JP6486686B2 - 単鎖抗体及び他のヘテロ多量体 - Google Patents

単鎖抗体及び他のヘテロ多量体 Download PDF

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Publication number
JP6486686B2
JP6486686B2 JP2014556732A JP2014556732A JP6486686B2 JP 6486686 B2 JP6486686 B2 JP 6486686B2 JP 2014556732 A JP2014556732 A JP 2014556732A JP 2014556732 A JP2014556732 A JP 2014556732A JP 6486686 B2 JP6486686 B2 JP 6486686B2
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tether
domain
antibody
clh
chain antibody
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Expired - Fee Related
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JP2015508077A5 (https=
JP2015508077A (ja
Inventor
ベルント ヴラニック，
ベルント ヴラニック，
ダン エル． イートン，
ダン エル． イートン，
エリン エイチ． クリステンセン，
エリン エイチ． クリステンセン，
チエンション ウー，
チエンション ウー，
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Genentech Inc
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Genentech Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2014556732A 2012-02-10 2013-02-08 単鎖抗体及び他のヘテロ多量体 Expired - Fee Related JP6486686B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261597486P 2012-02-10 2012-02-10
US61/597,486 2012-02-10
PCT/US2013/025365 WO2013119966A2 (en) 2012-02-10 2013-02-08 Single-chain antibodies and other heteromultimers

Related Child Applications (1)

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JP2017233979A Division JP2018070634A (ja) 2012-02-10 2017-12-06 単鎖抗体及び他のヘテロ多量体

Publications (3)

Publication Number Publication Date
JP2015508077A JP2015508077A (ja) 2015-03-16
JP2015508077A5 JP2015508077A5 (https=) 2016-04-07
JP6486686B2 true JP6486686B2 (ja) 2019-03-20

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JP2014556732A Expired - Fee Related JP6486686B2 (ja) 2012-02-10 2013-02-08 単鎖抗体及び他のヘテロ多量体
JP2017233979A Pending JP2018070634A (ja) 2012-02-10 2017-12-06 単鎖抗体及び他のヘテロ多量体

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US (1) US9688758B2 (https=)
EP (1) EP2812357B1 (https=)
JP (2) JP6486686B2 (https=)
KR (1) KR20140127854A (https=)
CN (1) CN104105711B (https=)
BR (1) BR112014019579A2 (https=)
CA (1) CA2861124A1 (https=)
MX (1) MX2014009565A (https=)
RU (1) RU2644341C2 (https=)
WO (1) WO2013119966A2 (https=)

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CN104105711A (zh) 2014-10-15
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