JP6431431B2 - 芳香族ジアミン及びその中間体、並びにこれらの製造方法 - Google Patents
芳香族ジアミン及びその中間体、並びにこれらの製造方法 Download PDFInfo
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- JP6431431B2 JP6431431B2 JP2015082591A JP2015082591A JP6431431B2 JP 6431431 B2 JP6431431 B2 JP 6431431B2 JP 2015082591 A JP2015082591 A JP 2015082591A JP 2015082591 A JP2015082591 A JP 2015082591A JP 6431431 B2 JP6431431 B2 JP 6431431B2
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- JP
- Japan
- Prior art keywords
- formula
- compound represented
- amino
- following formula
- nitrophenol
- Prior art date
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- 238000000034 method Methods 0.000 title claims description 19
- 150000004984 aromatic diamines Chemical class 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 52
- 125000004432 carbon atom Chemical group C* 0.000 claims description 18
- 238000006243 chemical reaction Methods 0.000 claims description 17
- 238000004519 manufacturing process Methods 0.000 claims description 13
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 12
- 125000000217 alkyl group Chemical group 0.000 claims description 11
- 125000003277 amino group Chemical group 0.000 claims description 11
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 11
- 125000005843 halogen group Chemical group 0.000 claims description 8
- KUCWUAFNGCMZDB-UHFFFAOYSA-N 2-amino-3-nitrophenol Chemical class NC1=C(O)C=CC=C1[N+]([O-])=O KUCWUAFNGCMZDB-UHFFFAOYSA-N 0.000 claims description 6
- 125000003545 alkoxy group Chemical group 0.000 claims description 6
- 150000005181 nitrobenzenes Chemical class 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 5
- IQUPABOKLQSFBK-UHFFFAOYSA-N 2-nitrophenol Chemical compound OC1=CC=CC=C1[N+]([O-])=O IQUPABOKLQSFBK-UHFFFAOYSA-N 0.000 claims description 4
- 150000001340 alkali metals Chemical class 0.000 claims description 3
- 229910052751 metal Inorganic materials 0.000 claims description 3
- 239000002184 metal Substances 0.000 claims description 3
- 229910052783 alkali metal Inorganic materials 0.000 claims description 2
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims description 2
- 150000001342 alkaline earth metals Chemical class 0.000 claims description 2
- DPJCXCZTLWNFOH-UHFFFAOYSA-N 2-nitroaniline Chemical class NC1=CC=CC=C1[N+]([O-])=O DPJCXCZTLWNFOH-UHFFFAOYSA-N 0.000 claims 1
- USIUVYZYUHIAEV-UHFFFAOYSA-N diphenyl ether Chemical compound C=1C=CC=CC=1OC1=CC=CC=C1 USIUVYZYUHIAEV-UHFFFAOYSA-N 0.000 description 48
- 238000006722 reduction reaction Methods 0.000 description 23
- -1 diamine compound Chemical class 0.000 description 15
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 14
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 12
- 239000004642 Polyimide Substances 0.000 description 12
- 238000004458 analytical method Methods 0.000 description 12
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 12
- 229920001721 polyimide Polymers 0.000 description 12
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 11
- 239000007787 solid Substances 0.000 description 11
- 239000003054 catalyst Substances 0.000 description 10
- 239000002904 solvent Substances 0.000 description 10
- 238000001914 filtration Methods 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- LGRFSURHDFAFJT-UHFFFAOYSA-N Phthalic anhydride Natural products C1=CC=C2C(=O)OC(=O)C2=C1 LGRFSURHDFAFJT-UHFFFAOYSA-N 0.000 description 8
- 230000015572 biosynthetic process Effects 0.000 description 8
- 238000006266 etherification reaction Methods 0.000 description 8
- 238000004128 high performance liquid chromatography Methods 0.000 description 8
- 238000005259 measurement Methods 0.000 description 8
- 238000003786 synthesis reaction Methods 0.000 description 8
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 7
- 238000009903 catalytic hydrogenation reaction Methods 0.000 description 7
- 150000004985 diamines Chemical class 0.000 description 7
- 239000008096 xylene Substances 0.000 description 7
- IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical compound [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 description 6
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 6
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 6
- 238000004949 mass spectrometry Methods 0.000 description 6
- 238000001035 drying Methods 0.000 description 5
- 238000005984 hydrogenation reaction Methods 0.000 description 5
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 5
- XNGIFLGASWRNHJ-UHFFFAOYSA-N o-dicarboxybenzene Natural products OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 description 5
- 239000002243 precursor Substances 0.000 description 5
- 239000002994 raw material Substances 0.000 description 5
- 238000005406 washing Methods 0.000 description 5
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 4
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 description 4
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 4
- 238000001460 carbon-13 nuclear magnetic resonance spectrum Methods 0.000 description 4
- 239000012043 crude product Substances 0.000 description 4
- 238000006358 imidation reaction Methods 0.000 description 4
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 4
- XTUSEBKMEQERQV-UHFFFAOYSA-N propan-2-ol;hydrate Chemical compound O.CC(C)O XTUSEBKMEQERQV-UHFFFAOYSA-N 0.000 description 4
- 238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 description 4
- MXVHUTKGCQIBCD-UHFFFAOYSA-N 4-(4-aminophenoxy)-3-phenylaniline Chemical group C1=CC(N)=CC=C1OC1=CC=C(N)C=C1C1=CC=CC=C1 MXVHUTKGCQIBCD-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 150000001555 benzenes Chemical class 0.000 description 3
- JHIWVOJDXOSYLW-UHFFFAOYSA-N butyl 2,2-difluorocyclopropane-1-carboxylate Chemical class CCCCOC(=O)C1CC1(F)F JHIWVOJDXOSYLW-UHFFFAOYSA-N 0.000 description 3
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 3
- ILCQYORZHHFLNL-UHFFFAOYSA-N n-bromoaniline Chemical compound BrNC1=CC=CC=C1 ILCQYORZHHFLNL-UHFFFAOYSA-N 0.000 description 3
- MGNPLIACIXIYJE-UHFFFAOYSA-N n-fluoroaniline Chemical compound FNC1=CC=CC=C1 MGNPLIACIXIYJE-UHFFFAOYSA-N 0.000 description 3
- RRHNGIRRWDWWQQ-UHFFFAOYSA-N n-iodoaniline Chemical compound INC1=CC=CC=C1 RRHNGIRRWDWWQQ-UHFFFAOYSA-N 0.000 description 3
- 229910052763 palladium Inorganic materials 0.000 description 3
- 125000005543 phthalimide group Chemical group 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 3
- 0 *c(c(*)c(*)c(*)c1C(N2C(C=CCC3)=C3Oc3ccccc3)=O)c1C2=O Chemical compound *c(c(*)c(*)c(*)c1C(N2C(C=CCC3)=C3Oc3ccccc3)=O)c1C2=O 0.000 description 2
- CYSGHNMQYZDMIA-UHFFFAOYSA-N 1,3-Dimethyl-2-imidazolidinon Chemical compound CN1CCN(C)C1=O CYSGHNMQYZDMIA-UHFFFAOYSA-N 0.000 description 2
- WFQDTOYDVUWQMS-UHFFFAOYSA-N 1-fluoro-4-nitrobenzene Chemical compound [O-][N+](=O)C1=CC=C(F)C=C1 WFQDTOYDVUWQMS-UHFFFAOYSA-N 0.000 description 2
- KJVBJICWGQIMOZ-UHFFFAOYSA-N 2-fluoro-5-nitroaniline Chemical compound NC1=CC([N+]([O-])=O)=CC=C1F KJVBJICWGQIMOZ-UHFFFAOYSA-N 0.000 description 2
- AGQAUEAEVWVSDM-UHFFFAOYSA-N 2-nitroaniline N-phenylnitramide Chemical class [N+](=O)([O-])NC1=CC=CC=C1.[N+](=O)([O-])C1=C(N)C=CC=C1 AGQAUEAEVWVSDM-UHFFFAOYSA-N 0.000 description 2
- RTZZCYNQPHTPPL-UHFFFAOYSA-N 3-nitrophenol Chemical compound OC1=CC=CC([N+]([O-])=O)=C1 RTZZCYNQPHTPPL-UHFFFAOYSA-N 0.000 description 2
- BTJIUGUIPKRLHP-UHFFFAOYSA-N 4-nitrophenol Chemical compound OC1=CC=C([N+]([O-])=O)C=C1 BTJIUGUIPKRLHP-UHFFFAOYSA-N 0.000 description 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 2
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 description 2
- NIQCNGHVCWTJSM-UHFFFAOYSA-N Dimethyl phthalate Chemical compound COC(=O)C1=CC=CC=C1C(=O)OC NIQCNGHVCWTJSM-UHFFFAOYSA-N 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- QAEPYFVEBCTNFW-UHFFFAOYSA-N [Mg].Nc1c(O)cccc1[N+]([O-])=O Chemical compound [Mg].Nc1c(O)cccc1[N+]([O-])=O QAEPYFVEBCTNFW-UHFFFAOYSA-N 0.000 description 2
- 239000003377 acid catalyst Substances 0.000 description 2
- 150000001448 anilines Chemical class 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 150000001721 carbon Chemical group 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- FLKPEMZONWLCSK-UHFFFAOYSA-N diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 2
- KUDPGZONDFORKU-UHFFFAOYSA-N n-chloroaniline Chemical compound ClNC1=CC=CC=C1 KUDPGZONDFORKU-UHFFFAOYSA-N 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 229910000027 potassium carbonate Inorganic materials 0.000 description 2
- 239000012265 solid product Substances 0.000 description 2
- HPGGPRDJHPYFRM-UHFFFAOYSA-J tin(iv) chloride Chemical compound Cl[Sn](Cl)(Cl)Cl HPGGPRDJHPYFRM-UHFFFAOYSA-J 0.000 description 2
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- ORPVVAKYSXQCJI-UHFFFAOYSA-N 1-bromo-2-nitrobenzene Chemical compound [O-][N+](=O)C1=CC=CC=C1Br ORPVVAKYSXQCJI-UHFFFAOYSA-N 0.000 description 1
- FWIROFMBWVMWLB-UHFFFAOYSA-N 1-bromo-3-nitrobenzene Chemical compound [O-][N+](=O)C1=CC=CC(Br)=C1 FWIROFMBWVMWLB-UHFFFAOYSA-N 0.000 description 1
- ZDFBKZUDCQQKAC-UHFFFAOYSA-N 1-bromo-4-nitrobenzene Chemical compound [O-][N+](=O)C1=CC=C(Br)C=C1 ZDFBKZUDCQQKAC-UHFFFAOYSA-N 0.000 description 1
- BFCFYVKQTRLZHA-UHFFFAOYSA-N 1-chloro-2-nitrobenzene Chemical compound [O-][N+](=O)C1=CC=CC=C1Cl BFCFYVKQTRLZHA-UHFFFAOYSA-N 0.000 description 1
- KMAQZIILEGKYQZ-UHFFFAOYSA-N 1-chloro-3-nitrobenzene Chemical compound [O-][N+](=O)C1=CC=CC(Cl)=C1 KMAQZIILEGKYQZ-UHFFFAOYSA-N 0.000 description 1
- PWKNBLFSJAVFAB-UHFFFAOYSA-N 1-fluoro-2-nitrobenzene Chemical compound [O-][N+](=O)C1=CC=CC=C1F PWKNBLFSJAVFAB-UHFFFAOYSA-N 0.000 description 1
- WMASLRCNNKMRFP-UHFFFAOYSA-N 1-fluoro-3-nitrobenzene Chemical compound [O-][N+](=O)C1=CC=CC(F)=C1 WMASLRCNNKMRFP-UHFFFAOYSA-N 0.000 description 1
- JXMZUNPWVXQADG-UHFFFAOYSA-N 1-iodo-2-nitrobenzene Chemical compound [O-][N+](=O)C1=CC=CC=C1I JXMZUNPWVXQADG-UHFFFAOYSA-N 0.000 description 1
- CBYAZOKPJYBCHE-UHFFFAOYSA-N 1-iodo-3-nitrobenzene Chemical compound [O-][N+](=O)C1=CC=CC(I)=C1 CBYAZOKPJYBCHE-UHFFFAOYSA-N 0.000 description 1
- SCCCFNJTCDSLCY-UHFFFAOYSA-N 1-iodo-4-nitrobenzene Chemical compound [O-][N+](=O)C1=CC=C(I)C=C1 SCCCFNJTCDSLCY-UHFFFAOYSA-N 0.000 description 1
- VLZVIIYRNMWPSN-UHFFFAOYSA-N 2-Amino-4-nitrophenol Chemical compound NC1=CC([N+]([O-])=O)=CC=C1O VLZVIIYRNMWPSN-UHFFFAOYSA-N 0.000 description 1
- XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 description 1
- BRFXNNKOCOUTSF-UHFFFAOYSA-N 2-amino-4-nitrophenol;sodium Chemical compound [Na].NC1=CC([N+]([O-])=O)=CC=C1O BRFXNNKOCOUTSF-UHFFFAOYSA-N 0.000 description 1
- CGPPWNTVTNCHDO-UHFFFAOYSA-N 2-bromo-4-nitroaniline Chemical compound NC1=CC=C([N+]([O-])=O)C=C1Br CGPPWNTVTNCHDO-UHFFFAOYSA-N 0.000 description 1
- BAAUCXCLMDAZEL-UHFFFAOYSA-N 2-bromo-5-nitroaniline Chemical compound NC1=CC([N+]([O-])=O)=CC=C1Br BAAUCXCLMDAZEL-UHFFFAOYSA-N 0.000 description 1
- RXNOYRCWKRFNIM-UHFFFAOYSA-N 2-carbonochloridoylbenzoic acid Chemical compound OC(=O)C1=CC=CC=C1C(Cl)=O RXNOYRCWKRFNIM-UHFFFAOYSA-N 0.000 description 1
- LOCWBQIWHWIRGN-UHFFFAOYSA-N 2-chloro-4-nitroaniline Chemical compound NC1=CC=C([N+]([O-])=O)C=C1Cl LOCWBQIWHWIRGN-UHFFFAOYSA-N 0.000 description 1
- ZNQVEEAIQZEUHB-UHFFFAOYSA-N 2-ethoxyethanol Chemical compound CCOCCO ZNQVEEAIQZEUHB-UHFFFAOYSA-N 0.000 description 1
- 229940093475 2-ethoxyethanol Drugs 0.000 description 1
- LETNCFZQCNCACQ-UHFFFAOYSA-N 2-fluoro-4-nitroaniline Chemical compound NC1=CC=C([N+]([O-])=O)C=C1F LETNCFZQCNCACQ-UHFFFAOYSA-N 0.000 description 1
- WSOUAAUSIHHTMX-UHFFFAOYSA-N 2-nitrophenol;potassium Chemical compound [K].OC1=CC=CC=C1[N+]([O-])=O WSOUAAUSIHHTMX-UHFFFAOYSA-N 0.000 description 1
- HOARRORFJXBJQW-UHFFFAOYSA-N 3-nitrophenol;sodium Chemical compound [Na].OC1=CC=CC([N+]([O-])=O)=C1 HOARRORFJXBJQW-UHFFFAOYSA-N 0.000 description 1
- PCRBEZAPWQZSSI-UHFFFAOYSA-N 4,5-di(propan-2-yl)-2-benzofuran-1,3-dione Chemical compound C(C)(C)C=1C(=C2C(C(=O)OC2=O)=CC=1)C(C)C PCRBEZAPWQZSSI-UHFFFAOYSA-N 0.000 description 1
- QJAVPPRWGRGEOJ-UHFFFAOYSA-N 4,5-diethyl-2-benzofuran-1,3-dione Chemical compound C(C)C=1C(=C2C(C(=O)OC2=O)=CC1)CC QJAVPPRWGRGEOJ-UHFFFAOYSA-N 0.000 description 1
- JFHFMHPKOSJJTE-UHFFFAOYSA-N 4,5-dimethyl-2-benzofuran-1,3-dione Chemical compound CC1=CC=C2C(=O)OC(=O)C2=C1C JFHFMHPKOSJJTE-UHFFFAOYSA-N 0.000 description 1
- SNXSEABIASKCKD-UHFFFAOYSA-N 4,5-dipropyl-2-benzofuran-1,3-dione Chemical compound C(CC)C1=C2C(C(=O)OC2=O)=CC=C1CCC SNXSEABIASKCKD-UHFFFAOYSA-N 0.000 description 1
- ZXVONLUNISGICL-UHFFFAOYSA-N 4,6-dinitro-o-cresol Chemical group CC1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1O ZXVONLUNISGICL-UHFFFAOYSA-N 0.000 description 1
- AXMANIZPMQZKTG-UHFFFAOYSA-N 4-(2-phenylethynyl)-2-benzofuran-1,3-dione Chemical compound O=C1OC(=O)C2=C1C=CC=C2C#CC1=CC=CC=C1 AXMANIZPMQZKTG-UHFFFAOYSA-N 0.000 description 1
- CZGCEKJOLUNIFY-UHFFFAOYSA-N 4-Chloronitrobenzene Chemical compound [O-][N+](=O)C1=CC=C(Cl)C=C1 CZGCEKJOLUNIFY-UHFFFAOYSA-N 0.000 description 1
- LIVHSQMNQCENSI-UHFFFAOYSA-N 4-ethyl-2-benzofuran-1,3-dione Chemical compound CCC1=CC=CC2=C1C(=O)OC2=O LIVHSQMNQCENSI-UHFFFAOYSA-N 0.000 description 1
- TWWAWPHAOPTQEU-UHFFFAOYSA-N 4-methyl-2-benzofuran-1,3-dione Chemical compound CC1=CC=CC2=C1C(=O)OC2=O TWWAWPHAOPTQEU-UHFFFAOYSA-N 0.000 description 1
- TVOGBZCPDVXFQL-UHFFFAOYSA-N 4-nitrophenol;potassium Chemical compound [K].OC1=CC=C([N+]([O-])=O)C=C1 TVOGBZCPDVXFQL-UHFFFAOYSA-N 0.000 description 1
- AAPZMJNYFJUWHR-UHFFFAOYSA-N 4-propan-2-yl-2-benzofuran-1,3-dione Chemical compound CC(C)C1=CC=CC2=C1C(=O)OC2=O AAPZMJNYFJUWHR-UHFFFAOYSA-N 0.000 description 1
- KNZIYNGMRBGXAR-UHFFFAOYSA-N 4-propyl-2-benzofuran-1,3-dione Chemical compound CCCC1=CC=CC2=C1C(=O)OC2=O KNZIYNGMRBGXAR-UHFFFAOYSA-N 0.000 description 1
- ZFKYZHOZHFVTLZ-UHFFFAOYSA-N 5-ethyl-2-benzofuran-1,3-dione Chemical compound CCC1=CC=C2C(=O)OC(=O)C2=C1 ZFKYZHOZHFVTLZ-UHFFFAOYSA-N 0.000 description 1
- ZOXBWJMCXHTKNU-UHFFFAOYSA-N 5-methyl-2-benzofuran-1,3-dione Chemical compound CC1=CC=C2C(=O)OC(=O)C2=C1 ZOXBWJMCXHTKNU-UHFFFAOYSA-N 0.000 description 1
- YYUDBVXABOBKEL-UHFFFAOYSA-N 5-propan-2-yl-2-benzofuran-1,3-dione Chemical compound CC(C)C1=CC=C2C(=O)OC(=O)C2=C1 YYUDBVXABOBKEL-UHFFFAOYSA-N 0.000 description 1
- SSWCTYRQNSCTGB-UHFFFAOYSA-N 5-propyl-2-benzofuran-1,3-dione Chemical compound CCCC1=CC=C2C(=O)OC(=O)C2=C1 SSWCTYRQNSCTGB-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- CYSACEXKJHKAIY-UHFFFAOYSA-N C1(=CC=CC=C1)O.NC1=C2C(C(=O)NC2=O)=CC=C1 Chemical compound C1(=CC=CC=C1)O.NC1=C2C(C(=O)NC2=O)=CC=C1 CYSACEXKJHKAIY-UHFFFAOYSA-N 0.000 description 1
- 229920000049 Carbon (fiber) Polymers 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 1
- 229910000564 Raney nickel Inorganic materials 0.000 description 1
- NPXOKRUENSOPAO-UHFFFAOYSA-N Raney nickel Chemical compound [Al].[Ni] NPXOKRUENSOPAO-UHFFFAOYSA-N 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- XPHBKQFEWLUMHN-UHFFFAOYSA-N [Ca].Nc1c(O)cccc1[N+]([O-])=O Chemical compound [Ca].Nc1c(O)cccc1[N+]([O-])=O XPHBKQFEWLUMHN-UHFFFAOYSA-N 0.000 description 1
- FKGHSUILWDCHPT-UHFFFAOYSA-N [Ca].Nc1cc(ccc1O)[N+]([O-])=O Chemical compound [Ca].Nc1cc(ccc1O)[N+]([O-])=O FKGHSUILWDCHPT-UHFFFAOYSA-N 0.000 description 1
- XHVXMLHVXSZEHK-UHFFFAOYSA-N [Ca].Nc1ccc(cc1O)[N+]([O-])=O Chemical compound [Ca].Nc1ccc(cc1O)[N+]([O-])=O XHVXMLHVXSZEHK-UHFFFAOYSA-N 0.000 description 1
- NMLYRQDLWOLOSB-UHFFFAOYSA-N [Ca].Nc1cccc(c1O)[N+]([O-])=O Chemical compound [Ca].Nc1cccc(c1O)[N+]([O-])=O NMLYRQDLWOLOSB-UHFFFAOYSA-N 0.000 description 1
- KMBXUMBPLIVZIY-UHFFFAOYSA-N [Ca].Oc1cccc(c1)[N+]([O-])=O Chemical compound [Ca].Oc1cccc(c1)[N+]([O-])=O KMBXUMBPLIVZIY-UHFFFAOYSA-N 0.000 description 1
- VTBFKLREUGFWNK-UHFFFAOYSA-N [Ca].Oc1ccccc1[N+]([O-])=O Chemical compound [Ca].Oc1ccccc1[N+]([O-])=O VTBFKLREUGFWNK-UHFFFAOYSA-N 0.000 description 1
- NNVHCRFCSWORFS-UHFFFAOYSA-N [K].Nc1c(O)cccc1[N+]([O-])=O Chemical compound [K].Nc1c(O)cccc1[N+]([O-])=O NNVHCRFCSWORFS-UHFFFAOYSA-N 0.000 description 1
- YDENYYIGQJRWQW-UHFFFAOYSA-N [K].Nc1cc(ccc1O)[N+]([O-])=O Chemical compound [K].Nc1cc(ccc1O)[N+]([O-])=O YDENYYIGQJRWQW-UHFFFAOYSA-N 0.000 description 1
- HWJIDPHKBISYAX-UHFFFAOYSA-N [K].Nc1cccc(c1O)[N+]([O-])=O Chemical compound [K].Nc1cccc(c1O)[N+]([O-])=O HWJIDPHKBISYAX-UHFFFAOYSA-N 0.000 description 1
- YGOFGOUWWUHENV-UHFFFAOYSA-N [K].Oc1cccc(c1)[N+]([O-])=O Chemical compound [K].Oc1cccc(c1)[N+]([O-])=O YGOFGOUWWUHENV-UHFFFAOYSA-N 0.000 description 1
- COHZXHRMTYLNRO-UHFFFAOYSA-N [Li].Nc1c(O)cccc1[N+]([O-])=O Chemical compound [Li].Nc1c(O)cccc1[N+]([O-])=O COHZXHRMTYLNRO-UHFFFAOYSA-N 0.000 description 1
- NJZMILPSZUVQGR-UHFFFAOYSA-N [Li].Nc1cc(ccc1O)[N+]([O-])=O Chemical compound [Li].Nc1cc(ccc1O)[N+]([O-])=O NJZMILPSZUVQGR-UHFFFAOYSA-N 0.000 description 1
- JIZVFOAEZBCWQM-UHFFFAOYSA-N [Li].Nc1ccc(cc1O)[N+]([O-])=O Chemical compound [Li].Nc1ccc(cc1O)[N+]([O-])=O JIZVFOAEZBCWQM-UHFFFAOYSA-N 0.000 description 1
- MNIRBPCMFZCWST-UHFFFAOYSA-N [Li].Nc1cccc(c1O)[N+]([O-])=O Chemical compound [Li].Nc1cccc(c1O)[N+]([O-])=O MNIRBPCMFZCWST-UHFFFAOYSA-N 0.000 description 1
- OMAJEBMECZRJLT-UHFFFAOYSA-N [Mg].Nc1cc(ccc1O)[N+]([O-])=O Chemical compound [Mg].Nc1cc(ccc1O)[N+]([O-])=O OMAJEBMECZRJLT-UHFFFAOYSA-N 0.000 description 1
- KUVOMVMDMMMFPM-UHFFFAOYSA-N [Mg].Nc1cccc(c1O)[N+]([O-])=O Chemical compound [Mg].Nc1cccc(c1O)[N+]([O-])=O KUVOMVMDMMMFPM-UHFFFAOYSA-N 0.000 description 1
- GHLVJYYWOWWNTB-UHFFFAOYSA-N [Na].Nc1c(O)cccc1[N+]([O-])=O Chemical compound [Na].Nc1c(O)cccc1[N+]([O-])=O GHLVJYYWOWWNTB-UHFFFAOYSA-N 0.000 description 1
- BVRGUAXWJKEZCQ-UHFFFAOYSA-N [Na].Nc1cccc(c1O)[N+]([O-])=O Chemical compound [Na].Nc1cccc(c1O)[N+]([O-])=O BVRGUAXWJKEZCQ-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000005456 alcohol based solvent Substances 0.000 description 1
- 229910000272 alkali metal oxide Inorganic materials 0.000 description 1
- 229910001860 alkaline earth metal hydroxide Inorganic materials 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 238000010533 azeotropic distillation Methods 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- OKDQLFKEXDEUCQ-UHFFFAOYSA-N calcium;4-nitrophenol Chemical compound [Ca].OC1=CC=C([N+]([O-])=O)C=C1 OKDQLFKEXDEUCQ-UHFFFAOYSA-N 0.000 description 1
- 239000006229 carbon black Substances 0.000 description 1
- 239000004917 carbon fiber Substances 0.000 description 1
- 239000007809 chemical reaction catalyst Substances 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- MGNZXYYWBUKAII-UHFFFAOYSA-N cyclohexa-1,3-diene Chemical group C1CC=CC=C1 MGNZXYYWBUKAII-UHFFFAOYSA-N 0.000 description 1
- FBSAITBEAPNWJG-UHFFFAOYSA-N dimethyl phthalate Natural products CC(=O)OC1=CC=CC=C1OC(C)=O FBSAITBEAPNWJG-UHFFFAOYSA-N 0.000 description 1
- 229960001826 dimethylphthalate Drugs 0.000 description 1
- 239000004210 ether based solvent Substances 0.000 description 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 125000001153 fluoro group Chemical group F* 0.000 description 1
- 229920001002 functional polymer Polymers 0.000 description 1
- 230000009477 glass transition Effects 0.000 description 1
- 229910002804 graphite Inorganic materials 0.000 description 1
- 239000010439 graphite Substances 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 125000003253 isopropoxy group Chemical group [H]C([H])([H])C([H])(O*)C([H])([H])[H] 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000008204 material by function Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 229910000510 noble metal Inorganic materials 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 150000003021 phthalic acid derivatives Chemical class 0.000 description 1
- XKJCHHZQLQNZHY-UHFFFAOYSA-N phthalimide Chemical compound C1=CC=C2C(=O)NC(=O)C2=C1 XKJCHHZQLQNZHY-UHFFFAOYSA-N 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229910052703 rhodium Inorganic materials 0.000 description 1
- 239000010948 rhodium Substances 0.000 description 1
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- AXKBOWBNOCUNJL-UHFFFAOYSA-M sodium;2-nitrophenolate Chemical compound [Na+].[O-]C1=CC=CC=C1[N+]([O-])=O AXKBOWBNOCUNJL-UHFFFAOYSA-M 0.000 description 1
- HXJUTPCZVOIRIF-UHFFFAOYSA-N sulfolane Chemical compound O=S1(=O)CCCC1 HXJUTPCZVOIRIF-UHFFFAOYSA-N 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 150000000000 tetracarboxylic acids Chemical class 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 229920001187 thermosetting polymer Polymers 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/06—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton from hydroxy amines by reactions involving the etherification or esterification of hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
- C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
- C07C217/90—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to a carbon atom of a six-membered aromatic ring, e.g. amino-diphenylethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
- C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
- C08G73/10—Polyimides; Polyester-imides; Polyamide-imides; Polyamide acids or similar polyimide precursors
- C08G73/1046—Polyimides containing oxygen in the form of ether bonds in the main chain
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
- C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
- C08G73/10—Polyimides; Polyester-imides; Polyamide-imides; Polyamide acids or similar polyimide precursors
- C08G73/1075—Partially aromatic polyimides
- C08G73/1078—Partially aromatic polyimides wholly aromatic in the diamino moiety
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/46—NMR spectroscopy
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- Chemical Kinetics & Catalysis (AREA)
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- Polymers & Plastics (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
本発明の化合物は下記式(1)で表される、アミノ基及び/又はニトロ基を有するフタルイミドジフェニルエーテル及びその誘導体である。
上記式(1−a)で表される化合物は、上記式(1−b)、式(1−c)、又は式(1−d)で表される化合物のニトロ基を還元することにより得ることができる。該式(1−b)、式(1−c)、及び式(1−d)で表される化合物は後述する方法により製造される。本発明における上記式(1−a)で表される化合物の製造方法は、還元反応工程の前に、上記式(1−b)、式(1−c)、又は式(1−d)で表される化合物を製造する工程を含んでいてよい。特に好ましくは、上記式(1−a)で表される化合物は、上記式(1−b)で表される化合物のニトロ基を還元して製造されるのがよい。
とを反応させて得ることができる(イミド化反応)。
上記各式においてハロゲン原子とは、塩素原子、フッ素原子、臭素原子、及びヨウ素原子等が挙げられる。
下記実施例においてHPLC測定にはSHIMADZU製SPD−10Aを使用し、融点測定にはYAMATO製MP−21を使用した。
2−アミノ−4,4’−ジニトロジフェニルエーテルの合成
撹拌機、温度計を備えた1Lの四つ口フラスコに2−アミノ−4−ニトロフェノールソーダ88.0g、4−フルオロニトロベンゼン53.6g、炭酸カリウム11.0g、及びN,N−ジメチルアセトアミド400gを仕込み、60℃で20時間、80℃で8時間反応した後、イオン交換水400gを滴下した。析出した固体を濾過し、洗浄及び乾燥して、2−アミノ−4,4’−ジニトロジフェニルエーテル85.7gを得た。HPLCで測定した純度は99.7%であり、mp.は170〜171℃であった。
4,4’−ジニトロ−2−フタルイミドジフェニルエーテルの合成
温度計、冷却管、ディーンスターク、撹拌機を取り付けた2L四つ口フラスコに2−アミノ−4,4’−ジニトロジフェニルエーテル50.0g、無水フタル酸28.7g、N−メチルピロリドン500g、キシレン400g、98%硫酸12.0gを仕込み、155℃でキシレンとの共沸水を系外に除去しながら、5時間反応を行った。その後、減圧下でキシレンを留去し、残液を75%イソプロパノール水1,500gにブローし、析出した固体を濾別した。水で洗浄後、濾過し、乾燥して、4,4’−ジニトロ−2−フタルイミドジフェニルエーテルの粗生成物68.4gを得た。HPLCで測定した純度は98.6%であり、mp.は130〜135℃であった。粗生成物68.0gをN−メチルピロリドン200g、活性炭6.8gに溶解させた後、活性炭を除去し、濾液を75%イソプロパノール水600gにブローし、析出した固体を濾別した。水で洗浄後、濾過し、乾燥して、精製された4,4’−ジニトロ−2−フタルイミドジフェニルエーテル61.2gを得た。HPLCで測定した純度は99.6%であり、mp.は132〜134℃であった。
4,4’−ジアミノ−2−フタルイミドジフェニルエーテルの合成
300mLオートクレーブに、実施例1で得た4,4’−ジニトロ−2−フタルイミドジフェニルエーテル10.0gとN,N−ジメチルホルムアミド100g、5%Pd/C 0.5gを仕込み、0.6MPaで75〜80℃を保ちながら接触水素化還元を行った。反応終了後、触媒を除去した後に濃縮後、加水し、固体7.7gを得た。HPLCで測定した純度は99.5%であり、mp.は244〜246℃であった。
・1H核磁気共鳴スペクトル分析には、Bruker Biospin製AVANCE400型を用い、共鳴周波数400MHzで測定した。測定溶媒はジメチルスルホキシド−d6であった。
・13C核磁気共鳴スペクトル分析には、JEOL製JNM−ECA600型を用い、共鳴周波数600MHzで測定した。測定溶媒はジメチルスルホキシド−d6であった。
・質量分析には、SHIMADZU製AXIMA Confidenceを使用した。
以下に示す結果より、得られた固体生成物は4,4’−ジアミノ−2−フタルイミドジフェニルエーテルであった。
δ4.8 ppm(2H)および5.1 ppm(2H)にアミノ基のプロトンのシングレット、δ6.4 ppm(2H)および6.6 ppm(2H)にベンゼン核のプロトンのダブレット、δ6.5 ppm(1H)、6.6 ppm(1H)および6.7 ppm(1H)にフタルイミド基のついたベンゼン核のダブレット、カルテット、ダブレット、δ7.9 ppm(2H)、8.0 ppm(2H)にフタルイミド基のベンゼン核のマルチプレットが確認された。
(ii)13C核磁気共鳴スペクトル分析の結果、14本のピークが確認された。13C−NMRスペクトルのチャートを図2に示す。
(iii)質量分析の結果、345にメインピークが確認された。
2−アミノ−3,4’−ジニトロジフェニルエーテルの合成
撹拌機、温度計を備えた200mLの四つ口フラスコに2−フルオロ−5−ニトロアニリン10.0g、3−ニトロフェノール9.8g、炭酸カリウム4.9g、及びN,N−ジメチルアセトアミド100gを仕込み、130℃で5時間反応した後、イオン交換水70gを滴下した。析出した固体を濾過し、洗浄及び乾燥して、2−アミノ−3,4’−ジニトロジフェニルエーテル14.6gを得た。HPLCで測定した純度は99.6%であり、mp.は175〜176℃であった。
3,4’−ジニトロ−2−フタルイミドジフェニルエーテルの合成
温度計、冷却管、ディーンスターク、撹拌機を取り付けた200mL四つ口フラスコに2−アミノ−3,4’−ジニトロジフェニルエーテル5.0g、無水フタル酸2.9g、N−メチルピロリドン50g、キシレン40g、98%硫酸1.2gを仕込み、155℃でキシレンとの共沸水を系外に除去しながら、2時間反応を行った。その後、減圧下でキシレンを留去し、残液を75%イソプロパノール水150gにブローし、析出した固体を濾別した。水で洗浄後、濾過し、乾燥して、3,4’−ジニトロ−2−フタルイミドジフェニルエーテルの粗生成物6.9gを得た。粗生成物6.5gをN−メチルピロリドン40g、活性炭0.7gに溶解させた後、活性炭を除去し、濾液を75%イソプロパノール水150gにブローし、析出した固体を濾別した。水で洗浄後、濾過し、乾燥して、精製された3,4’−ジニトロ−2−フタルイミドジフェニルエーテル6.1gを得た。HPLCで測定した純度は99.5%であり、mp.は163〜164℃であった。
3,4’−ジアミノ−2−フタルイミドジフェニルエーテルの合成
上記実施例3を更に1回繰り返した。
300mLオートクレーブに、上記で得た3,4’−ジニトロ−2−フタルイミドジフェニルエーテル10.0gとN,N−ジメチルホルムアミド100g、5%Pd/C 0.5gを仕込み、0.6MPaで75〜80℃を保ちながら接触水素化還元を行った。反応終了後、触媒を除去した後に濃縮後、加水し、固体6.9gを得た。HPLCで測定した純度は98.2%であり、mp.は200〜203℃であった。
・1H核磁気共鳴スペクトル分析および13C核磁気共鳴スペクトル分析には、Bruker Biospin製AVANCE400型を用い、共鳴周波数400MHzで測定した。測定溶媒はジメチルスルホキシド−d6であった。
・質量分析には、SHIMADZU製LCMS−2020を使用した。
以下に示す結果より、得られた固体生成物は3,4’−ジアミノ−2−フタルイミドジフェニルエーテルであった。
δ5.1 ppm(2H)および5.2 ppm(2H)にアミノ基のプロトンのシングレット、δ5.9 ppm(1H)、6.0 ppm(1H)、6.1 ppm(1H)および6.7 ppm(1H)にベンゼン核のプロトンのカルテット、トリプレット、カルテット、トリプレット、δ6.6 ppm(1H)、δ6.7 ppm(1H)、δ6.8 ppm(1H) フタルイミド基のついたベンゼン核のダブレット、カルテット、ダブレット、δ7.8 ppm〜8.0 ppm(4H)にフタルイミド基のベンゼン核のマルチプレットが確認された。
(ii)13C核磁気共鳴スペクトル分析の結果、16本のピークが確認された。13C−NMRスペクトルのチャートを図4に示す。
(iii)質量分析としてLCMS測定の結果、ポジ型で346にメインピークが確認された。
Claims (6)
- A及びBが共にアミノ基である、請求項1記載の化合物。
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