JP6694269B2 - S.アウレウス(S.aureus)表面決定基に対する抗体 - Google Patents

S.アウレウス(S.aureus)表面決定基に対する抗体 Download PDF

Info

Publication number
JP6694269B2
JP6694269B2 JP2015540879A JP2015540879A JP6694269B2 JP 6694269 B2 JP6694269 B2 JP 6694269B2 JP 2015540879 A JP2015540879 A JP 2015540879A JP 2015540879 A JP2015540879 A JP 2015540879A JP 6694269 B2 JP6694269 B2 JP 6694269B2
Authority
JP
Japan
Prior art keywords
amino acid
seq
antigen
aureus
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2015540879A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016507470A (ja
JP2016507470A5 (enExample
Inventor
セルマン,ブレット
トカチク,クリスティーン
チョードゥリー,パーサ,エス.
ホワ,レイ
パブリク,ピーター
ブォンパーネ,レベッカ
チャン,チュウ−シュン
Original Assignee
メディミューン,エルエルシー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by メディミューン,エルエルシー filed Critical メディミューン,エルエルシー
Publication of JP2016507470A publication Critical patent/JP2016507470A/ja
Publication of JP2016507470A5 publication Critical patent/JP2016507470A5/ja
Application granted granted Critical
Publication of JP6694269B2 publication Critical patent/JP6694269B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1271Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/40Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911Bacteria
    • G01N33/56938Staphylococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507Comprising a combination of two or more separate antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567Framework region [FR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2015540879A 2012-11-06 2013-11-06 S.アウレウス(S.aureus)表面決定基に対する抗体 Active JP6694269B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261723137P 2012-11-06 2012-11-06
US61/723,137 2012-11-06
US201361782405P 2013-03-14 2013-03-14
US61/782,405 2013-03-14
PCT/US2013/068624 WO2014074540A2 (en) 2012-11-06 2013-11-06 Antibodies to s. aureus surface determinants

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019011283A Division JP2019089801A (ja) 2012-11-06 2019-01-25 S.アウレウス(S.aureus)表面決定基に対する抗体

Publications (3)

Publication Number Publication Date
JP2016507470A JP2016507470A (ja) 2016-03-10
JP2016507470A5 JP2016507470A5 (enExample) 2016-12-22
JP6694269B2 true JP6694269B2 (ja) 2020-05-13

Family

ID=50685304

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2015540879A Active JP6694269B2 (ja) 2012-11-06 2013-11-06 S.アウレウス(S.aureus)表面決定基に対する抗体
JP2019011283A Withdrawn JP2019089801A (ja) 2012-11-06 2019-01-25 S.アウレウス(S.aureus)表面決定基に対する抗体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2019011283A Withdrawn JP2019089801A (ja) 2012-11-06 2019-01-25 S.アウレウス(S.aureus)表面決定基に対する抗体

Country Status (16)

Country Link
US (3) US9879070B2 (enExample)
EP (2) EP3640338A1 (enExample)
JP (2) JP6694269B2 (enExample)
KR (1) KR102288394B1 (enExample)
CN (2) CN104968797B (enExample)
AU (2) AU2013341361A1 (enExample)
BR (1) BR112015010125A2 (enExample)
CA (1) CA2890427C (enExample)
DK (1) DK2917360T3 (enExample)
ES (1) ES2776179T3 (enExample)
HU (1) HUE049012T2 (enExample)
MX (2) MX375324B (enExample)
PL (1) PL2917360T3 (enExample)
RU (1) RU2698131C2 (enExample)
SG (2) SG10201703678TA (enExample)
WO (1) WO2014074540A2 (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9527905B2 (en) * 2011-02-08 2016-12-27 Medimmune, Llc Antibodies that specifically bind Staphylococcus aureus alpha toxin and methods of use
RU2708977C2 (ru) 2011-06-10 2019-12-12 МЕДИММЬЮН, ЭлЭлСи Молекулы, связывающиеся с psl pseudomonas, и пути их применения
CA3161431A1 (en) 2011-11-07 2013-05-16 Medimmune Limited Combination therapies using anti-pseudomonas psl and pcrv binding molecules
US9988439B2 (en) 2011-12-23 2018-06-05 Nicholas B. Lydon Immunoglobulins and variants directed against pathogenic microbes
WO2013096948A1 (en) 2011-12-23 2013-06-27 Lydon Nicholas B Immunoglobulins and variants directed against pathogenic microbes
WO2014074470A1 (en) 2012-11-06 2014-05-15 Medimmune, Llc Methods of treating s. aureus-associated diseases
AU2013341361A1 (en) * 2012-11-06 2015-06-04 Medimmune, Llc Antibodies to S. aureus surface determinants
MY191346A (en) * 2014-06-03 2022-06-17 Xbiotech Inc Compositions and methods for treating and preventing staphylococcus aureus infections
TWI719938B (zh) 2014-06-19 2021-03-01 美商麥迪紐有限責任公司 多重細菌感染之治療
JP2017524943A (ja) * 2014-08-12 2017-08-31 アルサニス・バイオサイエンスズ・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング S.アウレウス疾患の予測
WO2016073860A1 (en) * 2014-11-06 2016-05-12 Medimmune, Llc Binding molecules specific for staphylococcus protein a and uses thereof
FR3033333A1 (fr) * 2015-03-06 2016-09-09 Commissariat Energie Atomique Procede et dispositif pour detecter en temps reel un compose secrete et la cible secretrice ainsi que leurs utilisations
MX2017012775A (es) * 2015-04-17 2019-04-29 Arsanis Biosciences Gmbh Preparacion combinatoria de anticuerpos anti-staphylococcus aureus.
US20190077851A1 (en) * 2015-10-30 2019-03-14 Bruno Francois Methods of using anti-alpha toxin antibody
CN105424930A (zh) * 2015-11-23 2016-03-23 天津科技大学 一种快速检测金黄色葡萄球菌的方法
BR112020004977A2 (pt) * 2017-09-29 2020-10-06 Regeneron Pharmaceuticals, Inc. moléculas de ligação de antígenos biespecíficas que ligam antígeno alvo de staphyocococcus e componente de complemento e usos dos mesmos
AU2019309366B2 (en) * 2018-07-24 2025-06-05 Humabs Biomed Sa Antibody directed against S. aureus clumping factor A (ClfA)
MX2021004173A (es) 2018-10-09 2021-09-08 Medimmune Llc Combinaciones de anticuerpos dirigidos contra staphylococcus aureus.
MX2021004114A (es) 2018-10-09 2021-07-16 Medimmune Llc Anticuerpos dirigidos contra leucotoxinas de staphylococcus aureus.
WO2020167919A1 (en) 2019-02-12 2020-08-20 Regeneron Pharmaceuticals, Inc. Compositions and methods for using bispecific antibodies to bind complement and a target antigen
US12264194B2 (en) 2019-03-13 2025-04-01 Medimmune, Llc Decreasing Staphylococcus aureus infections in colonized patients
WO2020210650A1 (en) 2019-04-12 2020-10-15 Medimmune, Llc Neutralization of tgf-beta or alpha-v-beta-8 integrin for s. aureus infections
CN112538112B (zh) * 2019-09-20 2023-10-27 迈威(上海)生物科技股份有限公司 抗α-溶血素的抗体及其应用
KR102397684B1 (ko) * 2019-12-09 2022-05-13 (주)옵토레인 항체의 항원 결합 부위에 결합하는 펩티드 및 이를 이용한 분석 방법
KR102504175B1 (ko) * 2020-06-17 2023-02-28 (주)옵토레인 항체의 항원 결합 부위에 결합하는 펩타이드, 이를 이용한 약물 복합체, 바이오센서 및 분석 방법
KR102674109B1 (ko) * 2021-01-14 2024-06-12 (주)옵토레인 스위칭 펩티드, 이를 포함하는 면역분석 장치 및 이를 이용한 면역분석 방법
KR102674098B1 (ko) * 2021-01-14 2024-06-12 (주)옵토레인 스위칭 펩티드 및 이를 이용한 멀티플렉스 면역분석 방법
KR102674120B1 (ko) * 2021-01-18 2024-06-12 (주)옵토레인 스위칭 펩티드 및 이를 이용한 면역분석 방법

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2017198A (en) * 1931-10-17 1935-10-15 Anglada Motor Corp Cuff valve engine
US20030044772A1 (en) 1997-08-04 2003-03-06 Applied Molecular Evolution [Formerly Ixsys] Methods for identifying ligand specific binding molecules
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US7396917B2 (en) * 2000-12-05 2008-07-08 Alexion Pharmaceuticals, Inc. Rationally designed antibodies
US7214786B2 (en) * 2000-12-14 2007-05-08 Kovalic David K Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement
AT410798B (de) * 2001-01-26 2003-07-25 Cistem Biotechnologies Gmbh Verfahren zur identifizierung, isolierung und herstellung von antigenen gegen ein spezifisches pathogen
AU2002256985B8 (en) * 2001-01-26 2008-03-20 Inhibitex, Inc Monoclonal antibodies to the ClfA protein and method of use in treating or preventing infections
AU2004291026A1 (en) * 2003-06-06 2005-06-02 Medimmune, Llc Use of EphA4 and modulator of EphA4 for diagnosis, treatment and prevention of cancer
AU2004266242A1 (en) 2003-08-12 2005-03-03 Dyax Corp. Tie1-binding ligands
US7329737B2 (en) * 2004-08-03 2008-02-12 Dyax Corp. Antibodies that bind hK-1
US20080050361A1 (en) * 2004-10-25 2008-02-28 Heinrichs David E Staphylococcus aureas specific anti-infectives
AU2007222798A1 (en) * 2006-03-06 2007-09-13 Symphogen A/S Recombinant polyclonal antibody for treatment of respiratory syncytial virus infections
US7910703B2 (en) 2006-03-10 2011-03-22 Zymogenetics, Inc. Antagonists to IL-17A, IL-17F, and IL-23P19 and methods of use
WO2007145689A1 (en) * 2006-06-12 2007-12-21 Nabi Biopharmaceuticals Use of alpha-toxin for treating and preventing staphylococcus infections
WO2008152447A2 (en) * 2006-10-30 2008-12-18 The University Of Western Ontario Staphylococcus aureus specific anti-infectives
US9526774B1 (en) * 2006-11-06 2016-12-27 Microvax, Llc Methods and compositions for suppressing virulence of methicillin resistant Staphylococcus aureus
JP5709527B2 (ja) * 2008-01-31 2015-04-30 ザ プロボスト フェローズ アンドスカラーズ オブ ザ カレッジ オブ ザ ホーリー アンド アンディバイデッドトリニティー オブ クイーン エリザベス ニア ダブリン 微生物感染症の治療
JP2011519974A (ja) * 2008-05-12 2011-07-14 ストロックス バイオファーマスーティカルズ,エルエルシー 黄色ブドウ球菌(Staphylococcusaureus)に特異的な抗体製剤
WO2010005513A2 (en) * 2008-06-30 2010-01-14 The Texas A&M University System Crystal structure of staphylococcus aureus clumping factor a in complex with fibrinogen derived peptide and uses thereof
CN102333540B (zh) * 2008-10-06 2015-04-22 芝加哥大学 与细菌eap、emp和/或adsa蛋白相关的组合物和方法
EP2432499A2 (en) * 2009-05-20 2012-03-28 Schering Corporation Modulation of pilr receptors to treat microbial infections
PL2445522T3 (pl) * 2009-06-22 2018-01-31 Wyeth Llc Kompozycje immunogenne antygenów Staphylococcus aureus
CN105440133A (zh) * 2009-07-15 2016-03-30 Aimm医疗股份公司 革兰氏阳性细菌特异性结合化合物
GB0913680D0 (en) * 2009-08-05 2009-09-16 Glaxosmithkline Biolog Sa Immunogenic composition
EP2284193A1 (en) * 2009-08-10 2011-02-16 Kenta Biotech AG Human monoclonal antibody against S. aureus derived apha-toxin and its use in treating or preventing abscess formation
WO2011079308A2 (en) * 2009-12-23 2011-06-30 Emergent Product Development Seattle, Llc Compositions comprising tnf-alpha and il-6 antagonists and methods of use thereof
US8808699B2 (en) * 2010-04-05 2014-08-19 The University Of Chicago Compositions and methods related to protein A (SpA) antibodies as an enhancer of immune response
JP5793194B2 (ja) * 2010-09-09 2015-10-14 ザ・ユニバーシティ・オブ・シカゴThe University Of Chicago 感染防御ブドウ球菌抗原が関与する方法および組成物
US20120202047A1 (en) 2011-02-07 2012-08-09 Baker Hughes Incorporated Nano-coatings for articles
US9527905B2 (en) * 2011-02-08 2016-12-27 Medimmune, Llc Antibodies that specifically bind Staphylococcus aureus alpha toxin and methods of use
US9556281B2 (en) * 2011-08-15 2017-01-31 The University Of Chicago Compositions and methods related to antibodies to staphylococcal protein A
CA2859667C (en) * 2011-12-20 2022-05-24 Medimmune, Llc Modified polypeptides for bispecific antibody scaffolds
US9968668B2 (en) * 2012-04-26 2018-05-15 The University Of Chicago Staphylococcal coagulase antigens and methods of their use
AU2013341361A1 (en) * 2012-11-06 2015-06-04 Medimmune, Llc Antibodies to S. aureus surface determinants
WO2014074470A1 (en) * 2012-11-06 2014-05-15 Medimmune, Llc Methods of treating s. aureus-associated diseases
WO2014127200A1 (en) * 2013-02-15 2014-08-21 Immunomedics, Inc. Chimeric and humanized anti-histone antibodies
CA2952930A1 (en) * 2013-10-15 2015-04-23 The Texas A&M University System Compositions and the use of a fibrinogn binding motif presence in efb and coa for vaccine against staphylococcus aureus and drug delivery
WO2015106226A2 (en) * 2014-01-10 2015-07-16 University Of Rochester Diagnostic device and method for detection of staphylococcus infection
WO2015112895A2 (en) * 2014-01-24 2015-07-30 Church William R Antibody specific to staphylococcus aureus, therapeutic method and detection method using same
MY191346A (en) * 2014-06-03 2022-06-17 Xbiotech Inc Compositions and methods for treating and preventing staphylococcus aureus infections
TWI719938B (zh) * 2014-06-19 2021-03-01 美商麥迪紐有限責任公司 多重細菌感染之治療
WO2016073860A1 (en) * 2014-11-06 2016-05-12 Medimmune, Llc Binding molecules specific for staphylococcus protein a and uses thereof
MX2017012775A (es) 2015-04-17 2019-04-29 Arsanis Biosciences Gmbh Preparacion combinatoria de anticuerpos anti-staphylococcus aureus.
US20190077851A1 (en) * 2015-10-30 2019-03-14 Bruno Francois Methods of using anti-alpha toxin antibody
WO2017186928A1 (en) * 2016-04-29 2017-11-02 Curevac Ag Rna encoding an antibody
BR112018077540A2 (pt) * 2016-07-08 2019-10-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services vírus quimérico da dengue/zika como vacinas de zika vírus vivo atenuado
AU2019309366B2 (en) 2018-07-24 2025-06-05 Humabs Biomed Sa Antibody directed against S. aureus clumping factor A (ClfA)
MX2021004114A (es) * 2018-10-09 2021-07-16 Medimmune Llc Anticuerpos dirigidos contra leucotoxinas de staphylococcus aureus.
MX2021004173A (es) * 2018-10-09 2021-09-08 Medimmune Llc Combinaciones de anticuerpos dirigidos contra staphylococcus aureus.
US12264194B2 (en) * 2019-03-13 2025-04-01 Medimmune, Llc Decreasing Staphylococcus aureus infections in colonized patients

Also Published As

Publication number Publication date
AU2018241107A1 (en) 2018-10-25
BR112015010125A2 (pt) 2017-08-22
CN104968797B (zh) 2018-11-30
HK1215452A1 (zh) 2016-08-26
KR102288394B1 (ko) 2021-08-09
RU2015121624A (ru) 2016-12-27
JP2019089801A (ja) 2019-06-13
US20150291685A1 (en) 2015-10-15
EP2917360A4 (en) 2017-01-25
MX375324B (es) 2025-03-06
HUE049012T2 (hu) 2020-09-28
MX2022008079A (es) 2022-07-11
AU2018241107B2 (en) 2020-09-17
ES2776179T3 (es) 2020-07-29
US11447543B2 (en) 2022-09-20
CN104968797A (zh) 2015-10-07
CA2890427C (en) 2022-05-31
PL2917360T3 (pl) 2020-06-29
AU2013341361A1 (en) 2015-06-04
JP2016507470A (ja) 2016-03-10
DK2917360T3 (da) 2020-03-30
EP2917360A2 (en) 2015-09-16
MX2015005477A (es) 2015-11-30
US20200407429A1 (en) 2020-12-31
HK1215054A1 (en) 2016-08-12
RU2019122610A (ru) 2020-02-18
US9879070B2 (en) 2018-01-30
EP3640338A1 (en) 2020-04-22
WO2014074540A3 (en) 2014-07-10
US10730934B2 (en) 2020-08-04
SG10201703678TA (en) 2017-06-29
CN109553681A (zh) 2019-04-02
RU2698131C2 (ru) 2019-08-22
KR20150094621A (ko) 2015-08-19
SG11201503232TA (en) 2015-05-28
EP2917360B1 (en) 2020-01-08
WO2014074540A2 (en) 2014-05-15
CA2890427A1 (en) 2014-05-15
US20190016787A1 (en) 2019-01-17

Similar Documents

Publication Publication Date Title
JP6694269B2 (ja) S.アウレウス(S.aureus)表面決定基に対する抗体
TWI719938B (zh) 多重細菌感染之治療
EP2464665B1 (en) Human monoclonal antibody against s. aureus derived alpha-toxin and its use in treating or preventing abscess formation
US20230151081A1 (en) Cellular factors involved in the cytotoxicity of staphylococcus aureus leukocidins: novel therapeutic targets
TW202126684A (zh) 抗α-溶血素的抗體及其應用
JP2022512647A (ja) 抗黄色ブドウ球菌(Staphylococcus aureus)抗体の組み合わせ
JP2018513168A (ja) 抗スタフィロコッカス・アウレウス抗体組み合わせ製剤
JP2017505758A (ja) 黄色ブドウ球菌のlukgh(lukab)毒素に対する抗体及び抗体配列
JP2022512904A (ja) 抗Staphylococcus抗体およびその使用
HK40025295A (en) Antibodies to s. aureus surface determinants
RU2808018C2 (ru) Антитела к поверхностным детерминантам s. aureus
HK1215452B (zh) 金黃色葡萄球菌表面決定簇的抗體
HK1215054B (en) Antibodies to s. aureus surface determinants
HK40004629B (en) Pharmaceutical compositions containing a mutated leukocidin e
HK40004629A (en) Pharmaceutical compositions containing a mutated leukocidin e
BR112012002892A2 (pt) anticorpo monoclonal específico para a alfa-toxina de s. aureus, hibridoma, ácido nucleico, vetor, célula hospedeira, método para produzir o anticorpo monoclonal, composição farmacêutica, uso de um anticorpo monoclonal e kit de teste para o diagnóstico de uma infecção de s. aureus

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20161104

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20161104

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20171031

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20180125

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180425

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20180925

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200226

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20200417

R150 Certificate of patent or registration of utility model

Ref document number: 6694269

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250