JP6431370B2 - 組換えＤｓｂＣを発現する細菌宿主系統 - Google Patents

組換えＤｓｂＣを発現する細菌宿主系統 Download PDF

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Publication number
JP6431370B2
JP6431370B2 JP2014519454A JP2014519454A JP6431370B2 JP 6431370 B2 JP6431370 B2 JP 6431370B2 JP 2014519454 A JP2014519454 A JP 2014519454A JP 2014519454 A JP2014519454 A JP 2014519454A JP 6431370 B2 JP6431370 B2 JP 6431370B2
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antibody
seq
protein
cell
gene
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JP2014521313A5 (enExample
JP2014521313A (ja
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エリス、マーク
ポール ハンフリーズ、デイビッド
ポール ハンフリーズ、デイビッド
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ユセベ ファルマ ソシエテ アノニム
ユセベ ファルマ ソシエテ アノニム
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
JP2014519454A 2011-07-13 2012-07-13 組換えＤｓｂＣを発現する細菌宿主系統 Active JP6431370B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11173880 2011-07-13
EP11173880.3 2011-07-13
PCT/EP2012/002945 WO2013007388A1 (en) 2011-07-13 2012-07-13 Bacterial host strain expressing recombinant dsbc

Related Child Applications (1)

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JP2017209932A Division JP2018019719A (ja) 2011-07-13 2017-10-31 組換えＤｓｂＣを発現する細菌宿主系統

Publications (3)

Publication Number Publication Date
JP2014521313A JP2014521313A (ja) 2014-08-28
JP2014521313A5 JP2014521313A5 (enExample) 2017-03-09
JP6431370B2 true JP6431370B2 (ja) 2018-11-28

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JP2014519454A Active JP6431370B2 (ja) 2011-07-13 2012-07-13 組換えＤｓｂＣを発現する細菌宿主系統
JP2017209932A Pending JP2018019719A (ja) 2011-07-13 2017-10-31 組換えＤｓｂＣを発現する細菌宿主系統
JP2019200029A Active JP7062626B2 (ja) 2011-07-13 2019-11-01 組換えＤｓｂＣを発現する細菌宿主系統

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JP2017209932A Pending JP2018019719A (ja) 2011-07-13 2017-10-31 組換えＤｓｂＣを発現する細菌宿主系統
JP2019200029A Active JP7062626B2 (ja) 2011-07-13 2019-11-01 組換えＤｓｂＣを発現する細菌宿主系統

Country Status (27)

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US (2) US9725516B2 (enExample)
EP (2) EP2731973B1 (enExample)
JP (3) JP6431370B2 (enExample)
KR (1) KR102023786B1 (enExample)
CN (1) CN103649124B (enExample)
AU (1) AU2012283388B2 (enExample)
BR (1) BR112013032871B1 (enExample)
CA (1) CA2841824C (enExample)
CY (1) CY1119985T1 (enExample)
DK (1) DK2731973T3 (enExample)
EA (1) EA031449B1 (enExample)
ES (1) ES2659155T3 (enExample)
HR (1) HRP20180226T1 (enExample)
HU (1) HUE035674T2 (enExample)
IL (1) IL229947B (enExample)
IN (1) IN2014DN00202A (enExample)
LT (1) LT2731973T (enExample)
ME (1) ME02957B (enExample)
MX (1) MX348738B (enExample)
NO (1) NO2731973T3 (enExample)
PL (1) PL2731973T3 (enExample)
PT (1) PT2731973T (enExample)
RS (1) RS56926B1 (enExample)
SG (1) SG10201807560XA (enExample)
SI (1) SI2731973T1 (enExample)
SM (1) SMT201800068T1 (enExample)
WO (1) WO2013007388A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020028299A (ja) * 2011-07-13 2020-02-27 ユセベ ファルマ ソシエテ アノニム 組換えＤｓｂＣを発現する細菌宿主系統

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2125894T3 (pl) * 2007-03-22 2019-08-30 Biogen Ma Inc. Białka wiążące, w tym przeciwciała, pochodne przeciwciał i fragmenty przeciwciał, które swoiście wiążą się z CD154 i ich zastosowania
ES2692811T3 (es) 2009-09-24 2018-12-05 Ucb Biopharma Sprl Cepa bacteriana para expresión de proteína recombinante que tiene los genes DEGP deficiente de proteasa que retiene actividad chaperona y TSP y PTR desactivados génicamente
GB201000590D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial host strain
GB201000591D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial hoist strain
GB201000587D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial hoist strain
GB201012599D0 (en) 2010-07-27 2010-09-08 Ucb Pharma Sa Process for purifying proteins
GB201208367D0 (en) * 2012-05-14 2012-06-27 Ucb Pharma Sa Biological product
GB201223276D0 (en) * 2012-12-21 2013-02-06 Ucb Pharma Sa Antibodies and methods of producing same
JP6807327B2 (ja) 2014-12-22 2021-01-06 ユーシービー バイオファルマ エスアールエル タンパク質製造
KR101810778B1 (ko) * 2015-06-23 2017-12-20 서울대학교산학협력단 Cd154 결합 폴리펩타이드 및 그 용도
RU2018128784A (ru) 2016-01-27 2020-02-27 МЕДИММЬЮН, ЭлЭлСи Способы получения антител с заданным профилем гликозилирования
WO2019193418A1 (en) 2018-04-05 2019-10-10 Bio-Rad Abd Serotec Gmbh Display systems for proteins of interest
AU2019375413A1 (en) * 2018-11-05 2021-05-27 Genentech, Inc. Methods of producing two chain proteins in prokaryotic host cells
CN109371049A (zh) * 2018-11-14 2019-02-22 天津大学 分子伴侣在促进单克隆抗体的形成和/或提高单克隆抗体的表达量中的应用
EP3942079A1 (en) 2019-03-18 2022-01-26 Bio-Rad ABD Serotec GmbH Protection of spytag-containing periplasmic fusion proteins from protease tsp and ompt degradation
ES3026707T3 (en) * 2019-08-05 2025-06-12 Wacker Chemie Ag Bacterial strain for releasing a recombinant protein in a fermentation method

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
GB8907617D0 (en) 1989-04-05 1989-05-17 Celltech Ltd Drug delivery system
US5508192A (en) 1990-11-09 1996-04-16 Board Of Regents, The University Of Texas System Bacterial host strains for producing proteolytically sensitive polypeptides
US5264365A (en) 1990-11-09 1993-11-23 Board Of Regents, The University Of Texas System Protease-deficient bacterial strains for production of proteolytically sensitive polypeptides
GB9112536D0 (en) 1991-06-11 1991-07-31 Celltech Ltd Chemical compounds
US5474771A (en) 1991-11-15 1995-12-12 The Trustees Of Columbia University In The City Of New York Murine monoclonal antibody (5c8) recognizes a human glycoprotein on the surface of T-lymphocytes, compositions containing same
JPH08500963A (ja) 1992-04-28 1996-02-06 ザ・リージェンツ・オブ・ザ・ユニヴァーシティー・オブ・ミシガン ヒューマンｃｒａｂｐ−▲ｉ▼及びｃｒａｂｐ−▲ｉｉ▼
GB9215540D0 (en) 1992-07-22 1992-09-02 Celltech Ltd Protein expression system
US5304472A (en) 1992-11-20 1994-04-19 Genentech, Inc. Method of controlling polypeptide production in bacterial cells
US5639635A (en) 1994-11-03 1997-06-17 Genentech, Inc. Process for bacterial production of polypeptides
WO1997038123A1 (en) 1996-04-05 1997-10-16 Board Of Regents, The University Of Texas System Methods for producing soluble, biologically-active disulfide bond-containing eukaryotic proteins in bacterial cells
GB9625640D0 (en) 1996-12-10 1997-01-29 Celltech Therapeutics Ltd Biological products
US6083715A (en) 1997-06-09 2000-07-04 Board Of Regents, The University Of Texas System Methods for producing heterologous disulfide bond-containing polypeptides in bacterial cells
JP2000083670A (ja) 1998-09-09 2000-03-28 Hsp Kenkyusho:Kk ＤｓｂＡ／ＤｓｂＢ／ＤｓｂＣ／ＤｓｂＤ発現プラスミド
ATE343790T1 (de) 1999-06-29 2006-11-15 Siga Technologies Inc Test für degp-protease inhibitoren
GB0006398D0 (en) 2000-03-16 2000-05-03 Novartis Ag Organic compounds
GB0013810D0 (en) 2000-06-06 2000-07-26 Celltech Chiroscience Ltd Biological products
EP1314037A2 (en) 2000-09-01 2003-05-28 Biogen, Inc. Methods of designing and producing compounds having improved binding affinity for cd154 or other trimeric proteins
AU8867501A (en) 2000-09-01 2002-03-13 Biogen Inc Co-crystal structure of monoclonal antibody 5c8 and cd154, and use thereof in drug design
US7041479B2 (en) 2000-09-06 2006-05-09 The Board Of Trustess Of The Leland Stanford Junior University Enhanced in vitro synthesis of active proteins containing disulfide bonds
CZ304484B6 (cs) 2000-12-14 2014-05-21 Genentech, Inc. Bakteriální hostitelské kmeny a způsob tvorby polypeptidu
JP4309656B2 (ja) * 2000-12-14 2009-08-05 ジェネンテック・インコーポレーテッド 原核生物で生成させた抗体とその用途
WO2004003019A2 (en) 2002-06-28 2004-01-08 Domantis Limited Immunoglobin single variant antigen-binding domains and dual-specific constructs
TWI327597B (en) 2001-08-01 2010-07-21 Centocor Inc Anti-tnf antibodies, compositions, methods and uses
CA2454731C (en) 2001-08-27 2010-11-02 Genentech, Inc. A system for antibody expression and assembly
GB0124317D0 (en) 2001-10-10 2001-11-28 Celltech R&D Ltd Biological products
EP2022799A2 (en) 2001-11-16 2009-02-11 Biogen Idec Inc. Polycistronic expression of antibodies
GB0129105D0 (en) * 2001-12-05 2002-01-23 Celltech R&D Ltd Expression control using variable intergenic sequences
US7608429B2 (en) 2002-10-31 2009-10-27 Genentech, Inc. Methods and compositions for increasing antibody production
WO2004051268A1 (en) 2002-12-03 2004-06-17 Celltech R & D Limited Assay for identifying antibody producing cells
GB0303337D0 (en) 2003-02-13 2003-03-19 Celltech R&D Ltd Biological products
KR20120090094A (ko) 2003-06-13 2012-08-16 바이오겐 아이덱 엠에이 인코포레이티드 아글리코실 항-ｃｄ154(ｃｄ40 리간드) 항체 및 이의 용도
ES2315664T3 (es) 2003-06-30 2009-04-01 Domantis Limited Anticuerpos de dominio unico (dab) pegilados.
GB0315457D0 (en) 2003-07-01 2003-08-06 Celltech R&D Ltd Biological products
GB0315450D0 (en) 2003-07-01 2003-08-06 Celltech R&D Ltd Biological products
AU2004261198A1 (en) 2003-07-26 2005-02-10 Biogen Idec Ma Inc. Altered antibodies having improved antigen-binding affinity
EA014226B1 (ru) 2004-07-26 2010-10-29 Байоджен Айдек Ма Инк. Антитела к cd154, их фрагменты и способы применения антител и фрагментов
JP2008511337A (ja) * 2004-09-02 2008-04-17 ジェネンテック・インコーポレーテッド ヘテロ多量体分子
US7563443B2 (en) 2004-09-17 2009-07-21 Domantis Limited Monovalent anti-CD40L antibody polypeptides and compositions thereof
GB0425534D0 (en) 2004-11-19 2004-12-22 Celltech R&D Ltd Process for obtaining antibodies
GB0520169D0 (en) 2005-10-04 2005-11-09 Celltech R&D Ltd Biological products
PL2125894T3 (pl) 2007-03-22 2019-08-30 Biogen Ma Inc. Białka wiążące, w tym przeciwciała, pochodne przeciwciał i fragmenty przeciwciał, które swoiście wiążą się z CD154 i ich zastosowania
ES2667729T3 (es) 2007-09-26 2018-05-14 Ucb Biopharma Sprl Fusiones de anticuerpos con doble especificidad
US7662587B1 (en) 2009-03-05 2010-02-16 E. I. Du Pont De Nemours And Company Gene knockout mutations that increase peptide production
ES2692811T3 (es) 2009-09-24 2018-12-05 Ucb Biopharma Sprl Cepa bacteriana para expresión de proteína recombinante que tiene los genes DEGP deficiente de proteasa que retiene actividad chaperona y TSP y PTR desactivados génicamente
US8470552B2 (en) 2009-10-12 2013-06-25 Keck Graduate Institute Strategy to reduce lactic acid production and control PH in animal cell culture
KR101968766B1 (ko) * 2009-11-05 2019-04-12 제넨테크, 인크. 이종 폴리펩티드의 분비를 위한 방법 및 조성물
GB201000588D0 (en) * 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial host strain
GB201000591D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial hoist strain
GB201000587D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial hoist strain
GB201000590D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial host strain
GB201001791D0 (en) 2010-02-03 2010-03-24 Ucb Pharma Sa Process for obtaining antibodies
GB201012599D0 (en) 2010-07-27 2010-09-08 Ucb Pharma Sa Process for purifying proteins
MX348738B (es) 2011-07-13 2017-06-27 Ucb Pharma Sa Cepa huesped bacteriana que expresa dsbc recombinante.
EP2546267A1 (en) 2011-07-13 2013-01-16 UCB Pharma S.A. Bacterial host strain expressing recombinant DsbC
GB201208367D0 (en) 2012-05-14 2012-06-27 Ucb Pharma Sa Biological product

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020028299A (ja) * 2011-07-13 2020-02-27 ユセベ ファルマ ソシエテ アノニム 組換えＤｓｂＣを発現する細菌宿主系統
JP7062626B2 (ja) 2011-07-13 2022-05-17 ユセベ ファルマ ソシエテ アノニム 組換えＤｓｂＣを発現する細菌宿主系統

Also Published As

Publication number Publication date
SG10201807560XA (en) 2018-10-30
IL229947B (en) 2019-10-31
WO2013007388A1 (en) 2013-01-17
CN103649124B (zh) 2016-04-13
EA201490274A1 (ru) 2014-05-30
DK2731973T3 (da) 2018-01-29
EP3339325A1 (en) 2018-06-27
AU2012283388B2 (en) 2017-04-20
RS56926B1 (sr) 2018-05-31
US20170335003A1 (en) 2017-11-23
US9725516B2 (en) 2017-08-08
CY1119985T1 (el) 2018-12-12
AU2012283388A1 (en) 2014-01-09
PL2731973T3 (pl) 2018-04-30
BR112013032871A2 (pt) 2017-01-24
CA2841824A1 (en) 2013-01-17
KR20140039240A (ko) 2014-04-01
US9957328B2 (en) 2018-05-01
CA2841824C (en) 2021-07-13
HRP20180226T1 (hr) 2018-03-09
MX348738B (es) 2017-06-27
ME02957B (me) 2018-07-20
HK1194393A1 (zh) 2014-10-17
IN2014DN00202A (enExample) 2015-06-05
JP7062626B2 (ja) 2022-05-17
EA031449B1 (ru) 2019-01-31
MX2014000302A (es) 2014-02-17
JP2014521313A (ja) 2014-08-28
KR102023786B1 (ko) 2019-09-20
JP2020028299A (ja) 2020-02-27
SI2731973T1 (en) 2018-04-30
HUE035674T2 (en) 2018-05-28
US20140141468A1 (en) 2014-05-22
PT2731973T (pt) 2018-02-22
NO2731973T3 (enExample) 2018-04-14
BR112013032871B1 (pt) 2022-09-27
LT2731973T (lt) 2018-02-26
ES2659155T3 (es) 2018-03-14
EP2731973A1 (en) 2014-05-21
JP2018019719A (ja) 2018-02-08
EP2731973B1 (en) 2017-11-15
SMT201800068T1 (it) 2018-03-08
CN103649124A (zh) 2014-03-19
BR112013032871A8 (pt) 2022-08-23

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