EA201490274A1 - БАКТЕРИАЛЬНЫЙ ШТАММ-АКЦЕПТОР, ЭКСПРЕССИРУЮЩИЙ РЕКОМБИНАНТНЫЙ DsbC - Google Patents

БАКТЕРИАЛЬНЫЙ ШТАММ-АКЦЕПТОР, ЭКСПРЕССИРУЮЩИЙ РЕКОМБИНАНТНЫЙ DsbC

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Publication number
EA201490274A1
EA201490274A1 EA201490274A EA201490274A EA201490274A1 EA 201490274 A1 EA201490274 A1 EA 201490274A1 EA 201490274 A EA201490274 A EA 201490274A EA 201490274 A EA201490274 A EA 201490274A EA 201490274 A1 EA201490274 A1 EA 201490274A1
Authority
EA
Eurasian Patent Office
Prior art keywords
acceptor
bacterial strain
expressing recombinant
recombinant dsbc
dsbc
Prior art date
Application number
EA201490274A
Other languages
English (en)
Other versions
EA031449B1 (ru
Inventor
Марк Эллис
Дэвид Пол Хамфриз
Original Assignee
Юсб Фарма, С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Юсб Фарма, С.А. filed Critical Юсб Фарма, С.А.
Publication of EA201490274A1 publication Critical patent/EA201490274A1/ru
Publication of EA031449B1 publication Critical patent/EA031449B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

Изобретение относится к рекомбинантной грамотрицательной бактериальной клетке, содержащей экспрессирующий вектор, содержащий рекомбинантный полинуклеотид, кодирующий DsbC, и один или несколько полинуклеотидов, кодирующих антитело или его антигенсвязывающий фрагмент, специфически связывающийся с CD154.
EA201490274A 2011-07-13 2012-07-13 Бактериальный штамм-акцептор, экспрессирующий рекомбинантный dsbc EA031449B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11173880 2011-07-13
PCT/EP2012/002945 WO2013007388A1 (en) 2011-07-13 2012-07-13 Bacterial host strain expressing recombinant dsbc

Publications (2)

Publication Number Publication Date
EA201490274A1 true EA201490274A1 (ru) 2014-05-30
EA031449B1 EA031449B1 (ru) 2019-01-31

Family

ID=46545736

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201490274A EA031449B1 (ru) 2011-07-13 2012-07-13 Бактериальный штамм-акцептор, экспрессирующий рекомбинантный dsbc

Country Status (27)

Country Link
US (2) US9725516B2 (ru)
EP (2) EP2731973B1 (ru)
JP (3) JP6431370B2 (ru)
KR (1) KR102023786B1 (ru)
CN (1) CN103649124B (ru)
AU (1) AU2012283388B2 (ru)
BR (1) BR112013032871B1 (ru)
CA (1) CA2841824C (ru)
CY (1) CY1119985T1 (ru)
DK (1) DK2731973T3 (ru)
EA (1) EA031449B1 (ru)
ES (1) ES2659155T3 (ru)
HK (1) HK1194393A1 (ru)
HR (1) HRP20180226T1 (ru)
HU (1) HUE035674T2 (ru)
IL (1) IL229947B (ru)
IN (1) IN2014DN00202A (ru)
LT (1) LT2731973T (ru)
ME (1) ME02957B (ru)
MX (1) MX348738B (ru)
NO (1) NO2731973T3 (ru)
PL (1) PL2731973T3 (ru)
PT (1) PT2731973T (ru)
RS (1) RS56926B1 (ru)
SG (1) SG10201807560XA (ru)
SI (1) SI2731973T1 (ru)
WO (1) WO2013007388A1 (ru)

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KR101810778B1 (ko) * 2015-06-23 2017-12-20 서울대학교산학협력단 Cd154 결합 폴리펩타이드 및 그 용도
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KR20210090645A (ko) * 2018-11-05 2021-07-20 제넨테크, 인크. 원핵 숙주 세포에서 2개의 사슬 단백질을 생산하는 방법
CN109371049A (zh) * 2018-11-14 2019-02-22 天津大学 分子伴侣在促进单克隆抗体的形成和/或提高单克隆抗体的表达量中的应用
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EP4010500A1 (de) * 2019-08-05 2022-06-15 Wacker Chemie AG Bakterienstamm zur freisetzung eines rekombinanten proteins in einem fermentationsverfahren

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Also Published As

Publication number Publication date
EP2731973A1 (en) 2014-05-21
ME02957B (me) 2018-07-20
AU2012283388B2 (en) 2017-04-20
DK2731973T3 (da) 2018-01-29
KR102023786B1 (ko) 2019-09-20
LT2731973T (lt) 2018-02-26
PL2731973T3 (pl) 2018-04-30
HUE035674T2 (en) 2018-05-28
US9725516B2 (en) 2017-08-08
EP3339325A1 (en) 2018-06-27
US20170335003A1 (en) 2017-11-23
CA2841824C (en) 2021-07-13
PT2731973T (pt) 2018-02-22
JP6431370B2 (ja) 2018-11-28
EA031449B1 (ru) 2019-01-31
ES2659155T3 (es) 2018-03-14
SG10201807560XA (en) 2018-10-30
BR112013032871A8 (pt) 2022-08-23
MX2014000302A (es) 2014-02-17
NO2731973T3 (ru) 2018-04-14
JP2018019719A (ja) 2018-02-08
KR20140039240A (ko) 2014-04-01
WO2013007388A1 (en) 2013-01-17
JP7062626B2 (ja) 2022-05-17
CN103649124B (zh) 2016-04-13
HRP20180226T1 (hr) 2018-03-09
HK1194393A1 (zh) 2014-10-17
IL229947B (en) 2019-10-31
MX348738B (es) 2017-06-27
IN2014DN00202A (ru) 2015-06-05
RS56926B1 (sr) 2018-05-31
CA2841824A1 (en) 2013-01-17
JP2020028299A (ja) 2020-02-27
JP2014521313A (ja) 2014-08-28
CY1119985T1 (el) 2018-12-12
SI2731973T1 (en) 2018-04-30
AU2012283388A1 (en) 2014-01-09
US9957328B2 (en) 2018-05-01
US20140141468A1 (en) 2014-05-22
CN103649124A (zh) 2014-03-19
BR112013032871A2 (pt) 2017-01-24
BR112013032871B1 (pt) 2022-09-27
EP2731973B1 (en) 2017-11-15

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