JP6702623B2 - メデトミジンの合成に有用な３−アリールブタナールなどの化合物の調製方法 - Google Patents

メデトミジンの合成に有用な３−アリールブタナールなどの化合物の調製方法 Download PDF

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JP6702623B2
JP6702623B2 JP2017540562A JP2017540562A JP6702623B2 JP 6702623 B2 JP6702623 B2 JP 6702623B2 JP 2017540562 A JP2017540562 A JP 2017540562A JP 2017540562 A JP2017540562 A JP 2017540562A JP 6702623 B2 JP6702623 B2 JP 6702623B2
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JP2018505179A5 (enExample
JP2018505179A (ja
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ラース エコルンデ，
ラース エコルンデ，
マルグス エエク，
マルグス エエク，
ラメシュ エカンバラム，
ラメシュ エカンバラム，
アントス マァーサル，
アントス マァーサル，
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I Tech AB
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/02—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of compounds containing imino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/24—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/455—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation with carboxylic acids or their derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C07C45/86—Use of additives, e.g. for stabilisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/228—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing six-membered aromatic rings, e.g. phenylacetaldehyde
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/228—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing six-membered aromatic rings, e.g. phenylacetaldehyde
    • C07C47/232—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing six-membered aromatic rings, e.g. phenylacetaldehyde having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/14—Esters of phosphoric acids containing P(=O)-halide groups
    • C07F9/1403—Esters of phosphoric acids containing P(=O)-halide groups containing the structure Hal-P(=O)-O-unsaturated acyclic group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/24—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing halogen

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2017540562A 2015-01-30 2016-01-29 メデトミジンの合成に有用な３−アリールブタナールなどの化合物の調製方法 Active JP6702623B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1501593.6 2015-01-30
GBGB1501593.6A GB201501593D0 (en) 2015-01-30 2015-01-30 New compounds and processes
PCT/GB2016/050204 WO2016120635A1 (en) 2015-01-30 2016-01-29 Processes for the preparation of compounds, such as 3-arylbutanals, useful in the synthesis of medetomidine

Publications (3)

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JP2018505179A JP2018505179A (ja) 2018-02-22
JP2018505179A5 JP2018505179A5 (enExample) 2019-03-07
JP6702623B2 true JP6702623B2 (ja) 2020-06-03

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JP2017540562A Active JP6702623B2 (ja) 2015-01-30 2016-01-29 メデトミジンの合成に有用な３−アリールブタナールなどの化合物の調製方法

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Country Link
US (1) US10053420B2 (enExample)
EP (1) EP3250556B1 (enExample)
JP (1) JP6702623B2 (enExample)
KR (1) KR102458638B1 (enExample)
CN (1) CN107428648B (enExample)
DK (1) DK3250556T3 (enExample)
ES (1) ES2716748T3 (enExample)
GB (1) GB201501593D0 (enExample)
HR (1) HRP20190286T1 (enExample)
HU (1) HUE042626T2 (enExample)
PL (1) PL3250556T3 (enExample)
TR (1) TR201902673T4 (enExample)
WO (1) WO2016120635A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12050293B2 (en) 2018-12-19 2024-07-30 Pgs Geophysical As Medetomidine compositions having improved anti-fouling characteristics
PT4038149T (pt) 2020-10-21 2023-05-29 I Tech Ab Compostos anti-incrustação
EP4506340A1 (en) * 2022-03-22 2025-02-12 Obshestvo s Ogranichennoj Otvetstvennostju "Vikzdorove Zhivotnyh" Method for producing medetomidine and its derivatives
WO2026015064A1 (en) 2024-07-09 2026-01-15 I-Tech Ab Antifouling paint composition with improved in-can stability

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2340812C2 (de) 1973-08-11 1982-05-27 Basf Ag, 6700 Ludwigshafen Phenylpropanale sowie ein Verfahren zu deren Herstellung
US4416902A (en) 1982-07-16 1983-11-22 International Flavors & Fragrances Inc. Flavoring with cyclohexenyl-beta-methyl acrolein derivatives
DE19714042A1 (de) 1997-04-05 1998-10-08 Henkel Kgaa Verfahren zur Herstellung aromatischer Aldehyde
WO2007111630A1 (en) * 2005-07-29 2007-10-04 Flexitral, Inc. Compounds which release an odor on a change in ph
CN102458659B (zh) * 2009-06-03 2014-07-09 高砂香料工业株式会社 不对称氢化催化剂
TW201223934A (en) 2010-11-26 2012-06-16 Lonza Ag 3-(2,3-dimethylphenyl)-2-butenal and its use as perfume
WO2012098067A1 (en) * 2011-01-19 2012-07-26 Dsm Ip Assets B.V. Preparation of 4-acetoxy-2-methylbutanal by catalytic carbon carbon double bond hydrogenation
TW201238603A (en) * 2011-03-10 2012-10-01 Lonza Ag Method for preparation of 3-(2,3-dimethylphenyl)-2-butenal
IN2014DN00144A (enExample) * 2011-07-22 2015-05-22 Cambrex Karlskoga Ab
WO2012172120A2 (en) * 2012-05-08 2012-12-20 Lonza Ltd 2-(2,3-dimethylphenyl)-1-propanal and its use as perfume
JP5777840B2 (ja) * 2012-05-08 2015-09-09 ロンザ・リミテッド ２−（２，３−ジメチルフェニル）−１−プロパナールを調製するための方法
WO2012172119A2 (en) * 2012-05-08 2012-12-20 Lonza Ltd Method for the preparation of medetomidine

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Publication number Publication date
KR102458638B1 (ko) 2022-10-24
KR20170108080A (ko) 2017-09-26
HUE042626T2 (hu) 2019-07-29
PL3250556T3 (pl) 2019-05-31
US10053420B2 (en) 2018-08-21
CN107428648B (zh) 2021-12-10
EP3250556A1 (en) 2017-12-06
CN107428648A (zh) 2017-12-01
JP2018505179A (ja) 2018-02-22
WO2016120635A1 (en) 2016-08-04
HRP20190286T1 (hr) 2019-04-05
DK3250556T3 (en) 2019-03-11
TR201902673T4 (tr) 2019-03-21
EP3250556B1 (en) 2018-12-05
ES2716748T3 (es) 2019-06-14
GB201501593D0 (en) 2015-03-18
US20180009744A1 (en) 2018-01-11

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