 (en) 2020-01-16
AU2015240806A1 (en) 2016-10-13
WO2015153753A3 (en) 2015-11-26
EP3139947A4 (en) 2018-01-17
WO2015153753A2 (en) 2015-10-08
ES2876433T3 (es) 2021-11-12
CA2942571A1 (en) 2015-10-08
JP2017511322A (ja) 2017-04-20
MX2021015492A (es) 2022-02-22
IL248169A0 (en) 2016-11-30
MX388865B (es) 2025-03-20
CN106456716A (zh) 2017-02-22
KR20170005793A (ko) 2017-01-16

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