AU2015240806B2 - Conjugates of an IL-15 moiety and a polymer - Google Patents
Conjugates of an IL-15 moiety and a polymer Download PDFInfo
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- AU2015240806B2 AU2015240806B2 AU2015240806A AU2015240806A AU2015240806B2 AU 2015240806 B2 AU2015240806 B2 AU 2015240806B2 AU 2015240806 A AU2015240806 A AU 2015240806A AU 2015240806 A AU2015240806 A AU 2015240806A AU 2015240806 B2 AU2015240806 B2 AU 2015240806B2
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- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- HLBBKKJFGFRGMU-UHFFFAOYSA-M sodium formate Chemical compound [Na+].[O-]C=O HLBBKKJFGFRGMU-UHFFFAOYSA-M 0.000 description 1
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- 239000008247 solid mixture Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
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- 238000010186 staining Methods 0.000 description 1
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- 125000005017 substituted alkenyl group Chemical group 0.000 description 1
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- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000759 toxicological effect Toxicity 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
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- 230000009466 transformation Effects 0.000 description 1
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- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2086—IL-13 to IL-16
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
- C08G65/48—Polymers modified by chemical after-treatment
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Polymers & Plastics (AREA)
- Oncology (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (2)
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| AU2019283778A AU2019283778A1 (en) | 2014-04-03 | 2019-12-16 | Conjugates of an IL-15 moiety and a polymer |
| AU2021258008A AU2021258008A1 (en) | 2014-04-03 | 2021-10-28 | Conjugates of an IL-15 moiety and a polymer |
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| US201461974914P | 2014-04-03 | 2014-04-03 | |
| US61/974,914 | 2014-04-03 | ||
| PCT/US2015/023871 WO2015153753A2 (en) | 2014-04-03 | 2015-04-01 | Conjugates of an il-15 moiety and a polymer |
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| AU2015240806A1 AU2015240806A1 (en) | 2016-10-13 |
| AU2015240806B2 true AU2015240806B2 (en) | 2019-09-19 |
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| AU2019283778A Abandoned AU2019283778A1 (en) | 2014-04-03 | 2019-12-16 | Conjugates of an IL-15 moiety and a polymer |
| AU2021258008A Abandoned AU2021258008A1 (en) | 2014-04-03 | 2021-10-28 | Conjugates of an IL-15 moiety and a polymer |
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| AU2021258008A Abandoned AU2021258008A1 (en) | 2014-04-03 | 2021-10-28 | Conjugates of an IL-15 moiety and a polymer |
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| EP (2) | EP3919071A1 (enExample) |
| JP (2) | JP6728055B2 (enExample) |
| KR (1) | KR102432169B1 (enExample) |
| CN (1) | CN106456716A (enExample) |
| AU (3) | AU2015240806B2 (enExample) |
| CA (1) | CA2942571C (enExample) |
| ES (1) | ES2876433T3 (enExample) |
| IL (1) | IL248169A0 (enExample) |
| MA (1) | MA39711A (enExample) |
| MX (2) | MX388865B (enExample) |
| WO (1) | WO2015153753A2 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US9943568B2 (en) | 2013-04-18 | 2018-04-17 | Armo Biosciences, Inc. | Methods of using pegylated interleukin-10 for treating cancer |
| US9823255B2 (en) | 2013-06-17 | 2017-11-21 | Armo Biosciences, Inc. | Method for assessing protein identity and stability |
| EP3038642A4 (en) | 2013-08-30 | 2017-01-18 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
| EP3068425B1 (en) | 2013-11-11 | 2021-01-27 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
| CN106573072A (zh) | 2014-06-02 | 2017-04-19 | 阿尔莫生物科技股份有限公司 | 降低血清胆固醇的方法 |
| AU2015333827A1 (en) | 2014-10-14 | 2017-04-20 | Armo Biosciences, Inc. | Interleukin-15 compositions and uses thereof |
| CN107106655A (zh) | 2014-10-22 | 2017-08-29 | 阿尔莫生物科技股份有限公司 | 使用白细胞介素‑10治疗疾病和病症的方法 |
| US10618970B2 (en) | 2015-02-03 | 2020-04-14 | Armo Biosciences, Inc. | Method of treating cancer with IL-10 and antibodies that induce ADCC |
| HK1248137A1 (zh) | 2015-05-28 | 2018-10-12 | 阿尔莫生物科技股份有限公司 | 用於治疗癌症的聚乙二醇化白细胞介素-10 |
| WO2017035232A1 (en) | 2015-08-25 | 2017-03-02 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
| WO2017062832A1 (en) | 2015-10-08 | 2017-04-13 | Nektar Therapeutics | Combination of an il-2rbeta-selective agonist and a long-acting il-15 agonist |
| KR20180089516A (ko) * | 2015-12-21 | 2018-08-08 | 아르모 바이오사이언시스 인코포레이티드 | 인터류킨-15 조성물 및 이의 용도 |
| CN109715196A (zh) | 2016-06-13 | 2019-05-03 | 转矩医疗股份有限公司 | 用于促进免疫细胞功能的组合物和方法 |
| CN119700941A (zh) * | 2017-05-15 | 2025-03-28 | 尼克塔治疗公司 | 长效白细胞介素-15受体激动剂以及相关免疫治疗组合物和方法 |
| CA3074826A1 (en) | 2017-09-05 | 2019-03-14 | Torque Therapeutics, Inc. | Therapeutic protein compositions and methods of making and using the same |
| MY203509A (en) * | 2018-02-26 | 2024-06-30 | Synthorx Inc | Il-15 conjugates and uses thereof |
| EP3876974A4 (en) * | 2018-11-09 | 2022-11-23 | Nektar Therapeutics | LONG-ACTING INTERLEUKIN-15 RECEPTOR AGONIST IN COMBINATION WITH ANOTHER PHARMACOLOGICALLY ACTIVE AGENT |
| EP3958888A4 (en) * | 2019-04-26 | 2023-07-12 | Prolynx LLC | SLOW-RELEASE CYTOKINE CONJUGATES |
| WO2020247388A2 (en) | 2019-06-03 | 2020-12-10 | Medikine, Inc. | Il-2alpha receptor subunit binding compounds |
| EP4017540A1 (en) * | 2019-08-23 | 2022-06-29 | Synthorx, Inc. | Il-15 conjugates and uses thereof |
| EP4313154A4 (en) * | 2021-03-29 | 2025-05-07 | AJ Sciences (Yixing) Co., Ltd | Protein-macromolecule conjugates and methods of use thereof |
| KR20240024241A (ko) | 2021-06-23 | 2024-02-23 | 싸이튠 파마 | 인터루킨 15 변이체 |
| EP4370536A2 (en) * | 2021-07-12 | 2024-05-22 | Nektar Therapeutics | Polymer engineered forms of interferon-gamma and methods of use |
| WO2023133595A2 (en) | 2022-01-10 | 2023-07-13 | Sana Biotechnology, Inc. | Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses |
| WO2023193015A1 (en) | 2022-04-01 | 2023-10-05 | Sana Biotechnology, Inc. | Cytokine receptor agonist and viral vector combination therapies |
| WO2025101551A1 (en) * | 2023-11-06 | 2025-05-15 | Regents Of The University Of Minnesota | Prostate-specific membrane antigen (psma)-binding peptides and method of use |
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| US20040253587A1 (en) * | 1995-02-22 | 2004-12-16 | Immunex Corporation | Antagonists of interleukin-15 |
| WO2012016131A1 (en) * | 2010-07-30 | 2012-02-02 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
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| US5166322A (en) | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
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| US5446090A (en) | 1993-11-12 | 1995-08-29 | Shearwater Polymers, Inc. | Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules |
| ATE196315T1 (de) | 1994-04-06 | 2000-09-15 | Immunex Corp | Interleukin-15 |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| US5795966A (en) * | 1995-02-22 | 1998-08-18 | Immunex Corp | Antagonists of interleukin-15 |
| EP1411075B1 (en) | 1998-03-12 | 2008-07-02 | Nektar Therapeutics Al, Corporation | Method for preparing polymer conjugates |
| AU2001238595A1 (en) | 2000-02-22 | 2001-09-03 | Shearwater Corporation | N-maleimidyl polymer derivatives |
| ATE444984T1 (de) * | 2002-12-31 | 2009-10-15 | Nektar Therapeutics Al Corp | Hydrolysestabile maleimidendgruppen-enthaltende polymere |
| DE602004029646D1 (en) | 2003-01-06 | 2010-12-02 | Nektar Therapeutics San Carlos | Thiolselektive wasserlösliche polymerderivate |
| WO2005030196A2 (en) * | 2003-09-25 | 2005-04-07 | Zymogenetics, Inc. | Methods of treating autoimmune diseases using il-21 |
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-
2015
- 2015-03-31 MA MA039711A patent/MA39711A/fr unknown
- 2015-04-01 ES ES15773976T patent/ES2876433T3/es active Active
- 2015-04-01 US US15/301,681 patent/US20170035898A1/en not_active Abandoned
- 2015-04-01 EP EP21169371.8A patent/EP3919071A1/en active Pending
- 2015-04-01 EP EP15773976.4A patent/EP3139947B8/en active Active
- 2015-04-01 CN CN201580017361.XA patent/CN106456716A/zh active Pending
- 2015-04-01 JP JP2016559891A patent/JP6728055B2/ja active Active
- 2015-04-01 MX MX2016012908A patent/MX388865B/es unknown
- 2015-04-01 KR KR1020167027127A patent/KR102432169B1/ko active Active
- 2015-04-01 WO PCT/US2015/023871 patent/WO2015153753A2/en not_active Ceased
- 2015-04-01 AU AU2015240806A patent/AU2015240806B2/en active Active
- 2015-04-01 CA CA2942571A patent/CA2942571C/en active Active
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2016
- 2016-09-30 MX MX2021015492A patent/MX2021015492A/es unknown
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2019
- 2019-12-16 AU AU2019283778A patent/AU2019283778A1/en not_active Abandoned
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2020
- 2020-04-20 JP JP2020074680A patent/JP2020114875A/ja not_active Withdrawn
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2021
- 2021-10-28 AU AU2021258008A patent/AU2021258008A1/en not_active Abandoned
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Also Published As
| Publication number | Publication date |
|---|---|
| MX2016012908A (es) | 2017-01-11 |
| EP3139947B8 (en) | 2021-06-30 |
| CA2942571C (en) | 2023-09-19 |
| JP2020114875A (ja) | 2020-07-30 |
| US20170035898A1 (en) | 2017-02-09 |
| EP3139947B1 (en) | 2021-05-26 |
| EP3919071A1 (en) | 2021-12-08 |
| EP3139947A2 (en) | 2017-03-15 |
| KR102432169B1 (ko) | 2022-08-11 |
| MA39711A (fr) | 2015-10-08 |
| AU2021258008A1 (en) | 2021-11-25 |
| AU2019283778A1 (en) | 2020-01-16 |
| AU2015240806A1 (en) | 2016-10-13 |
| WO2015153753A3 (en) | 2015-11-26 |
| EP3139947A4 (en) | 2018-01-17 |
| WO2015153753A2 (en) | 2015-10-08 |
| ES2876433T3 (es) | 2021-11-12 |
| CA2942571A1 (en) | 2015-10-08 |
| JP2017511322A (ja) | 2017-04-20 |
| MX2021015492A (es) | 2022-02-22 |
| IL248169A0 (en) | 2016-11-30 |
| MX388865B (es) | 2025-03-20 |
| CN106456716A (zh) | 2017-02-22 |
| KR20170005793A (ko) | 2017-01-16 |
| JP6728055B2 (ja) | 2020-07-22 |
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