JP6443812B2 - ハリコンドリンｂ類縁体の合成に有用な方法 - Google Patents

ハリコンドリンｂ類縁体の合成に有用な方法 Download PDF

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Publication number
JP6443812B2
JP6443812B2 JP2016532033A JP2016532033A JP6443812B2 JP 6443812 B2 JP6443812 B2 JP 6443812B2 JP 2016532033 A JP2016532033 A JP 2016532033A JP 2016532033 A JP2016532033 A JP 2016532033A JP 6443812 B2 JP6443812 B2 JP 6443812B2
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eribulin
pharmaceutically acceptable
acceptable salt
alkyl
acetonitrile
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Japanese (ja)
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JP2016540752A (ja
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ルイス，ブライアン，エム
フ，ヨンボ
ツァン，ヒュイミン
千葉　博之
博之 千葉
雄毅 小松
雄毅 小松
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Eisai R&D Management Co Ltd
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Eisai R&D Management Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2016532033A 2013-12-06 2014-12-05 ハリコンドリンｂ類縁体の合成に有用な方法 Active JP6443812B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361912714P 2013-12-06 2013-12-06
US61/912,714 2013-12-06
PCT/US2014/068834 WO2015085193A1 (en) 2013-12-06 2014-12-05 Methods useful in the synthesis of halichondrin b analogs

Related Child Applications (1)

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JP2018194871A Division JP6634135B2 (ja) 2013-12-06 2018-10-16 ハリコンドリンｂ類縁体の合成に有用な方法

Publications (2)

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JP2016540752A JP2016540752A (ja) 2016-12-28
JP6443812B2 true JP6443812B2 (ja) 2018-12-26

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Family Applications (3)

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JP2016532033A Active JP6443812B2 (ja) 2013-12-06 2014-12-05 ハリコンドリンｂ類縁体の合成に有用な方法
JP2018194871A Active JP6634135B2 (ja) 2013-12-06 2018-10-16 ハリコンドリンｂ類縁体の合成に有用な方法
JP2019225297A Active JP6905041B2 (ja) 2013-12-06 2019-12-13 ハリコンドリンｂ類縁体の合成に有用な方法

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JP2018194871A Active JP6634135B2 (ja) 2013-12-06 2018-10-16 ハリコンドリンｂ類縁体の合成に有用な方法
JP2019225297A Active JP6905041B2 (ja) 2013-12-06 2019-12-13 ハリコンドリンｂ類縁体の合成に有用な方法

Country Status (13)

Country Link
US (4) US9303039B2 (https=)
EP (2) EP3077399B1 (https=)
JP (3) JP6443812B2 (https=)
CN (1) CN105916861B (https=)
BR (1) BR112016012237B1 (https=)
CA (1) CA2931788C (https=)
ES (1) ES2723355T3 (https=)
HU (1) HUE043088T2 (https=)
IL (4) IL245661A0 (https=)
MX (3) MX384292B (https=)
RU (1) RU2676486C1 (https=)
SG (2) SG11201604545XA (https=)
WO (1) WO2015085193A1 (https=)

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US10556910B2 (en) 2014-06-30 2020-02-11 President And Fellows Of Harvard College Synthesis of halichondrin analogs and uses thereof
US10344038B2 (en) 2015-04-30 2019-07-09 President And Fellows Of Harvard College Chromium-mediated coupling and application to the synthesis of halichondrins
KR102743950B1 (ko) 2015-05-07 2024-12-18 에자이 알앤드디 매니지먼트 가부시키가이샤 할리콘드린 마크롤라이드의 합성에 유용한 마크로고리화 반응 및 중간체 및 기타 단편
EP3413887B1 (en) * 2016-02-12 2021-04-07 Eisai R&D Management Co., Ltd. Intermediates in the synthesis of eribulin and related methods of synthesis
EP3423105B1 (en) 2016-03-02 2021-05-05 Eisai R&D Management Co., Ltd. Eribulin-based antibody-drug conjugates and methods of use
US11136335B2 (en) 2016-06-30 2021-10-05 Eisai R&D Management Co., Ltd. Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof
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US9938288B1 (en) 2017-04-05 2018-04-10 President And Fellows Of Harvard College Macrocyclic compound and uses thereof
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US11498892B2 (en) 2017-07-06 2022-11-15 President And Fellows Of Harvard College Fe/Cu-mediated ketone synthesis
HUE061306T2 (hu) 2017-07-06 2023-06-28 Harvard College Halikondrinok szintézise
CN109694379B (zh) * 2017-10-24 2020-09-11 江苏恒瑞医药股份有限公司 用于制备艾日布林的中间体及其制备方法
CN111566113B (zh) 2017-11-15 2024-01-09 哈佛大学的校长及成员们 大环化合物及其用途
US11419856B2 (en) 2017-11-20 2022-08-23 Basilea Pharmaceutica International AG Pharmaceutical combinations for use in the treatment of neoplastic diseases
SG11202005548WA (en) 2018-01-03 2020-07-29 Eisai R&D Man Co Ltd Prins reaction and compounds useful in the synthesis of halichondrin macrolides and analogs thereof
JP2021532102A (ja) * 2018-07-20 2021-11-25 ドクター レディズ ラボラトリーズ リミテッド エリブリンおよびその中間体の調製のための精製プロセス
EP3864011A4 (en) * 2018-10-09 2022-06-29 Dr. Reddy's Laboratories Ltd. Process for preparation of eribulin and intermediates thereof
US12522611B2 (en) * 2018-11-28 2026-01-13 Natco Pharma Limited Process for the preparation of high pure Eribulin and its Mesylate salt
US11447499B2 (en) 2019-06-14 2022-09-20 Rk Pharma Inc. Process for the preparation of eribulin mesylate intermediate
WO2022101931A1 (en) * 2020-11-10 2022-05-19 Natco Pharma Limited Process for the preparation of eribulin and its intermediates
CN113354659B (zh) * 2021-06-08 2022-04-08 江苏慧聚药业股份有限公司 甲磺酸艾日布林的合成
CN114380840B (zh) * 2022-01-27 2024-01-26 江苏慧聚药业股份有限公司 艾日布林的合成
WO2025106586A1 (en) * 2023-11-13 2025-05-22 Luxvitae Therapeutics Inc. Macrocyclic ketone compounds and applications thereof

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CN105801599A (zh) 2008-04-04 2016-07-27 卫材R&D管理有限公司 软海绵素b类似物
JP5371091B2 (ja) 2009-01-23 2013-12-18 三菱レイヨン株式会社 モノスルホン酸エステルの製造方法
WO2011094339A1 (en) 2010-01-26 2011-08-04 Eisai R&D Management Co., Ltd. Furo [3, 2 -b] pyrane derivatives useful in the synthesis of halichondrin b analogs
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WO2012147900A1 (en) 2011-04-28 2012-11-01 Eisai R&D Management Co., Ltd. Microreactor process for halichondrin b analog synthesis
EP2785687B1 (en) 2011-11-30 2019-02-20 Sandoz AG Process for preparation of (3r)-2,4-di-leaving group-3-methylbut-1-ene
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EP3689881B1 (en) 2013-11-04 2022-01-12 Eisai R&D Management Co., Ltd. Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin b
MX384292B (es) * 2013-12-06 2025-03-14 Eisai R&D Man Co Ltd Metodos utiles en la sintesis de analogos de halicondrina b.
KR102743950B1 (ko) 2015-05-07 2024-12-18 에자이 알앤드디 매니지먼트 가부시키가이샤 할리콘드린 마크롤라이드의 합성에 유용한 마크로고리화 반응 및 중간체 및 기타 단편
EP3413887B1 (en) 2016-02-12 2021-04-07 Eisai R&D Management Co., Ltd. Intermediates in the synthesis of eribulin and related methods of synthesis
US11136335B2 (en) 2016-06-30 2021-10-05 Eisai R&D Management Co., Ltd. Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof

Also Published As

Publication number Publication date
IL273736B (en) 2021-03-25
JP6905041B2 (ja) 2021-07-21
BR112016012237B1 (pt) 2023-02-07
EP3505520A1 (en) 2019-07-03
US20170298078A1 (en) 2017-10-19
EP3077399A4 (en) 2017-05-10
IL273736A (en) 2020-05-31
US10030032B2 (en) 2018-07-24
SG11201604545XA (en) 2016-07-28
BR112016012237A2 (https=) 2017-08-08
MX376869B (es) 2025-03-07
CA2931788A1 (en) 2015-06-11
ES2723355T3 (es) 2019-08-26
EP3077399B1 (en) 2019-02-20
WO2015085193A1 (en) 2015-06-11
JP2016540752A (ja) 2016-12-28
CN105916861A (zh) 2016-08-31
US9695188B2 (en) 2017-07-04
US20160176895A1 (en) 2016-06-23
CN105916861B (zh) 2018-12-14
IL281275A (en) 2021-04-29
US20150158881A1 (en) 2015-06-11
IL281275B (en) 2021-12-01
MX2020004855A (es) 2021-07-08
JP2019031530A (ja) 2019-02-28
CA2931788C (en) 2022-05-24
IL265640A (en) 2019-05-30
RU2676486C1 (ru) 2018-12-29
MX2016006891A (es) 2017-06-12
JP2020059739A (ja) 2020-04-16
MX370611B (es) 2019-12-18
EP3077399A1 (en) 2016-10-12
US9303039B2 (en) 2016-04-05
IL245661A0 (en) 2016-06-30
US10450324B2 (en) 2019-10-22
IL265640B (en) 2020-04-30
JP6634135B2 (ja) 2020-01-22
MX2019011926A (es) 2019-11-18
MX384292B (es) 2025-03-14
SG10201805024YA (en) 2018-07-30
US20190010166A1 (en) 2019-01-10
HUE043088T2 (hu) 2019-08-28

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