MX355107B - Composiciones y metodos para tratar y prevenir infecciones por staphylococcus aureus. - Google Patents
Composiciones y metodos para tratar y prevenir infecciones por staphylococcus aureus.Info
- Publication number
- MX355107B MX355107B MX2016015812A MX2016015812A MX355107B MX 355107 B MX355107 B MX 355107B MX 2016015812 A MX2016015812 A MX 2016015812A MX 2016015812 A MX2016015812 A MX 2016015812A MX 355107 B MX355107 B MX 355107B
- Authority
- MX
- Mexico
- Prior art keywords
- staphylococcus aureus
- treating
- methods
- compositions
- aureus infections
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Gram-positive bacteria
- C07K16/1271—Micrococcaceae (F); Staphylococcaceae (F), e.g. Staphylococcus (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/085—Staphylococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente invención se refiere a una composición farmacéutica que comprende un portador farmacéuticamente aceptable y un anticuerpo monoclonal purificado que comprende un dominio variable de cadena pesada que comprende un CDR1, CDR2 y CDR3 de SEQ ID NO: 2, 3 y 4, respectivamente, y un dominio variable de cadena ligera que comprende un CDR1, CDR2 y CDR3 de SEQ ID NO: 7, 8 y 9, respectivamente, en donde el anticuerpo monoclonal se une específicamente a la proteína A de Staphylococcus aureus (spA) con una KD inferior a 1 x 10-10 M mediante su parátopo de la región Fab, en donde el anticuerpo monoclonal es capaz de desplazar inmunoglobulinas IgG de humano a SpA en la bacteria de Staphylococcus aureus mediante sus regiones Fc.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462007242P | 2014-06-03 | 2014-06-03 | |
| US201462041423P | 2014-08-25 | 2014-08-25 | |
| US201562115665P | 2015-02-13 | 2015-02-13 | |
| PCT/US2015/033902 WO2015187779A1 (en) | 2014-06-03 | 2015-06-03 | Compositions and methods for treating and preventing staphylococcus aureus infections |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2016015812A MX2016015812A (es) | 2017-04-25 |
| MX355107B true MX355107B (es) | 2018-04-04 |
Family
ID=54700993
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018004092A MX394895B (es) | 2014-06-03 | 2015-06-03 | Composiciones útiles para el tratamiento de infecciones por staphylococcus aureus. |
| MX2016015812A MX355107B (es) | 2014-06-03 | 2015-06-03 | Composiciones y metodos para tratar y prevenir infecciones por staphylococcus aureus. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018004092A MX394895B (es) | 2014-06-03 | 2015-06-03 | Composiciones útiles para el tratamiento de infecciones por staphylococcus aureus. |
Country Status (19)
| Country | Link |
|---|---|
| US (7) | US9416172B2 (es) |
| EP (2) | EP3154584B1 (es) |
| JP (5) | JP6166000B1 (es) |
| KR (4) | KR102015451B1 (es) |
| CN (2) | CN108404128A (es) |
| AU (2) | AU2015271749B2 (es) |
| BR (1) | BR112016028043B1 (es) |
| CA (1) | CA2950840C (es) |
| CL (1) | CL2016003071A1 (es) |
| ES (1) | ES2894867T3 (es) |
| IL (1) | IL248959B (es) |
| MX (2) | MX394895B (es) |
| MY (1) | MY191346A (es) |
| NZ (1) | NZ726911A (es) |
| PH (2) | PH12018501429B1 (es) |
| RU (2) | RU2636780C1 (es) |
| SG (2) | SG11201609487QA (es) |
| WO (1) | WO2015187779A1 (es) |
| ZA (1) | ZA201608604B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2582391T (pt) | 2010-06-18 | 2019-01-11 | Xbiotech Inc | Tratamento da artrite |
| RU2013110030A (ru) | 2010-08-23 | 2014-09-27 | ИксБиотеч, Инк. | Лечение неопластических заболеваний |
| US9724409B2 (en) | 2011-04-01 | 2017-08-08 | Xbiotech, Inc. | Treatment of inflammatory skin disease |
| US9988439B2 (en) | 2011-12-23 | 2018-06-05 | Nicholas B. Lydon | Immunoglobulins and variants directed against pathogenic microbes |
| EP2793944B1 (en) | 2011-12-23 | 2025-10-08 | Nicholas B. Lydon | Immunoglobulins and variants directed against pathogenic microbes |
| CN104968797B (zh) | 2012-11-06 | 2018-11-30 | 米迪缪尼有限公司 | 金黄色葡萄球菌表面决定簇的抗体 |
| PH12018501429B1 (en) * | 2014-06-03 | 2022-04-27 | Xbiotech Inc | Compositions and methods for treating and preventing staphylococcus aureus infections |
| BR112018014810A2 (pt) | 2016-01-22 | 2018-12-11 | Merck Sharp & Dohme Corp. | anticorpos anti-fator xi de coagulação |
| CN116425879A (zh) | 2016-06-14 | 2023-07-14 | 默沙东有限责任公司 | 抗-凝血因子xi抗体 |
| KR20190117579A (ko) | 2017-02-16 | 2019-10-16 | 엑스바이오테크, 인크. | 화농성 한선염의 치료 |
| WO2018237010A2 (en) | 2017-06-20 | 2018-12-27 | The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Vaccine compositions and methods of using the same |
| US20210017257A1 (en) * | 2017-06-30 | 2021-01-21 | John Simard | Compositions and Methods for Treating and Preventing Staphylococcus Aureus Infections |
| EP3530282A1 (en) * | 2018-02-27 | 2019-08-28 | Diaccurate | Therapeutic methods |
| CN109705213B (zh) * | 2018-12-04 | 2023-04-18 | 上海长征医院 | 抗金黄色葡萄球菌毒素抗体及其用途 |
| KR20250130862A (ko) | 2019-01-22 | 2025-09-02 | 클렘손 유니버서티 리서치 화운데이션 | 항-엘라스틴 항체 및 사용 방법 |
| US12459991B2 (en) | 2019-02-12 | 2025-11-04 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for using bispecific antibodies to bind complement and a target antigen |
| TW202045537A (zh) | 2019-02-28 | 2020-12-16 | 美商健生生物科技公司 | 化膿性汗腺炎的治療 |
| WO2021211927A1 (en) | 2020-04-16 | 2021-10-21 | Janssen Biotech, Inc. | Treatment of hidradenitis suppurativa |
| TW202212354A (zh) | 2020-08-03 | 2022-04-01 | 美商健生生物科技公司 | 用於病毒治療劑中之多向生物運輸的材料及方法 |
| CN120399078B (zh) * | 2025-05-08 | 2026-03-06 | 上海天泽云泰生物医药股份有限公司 | 靶向cd117的纳米抗体及其应用 |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
| US5258499A (en) | 1988-05-16 | 1993-11-02 | Vestar, Inc. | Liposome targeting using receptor specific ligands |
| DE3825429C2 (de) | 1988-07-27 | 1994-02-10 | Biotest Pharma Gmbh | Verfahren zur Herstellung eines intravenös verabreichbaren polyklonalen Immunglobulin-Präparates mit hohem IgM-Gehalt |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| EP1541682A3 (en) | 1988-09-02 | 2005-07-06 | Dyax Corp. | Generation and selection of recombinant varied binding proteins |
| US5077391A (en) | 1989-12-01 | 1991-12-31 | Raison Robert L | Purification of immunoglobulin M |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5111074A (en) | 1990-07-26 | 1992-05-05 | Regents Of The University Of Minnesota | Multi-input compound function complementary noise-immune logic |
| US5112952A (en) | 1990-09-28 | 1992-05-12 | Pierce Chemical Company | Composition and method for isolation and purification of Immunoglobulin M |
| DE69129154T2 (de) | 1990-12-03 | 1998-08-20 | Genentech, Inc., South San Francisco, Calif. | Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften |
| DE69233769D1 (de) | 1991-03-01 | 2009-09-24 | Dyax Corp | Chimäres Protein mit Mikroprotein mit zwei oder mehr Disulfidbindungen und Ausgestaltungen davon |
| ATE414768T1 (de) | 1991-04-10 | 2008-12-15 | Scripps Research Inst | Bibliotheken heterodimerer rezeptoren mittels phagemiden |
| DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
| US5891438A (en) | 1992-10-30 | 1999-04-06 | The Regents Of The University Of California | Method for stimulating production of variable region gene family restricted antibodies through B-cell superantigen vaccination |
| US5545721A (en) | 1992-12-21 | 1996-08-13 | Ophidian Pharmaceuticals, Inc. | Conjugates for the prevention and treatment of sepsis |
| US5770208A (en) | 1996-09-11 | 1998-06-23 | Nabi | Staphylococcus aureus B-linked hexosamine antigen |
| EP0835880A1 (de) | 1996-10-14 | 1998-04-15 | Rotkreuzstiftung Zentrallaboratorium Blutspendedienst Srk | Verfahren zur Herstellung eines IgM Präparates für die intravenöse Applikation |
| ES2434961T5 (es) | 1998-04-20 | 2018-01-18 | Roche Glycart Ag | Ingeniería de glicosilación de anticuerpos para mejorar la citotoxicidad celular dependiente del anticuerpo |
| US8142780B2 (en) | 1998-08-20 | 2012-03-27 | Strox Biopharmaceuticals, Llc | Anti-bacterial antibodies |
| US6322788B1 (en) | 1998-08-20 | 2001-11-27 | Stanley Arthur Kim | Anti-bacterial antibodies and methods of use |
| US6692739B1 (en) | 1998-08-31 | 2004-02-17 | Inhibitex, Inc. | Staphylococcal immunotherapeutics via donor selection and donor stimulation |
| EP1176195B1 (en) | 1999-04-09 | 2013-05-22 | Kyowa Hakko Kirin Co., Ltd. | Method for controlling the activity of immunologically functional molecule |
| CN102311986B (zh) | 2000-10-06 | 2015-08-19 | 协和发酵麒麟株式会社 | 产生抗体组合物的细胞 |
| JP2005500018A (ja) | 2001-04-02 | 2005-01-06 | アイデック ファーマスーティカルズ コーポレイション | ＧｎＴＩＩＩと同時発現する組換え抗体 |
| US7169903B2 (en) | 2001-12-21 | 2007-01-30 | Biosynexus Incorporated | Multifunctional monoclonal antibodies directed to peptidoglycan of gram-positive bacteria |
| US7632497B2 (en) | 2004-11-10 | 2009-12-15 | Macrogenics, Inc. | Engineering Fc Antibody regions to confer effector function |
| EP2208783A1 (en) | 2004-12-22 | 2010-07-21 | Chugai Seiyaku Kabushiki Kaisha | Method of producing an antibody using a cell in which the function of fucose transporter is inhibited |
| TWI671403B (zh) | 2005-03-31 | 2019-09-11 | 中外製藥股份有限公司 | 控制組裝之多肽的製造方法 |
| WO2006116260A2 (en) | 2005-04-26 | 2006-11-02 | Medimmune, Inc. | Modulation of antibody effector function by hinge domain engineering |
| CN101074263B (zh) * | 2006-05-17 | 2011-07-06 | 上海抗体药物国家工程研究中心有限公司 | 一种重组抗proteinA单克隆抗体及其制备方法和用途 |
| US7488807B2 (en) | 2006-11-22 | 2009-02-10 | 3M Innovative Properties Company | Antibody with protein A selectivity |
| WO2008127457A2 (en) * | 2006-12-06 | 2008-10-23 | Repligen Corporation | Nucleic acids encoding recombinant protein a |
| WO2009023043A1 (en) | 2007-04-23 | 2009-02-19 | Sudhir Paul | Immunoglobulins directed to bacterial viral and endogenous polypeptides |
| DK3059246T3 (en) | 2007-09-26 | 2018-10-01 | Chugai Pharmaceutical Co Ltd | Modified constant region of an antibody |
| AU2009246510B2 (en) | 2008-05-12 | 2014-02-13 | Strox Biopharmaceuticals, Llc | Staphylococcus aureus-specific antibody preparations |
| CN101339197B (zh) * | 2008-07-30 | 2012-07-04 | 广州康盛生物科技有限公司 | 葡萄球菌蛋白a定量检测试剂盒及定量检测方法 |
| US20100092470A1 (en) | 2008-09-22 | 2010-04-15 | Icb International, Inc. | Antibodies, analogs and uses thereof |
| WO2011057198A1 (en) | 2009-11-09 | 2011-05-12 | Carson Cantwell G | Vaccine testing system |
| MX341925B (es) | 2010-03-29 | 2016-09-07 | Zymeworks Inc | Anticuerpos con funcion efectora suprimida o mejorada. |
| EP2555794A4 (en) * | 2010-04-05 | 2014-01-15 | Univ Chicago | COMPOSITIONS AND METHODS RELATING TO PROTEIN A (SPA) ANTIBODIES AS IMMUNE REACTION AMPLIFIERS |
| EP3604330A1 (en) | 2011-02-25 | 2020-02-05 | Chugai Seiyaku Kabushiki Kaisha | Fcgammariib-specific fc antibody |
| CN107090459A (zh) | 2011-07-12 | 2017-08-25 | 埃克斯生物科技公司 | 鉴定亲和力成熟的人类抗体 |
| EP2744517B1 (en) * | 2011-08-15 | 2019-03-13 | The University of Chicago | Compositions and methods related to antibodies to staphylococcal protein a |
| MX2014006739A (es) | 2011-12-05 | 2015-06-05 | Igenica Biotherapeutics Inc | Conjugados de anticuerpo-farmaco y compuestos relacionados, composiciones , y metodos. |
| EP2793944B1 (en) * | 2011-12-23 | 2025-10-08 | Nicholas B. Lydon | Immunoglobulins and variants directed against pathogenic microbes |
| EP2705852A1 (en) * | 2012-09-06 | 2014-03-12 | Université de Lausanne | An immunogenic composition against Staphylococcus aureus comprising an inactivated recombinant non-pathogenic bacterium |
| CN104968797B (zh) * | 2012-11-06 | 2018-11-30 | 米迪缪尼有限公司 | 金黄色葡萄球菌表面决定簇的抗体 |
| PH12018501429B1 (en) * | 2014-06-03 | 2022-04-27 | Xbiotech Inc | Compositions and methods for treating and preventing staphylococcus aureus infections |
-
2015
- 2015-06-03 PH PH1/2018/501429A patent/PH12018501429B1/en unknown
- 2015-06-03 CN CN201810179664.7A patent/CN108404128A/zh active Pending
- 2015-06-03 JP JP2016570290A patent/JP6166000B1/ja active Active
- 2015-06-03 ES ES15802959T patent/ES2894867T3/es active Active
- 2015-06-03 SG SG11201609487QA patent/SG11201609487QA/en unknown
- 2015-06-03 KR KR1020177017485A patent/KR102015451B1/ko active Active
- 2015-06-03 WO PCT/US2015/033902 patent/WO2015187779A1/en not_active Ceased
- 2015-06-03 KR KR1020197024523A patent/KR20190100471A/ko not_active Ceased
- 2015-06-03 SG SG10201703965SA patent/SG10201703965SA/en unknown
- 2015-06-03 CN CN201580028466.5A patent/CN106456763B/zh active Active
- 2015-06-03 US US14/729,260 patent/US9416172B2/en active Active
- 2015-06-03 EP EP15802959.5A patent/EP3154584B1/en active Active
- 2015-06-03 MX MX2018004092A patent/MX394895B/es unknown
- 2015-06-03 MX MX2016015812A patent/MX355107B/es active IP Right Grant
- 2015-06-03 KR KR1020167036812A patent/KR101753553B1/ko active Active
- 2015-06-03 RU RU2016149523A patent/RU2636780C1/ru active
- 2015-06-03 NZ NZ726911A patent/NZ726911A/en unknown
- 2015-06-03 BR BR112016028043-1A patent/BR112016028043B1/pt active IP Right Grant
- 2015-06-03 RU RU2017135458A patent/RU2764981C1/ru active
- 2015-06-03 KR KR1020217010668A patent/KR20210047355A/ko not_active Ceased
- 2015-06-03 AU AU2015271749A patent/AU2015271749B2/en active Active
- 2015-06-03 MY MYPI2016002126A patent/MY191346A/en unknown
- 2015-06-03 CA CA2950840A patent/CA2950840C/en active Active
- 2015-06-03 EP EP21187744.4A patent/EP3970747A3/en active Pending
-
2016
- 2016-06-06 US US15/174,068 patent/US9486523B2/en active Active
- 2016-09-30 US US15/281,676 patent/US9783598B2/en active Active
- 2016-11-14 IL IL248959A patent/IL248959B/en unknown
- 2016-11-28 PH PH12016502372A patent/PH12016502372B1/en unknown
- 2016-11-29 CL CL2016003071A patent/CL2016003071A1/es unknown
- 2016-12-13 ZA ZA2016/08604A patent/ZA201608604B/en unknown
-
2017
- 2017-06-21 JP JP2017120971A patent/JP6672221B2/ja active Active
- 2017-08-18 US US15/680,533 patent/US10214581B2/en active Active
-
2018
- 2018-02-07 AU AU2018200886A patent/AU2018200886B2/en active Active
-
2019
- 2019-01-07 US US16/241,809 patent/US10577410B2/en active Active
- 2019-12-27 JP JP2019238373A patent/JP2020073548A/ja active Pending
-
2020
- 2020-01-08 US US16/737,841 patent/US11370831B2/en active Active
-
2022
- 2022-04-15 US US17/659,466 patent/US11773157B2/en active Active
- 2022-05-06 JP JP2022076737A patent/JP7811143B2/ja active Active
-
2024
- 2024-06-06 JP JP2024092217A patent/JP2024119907A/ja not_active Withdrawn
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12016502372A1 (en) | Compositions and methods for treating and preventing staphylococcus aureus infections | |
| EA201691488A1 (ru) | Молекулы антител против pd-1 и их применения | |
| MX2022003891A (es) | Anticuerpos anti-muc16 y sus usos. | |
| SI3176181T1 (sl) | Monoklonsko protitelo proti CTLA4 ali njegov antigen-vezavni fragment, zdravilni sestavek in uporaba | |
| EP3244926C0 (en) | TREATMENT OF CANCER WITH ANTI-LAP MONOCLONAL ANTIBODIES | |
| MX388181B (es) | Anticuerpos anti-pd-1. | |
| LT3119808T (lt) | Antikūnų kompozicijos vėžio gydymui | |
| EP4631978A3 (en) | Humanized or chimeric cd3 antibodies | |
| WO2014151680A8 (en) | Treatment and prevention of acute kidney injury using anti-alpha v beta 5 antibodies | |
| EP3925969C0 (en) | Peptide compounds and peptide conjugates for the treatment of cancer by receptor-mediated chemotherapy | |
| EP3500294A4 (en) | ANTI-PD-1 ANTIBODIES, OR THEIR FRAGMENTS, FOR THE TREATMENT OF HEPATITIS B | |
| CO2017001087A2 (es) | Anticuerpos anti proteína similar a angiopoyetina 4 | |
| IL246160A0 (en) | Antibodies directed against the toxin (lukgh (lukab) of staphylococcus aureus and antibody sequences | |
| BR112017011076A2 (pt) | métodos e composições para prevenir ou reduzir infecções de plantas cultivadas por agentes patogênicos fúngicos e bacterianos | |
| IL291266A (en) | Preparations and methods for treating infections | |
| EP3493823C0 (en) | POSTBIOTIC BASED COMPOUND FOR THE TREATMENT OF OCULAR INFLAMMATION | |
| EP3291837A4 (en) | MONOCLONAL ANTIBODY COCOA TAILS FOR THE TREATMENT OF EBOLA INFECTIONS | |
| MX2015008486A (es) | Composiciones y metodos para tratar infecciones bacterianas. | |
| EP3183002A4 (en) | Monoclonal antibodies for treatment of microbial infections | |
| EP3190893A4 (en) | Compositions and methods for treating and preventing bacterial infections | |
| EP3634471A4 (en) | Carbapenem compounds and compositions for the treatment of bacterial infections | |
| EP3459974C0 (en) | SPECIFIC INACTIVATION OF PLASMIN BY ANTICATALYTIC ANTIBODY | |
| FR3026010B1 (fr) | Compositions comprenant un compose de la famille des avermectines et de la doxycycline pour le traitement de la rosacee | |
| HK1236389A1 (en) | Compositions and methods for treating and preventing staphylococcus aureus infections | |
| HK40008308A (en) | Treatment of ige-mediated diseases with antibodies that specifically bind cd38 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |