ES2776179T3 - Anticuerpos dirigidos contra determinantes de la superficie de S. aureus - Google Patents

Anticuerpos dirigidos contra determinantes de la superficie de S. aureus Download PDF

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Publication number
ES2776179T3
ES2776179T3 ES13852597T ES13852597T ES2776179T3 ES 2776179 T3 ES2776179 T3 ES 2776179T3 ES 13852597 T ES13852597 T ES 13852597T ES 13852597 T ES13852597 T ES 13852597T ES 2776179 T3 ES2776179 T3 ES 2776179T3
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Prior art keywords
seq
amino acid
acid sequence
aureus
cdr1
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ES13852597T
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English (en)
Spanish (es)
Inventor
Bret Sellman
Christine Tkaczyk
Partha Chowdhury
Lei Hua
Peter Pavlik
Rebecca Buonpane
Chew-Shun Chang
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MedImmune LLC
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MedImmune LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Gram-positive bacteria
    • C07K16/1271—Micrococcaceae (F); Staphylococcaceae (F), e.g. Staphylococcus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/56938—Staphylococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
ES13852597T 2012-11-06 2013-11-06 Anticuerpos dirigidos contra determinantes de la superficie de S. aureus Active ES2776179T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261723137P 2012-11-06 2012-11-06
US201361782405P 2013-03-14 2013-03-14
PCT/US2013/068624 WO2014074540A2 (en) 2012-11-06 2013-11-06 Antibodies to s. aureus surface determinants

Publications (1)

Publication Number Publication Date
ES2776179T3 true ES2776179T3 (es) 2020-07-29

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
ES13852597T Active ES2776179T3 (es) 2012-11-06 2013-11-06 Anticuerpos dirigidos contra determinantes de la superficie de S. aureus

Country Status (16)

Country Link
US (3) US9879070B2 (enExample)
EP (2) EP3640338A1 (enExample)
JP (2) JP6694269B2 (enExample)
KR (1) KR102288394B1 (enExample)
CN (2) CN104968797B (enExample)
AU (2) AU2013341361A1 (enExample)
BR (1) BR112015010125A2 (enExample)
CA (1) CA2890427C (enExample)
DK (1) DK2917360T3 (enExample)
ES (1) ES2776179T3 (enExample)
HU (1) HUE049012T2 (enExample)
MX (2) MX375324B (enExample)
PL (1) PL2917360T3 (enExample)
RU (1) RU2698131C2 (enExample)
SG (2) SG10201703678TA (enExample)
WO (1) WO2014074540A2 (enExample)

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Publication number Publication date
AU2018241107B2 (en) 2020-09-17
JP6694269B2 (ja) 2020-05-13
US11447543B2 (en) 2022-09-20
RU2698131C2 (ru) 2019-08-22
WO2014074540A2 (en) 2014-05-15
SG10201703678TA (en) 2017-06-29
KR20150094621A (ko) 2015-08-19
PL2917360T3 (pl) 2020-06-29
AU2013341361A1 (en) 2015-06-04
CN104968797A (zh) 2015-10-07
JP2019089801A (ja) 2019-06-13
RU2015121624A (ru) 2016-12-27
HUE049012T2 (hu) 2020-09-28
HK1215452A1 (zh) 2016-08-26
HK1215054A1 (en) 2016-08-12
DK2917360T3 (da) 2020-03-30
RU2019122610A (ru) 2020-02-18
US20150291685A1 (en) 2015-10-15
MX2015005477A (es) 2015-11-30
US20190016787A1 (en) 2019-01-17
BR112015010125A2 (pt) 2017-08-22
AU2018241107A1 (en) 2018-10-25
EP3640338A1 (en) 2020-04-22
MX375324B (es) 2025-03-06
EP2917360A2 (en) 2015-09-16
JP2016507470A (ja) 2016-03-10
SG11201503232TA (en) 2015-05-28
CA2890427C (en) 2022-05-31
MX2022008079A (es) 2022-07-11
CN104968797B (zh) 2018-11-30
US9879070B2 (en) 2018-01-30
US10730934B2 (en) 2020-08-04
WO2014074540A3 (en) 2014-07-10
EP2917360B1 (en) 2020-01-08
US20200407429A1 (en) 2020-12-31
KR102288394B1 (ko) 2021-08-09
CA2890427A1 (en) 2014-05-15
EP2917360A4 (en) 2017-01-25
CN109553681A (zh) 2019-04-02

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