JP6670166B2 - 化粧料 - Google Patents
化粧料 Download PDFInfo
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- JP6670166B2 JP6670166B2 JP2016094711A JP2016094711A JP6670166B2 JP 6670166 B2 JP6670166 B2 JP 6670166B2 JP 2016094711 A JP2016094711 A JP 2016094711A JP 2016094711 A JP2016094711 A JP 2016094711A JP 6670166 B2 JP6670166 B2 JP 6670166B2
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Description
〔シロキクラゲ抽出発酵物〕
本実施形態に係るシロキクラゲ抽出発酵物は、シロキクラゲからの抽出物の、微生物による発酵物である。
本実施形態に係る抗炎症剤、抗老化剤、美白剤および育毛剤は、前述のようにして得られるシロキクラゲ抽出発酵物を有効成分とするものである。本実施形態の抗炎症剤、抗老化剤、美白剤および育毛剤は、医薬品、医薬部外品、化粧品等の幅広い用途に使用することができる。
本実施形態の化粧料は、前述したシロキクラゲ抽出発酵物が配合されるものである。本実施形態に係る化粧料には、シロキクラゲ抽出発酵物をそのまま配合してもよいし、シロキクラゲ抽出発酵物から製剤化した抗炎症剤、抗老化剤、美白剤または育毛剤を配合してもよい。
本実施形態の飲食品組成物は、前述したシロキクラゲ抽出発酵物が配合されるものである。本実施形態に係る飲食品組成物には、シロキクラゲ抽出発酵物をそのまま配合してもよいし、シロキクラゲ抽出発酵物から製剤化した抗炎症剤、抗老化剤、美白剤または育毛剤を配合してもよい。
乾燥したシロキクラゲ(9g)に水(300mL)を加え、還流冷却器を用いて、80〜90℃にて2時間抽出を行った後、滅菌処理を行い、シロキクラゲ抽出液を得た(300g)。
製造例1の過程で得られたシロキクラゲ抽出液を用い、当該シロキクラゲ抽出液(100g)に発酵用酵母(サッカロミセス・ヴェローナ,秋田今野商店社製)を植菌し、30℃で24時間発酵させた。得られた発酵液を濾過し、濾液を濃縮乾固することにより、シロキクラゲ抽出酵母発酵物(1.5g,試料2)を得た。
製造例1で得られたシロキクラゲ抽出乳酸菌発酵物(試料1)および製造例2で得られたシロキクラゲ抽出酵母発酵物(試料2)について、以下のようにしてヒアルロニダーゼ活性阻害作用を試験した。
得られた結果から、下記式によりヒアルロニダーゼ活性阻害率(%)を算出した。
ヒアルロニダーゼ活性阻害率(%)={1−(A−B)/(C−D)}×100
式中の各項はそれぞれ以下を表す。
A:被験試料添加・酵素添加での波長585nmにおける吸光度
B:被験試料添加・酵素無添加での波長585nmにおける吸光度
C:試料無添加・酵素添加での波長585nmにおける吸光度
D:試料無添加・酵素無添加での波長585nmにおける吸光度
結果を表1に示す。
製造例1で得られたシロキクラゲ抽出乳酸菌発酵物(試料1)および製造例2で得られたシロキクラゲ抽出酵母発酵物(試料2)について、以下のようにしてTNF−α産生抑制作用を試験した。
式中の各項はそれぞれ以下を表す。
A:被験試料添加でのTNF−α量
B:試料無添加でのTNF−α量
結果を表2に示す。
製造例1で得られたシロキクラゲ抽出乳酸菌発酵物(試料1)および製造例2で得られたシロキクラゲ抽出酵母発酵物(試料2)について、以下のようにしてエラスチン産生促進作用を試験した。
式中の各項はそれぞれ以下を表す。
A:被験試料添加でのエラスチン量
B:試料無添加でのエラスチン量
結果を表3に示す。
製造例1で得られたシロキクラゲ抽出乳酸菌発酵物(試料1)および製造例2で得られたシロキクラゲ抽出酵母発酵物(試料2)について、以下のようにして表皮ヒアルロン酸産生促進作用を試験した。
式中の各項はそれぞれ以下を表す。
A:被験試料添加でのヒアルロン酸量
B:試料無添加でのヒアルロン酸量
結果を表4に示す。
製造例2で得られたシロキクラゲ抽出酵母発酵物(試料2)について、以下のようにしてIV型コラーゲン産生促進作用を試験した。
式中の各項はそれぞれ以下を表す。
A:被験試料添加でのIV型コラーゲン量
B:試料無添加でのIV型コラーゲン量
結果を表5に示す。
製造例1で得られたシロキクラゲ抽出乳酸菌発酵物(試料1)および製造例2で得られたシロキクラゲ抽出酵母発酵物(試料2)について、以下のようにして表皮角化細胞増殖促進作用を試験した。
式中の各項はそれぞれ以下を表す。
A:被験試料添加でのブルーホルマザン生成量
B:試料無添加でのブルーホルマザン生成量
結果を表6に示す。
製造例1で得られたシロキクラゲ抽出乳酸菌発酵物(試料1)および製造例2で得られたシロキクラゲ抽出酵母発酵物(試料2)について、以下のようにTG−1産生促進作用を試験した。
式中の各項はそれぞれ以下を表す。
A:被験試料添加でのトランスグルタミナーゼ−1量
B:試料無添加でのトランスグルタミナーゼ−1量
結果を表7に示す。
製造例1で得られたシロキクラゲ抽出乳酸菌発酵物(試料1)および製造例2で得られたシロキクラゲ抽出酵母発酵物(試料2)について、以下のようにしてプロフィラグリンmRNA発現促進作用を試験した。
式中の各項はそれぞれ以下を表す。
A:被験試料添加での補正値
B:試料無添加での補正値
結果を表8に示す。
製造例1で得られたシロキクラゲ抽出乳酸菌発酵物(試料1)および製造例2で得られたシロキクラゲ抽出酵母発酵物(試料2)について、以下のようにしてSPTmRNA発現促進作用を試験した。
式中の各項はそれぞれ以下を表す。
A:被験試料添加での補正値
B:試料無添加での補正値
結果を表9に示す。
製造例1で得られたシロキクラゲ抽出乳酸菌発酵物(試料1)および製造例2で得られたシロキクラゲ抽出酵母発酵物(試料2)について、以下のようにしてAQP3mRNA発現促進作用を試験した。
式中の各項はそれぞれ以下を表す。
A:被験試料添加での補正値
B:試料無添加での補正値
結果を表10に示す。
製造例1で得られたシロキクラゲ抽出乳酸菌発酵物(試料1)および製造例2で得られたシロキクラゲ抽出酵母発酵物(試料2)について、以下のようにしてHAS3mRNA発現促進作用を試験した。
式中の各項はそれぞれ以下を表す。
A:被験試料添加での補正値
B:試料無添加での補正値
結果を表11に示す。
製造例1で得られたシロキクラゲ抽出乳酸菌発酵物(試料1)および製造例2で得られたシロキクラゲ抽出酵母発酵物(試料2)について、以下のようにしてB16メラノーマ細胞に対するグルタチオン産生促進作用を試験した。
式中の各項はそれぞれ以下を表す。
A:被験試料を添加した細胞中における総タンパク量当たりのグルタチオン量
B:試料無添加の細胞中における総タンパク量当たりのグルタチオン量(対照)
結果を表12に示す。
製造例1で得られたシロキクラゲ抽出乳酸菌発酵物(試料1)および製造例2で得られたシロキクラゲ抽出酵母発酵物(試料2)について、以下のようにして毛乳頭細胞増殖促進作用を試験した。
式中の各項はそれぞれ以下を表す。
A:被験試料添加でのブルーホルマザン生成量
B:試料無添加でのブルーホルマザン生成量
結果を表13に示す。
製造例1で得られたシロキクラゲ抽出乳酸菌発酵物(試料1)および製造例2で得られたシロキクラゲ抽出酵母発酵物(試料2)について、以下のようにしてKAP5.1mRNA発現促進作用を試験した。
式中の各項はそれぞれ以下を表す。
A:被験試料添加時の補正値
B:試料無添加時の補正値
結果を表14に示す。
下記組成に従い、乳液を常法により製造した。
シロキクラゲ抽出乳酸菌発酵物(製造例1) 0.01g
ホホバオイル 4.00g
1,3−ブチレングリコール 3.00g
アルブチン 3.00g
ポリオキシエチレンセチルエーテル(20E.O.) 2.50g
オリーブオイル 2.00g
スクワラン 2.00g
セタノール 2.00g
モノステアリン酸グリセリル 2.00g
オレイン酸ポリオキシエチレンソルビタン(20E.O.) 2.00g
パラオキシ安息香酸メチル 0.15g
グリチルリチン酸ステアリル 0.10g
黄杞エキス 0.10g
グリチルリチン酸ジカリウム 0.10g
イチョウ葉エキス 0.10g
コンキオリン 0.10g
オウバクエキス 0.10g
カミツレエキス 0.10g
香料 0.05g
精製水 残部(全量を100gとする)
下記組成のクリームを常法により製造した。
シロキクラゲ抽出酵母発酵物(製造例2) 0.05g
クジンエキス 0.1g
オウゴンエキス 0.1g
流動パラフィン 5.0g
サラシミツロウ 4.0g
スクワラン 10.0g
セタノール 3.0g
ラノリン 2.0g
ステアリン酸 1.0g
オレイン酸ポリオキシエチレンソルビタン(20E.O.) 1.5g
モノステアリン酸グリセリル 3.0g
油溶性甘草エキス 0.1g
1,3−ブチレングリコール 6.0g
パラオキシ安息香酸メチル 1.5g
香料 0.1g
精製水 残部(全量を100gとする)
下記組成の美容液を常法により製造した。
シロキクラゲ抽出酵母発酵物(製造例2) 0.01g
カミツレエキス 0.1g
ニンジンエキス 0.1g
キサンタンガム 0.3g
ヒドロキシエチルセルロース 0.1g
カルボキシビニルポリマー 0.1g
1,3−ブチレングリコール 4.0g
グリチルリチン酸ジカリウム 0.1g
グリセリン 2.0g
水酸化カリウム 0.25g
香料 0.01g
防腐剤(パラオキシ安息香酸メチル) 0.15g
エタノール 2.0g
精製水 残部(全量を100gとする)
下記組成のヘアトニックを常法により製造した。
シロキクラゲ抽出乳酸菌発酵物(製造例1) 0.4g
酢酸トコフェロール 適量
セファラチン 0.002g
イソプロピルメチルフェノール 0.1g
ヒアルロン酸ナトリウム 0.15g
グリセリン 15.0g
エタノール 15.0g
香料 適量
キレート剤(エデト酸ナトリウム) 適量
防腐剤(ヒノキチオール) 適量
可溶化剤(ポリオキシエチレンセチルエーテル) 適量
精製水 残部(全量を100gとする)
下記組成のシャンプーを常法により製造した。
シロキクラゲ抽出酵母発酵物(製造例2) 0.5g
マジョラム抽出物 1.0g
ウメ果実部抽出物 0.2g
ヤシ油脂肪酸メチルタウリンナトリウム 10.0g
ヤシ油脂肪酸アミドプロピルベタイン 10.0g
ポリオキシエチレンアルキルエーテル硫酸ナトリウム 20.0g
ヤシ油脂肪酸ジエタノールアミド 4.0g
プロピレングリコール 2.0g
香料 適量
精製水 残部(全量を100gとする)
常法により、以下の組成を有する錠剤を製造した。
シロキクラゲ抽出乳酸菌発酵物(製造例1) 5.0mg
ドロマイト(カルシウム20%、マグネシウム10%含有) 83.4mg
カゼインホスホペプチド 16.7mg
ビタミンC 33.4mg
マルチトール 136.8mg
コラーゲン 12.7mg
ショ糖脂肪酸エステル 12.0mg
常法により、以下の組成を有する経口液状製剤を製造した。
<1アンプル(1本100mL)中の組成>
シロキクラゲ抽出酵母発酵物(製造例2) 0.3質量%
ソルビット 12.0質量%
安息香酸ナトリウム 0.1質量%
香料 1.0質量%
硫酸カルシウム 0.5質量%
精製水 残部(100質量%)
Claims (9)
- シロキクラゲ抽出物の酵母による発酵物であるシロキクラゲ抽出発酵物を有効成分とすることを特徴とする抗炎症剤。
- ヒアルロニダーゼ活性阻害用途および/または腫瘍壊死因子(TNF−α)産生抑制用途に用いられることを特徴とする請求項1に記載の抗炎症剤。
- シロキクラゲ抽出物の酵母による発酵物であるシロキクラゲ抽出発酵物を有効成分とすることを特徴とする抗老化剤。
- エラスチン産生促進用途、ヒアルロン酸産生促進用途、IV型コラーゲン産生促進用途、表皮角化細胞増殖用途、トランスグルタミナーゼ−1産生促進用途、プロフィラグリンmRNA発現促進用途、セリンパルミトイルトランスフェラーゼmRNA発現促進用途、アクアポリン3mRNA発現促進用途およびヒアルロン酸合成酵素3mRNA発現促進用途からなる群より選択される1種または2種以上の用途に用いられることを特徴とする請求項3に記載の抗老化剤。
- シロキクラゲ抽出物の酵母による発酵物であるシロキクラゲ抽出発酵物を有効成分とすることを特徴とする美白剤。
- グルタチオン産生促進用途に用いられることを特徴とする請求項5に記載の美白剤。
- シロキクラゲ抽出発酵物を有効成分とすることを特徴とする育毛剤。
- 毛乳頭細胞増殖促進用途および/またはケラチン関連タンパク質5.1mRNA発現促進用途に用いられることを特徴とする請求項7に記載の育毛剤。
- シロキクラゲ抽出物の酵母による発酵物であるシロキクラゲ抽出発酵物を配合したことを特徴とする化粧料。
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JP7266202B2 (ja) * | 2018-02-19 | 2023-04-28 | 株式会社ファンケル | 化粧料及び抗炎症剤 |
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