JP6694269B2 - Ｓ．アウレウス（Ｓ．ａｕｒｅｕｓ）表面決定基に対する抗体 - Google Patents

Ｓ．アウレウス（Ｓ．ａｕｒｅｕｓ）表面決定基に対する抗体 Download PDF

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JP6694269B2
JP6694269B2 JP2015540879A JP2015540879A JP6694269B2 JP 6694269 B2 JP6694269 B2 JP 6694269B2 JP 2015540879 A JP2015540879 A JP 2015540879A JP 2015540879 A JP2015540879 A JP 2015540879A JP 6694269 B2 JP6694269 B2 JP 6694269B2
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amino acid
seq
antigen
aureus
antibody
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JP2016507470A5 (enExample
JP2016507470A (ja
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セルマン，ブレット
トカチク，クリスティーン
チョードゥリー，パーサ，エス．
ホワ，レイ
パブリク，ピーター
ブォンパーネ，レベッカ
チャン，チュウ−シュン
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メディミューン，エルエルシー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Gram-positive bacteria
    • C07K16/1271—Micrococcaceae (F); Staphylococcaceae (F), e.g. Staphylococcus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/56938—Staphylococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Virology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2015540879A 2012-11-06 2013-11-06 Ｓ．アウレウス（Ｓ．ａｕｒｅｕｓ）表面決定基に対する抗体 Active JP6694269B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261723137P 2012-11-06 2012-11-06
US61/723,137 2012-11-06
US201361782405P 2013-03-14 2013-03-14
US61/782,405 2013-03-14
PCT/US2013/068624 WO2014074540A2 (en) 2012-11-06 2013-11-06 Antibodies to s. aureus surface determinants

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JP2019011283A Division JP2019089801A (ja) 2012-11-06 2019-01-25 Ｓ．アウレウス（Ｓ．ａｕｒｅｕｓ）表面決定基に対する抗体

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JP2016507470A JP2016507470A (ja) 2016-03-10
JP2016507470A5 JP2016507470A5 (enExample) 2016-12-22
JP6694269B2 true JP6694269B2 (ja) 2020-05-13

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JP2019011283A Withdrawn JP2019089801A (ja) 2012-11-06 2019-01-25 Ｓ．アウレウス（Ｓ．ａｕｒｅｕｓ）表面決定基に対する抗体

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US (3) US9879070B2 (enExample)
EP (2) EP2917360B1 (enExample)
JP (2) JP6694269B2 (enExample)
KR (1) KR102288394B1 (enExample)
CN (2) CN104968797B (enExample)
AU (2) AU2013341361A1 (enExample)
BR (1) BR112015010125A2 (enExample)
CA (1) CA2890427C (enExample)
DK (1) DK2917360T3 (enExample)
ES (1) ES2776179T3 (enExample)
HU (1) HUE049012T2 (enExample)
MX (2) MX375324B (enExample)
PL (1) PL2917360T3 (enExample)
RU (1) RU2698131C2 (enExample)
SG (2) SG11201503232TA (enExample)
WO (1) WO2014074540A2 (enExample)

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CN104968797A (zh) 2015-10-07
KR20150094621A (ko) 2015-08-19
MX2022008079A (es) 2022-07-11
US10730934B2 (en) 2020-08-04
WO2014074540A3 (en) 2014-07-10
US20190016787A1 (en) 2019-01-17
RU2019122610A (ru) 2020-02-18
EP2917360B1 (en) 2020-01-08
DK2917360T3 (da) 2020-03-30
AU2018241107A1 (en) 2018-10-25
JP2016507470A (ja) 2016-03-10
EP2917360A2 (en) 2015-09-16
JP2019089801A (ja) 2019-06-13
CA2890427A1 (en) 2014-05-15
US11447543B2 (en) 2022-09-20
RU2698131C2 (ru) 2019-08-22
HK1215452A1 (zh) 2016-08-26
SG11201503232TA (en) 2015-05-28
MX375324B (es) 2025-03-06
AU2013341361A1 (en) 2015-06-04
AU2018241107B2 (en) 2020-09-17
EP2917360A4 (en) 2017-01-25
KR102288394B1 (ko) 2021-08-09
ES2776179T3 (es) 2020-07-29
US9879070B2 (en) 2018-01-30
HK1215054A1 (en) 2016-08-12
EP3640338A1 (en) 2020-04-22
MX2015005477A (es) 2015-11-30
HUE049012T2 (hu) 2020-09-28
RU2015121624A (ru) 2016-12-27
CN109553681A (zh) 2019-04-02
WO2014074540A2 (en) 2014-05-15
SG10201703678TA (en) 2017-06-29
US20150291685A1 (en) 2015-10-15
US20200407429A1 (en) 2020-12-31
CN104968797B (zh) 2018-11-30
PL2917360T3 (pl) 2020-06-29
CA2890427C (en) 2022-05-31
BR112015010125A2 (pt) 2017-08-22

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