HUE042626T2 - Eljárások a medetomidin szintézisnél hasznosítható vegyületek, például 3 aril-butiral-dehidek elõállítására - Google Patents
Eljárások a medetomidin szintézisnél hasznosítható vegyületek, például 3 aril-butiral-dehidek elõállításáraInfo
- Publication number
- HUE042626T2 HUE042626T2 HUE16706396A HUE16706396A HUE042626T2 HU E042626 T2 HUE042626 T2 HU E042626T2 HU E16706396 A HUE16706396 A HU E16706396A HU E16706396 A HUE16706396 A HU E16706396A HU E042626 T2 HUE042626 T2 HU E042626T2
- Authority
- HU
- Hungary
- Prior art keywords
- arylbutanals
- medetomidine
- synthesis
- compounds
- useful
- Prior art date
Links
- -1 3-arylbutanals Chemical class 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- HRLIOXLXPOHXTA-UHFFFAOYSA-N medetomidine Chemical compound C=1C=CC(C)=C(C)C=1C(C)C1=CN=C[N]1 HRLIOXLXPOHXTA-UHFFFAOYSA-N 0.000 title 1
- 229960002140 medetomidine Drugs 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/24—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C249/02—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of compounds containing imino groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/455—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation with carboxylic acids or their derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/78—Separation; Purification; Stabilisation; Use of additives
- C07C45/86—Use of additives, e.g. for stabilisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
- C07C47/228—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing six-membered aromatic rings, e.g. phenylacetaldehyde
- C07C47/232—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing six-membered aromatic rings, e.g. phenylacetaldehyde having unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/14—Esters of phosphoric acids containing P(=O)-halide groups
- C07F9/1403—Esters of phosphoric acids containing P(=O)-halide groups containing the structure Hal-P(=O)-O-unsaturated acyclic group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
- C07C47/228—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing six-membered aromatic rings, e.g. phenylacetaldehyde
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
- C07C47/24—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1501593.6A GB201501593D0 (en) | 2015-01-30 | 2015-01-30 | New compounds and processes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE042626T2 true HUE042626T2 (hu) | 2019-07-29 |
Family
ID=52705534
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE16706396A HUE042626T2 (hu) | 2015-01-30 | 2016-01-29 | Eljárások a medetomidin szintézisnél hasznosítható vegyületek, például 3 aril-butiral-dehidek elõállítására |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10053420B2 (enExample) |
| EP (1) | EP3250556B1 (enExample) |
| JP (1) | JP6702623B2 (enExample) |
| KR (1) | KR102458638B1 (enExample) |
| CN (1) | CN107428648B (enExample) |
| DK (1) | DK3250556T3 (enExample) |
| ES (1) | ES2716748T3 (enExample) |
| GB (1) | GB201501593D0 (enExample) |
| HR (1) | HRP20190286T1 (enExample) |
| HU (1) | HUE042626T2 (enExample) |
| PL (1) | PL3250556T3 (enExample) |
| TR (1) | TR201902673T4 (enExample) |
| WO (1) | WO2016120635A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12050293B2 (en) | 2018-12-19 | 2024-07-30 | Pgs Geophysical As | Medetomidine compositions having improved anti-fouling characteristics |
| CN118772061A (zh) | 2020-10-21 | 2024-10-15 | I-技术有限公司 | 防污化合物 |
| CN117295718A (zh) * | 2022-03-22 | 2023-12-26 | 维科-兹多洛夫希沃特尼赫有限责任公司 | 美托咪定及其衍生物的制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2340812C2 (de) | 1973-08-11 | 1982-05-27 | Basf Ag, 6700 Ludwigshafen | Phenylpropanale sowie ein Verfahren zu deren Herstellung |
| US4416902A (en) | 1982-07-16 | 1983-11-22 | International Flavors & Fragrances Inc. | Flavoring with cyclohexenyl-beta-methyl acrolein derivatives |
| DE19714042A1 (de) * | 1997-04-05 | 1998-10-08 | Henkel Kgaa | Verfahren zur Herstellung aromatischer Aldehyde |
| WO2007111630A1 (en) * | 2005-07-29 | 2007-10-04 | Flexitral, Inc. | Compounds which release an odor on a change in ph |
| CN102458659B (zh) * | 2009-06-03 | 2014-07-09 | 高砂香料工业株式会社 | 不对称氢化催化剂 |
| TW201223934A (en) * | 2010-11-26 | 2012-06-16 | Lonza Ag | 3-(2,3-dimethylphenyl)-2-butenal and its use as perfume |
| BR112013018345B1 (pt) * | 2011-01-19 | 2019-02-26 | Dsm Ip Assets B.V. | Hidrogenação de ligação dupla carbono-carbono catalítica |
| TW201238603A (en) * | 2011-03-10 | 2012-10-01 | Lonza Ag | Method for preparation of 3-(2,3-dimethylphenyl)-2-butenal |
| JP5996647B2 (ja) * | 2011-07-22 | 2016-09-21 | カンブレックス カルルスクーガ アクチ ボラケットＣａｍｂｒｅｘ Ｋａｒｌｓｋｏｇａ Ａｂ | ４−置換イミダゾールの新規な調製プロセス |
| WO2012172120A2 (en) | 2012-05-08 | 2012-12-20 | Lonza Ltd | 2-(2,3-dimethylphenyl)-1-propanal and its use as perfume |
| PT2847157E (pt) * | 2012-05-08 | 2016-01-27 | Lonza Ag | Método para a preparação de 2-(2,3-dimetilfenil)-1-propanal |
| WO2012172119A2 (en) * | 2012-05-08 | 2012-12-20 | Lonza Ltd | Method for the preparation of medetomidine |
-
2015
- 2015-01-30 GB GBGB1501593.6A patent/GB201501593D0/en not_active Ceased
-
2016
- 2016-01-29 WO PCT/GB2016/050204 patent/WO2016120635A1/en not_active Ceased
- 2016-01-29 TR TR2019/02673T patent/TR201902673T4/tr unknown
- 2016-01-29 CN CN201680012547.0A patent/CN107428648B/zh active Active
- 2016-01-29 US US15/547,288 patent/US10053420B2/en active Active
- 2016-01-29 PL PL16706396T patent/PL3250556T3/pl unknown
- 2016-01-29 HU HUE16706396A patent/HUE042626T2/hu unknown
- 2016-01-29 ES ES16706396T patent/ES2716748T3/es active Active
- 2016-01-29 JP JP2017540562A patent/JP6702623B2/ja active Active
- 2016-01-29 EP EP16706396.5A patent/EP3250556B1/en active Active
- 2016-01-29 HR HRP20190286TT patent/HRP20190286T1/hr unknown
- 2016-01-29 DK DK16706396.5T patent/DK3250556T3/en active
- 2016-01-29 KR KR1020177023707A patent/KR102458638B1/ko active Active
Also Published As
| Publication number | Publication date |
|---|---|
| KR102458638B1 (ko) | 2022-10-24 |
| JP2018505179A (ja) | 2018-02-22 |
| TR201902673T4 (tr) | 2019-03-21 |
| PL3250556T3 (pl) | 2019-05-31 |
| DK3250556T3 (en) | 2019-03-11 |
| KR20170108080A (ko) | 2017-09-26 |
| CN107428648A (zh) | 2017-12-01 |
| WO2016120635A1 (en) | 2016-08-04 |
| US10053420B2 (en) | 2018-08-21 |
| EP3250556A1 (en) | 2017-12-06 |
| HRP20190286T1 (hr) | 2019-04-05 |
| CN107428648B (zh) | 2021-12-10 |
| US20180009744A1 (en) | 2018-01-11 |
| ES2716748T3 (es) | 2019-06-14 |
| EP3250556B1 (en) | 2018-12-05 |
| JP6702623B2 (ja) | 2020-06-03 |
| GB201501593D0 (en) | 2015-03-18 |
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