JP6694269B2 - S.アウレウス(S.aureus)表面決定基に対する抗体 - Google Patents

S.アウレウス(S.aureus)表面決定基に対する抗体 Download PDF

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JP6694269B2
JP6694269B2 JP2015540879A JP2015540879A JP6694269B2 JP 6694269 B2 JP6694269 B2 JP 6694269B2 JP 2015540879 A JP2015540879 A JP 2015540879A JP 2015540879 A JP2015540879 A JP 2015540879A JP 6694269 B2 JP6694269 B2 JP 6694269B2
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amino acid
seq
antigen
aureus
antibody
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JP2016507470A (ja
JP2016507470A5 (Direct
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セルマン,ブレット
トカチク,クリスティーン
チョードゥリー,パーサ,エス.
ホワ,レイ
パブリク,ピーター
ブォンパーネ,レベッカ
チャン,チュウ−シュン
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メディミューン,エルエルシー
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1271Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/40Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911Bacteria
    • G01N33/56938Staphylococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507Comprising a combination of two or more separate antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567Framework region [FR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2015540879A 2012-11-06 2013-11-06 S.アウレウス(S.aureus)表面決定基に対する抗体 Active JP6694269B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261723137P 2012-11-06 2012-11-06
US61/723,137 2012-11-06
US201361782405P 2013-03-14 2013-03-14
US61/782,405 2013-03-14
PCT/US2013/068624 WO2014074540A2 (en) 2012-11-06 2013-11-06 Antibodies to s. aureus surface determinants

Related Child Applications (1)

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JP2019011283A Division JP2019089801A (ja) 2012-11-06 2019-01-25 S.アウレウス(S.aureus)表面決定基に対する抗体

Publications (3)

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JP2016507470A JP2016507470A (ja) 2016-03-10
JP2016507470A5 JP2016507470A5 (Direct) 2016-12-22
JP6694269B2 true JP6694269B2 (ja) 2020-05-13

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JP2019011283A Withdrawn JP2019089801A (ja) 2012-11-06 2019-01-25 S.アウレウス(S.aureus)表面決定基に対する抗体

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US (3) US9879070B2 (Direct)
EP (2) EP3640338A1 (Direct)
JP (2) JP6694269B2 (Direct)
KR (1) KR102288394B1 (Direct)
CN (2) CN109553681A (Direct)
AU (2) AU2013341361A1 (Direct)
BR (1) BR112015010125A2 (Direct)
CA (1) CA2890427C (Direct)
DK (1) DK2917360T3 (Direct)
ES (1) ES2776179T3 (Direct)
HU (1) HUE049012T2 (Direct)
MX (2) MX375324B (Direct)
PL (1) PL2917360T3 (Direct)
RU (1) RU2698131C2 (Direct)
SG (2) SG11201503232TA (Direct)
WO (1) WO2014074540A2 (Direct)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT2673373T (lt) 2011-02-08 2019-01-25 Medimmune, Llc Antikūnai, kurie specifiškai jungiasi prie staphylococcus aureus alfa toksino, ir naudojimo būdai
ES2664972T3 (es) 2011-06-10 2018-04-24 Medimmune Limited Moléculas de unión anti-Psl de Pseudomonas y usos de las mismas
AU2012336028A1 (en) 2011-11-07 2014-06-26 Medimmune, Llc Combination therapies using anti- Pseudomonas Psl and PcrV binding molecules
EP2793944B1 (en) 2011-12-23 2025-10-08 Nicholas B. Lydon Immunoglobulins and variants directed against pathogenic microbes
US9988439B2 (en) 2011-12-23 2018-06-05 Nicholas B. Lydon Immunoglobulins and variants directed against pathogenic microbes
JP6506172B2 (ja) 2012-11-06 2019-04-24 メディミューン,エルエルシー 黄色ブドウ球菌(S.aureus)関連性疾患を治療する方法
HUE049012T2 (hu) * 2012-11-06 2020-09-28 Medimmune Llc Antitestek S. aureus felszíni determinánsok ellen
MX355107B (es) * 2014-06-03 2018-04-04 Xbiotech Inc Composiciones y metodos para tratar y prevenir infecciones por staphylococcus aureus.
TWI719938B (zh) 2014-06-19 2021-03-01 美商麥迪紐有限責任公司 多重細菌感染之治療
JP2017524943A (ja) * 2014-08-12 2017-08-31 アルサニス・バイオサイエンスズ・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング S.アウレウス疾患の予測
WO2016073860A1 (en) * 2014-11-06 2016-05-12 Medimmune, Llc Binding molecules specific for staphylococcus protein a and uses thereof
FR3033333A1 (fr) * 2015-03-06 2016-09-09 Commissariat Energie Atomique Procede et dispositif pour detecter en temps reel un compose secrete et la cible secretrice ainsi que leurs utilisations
MX2017012775A (es) * 2015-04-17 2019-04-29 Arsanis Biosciences Gmbh Preparacion combinatoria de anticuerpos anti-staphylococcus aureus.
US20190077851A1 (en) * 2015-10-30 2019-03-14 Bruno Francois Methods of using anti-alpha toxin antibody
CN105424930A (zh) * 2015-11-23 2016-03-23 天津科技大学 一种快速检测金黄色葡萄球菌的方法
SG11202001160XA (en) * 2017-09-29 2020-03-30 Regeneron Pharma Bispecific antigen-binding molecules that bind a staphylococcus target antigen and a complement component and uses thereof
CN119176871A (zh) 2018-07-24 2024-12-24 免疫医疗有限责任公司 抗金黄色葡萄球菌凝集因子a(clfa)的抗体
KR20210080411A (ko) 2018-10-09 2021-06-30 메디뮨 엘엘씨 스타필로코커스 오레우스(staphylococcus aureus) 류코톡신에 대한 항체
MX2021004173A (es) 2018-10-09 2021-09-08 Medimmune Llc Combinaciones de anticuerpos dirigidos contra staphylococcus aureus.
MA54945A (fr) 2019-02-12 2021-12-22 Regeneron Pharma Compositions et procédés d'utilisation d'anticorps bispécifiques pour lier un complément et un antigène cible
JP7682795B2 (ja) 2019-03-13 2025-05-26 メディミューン,エルエルシー コロニー形成患者における黄色ブドウ球菌(Staphylococcus aureus)感染症の低減
WO2020210650A1 (en) 2019-04-12 2020-10-15 Medimmune, Llc Neutralization of tgf-beta or alpha-v-beta-8 integrin for s. aureus infections
CN112538112B (zh) * 2019-09-20 2023-10-27 迈威(上海)生物科技股份有限公司 抗α-溶血素的抗体及其应用
KR102504175B1 (ko) * 2020-06-17 2023-02-28 (주)옵토레인 항체의 항원 결합 부위에 결합하는 펩타이드, 이를 이용한 약물 복합체, 바이오센서 및 분석 방법
KR102397684B1 (ko) * 2019-12-09 2022-05-13 (주)옵토레인 항체의 항원 결합 부위에 결합하는 펩티드 및 이를 이용한 분석 방법
KR102674098B1 (ko) * 2021-01-14 2024-06-12 (주)옵토레인 스위칭 펩티드 및 이를 이용한 멀티플렉스 면역분석 방법
KR102674109B1 (ko) * 2021-01-14 2024-06-12 (주)옵토레인 스위칭 펩티드, 이를 포함하는 면역분석 장치 및 이를 이용한 면역분석 방법
KR102674120B1 (ko) * 2021-01-18 2024-06-12 (주)옵토레인 스위칭 펩티드 및 이를 이용한 면역분석 방법

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2017198A (en) * 1931-10-17 1935-10-15 Anglada Motor Corp Cuff valve engine
US20030044772A1 (en) 1997-08-04 2003-03-06 Applied Molecular Evolution [Formerly Ixsys] Methods for identifying ligand specific binding molecules
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US7396917B2 (en) * 2000-12-05 2008-07-08 Alexion Pharmaceuticals, Inc. Rationally designed antibodies
US7214786B2 (en) 2000-12-14 2007-05-08 Kovalic David K Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement
AT410798B (de) * 2001-01-26 2003-07-25 Cistem Biotechnologies Gmbh Verfahren zur identifizierung, isolierung und herstellung von antigenen gegen ein spezifisches pathogen
PT1377314E (pt) * 2001-01-26 2012-01-02 Inhibitex Inc Anticorpos monoclonais para a proteína clfa e método de utilização no tratamento ou prevenção de infecções
US7604799B2 (en) * 2003-06-06 2009-10-20 Medimmune, Llc EphA4 Antibodies
US7348001B2 (en) 2003-08-12 2008-03-25 Dyax Corp. Tie1-binding ligands
CA2575791A1 (en) * 2004-08-03 2006-02-16 Dyax Corp. Hk1-binding proteins
US20080050361A1 (en) 2004-10-25 2008-02-28 Heinrichs David E Staphylococcus aureas specific anti-infectives
MX2008011280A (es) 2006-03-06 2008-09-12 Symphogen As Anticuerpor policlonal recombinante para el tratamiento de infecciones por el virus sincitial respiratorio.
US7910703B2 (en) 2006-03-10 2011-03-22 Zymogenetics, Inc. Antagonists to IL-17A, IL-17F, and IL-23P19 and methods of use
CA2655133C (en) * 2006-06-12 2018-03-20 Nabi Biopharmaceuticals Use of alpha-toxin for treating and preventing staphylococcus infections
CA2667788A1 (en) * 2006-10-30 2008-12-18 The University Of Western Ontario Staphylococcus aureus specific anti-infectives
US9526774B1 (en) * 2006-11-06 2016-12-27 Microvax, Llc Methods and compositions for suppressing virulence of methicillin resistant Staphylococcus aureus
CA2713241C (en) * 2008-01-31 2022-10-04 Timothy Foster Treatment of microbial infections
JP2011519974A (ja) * 2008-05-12 2011-07-14 ストロックス バイオファーマスーティカルズ,エルエルシー 黄色ブドウ球菌(Staphylococcusaureus)に特異的な抗体製剤
WO2010005513A2 (en) * 2008-06-30 2010-01-14 The Texas A&M University System Crystal structure of staphylococcus aureus clumping factor a in complex with fibrinogen derived peptide and uses thereof
CA2739581A1 (en) * 2008-10-06 2010-04-15 University Of Chicago Compositions and methods related to bacterial eap, emp, and/or adsa proteins
US20120128673A1 (en) * 2009-05-20 2012-05-24 Schering Corporation Modulation of pilr receptors to treat microbial infections
SG176837A1 (en) * 2009-06-22 2012-01-30 Wyeth Llc Immunogenic compositions of staphylococcus aureus antigens
SG177653A1 (en) * 2009-07-15 2012-02-28 Aimm Therapeutics Bv Gram-positive bacteria specific binding compounds
GB0913680D0 (en) * 2009-08-05 2009-09-16 Glaxosmithkline Biolog Sa Immunogenic composition
EP2284193A1 (en) * 2009-08-10 2011-02-16 Kenta Biotech AG Human monoclonal antibody against S. aureus derived apha-toxin and its use in treating or preventing abscess formation
EP2516467A2 (en) * 2009-12-23 2012-10-31 Emergent Product Development Seattle, LLC Compositions comprising tnf-alpha and il-6 antagonists and methods of use thereof
US8808699B2 (en) * 2010-04-05 2014-08-19 The University Of Chicago Compositions and methods related to protein A (SpA) antibodies as an enhancer of immune response
EP2614074A1 (en) * 2010-09-09 2013-07-17 The University of Chicago Methods and compositions involving protective staphylococcal antigens
US20120202047A1 (en) 2011-02-07 2012-08-09 Baker Hughes Incorporated Nano-coatings for articles
LT2673373T (lt) * 2011-02-08 2019-01-25 Medimmune, Llc Antikūnai, kurie specifiškai jungiasi prie staphylococcus aureus alfa toksino, ir naudojimo būdai
EP2744517B1 (en) * 2011-08-15 2019-03-13 The University of Chicago Compositions and methods related to antibodies to staphylococcal protein a
RS60499B1 (sr) * 2011-12-20 2020-08-31 Medimmune Llc Modifikovani polipeptidi za bispecifične skelete antitela
HRP20201127T1 (hr) * 2012-04-26 2020-11-27 University Of Chicago Antigeni stafilokokne koagulaze i metode primjene istih
HUE049012T2 (hu) * 2012-11-06 2020-09-28 Medimmune Llc Antitestek S. aureus felszíni determinánsok ellen
JP6506172B2 (ja) * 2012-11-06 2019-04-24 メディミューン,エルエルシー 黄色ブドウ球菌(S.aureus)関連性疾患を治療する方法
CA2898472C (en) * 2013-02-15 2023-03-07 Immunomedics, Inc. Chimeric and humanized anti-histone antibodies
EP3057988A2 (en) * 2013-10-15 2016-08-24 The Texas A&M University System Compositions and the use of a fibrinogn binding motif presence in efb and coa for vaccine against staphylococcus aureus and drug delivery
US20170023569A1 (en) * 2014-01-10 2017-01-26 University Of Rochester Diagnostic device and method for detection of staphylococcus infection
AU2015209140B2 (en) * 2014-01-24 2020-01-02 William R. Church Antibody specific to Staphylococcus aureus, therapeutic method and detection method using same
MX355107B (es) * 2014-06-03 2018-04-04 Xbiotech Inc Composiciones y metodos para tratar y prevenir infecciones por staphylococcus aureus.
TWI719938B (zh) * 2014-06-19 2021-03-01 美商麥迪紐有限責任公司 多重細菌感染之治療
WO2016073860A1 (en) * 2014-11-06 2016-05-12 Medimmune, Llc Binding molecules specific for staphylococcus protein a and uses thereof
MX2017012775A (es) 2015-04-17 2019-04-29 Arsanis Biosciences Gmbh Preparacion combinatoria de anticuerpos anti-staphylococcus aureus.
US20190077851A1 (en) * 2015-10-30 2019-03-14 Bruno Francois Methods of using anti-alpha toxin antibody
WO2017186928A1 (en) * 2016-04-29 2017-11-02 Curevac Ag Rna encoding an antibody
CA3030154A1 (en) * 2016-07-08 2018-01-11 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Chimeric dengue/zika viruses live-attenuated zika virus vaccines
CN119176871A (zh) * 2018-07-24 2024-12-24 免疫医疗有限责任公司 抗金黄色葡萄球菌凝集因子a(clfa)的抗体
MX2021004173A (es) * 2018-10-09 2021-09-08 Medimmune Llc Combinaciones de anticuerpos dirigidos contra staphylococcus aureus.
KR20210080411A (ko) * 2018-10-09 2021-06-30 메디뮨 엘엘씨 스타필로코커스 오레우스(staphylococcus aureus) 류코톡신에 대한 항체
JP7682795B2 (ja) * 2019-03-13 2025-05-26 メディミューン,エルエルシー コロニー形成患者における黄色ブドウ球菌(Staphylococcus aureus)感染症の低減

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HUE049012T2 (hu) 2020-09-28
EP2917360A2 (en) 2015-09-16
EP2917360B1 (en) 2020-01-08
AU2018241107B2 (en) 2020-09-17
CA2890427C (en) 2022-05-31
ES2776179T3 (es) 2020-07-29
DK2917360T3 (da) 2020-03-30
EP3640338A1 (en) 2020-04-22
MX2015005477A (es) 2015-11-30
CN104968797B (zh) 2018-11-30
JP2016507470A (ja) 2016-03-10
US10730934B2 (en) 2020-08-04
EP2917360A4 (en) 2017-01-25
US20190016787A1 (en) 2019-01-17
RU2019122610A (ru) 2020-02-18
MX2022008079A (es) 2022-07-11
WO2014074540A3 (en) 2014-07-10
US20200407429A1 (en) 2020-12-31
US9879070B2 (en) 2018-01-30
SG10201703678TA (en) 2017-06-29
CN109553681A (zh) 2019-04-02
RU2015121624A (ru) 2016-12-27
KR20150094621A (ko) 2015-08-19
MX375324B (es) 2025-03-06
HK1215452A1 (zh) 2016-08-26
BR112015010125A2 (pt) 2017-08-22
PL2917360T3 (pl) 2020-06-29
US11447543B2 (en) 2022-09-20
CN104968797A (zh) 2015-10-07
AU2013341361A1 (en) 2015-06-04
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CA2890427A1 (en) 2014-05-15
JP2019089801A (ja) 2019-06-13
WO2014074540A2 (en) 2014-05-15
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US20150291685A1 (en) 2015-10-15

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