JP6664385B2 - Bub1阻害薬としてのベンジル置換インダゾール類 - Google Patents

Bub1阻害薬としてのベンジル置換インダゾール類 Download PDF

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JP6664385B2
JP6664385B2 JP2017514825A JP2017514825A JP6664385B2 JP 6664385 B2 JP6664385 B2 JP 6664385B2 JP 2017514825 A JP2017514825 A JP 2017514825A JP 2017514825 A JP2017514825 A JP 2017514825A JP 6664385 B2 JP6664385 B2 JP 6664385B2
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methyl
amino
indazol
difluoro
alkyl
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JP2017530962A5 (OSRAM
JP2017530962A (ja
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メンゲル,アンヌ
ラーチェン,ハンス−ゲオルク
モーヴェス,マンフレッド
ミュラー,トーマス
バルファッカー,ラルス
ヒッチコック,マリオン
クレーブ,アルウェド
クーンケ,ヨアヒム
ブリーム,ハンス
シーメイスター,ゲルハルト
ボネ,ヴィルヘルム
フェルナンデス−モンタルヴァン,アマウリー・エルネスト
シュレーダー,イェンス
メンニング,ウルスラ
ホルトン,シモン
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バイエル ファーマ アクチエンゲゼルシャフト
バイエル ファーマ アクチエンゲゼルシャフト
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2017514825A 2014-09-19 2015-09-17 Bub1阻害薬としてのベンジル置換インダゾール類 Expired - Fee Related JP6664385B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP14185604.7 2014-09-19
EP14185604 2014-09-19
EP15176903 2015-07-15
EP15176903.1 2015-07-15
PCT/EP2015/071340 WO2016042084A1 (en) 2014-09-19 2015-09-17 Benzyl substituted indazoles as bub1 inhibitors

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JP2017530962A JP2017530962A (ja) 2017-10-19
JP2017530962A5 JP2017530962A5 (OSRAM) 2018-10-25
JP6664385B2 true JP6664385B2 (ja) 2020-03-13

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JP2017514825A Expired - Fee Related JP6664385B2 (ja) 2014-09-19 2015-09-17 Bub1阻害薬としてのベンジル置換インダゾール類

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US (1) US10350206B2 (OSRAM)
EP (1) EP3194379A1 (OSRAM)
JP (1) JP6664385B2 (OSRAM)
KR (1) KR20170049604A (OSRAM)
CN (1) CN107001331A (OSRAM)
AP (1) AP2017009803A0 (OSRAM)
AU (1) AU2015316796A1 (OSRAM)
BR (1) BR112017005444A2 (OSRAM)
CA (1) CA2961589A1 (OSRAM)
CL (1) CL2017000654A1 (OSRAM)
CO (1) CO2017002532A2 (OSRAM)
CR (1) CR20170100A (OSRAM)
CU (1) CU20170029A7 (OSRAM)
DO (1) DOP2017000078A (OSRAM)
EA (1) EA032401B1 (OSRAM)
EC (1) ECSP17016797A (OSRAM)
IL (1) IL251071A0 (OSRAM)
MA (1) MA39484A (OSRAM)
MX (1) MX2017003664A (OSRAM)
NI (1) NI201700034A (OSRAM)
PE (1) PE20170697A1 (OSRAM)
PH (1) PH12017500509A1 (OSRAM)
SG (1) SG11201702082VA (OSRAM)
TN (1) TN2017000092A1 (OSRAM)
TW (1) TW201615636A (OSRAM)
UY (1) UY36311A (OSRAM)
WO (1) WO2016042084A1 (OSRAM)

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Publication number Publication date
CR20170100A (es) 2017-04-24
KR20170049604A (ko) 2017-05-10
DOP2017000078A (es) 2017-06-30
EA032401B1 (ru) 2019-05-31
CA2961589A1 (en) 2016-03-24
PE20170697A1 (es) 2017-06-24
IL251071A0 (en) 2017-04-30
TN2017000092A1 (en) 2018-07-04
US20170273980A1 (en) 2017-09-28
SG11201702082VA (en) 2017-04-27
ECSP17016797A (es) 2017-05-31
AU2015316796A1 (en) 2017-03-30
TW201615636A (zh) 2016-05-01
JP2017530962A (ja) 2017-10-19
EP3194379A1 (en) 2017-07-26
NI201700034A (es) 2017-06-16
CN107001331A (zh) 2017-08-01
MX2017003664A (es) 2017-07-13
CO2017002532A2 (es) 2017-07-11
EA201790649A1 (ru) 2017-09-29
WO2016042084A1 (en) 2016-03-24
CL2017000654A1 (es) 2017-12-11
AP2017009803A0 (en) 2017-03-31
PH12017500509A1 (en) 2017-08-30
BR112017005444A2 (pt) 2018-04-24
CU20170029A7 (es) 2017-08-08
MA39484A (fr) 2016-03-24
UY36311A (es) 2016-04-29
US10350206B2 (en) 2019-07-16

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