JP6603712B2 - Ｓｕｍｏ活性化酵素の阻害薬として有用なヘテロアリール化合物 - Google Patents

Ｓｕｍｏ活性化酵素の阻害薬として有用なヘテロアリール化合物 Download PDF

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JP6603712B2
JP6603712B2 JP2017521031A JP2017521031A JP6603712B2 JP 6603712 B2 JP6603712 B2 JP 6603712B2 JP 2017521031 A JP2017521031 A JP 2017521031A JP 2017521031 A JP2017521031 A JP 2017521031A JP 6603712 B2 JP6603712 B2 JP 6603712B2
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amino
carbonyl
methylsulfamate
thienyl
pyrimidin
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JP2017524734A5 (https=
JP2017524734A (ja
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マシュー オー． ダフィー，
ディラン イングランド，
スコット フリーズ，
ジゲン フー，
スティーブン ピー． ラングストン，
チャールズ マッキンタイア，
ヒロタケ ミズタニ，
宏司 小野
へ シュー，
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Millennium Pharmaceuticals Inc
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
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JP2017521031A 2014-07-01 2015-06-30 Ｓｕｍｏ活性化酵素の阻害薬として有用なヘテロアリール化合物 Active JP6603712B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462019756P 2014-07-01 2014-07-01
US62/019,756 2014-07-01
US201562185678P 2015-06-28 2015-06-28
US62/185,678 2015-06-28
PCT/US2015/038712 WO2016004136A1 (en) 2014-07-01 2015-06-30 Heteroaryl compounds useful as inhibitors of sumo activating enzyme

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JP2019187426A Division JP2020023538A (ja) 2014-07-01 2019-10-11 Ｓｕｍｏ活性化酵素の阻害薬として有用なヘテロアリール化合物

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JP2017524734A JP2017524734A (ja) 2017-08-31
JP2017524734A5 JP2017524734A5 (https=) 2019-07-11
JP6603712B2 true JP6603712B2 (ja) 2019-11-06

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JP2017521031A Active JP6603712B2 (ja) 2014-07-01 2015-06-30 Ｓｕｍｏ活性化酵素の阻害薬として有用なヘテロアリール化合物
JP2019187426A Withdrawn JP2020023538A (ja) 2014-07-01 2019-10-11 Ｓｕｍｏ活性化酵素の阻害薬として有用なヘテロアリール化合物
JP2021131914A Pending JP2021178869A (ja) 2014-07-01 2021-08-13 Ｓｕｍｏ活性化酵素の阻害薬として有用なヘテロアリール化合物
JP2023191459A Withdrawn JP2024012558A (ja) 2014-07-01 2023-11-09 Ｓｕｍｏ活性化酵素の阻害薬として有用なヘテロアリール化合物

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JP2019187426A Withdrawn JP2020023538A (ja) 2014-07-01 2019-10-11 Ｓｕｍｏ活性化酵素の阻害薬として有用なヘテロアリール化合物
JP2021131914A Pending JP2021178869A (ja) 2014-07-01 2021-08-13 Ｓｕｍｏ活性化酵素の阻害薬として有用なヘテロアリール化合物
JP2023191459A Withdrawn JP2024012558A (ja) 2014-07-01 2023-11-09 Ｓｕｍｏ活性化酵素の阻害薬として有用なヘテロアリール化合物

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US (6) US9683003B2 (https=)
EP (3) EP3517112B1 (https=)
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KR (1) KR102491125B1 (https=)
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EP2879681A4 (en) 2012-08-03 2015-12-23 Millennium Pharm Inc INDOINDUBSTITUTED PYRROLOPYRIMIDINYL HIBITORS OF UBA6
SG11201610476VA (en) 2014-07-01 2017-01-27 Millennium Pharm Inc Heteroaryl compounds useful as inhibitors of sumo activating enzyme
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TWI870767B (zh) 2015-08-26 2025-01-21 比利時商健生藥品公司 使用作為prmt5抑制劑之新穎經6-6雙環芳香環取代之核苷類似物
CN115626935B (zh) 2016-10-03 2025-07-15 詹森药业有限公司 用作prmt5抑制剂的单环和双环系统取代的卡巴核苷类似物
CN110382707A (zh) 2017-02-27 2019-10-25 詹森药业有限公司 生物标志在鉴定将对用prmt5抑制剂治疗有响应的癌症患者中的用途
WO2018166855A1 (en) 2017-03-16 2018-09-20 Basf Se Heterobicyclic substituted dihydroisoxazoles
US10400517B2 (en) 2017-05-02 2019-09-03 Baker Hughes, A Ge Company, Llc Cutting elements configured to reduce impact damage and related tools and methods
EP3684363A4 (en) 2017-09-21 2021-05-12 Millennium Pharmaceuticals, Inc. CO-CRYSTALLINE FORMS OF ((1S, 2S, 4R) -4- {4 - [(1S) -2,3-DIHYDRO-1H-INDÉN-1-YLAMINO] -7H-PYRROLO [2,3-D] PYRIMIDIN -7-YL} -2-HYDROXYCYCLOPENTYL) METHYLSULFAMATE, THEIR FORMULATIONS AND USES
IL275129B2 (en) 2017-12-08 2023-10-01 Janssen Pharmaceutica Nv Novel spirobicyclic analogues
US20210015915A1 (en) 2018-03-23 2021-01-21 Takeda Pharmaceutical Company Limited Sting modulator compounds with sulfamate linkages, and methods of making and using
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JP7352582B2 (ja) * 2018-07-09 2023-09-28 武田薬品工業株式会社 Ｓｕｍｏ活性化酵素阻害剤及び抗ｃｄ２０抗体の投与
US10570668B2 (en) 2018-07-27 2020-02-25 Baker Hughes, A Ge Company, Llc Cutting elements configured to reduce impact damage and mitigate polycrystalline, superabrasive material failure earth-boring tools including such cutting elements, and related methods
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