JP6375100B2 - 抗老化剤、美白剤、皮膚化粧料および飲食品 - Google Patents
抗老化剤、美白剤、皮膚化粧料および飲食品 Download PDFInfo
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- JP6375100B2 JP6375100B2 JP2013123080A JP2013123080A JP6375100B2 JP 6375100 B2 JP6375100 B2 JP 6375100B2 JP 2013123080 A JP2013123080 A JP 2013123080A JP 2013123080 A JP2013123080 A JP 2013123080A JP 6375100 B2 JP6375100 B2 JP 6375100B2
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Landscapes
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Description
本実施形態の抗老化剤および美白剤は、米麹の加温加圧処理物を有効成分として含有するものである。また、本実施形態の皮膚化粧料および飲食品は、米麹の加温加圧処理物が配合されるものである。
以上のようにして得られる米麹の加温加圧処理物は、優れた抗老化作用および美白作用を有しているため、抗老化剤または美白剤の有効成分として用いることができる。本実施形態の抗老化剤または美白剤は、医薬品、医薬部外品、化粧品等の幅広い用途に使用することができる。
米麹の加温加圧処理物は、優れた抗老化作用および美白作用を有しているため、皮膚化粧料に配合するのに好適である。この場合に、米麹の加温加圧処理物をそのまま配合してもよいし、米麹の加温加圧処理物から製剤化した抗老化剤または美白剤を配合してもよい。米麹の加温加圧処理物、抗老化剤または美白剤を皮膚化粧料に配合することによって、皮膚化粧料に抗老化作用または美白作用を付与することができる。
米麹の加温加圧処理物は、優れた抗老化作用および美白作用を有しているため、飲食品に配合するのに好適である。この場合、米麹の加温加圧処理物をそのまま配合してもよいし、米麹の加温加圧処理物から製剤化した抗老化剤または美白剤を配合してもよい。
米麹100gに水500mLを加え、さらにα−アミラーゼ(エイチビィアイ社製,液化酵素T)1.0gを添加して攪拌した。これを圧力酵素分解機(ヤンマー社製)を用いて50℃、60MPaにて24時間反応させた。その後、90℃で30分処理することにより酵素を失活させ、得られた反応液を濾過し、得られた濾液を減圧濃縮することにより、米麹加温加圧処理物(76g,試料1)を得た。
製造例1で得られた米麹加温加圧処理物(試料1)について、以下のようにしてプロフィラグリン/フィラグリン産生促進作用を試験した。
式中、Aは「被験試料添加サンプルのNet intensity(プロフィラグリンおよびフィラグリンの合計値)」を表し、Bは「試料無添加サンプル(コントロール)のNet intensity」を表す。
結果を表1に示す。
製造例1で得られた米麹加温加圧処理物(試料1)について、以下のようにして皮膚線維芽細胞増殖促進作用を試験した。
式中、Stは「被験試料を添加した細胞でのブルーホルマザン生成量」を表し、Ctは「試料無添加の細胞でのブルーホルマザン生成量」を表す。
結果を表2に示す。
製造例1で得られた米麹加温加圧処理物(試料1)について、以下のようにして表皮角化細胞増殖促進作用を試験した。
式中、Stは「被験試料を添加した細胞でのブルーホルマザン生成量」を表し、Ctは「試料無添加の細胞でのブルーホルマザン生成量」を表す。
上記試験の結果を表3に示す。
製造例1で得られた米麹加温加圧処理物(試料1)について、以下のようにしてB16メラノーマ細胞に対するメラニン産生抑制作用を試験した。
式中、Aは「試料無添加のサンプルにおけるメラニン量」を表し、Bは「被験試料を添加したサンプルにおけるメラニン量」を表し、Cは「試料無添加のサンプルにおける540nmにおける吸光度」を表し、Dは「被験試料添加のサンプルにおける540nmにおける吸光度」を表す。
結果を表4に示す。
製造例1で得られた米麹加温加圧処理物(試料1)について、以下のようにメラニン取込抑制作用を試験した。
式中、Aは「被験試料を添加した細胞における蛍光量」を表し、Bは「試料無添加の細胞における蛍光量」を表す。
結果を表5に示す。
下記組成に従い、乳液を常法により製造した。
米麹加温加圧処理物(製造例1) 0.01g
ホホバオイル 4.00g
1,3−ブチレングリコール 3.00g
アルブチン 3.00g
ポリオキシエチレンセチルエーテル(20E.O.) 2.50g
オリーブオイル 2.00g
スクワラン 2.00g
セタノール 2.00g
モノステアリン酸グリセリル 2.00g
オレイン酸ポリオキシエチレンソルビタン(20E.O.) 2.00g
パラオキシ安息香酸メチル 0.15g
グリチルリチン酸ステアリル 0.10g
黄杞エキス 0.10g
グリチルリチン酸ジカリウム 0.10g
イチョウ葉エキス 0.10g
コンキオリン 0.10g
オウバクエキス 0.10g
カミツレエキス 0.10g
香料 0.05g
精製水 残部(全量を100gとする)
下記組成のクリームを常法により製造した。
米麹加温加圧処理物(製造例1) 0.05g
クジンエキス 0.1g
オウゴンエキス 0.1g
流動パラフィン 5.0g
サラシミツロウ 4.0g
スクワラン 10.0g
セタノール 3.0g
ラノリン 2.0g
ステアリン酸 1.0g
オレイン酸ポリオキシエチレンソルビタン(20E.O.) 1.5g
モノステアリン酸グリセリル 3.0g
油溶性甘草エキス 0.1g
1,3−ブチレングリコール 6.0g
パラオキシ安息香酸メチル 1.5g
香料 0.1g
精製水 残部(全量を100gとする)
下記組成の美容液を常法により製造した。
米麹加温加圧処理物(製造例1) 0.01g
カミツレエキス 0.1g
ニンジンエキス 0.1g
キサンタンガム 0.3g
ヒドロキシエチルセルロース 0.1g
カルボキシビニルポリマー 0.1g
1,3−ブチレングリコール 4.0g
グリチルリチン酸ジカリウム 0.1g
グリセリン 2.0g
水酸化カリウム 0.25g
香料 0.01g
防腐剤(パラオキシ安息香酸メチル) 0.15g
エタノール 2.0g
精製水 残部(全量を100gとする)
常法により、以下の組成を有する錠剤を製造した。
米麹加温加圧処理物(製造例1) 5.0mg
ドロマイト(カルシウム20%、マグネシウム10%含有) 83.4mg
カゼインホスホペプチド 16.7mg
ビタミンC 33.4mg
マルチトール 136.8mg
コラーゲン 12.7mg
ショ糖脂肪酸エステル 12.0mg
常法により、以下の組成を有する経口液状製剤を製造した。
<1アンプル(1本100mL)中の組成>
米麹加温加圧処理物(製造例1) 0.3質量%
ソルビット 12.0質量%
安息香酸ナトリウム 0.1質量%
香料 1.0質量%
硫酸カルシウム 0.5質量%
精製水 残部(100質量%)
Claims (6)
- 米麹を温度40〜80℃、圧力40〜200MPaで1〜48時間処理した加温加圧処理物を有効成分とすることを特徴とする抗老化剤。
- 前記加温加圧処理物が、フィラグリン産生促進作用、プロフィラグリン産生促進作用、線維芽細胞増殖促進作用および表皮角化細胞増殖促進作用からなる群より選択される1種または2種以上の作用を有することを特徴とする請求項1に記載の抗老化剤。
- 米麹を温度40〜80℃、圧力40〜200MPaで1〜48時間処理した加温加圧処理物を有効成分とすることを特徴とする美白剤。
- 前記加温加圧処理物が、メラニン産生抑制作用および/またはメラニン取込抑制作用を有することを特徴とする請求項3に記載の美白剤。
- 米麹を温度40〜80℃、圧力40〜200MPaで1〜48時間処理した加温加圧処理物を配合したことを特徴とする皮膚化粧料。
- 米麹を温度40〜80℃、圧力40〜200MPaで1〜48時間処理した加温加圧処理物を配合したことを特徴とする、抗老化用途および/または美白用途に用いられる飲食品。
Priority Applications (1)
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