JP6693744B2 - アルツハイマー病の治療方法およびその医薬組成物 - Google Patents

アルツハイマー病の治療方法およびその医薬組成物 Download PDF

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JP6693744B2
JP6693744B2 JP2015530420A JP2015530420A JP6693744B2 JP 6693744 B2 JP6693744 B2 JP 6693744B2 JP 2015530420 A JP2015530420 A JP 2015530420A JP 2015530420 A JP2015530420 A JP 2015530420A JP 6693744 B2 JP6693744 B2 JP 6693744B2
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シュミット，エレン
アーバーグ，ヨハン
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ハー・ルンドベック・アクチエゼルスカベット
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2015530420A 2012-09-09 2013-09-06 アルツハイマー病の治療方法およびその医薬組成物 Active JP6693744B2 (ja)

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US201261698664P 2012-09-09 2012-09-09
US61/698,664 2012-09-09
US201361782084P 2013-03-14 2013-03-14
US61/782,084 2013-03-14
PCT/EP2013/068516 WO2014037532A1 (en) 2012-09-09 2013-09-06 Methods of treating alzheimer's disease and pharmaceutical compositions thereof

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JP2018228631A Division JP2019059760A (ja) 2012-09-09 2018-12-06 アルツハイマー病の治療方法およびその医薬組成物

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JP2015528471A JP2015528471A (ja) 2015-09-28
JP2015528471A5 JP2015528471A5 (https=) 2016-10-20
JP6693744B2 true JP6693744B2 (ja) 2020-05-13

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JP2018228631A Pending JP2019059760A (ja) 2012-09-09 2018-12-06 アルツハイマー病の治療方法およびその医薬組成物

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CN (1) CN104619344A (https=)
AP (1) AP2015008306A0 (https=)
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BR (1) BR112015005117B1 (https=)
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CL (1) CL2015000578A1 (https=)
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US10383849B2 (en) * 2016-04-26 2019-08-20 H. Lundbeck A/S Use of an acetylcholinesterase inhibitor and idalopirdine for reducing falls in Parkinson's disease patients
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EA036347B1 (ru) 2016-05-18 2020-10-29 Сувен Лайф Сайенсиз Лимитед Комбинация чистых антагонистов 5-ht6 рецепторов с ингибиторами ацетилхолинэстеразы
CN106309436A (zh) * 2016-07-25 2017-01-11 宁波大学 可用作乙酰胆碱酯酶抑制剂的色胺衍生物及其用途
CN107118146B (zh) * 2017-04-13 2019-09-03 宁波大学 一种6-溴色胺衍生物及其制备方法和用途
BR112019001145A2 (pt) * 2017-05-24 2019-04-30 H. Lundbeck A/S combinação de um antagonista do receptor 5-ht6 e de um inibidor de acetilcolinesterase para uso no tratamento da doença de alzheimer em uma subpopulação de pacientes portadores de alelos de apoe4
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BR112015005117A2 (pt) 2017-07-04
IL237369B (en) 2018-11-29
SG11201501774QA (en) 2015-05-28
MX2015002879A (es) 2015-07-06
CA2883751A1 (en) 2014-03-13
US20160256437A1 (en) 2016-09-08
AU2013311573B2 (en) 2017-10-12
BR112015005117B1 (pt) 2022-06-21
WO2014037532A1 (en) 2014-03-13
AU2013311573A1 (en) 2015-03-12
RU2675786C2 (ru) 2018-12-25
TW201414474A (zh) 2014-04-16
US10660878B2 (en) 2020-05-26
CY1121062T1 (el) 2019-12-11
TN2015000076A1 (en) 2016-06-29
KR20150065680A (ko) 2015-06-15
US20180071254A1 (en) 2018-03-15
DK2892563T3 (en) 2019-01-21
RS58104B1 (sr) 2019-02-28
SI2892563T1 (sl) 2019-02-28
NI201500031A (es) 2016-02-15
JP2019059760A (ja) 2019-04-18
CA2883751C (en) 2020-11-24
US9687473B2 (en) 2017-06-27
AU2013311573A8 (en) 2015-03-19
HK1212217A1 (en) 2016-06-10
AP2015008306A0 (en) 2015-03-31
LT2892563T (lt) 2019-01-10
EP2892563B1 (en) 2018-11-14
MY182539A (en) 2021-01-25
CL2015000578A1 (es) 2015-05-15
US20160354343A1 (en) 2016-12-08
KR102342127B1 (ko) 2021-12-21
NZ630589A (en) 2015-12-24
KR20200137028A (ko) 2020-12-08
US9375418B2 (en) 2016-06-28
IL237369A0 (en) 2015-04-30
EA201590353A1 (ru) 2016-03-31
EA030448B1 (ru) 2018-08-31
US9789085B2 (en) 2017-10-17
RU2015107877A (ru) 2016-10-27
MX368305B (es) 2019-09-27
JO3459B1 (ar) 2020-07-05
GEP201706776B (en) 2017-11-27
HRP20182069T1 (hr) 2019-02-08
CN104619344A (zh) 2015-05-13
PL2892563T3 (pl) 2019-04-30
PT2892563T (pt) 2019-01-10
SMT201800678T1 (it) 2019-02-28
TWI632909B (zh) 2018-08-21
EP2892563A1 (en) 2015-07-15
US20140073681A1 (en) 2014-03-13
JP2015528471A (ja) 2015-09-28
ES2703630T3 (es) 2019-03-11

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