JP6637220B2 - 薬物動態及び／又は安全性に優れるテリパラチド含有液状医薬組成物 - Google Patents

薬物動態及び／又は安全性に優れるテリパラチド含有液状医薬組成物 Download PDF

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JP6637220B2
JP6637220B2 JP2019516021A JP2019516021A JP6637220B2 JP 6637220 B2 JP6637220 B2 JP 6637220B2 JP 2019516021 A JP2019516021 A JP 2019516021A JP 2019516021 A JP2019516021 A JP 2019516021A JP 6637220 B2 JP6637220 B2 JP 6637220B2
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liquid pharmaceutical
component
teriparatide
pharmaceutical preparation
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JPWO2019059303A1 (ja
Inventor
康平 宮部
康平 宮部
淳 尾瀬
淳 尾瀬
佐藤　友紀
友紀 佐藤
俊幸 児玉
俊幸 児玉
保宏 松縄
保宏 松縄
山本　光
光 山本
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Asahi Kasei Pharma Corp
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Asahi Kasei Pharma Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
JP2019516021A 2017-09-22 2018-09-20 薬物動態及び／又は安全性に優れるテリパラチド含有液状医薬組成物 Active JP6637220B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2017182615 2017-09-22
JP2017182615 2017-09-22
PCT/JP2018/034889 WO2019059303A1 (ja) 2017-09-22 2018-09-20 薬物動態及び／又は安全性に優れるテリパラチド含有液状医薬組成物

Related Child Applications (1)

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JP2019229592A Division JP2020040998A (ja) 2017-09-22 2019-12-19 薬物動態及び／又は安全性に優れるテリパラチド含有液状医薬組成物

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JPWO2019059303A1 JPWO2019059303A1 (ja) 2019-11-14
JP6637220B2 true JP6637220B2 (ja) 2020-01-29

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JP2019516021A Active JP6637220B2 (ja) 2017-09-22 2018-09-20 薬物動態及び／又は安全性に優れるテリパラチド含有液状医薬組成物
JP2019229592A Pending JP2020040998A (ja) 2017-09-22 2019-12-19 薬物動態及び／又は安全性に優れるテリパラチド含有液状医薬組成物
JP2021122390A Pending JP2021167354A (ja) 2017-09-22 2021-07-27 薬物動態及び／又は安全性に優れるテリパラチド含有液状医薬組成物
JP2023060783A Pending JP2023082167A (ja) 2017-09-22 2023-04-04 薬物動態及び／又は安全性に優れるテリパラチド含有液状医薬組成物
JP2024062188A Pending JP2024086815A (ja) 2017-09-22 2024-04-08 薬物動態及び／又は安全性に優れるテリパラチド含有液状医薬組成物

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JP2019229592A Pending JP2020040998A (ja) 2017-09-22 2019-12-19 薬物動態及び／又は安全性に優れるテリパラチド含有液状医薬組成物
JP2021122390A Pending JP2021167354A (ja) 2017-09-22 2021-07-27 薬物動態及び／又は安全性に優れるテリパラチド含有液状医薬組成物
JP2023060783A Pending JP2023082167A (ja) 2017-09-22 2023-04-04 薬物動態及び／又は安全性に優れるテリパラチド含有液状医薬組成物
JP2024062188A Pending JP2024086815A (ja) 2017-09-22 2024-04-08 薬物動態及び／又は安全性に優れるテリパラチド含有液状医薬組成物

Country Status (6)

Country Link
US (1) US20200289622A1 (enExample)
EP (1) EP3685850A4 (enExample)
JP (5) JP6637220B2 (enExample)
CN (1) CN111032073A (enExample)
CA (2) CA3075984C (enExample)
WO (1) WO2019059303A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119258199A (zh) * 2018-10-29 2025-01-07 旭化成制药株式会社 特立帕肽或其盐在骨质疏松症治疗和/或预防剂的制备中的应用

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6357527A (ja) 1986-08-28 1988-03-12 Toyo Jozo Co Ltd 薬剤の吸着防止方法
JPH0669956B2 (ja) 1988-09-30 1994-09-07 旭化成工業株式会社 ポリペプタイド類の吸着防止剤
JP2662842B2 (ja) * 1991-12-09 1997-10-15 旭化成工業株式会社 パラサイロイドホルモンの安定化組成物
JPH0873376A (ja) * 1994-09-07 1996-03-19 Asahi Chem Ind Co Ltd 骨粗鬆症治療薬
ZA9811127B (en) 1997-12-09 2000-07-11 Lilly Co Eli Stabilized teriparatide solutions.
IL147731A0 (en) 2000-05-19 2002-08-14 Bionebraska Inc Peptide pharmaceutical formulations
JP4931306B2 (ja) * 2001-09-27 2012-05-16 旭化成ファーマ株式会社 骨形成を安全に促進させる医薬複合剤
JP4252260B2 (ja) * 2002-06-05 2009-04-08 旭化成ファーマ株式会社 Ｐｔｈの安定化水溶液注射剤
WO2004067021A1 (en) * 2003-01-24 2004-08-12 Gardella Thomas J Conformationally constrained parathyroid hormone (pth) analogs with lactam bridges
JP4707327B2 (ja) 2004-01-27 2011-06-22 旭化成ファーマ株式会社 ポリペプタイド類の吸着防止剤
JP4951344B2 (ja) 2004-08-24 2012-06-13 第一三共株式会社 生理活性ペプチド液状製剤
JP2009511472A (ja) * 2005-10-06 2009-03-19 エムディーアールエヌエー，インコーポレイテッド Ｐｔｈ剤形及びその使用方法
JP5522879B2 (ja) 2006-01-16 2014-06-18 旭化成ファーマ株式会社 樹脂容器中の生理活性ペプチドの安定性改善方法
CA2659846A1 (en) * 2006-07-31 2008-02-07 Zelos Therapeutics, Inc. Parathyroid hormone analogues and methods of use
KR20150021590A (ko) * 2009-09-09 2015-03-02 아사히 가세이 파마 가부시키가이샤 1회당 100∼200 단위의 ｐｔｈ가 주 1회 투여되는 것을 특징으로 하는, ｐｔｈ 함유 골다공증 치료/예방제
WO2011139838A2 (en) 2010-04-28 2011-11-10 Zelos Therapeutics, Inc. Intranasal formulations
SG193389A1 (en) 2011-03-10 2013-10-30 Xeris Pharmaceuticals Inc Stable formulations for parenteral injection of peptide drugs
CN103561757B (zh) 2011-06-07 2016-01-06 旭化成制药株式会社 高纯度含pth冷冻干燥制剂及其制造方法
MX2014008668A (es) 2012-01-20 2014-10-06 Lupin Ltd Formulacion de pth estabilizada.
CN103301058A (zh) * 2013-06-17 2013-09-18 深圳翰宇药业股份有限公司 一种特立帕肽注射用组合物及其制备方法和制剂
JP6634758B2 (ja) * 2015-09-25 2020-01-22 ニプロ株式会社 液体組成物及び凍結乾燥製剤
SMT202100411T1 (it) * 2015-10-09 2021-11-12 Radius Health Inc Formulazioni di analoghi di pthrp, loro cerotti transdermici, e loro usi

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Publication number Publication date
WO2019059303A1 (ja) 2019-03-28
JP2021167354A (ja) 2021-10-21
JPWO2019059303A1 (ja) 2019-11-14
JP2024086815A (ja) 2024-06-28
JP2023082167A (ja) 2023-06-13
CA3075984A1 (en) 2019-03-28
EP3685850A1 (en) 2020-07-29
CA3075984C (en) 2024-10-01
US20200289622A1 (en) 2020-09-17
CN111032073A (zh) 2020-04-17
JP2020040998A (ja) 2020-03-19
EP3685850A4 (en) 2021-06-16
CA3167644A1 (en) 2019-03-28

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