JP7351541B2 - 皮膚化粧料、頭髪化粧料および飲食品 - Google Patents
皮膚化粧料、頭髪化粧料および飲食品 Download PDFInfo
- Publication number
- JP7351541B2 JP7351541B2 JP2021184224A JP2021184224A JP7351541B2 JP 7351541 B2 JP7351541 B2 JP 7351541B2 JP 2021184224 A JP2021184224 A JP 2021184224A JP 2021184224 A JP2021184224 A JP 2021184224A JP 7351541 B2 JP7351541 B2 JP 7351541B2
- Authority
- JP
- Japan
- Prior art keywords
- effect
- activity
- vinylcatechol
- agent
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 235000013305 food Nutrition 0.000 title claims description 34
- 235000013361 beverage Nutrition 0.000 title claims description 5
- 239000002537 cosmetic Substances 0.000 title description 26
- 239000003676 hair preparation Substances 0.000 title description 17
- FBTSUTGMWBDAAC-UHFFFAOYSA-N 3,4-Dihydroxystyrene Chemical compound OC1=CC=C(C=C)C=C1O FBTSUTGMWBDAAC-UHFFFAOYSA-N 0.000 claims description 285
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims description 196
- 239000003112 inhibitor Substances 0.000 claims description 123
- 108010024636 Glutathione Proteins 0.000 claims description 98
- 229960003180 glutathione Drugs 0.000 claims description 98
- 230000009467 reduction Effects 0.000 claims description 50
- 230000007423 decrease Effects 0.000 claims description 31
- 239000004480 active ingredient Substances 0.000 claims description 24
- 230000000694 effects Effects 0.000 description 381
- 239000000523 sample Substances 0.000 description 172
- 230000002401 inhibitory effect Effects 0.000 description 137
- 210000004027 cell Anatomy 0.000 description 114
- 239000003795 chemical substances by application Substances 0.000 description 111
- 238000012360 testing method Methods 0.000 description 103
- 230000001737 promoting effect Effects 0.000 description 95
- 230000005764 inhibitory process Effects 0.000 description 72
- 210000003491 skin Anatomy 0.000 description 72
- 102100025012 Dipeptidyl peptidase 4 Human genes 0.000 description 64
- 101000930822 Giardia intestinalis Dipeptidyl-peptidase 4 Proteins 0.000 description 63
- 230000003712 anti-aging effect Effects 0.000 description 59
- 239000002609 medium Substances 0.000 description 57
- 238000004519 manufacturing process Methods 0.000 description 55
- 230000003779 hair growth Effects 0.000 description 52
- 239000000203 mixture Substances 0.000 description 52
- 108010005094 Advanced Glycation End Products Proteins 0.000 description 51
- 102000001707 3',5'-Cyclic-AMP Phosphodiesterases Human genes 0.000 description 50
- 108010054479 3',5'-Cyclic-AMP Phosphodiesterases Proteins 0.000 description 50
- 239000000051 antiandrogen Substances 0.000 description 50
- 230000014509 gene expression Effects 0.000 description 46
- 230000002087 whitening effect Effects 0.000 description 42
- 238000002835 absorbance Methods 0.000 description 39
- 238000006243 chemical reaction Methods 0.000 description 39
- 108020004999 messenger RNA Proteins 0.000 description 39
- 239000000284 extract Substances 0.000 description 37
- 238000011282 treatment Methods 0.000 description 37
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 37
- 239000002260 anti-inflammatory agent Substances 0.000 description 36
- 239000000047 product Substances 0.000 description 36
- 229940121363 anti-inflammatory agent Drugs 0.000 description 35
- IVOMOUWHDPKRLL-KQYNXXCUSA-N Cyclic adenosine monophosphate Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=CN=C2N)=C2N=C1 IVOMOUWHDPKRLL-KQYNXXCUSA-N 0.000 description 34
- IVOMOUWHDPKRLL-UHFFFAOYSA-N UNPD107823 Natural products O1C2COP(O)(=O)OC2C(O)C1N1C(N=CN=C2N)=C2N=C1 IVOMOUWHDPKRLL-UHFFFAOYSA-N 0.000 description 34
- 229940095074 cyclic amp Drugs 0.000 description 34
- 239000000243 solution Substances 0.000 description 33
- 239000000883 anti-obesity agent Substances 0.000 description 32
- 229940125710 antiobesity agent Drugs 0.000 description 32
- 230000015572 biosynthetic process Effects 0.000 description 32
- 102000004190 Enzymes Human genes 0.000 description 31
- 108090000790 Enzymes Proteins 0.000 description 31
- 229940088598 enzyme Drugs 0.000 description 31
- 108010028309 kalinin Proteins 0.000 description 31
- 230000002500 effect on skin Effects 0.000 description 30
- 102000000424 Matrix Metalloproteinase 2 Human genes 0.000 description 29
- 108010016165 Matrix Metalloproteinase 2 Proteins 0.000 description 29
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 29
- 239000000126 substance Substances 0.000 description 29
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 28
- 108010037462 Cyclooxygenase 2 Proteins 0.000 description 27
- 102100038280 Prostaglandin G/H synthase 2 Human genes 0.000 description 27
- 102000000380 Matrix Metalloproteinase 1 Human genes 0.000 description 26
- 108010016113 Matrix Metalloproteinase 1 Proteins 0.000 description 26
- 230000009471 action Effects 0.000 description 26
- 102000004363 Aquaporin 3 Human genes 0.000 description 25
- 108090000991 Aquaporin 3 Proteins 0.000 description 25
- 102000002268 Hexosaminidases Human genes 0.000 description 25
- 108010000540 Hexosaminidases Proteins 0.000 description 25
- 108010003272 Hyaluronate lyase Proteins 0.000 description 25
- 102000001974 Hyaluronidases Human genes 0.000 description 25
- 229960002773 hyaluronidase Drugs 0.000 description 25
- 108090000623 proteins and genes Proteins 0.000 description 25
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 24
- 102000015785 Serine C-Palmitoyltransferase Human genes 0.000 description 24
- 108010024814 Serine C-palmitoyltransferase Proteins 0.000 description 24
- 230000037319 collagen production Effects 0.000 description 24
- 238000000605 extraction Methods 0.000 description 24
- 235000018102 proteins Nutrition 0.000 description 24
- 102000004169 proteins and genes Human genes 0.000 description 24
- 108010029908 3-oxo-5-alpha-steroid 4-dehydrogenase Proteins 0.000 description 23
- 102000001779 3-oxo-5-alpha-steroid 4-dehydrogenase Human genes 0.000 description 23
- 239000000872 buffer Substances 0.000 description 23
- 201000010099 disease Diseases 0.000 description 23
- 102000012422 Collagen Type I Human genes 0.000 description 22
- 108010022452 Collagen Type I Proteins 0.000 description 22
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 22
- 210000004209 hair Anatomy 0.000 description 22
- 102000003425 Tyrosinase Human genes 0.000 description 20
- 108060008724 Tyrosinase Proteins 0.000 description 20
- 210000002469 basement membrane Anatomy 0.000 description 20
- 230000008099 melanin synthesis Effects 0.000 description 19
- 230000002280 anti-androgenic effect Effects 0.000 description 18
- 230000003110 anti-inflammatory effect Effects 0.000 description 18
- 239000002904 solvent Substances 0.000 description 17
- 102000008186 Collagen Human genes 0.000 description 16
- 108010035532 Collagen Proteins 0.000 description 16
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 description 16
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 description 16
- 229920001436 collagen Polymers 0.000 description 16
- 238000000354 decomposition reaction Methods 0.000 description 16
- 230000006872 improvement Effects 0.000 description 16
- 238000000034 method Methods 0.000 description 16
- 230000002265 prevention Effects 0.000 description 16
- 230000003579 anti-obesity Effects 0.000 description 15
- 230000004663 cell proliferation Effects 0.000 description 15
- 239000002953 phosphate buffered saline Substances 0.000 description 15
- 208000024891 symptom Diseases 0.000 description 15
- 230000015556 catabolic process Effects 0.000 description 14
- 238000006731 degradation reaction Methods 0.000 description 14
- 230000006870 function Effects 0.000 description 14
- 229960003604 testosterone Drugs 0.000 description 14
- 201000004384 Alopecia Diseases 0.000 description 13
- 238000012258 culturing Methods 0.000 description 13
- NVKAWKQGWWIWPM-ABEVXSGRSA-N 17-β-hydroxy-5-α-Androstan-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 NVKAWKQGWWIWPM-ABEVXSGRSA-N 0.000 description 12
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 12
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 12
- 229960001340 histamine Drugs 0.000 description 12
- 230000001976 improved effect Effects 0.000 description 12
- 238000007796 conventional method Methods 0.000 description 11
- 238000012937 correction Methods 0.000 description 11
- 239000003814 drug Substances 0.000 description 11
- 230000036252 glycation Effects 0.000 description 11
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 10
- 208000008589 Obesity Diseases 0.000 description 10
- 102000004142 Trypsin Human genes 0.000 description 10
- 108090000631 Trypsin Proteins 0.000 description 10
- -1 and the like Substances 0.000 description 10
- 229910002091 carbon monoxide Inorganic materials 0.000 description 10
- 210000002744 extracellular matrix Anatomy 0.000 description 10
- 208000027866 inflammatory disease Diseases 0.000 description 10
- 235000020824 obesity Nutrition 0.000 description 10
- QAIPRVGONGVQAS-DUXPYHPUSA-N trans-caffeic acid Chemical compound OC(=O)\C=C\C1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-DUXPYHPUSA-N 0.000 description 10
- 239000012588 trypsin Substances 0.000 description 10
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 9
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 9
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 9
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 9
- 230000032683 aging Effects 0.000 description 9
- 150000001875 compounds Chemical class 0.000 description 9
- 210000005175 epidermal keratinocyte Anatomy 0.000 description 9
- 238000002156 mixing Methods 0.000 description 9
- 239000002994 raw material Substances 0.000 description 9
- 230000009759 skin aging Effects 0.000 description 9
- 239000000758 substrate Substances 0.000 description 9
- 230000037303 wrinkles Effects 0.000 description 9
- 206010013786 Dry skin Diseases 0.000 description 8
- 229940106189 ceramide Drugs 0.000 description 8
- 230000006378 damage Effects 0.000 description 8
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 description 8
- 230000037336 dry skin Effects 0.000 description 8
- 210000002615 epidermis Anatomy 0.000 description 8
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 8
- 238000005259 measurement Methods 0.000 description 8
- 230000035755 proliferation Effects 0.000 description 8
- CBMYJHIOYJEBSB-KHOSGYARSA-N 5alpha-androstane-3alpha,17beta-diol Chemical compound C1[C@H](O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 CBMYJHIOYJEBSB-KHOSGYARSA-N 0.000 description 7
- 206010003210 Arteriosclerosis Diseases 0.000 description 7
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 description 7
- 241000196324 Embryophyta Species 0.000 description 7
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 description 7
- 201000004681 Psoriasis Diseases 0.000 description 7
- 208000011775 arteriosclerosis disease Diseases 0.000 description 7
- 239000007844 bleaching agent Substances 0.000 description 7
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 description 7
- 235000014113 dietary fatty acids Nutrition 0.000 description 7
- 229940079593 drug Drugs 0.000 description 7
- 210000002919 epithelial cell Anatomy 0.000 description 7
- 229930195729 fatty acid Natural products 0.000 description 7
- 239000000194 fatty acid Substances 0.000 description 7
- 239000003205 fragrance Substances 0.000 description 7
- 210000004185 liver Anatomy 0.000 description 7
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 7
- 239000008213 purified water Substances 0.000 description 7
- 210000001519 tissue Anatomy 0.000 description 7
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- 206010012438 Dermatitis atopic Diseases 0.000 description 6
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- 241000282412 Homo Species 0.000 description 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 208000001132 Osteoporosis Diseases 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000000654 additive Substances 0.000 description 6
- 201000008937 atopic dermatitis Diseases 0.000 description 6
- 230000004888 barrier function Effects 0.000 description 6
- 230000010261 cell growth Effects 0.000 description 6
- 230000003247 decreasing effect Effects 0.000 description 6
- 150000004665 fatty acids Chemical class 0.000 description 6
- 238000009472 formulation Methods 0.000 description 6
- 210000003780 hair follicle Anatomy 0.000 description 6
- 230000001965 increasing effect Effects 0.000 description 6
- 239000000859 incretin Substances 0.000 description 6
- 230000003020 moisturizing effect Effects 0.000 description 6
- 201000008482 osteoarthritis Diseases 0.000 description 6
- 206010039073 rheumatoid arthritis Diseases 0.000 description 6
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 6
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 6
- CBOJBBMQJBVCMW-NQZVPSPJSA-N (2r,3r,4r,5r)-2-amino-3,4,5,6-tetrahydroxyhexanal;hydrochloride Chemical compound Cl.O=C[C@H](N)[C@@H](O)[C@@H](O)[C@H](O)CO CBOJBBMQJBVCMW-NQZVPSPJSA-N 0.000 description 5
- ACEAELOMUCBPJP-UHFFFAOYSA-N (E)-3,4,5-trihydroxycinnamic acid Natural products OC(=O)C=CC1=CC(O)=C(O)C(O)=C1 ACEAELOMUCBPJP-UHFFFAOYSA-N 0.000 description 5
- 238000002965 ELISA Methods 0.000 description 5
- 206010014970 Ephelides Diseases 0.000 description 5
- 206010061218 Inflammation Diseases 0.000 description 5
- 208000003351 Melanosis Diseases 0.000 description 5
- 208000012641 Pigmentation disease Diseases 0.000 description 5
- 231100000360 alopecia Toxicity 0.000 description 5
- 239000003098 androgen Substances 0.000 description 5
- 206010068168 androgenetic alopecia Diseases 0.000 description 5
- 201000002996 androgenic alopecia Diseases 0.000 description 5
- 230000033115 angiogenesis Effects 0.000 description 5
- 229940074360 caffeic acid Drugs 0.000 description 5
- 235000004883 caffeic acid Nutrition 0.000 description 5
- QAIPRVGONGVQAS-UHFFFAOYSA-N cis-caffeic acid Natural products OC(=O)C=CC1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-UHFFFAOYSA-N 0.000 description 5
- 230000007812 deficiency Effects 0.000 description 5
- 206010012601 diabetes mellitus Diseases 0.000 description 5
- 239000002158 endotoxin Substances 0.000 description 5
- 235000011187 glycerol Nutrition 0.000 description 5
- 239000001963 growth medium Substances 0.000 description 5
- 230000036541 health Effects 0.000 description 5
- 210000003494 hepatocyte Anatomy 0.000 description 5
- 229940088597 hormone Drugs 0.000 description 5
- 239000005556 hormone Substances 0.000 description 5
- 230000004054 inflammatory process Effects 0.000 description 5
- 150000002632 lipids Chemical class 0.000 description 5
- 229920006008 lipopolysaccharide Polymers 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- VMGAPWLDMVPYIA-HIDZBRGKSA-N n'-amino-n-iminomethanimidamide Chemical compound N\N=C\N=N VMGAPWLDMVPYIA-HIDZBRGKSA-N 0.000 description 5
- 239000013642 negative control Substances 0.000 description 5
- 230000036542 oxidative stress Effects 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- BOLDJAUMGUJJKM-LSDHHAIUSA-N renifolin D Natural products CC(=C)[C@@H]1Cc2c(O)c(O)ccc2[C@H]1CC(=O)c3ccc(O)cc3O BOLDJAUMGUJJKM-LSDHHAIUSA-N 0.000 description 5
- 235000000346 sugar Nutrition 0.000 description 5
- 239000006228 supernatant Substances 0.000 description 5
- 230000001629 suppression Effects 0.000 description 5
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 4
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 4
- 208000002874 Acne Vulgaris Diseases 0.000 description 4
- 102000029816 Collagenase Human genes 0.000 description 4
- 108060005980 Collagenase Proteins 0.000 description 4
- 206010012442 Dermatitis contact Diseases 0.000 description 4
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 4
- 208000010201 Exanthema Diseases 0.000 description 4
- 102100031181 Glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 4
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 4
- 108010085895 Laminin Proteins 0.000 description 4
- 206010067125 Liver injury Diseases 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 4
- 201000011152 Pemphigus Diseases 0.000 description 4
- 241000700159 Rattus Species 0.000 description 4
- 206010052428 Wound Diseases 0.000 description 4
- 208000027418 Wounds and injury Diseases 0.000 description 4
- 206010000496 acne Diseases 0.000 description 4
- 230000003698 anagen phase Effects 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 239000012752 auxiliary agent Substances 0.000 description 4
- 210000004204 blood vessel Anatomy 0.000 description 4
- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 description 4
- 230000009087 cell motility Effects 0.000 description 4
- 229960002424 collagenase Drugs 0.000 description 4
- 208000010247 contact dermatitis Diseases 0.000 description 4
- 239000006071 cream Substances 0.000 description 4
- 239000007854 depigmenting agent Substances 0.000 description 4
- 210000004207 dermis Anatomy 0.000 description 4
- 230000004069 differentiation Effects 0.000 description 4
- 201000005884 exanthem Diseases 0.000 description 4
- 210000002950 fibroblast Anatomy 0.000 description 4
- 238000004817 gas chromatography Methods 0.000 description 4
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 4
- 230000035876 healing Effects 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 231100000234 hepatic damage Toxicity 0.000 description 4
- 208000006454 hepatitis Diseases 0.000 description 4
- 229960000890 hydrocortisone Drugs 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 230000008818 liver damage Effects 0.000 description 4
- 208000019423 liver disease Diseases 0.000 description 4
- 210000002540 macrophage Anatomy 0.000 description 4
- 201000001976 pemphigus vulgaris Diseases 0.000 description 4
- 239000013641 positive control Substances 0.000 description 4
- 108090000765 processed proteins & peptides Proteins 0.000 description 4
- 206010037844 rash Diseases 0.000 description 4
- 238000003757 reverse transcription PCR Methods 0.000 description 4
- 239000012488 sample solution Substances 0.000 description 4
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 4
- 210000004881 tumor cell Anatomy 0.000 description 4
- 230000029663 wound healing Effects 0.000 description 4
- 229940058015 1,3-butylene glycol Drugs 0.000 description 3
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
- OMRLTNCLYHKQCK-DHGKCCLASA-N 4-nitrophenyl N-acetyl-beta-D-glucosaminide Chemical compound CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C([N+]([O-])=O)C=C1 OMRLTNCLYHKQCK-DHGKCCLASA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- 102000010637 Aquaporins Human genes 0.000 description 3
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 3
- 102000004266 Collagen Type IV Human genes 0.000 description 3
- 108010042086 Collagen Type IV Proteins 0.000 description 3
- 208000002249 Diabetes Complications Diseases 0.000 description 3
- 206010012655 Diabetic complications Diseases 0.000 description 3
- 208000001382 Experimental Melanoma Diseases 0.000 description 3
- 230000005526 G1 to G0 transition Effects 0.000 description 3
- 108010051696 Growth Hormone Proteins 0.000 description 3
- 206010020601 Hyperchlorhydria Diseases 0.000 description 3
- 206010020772 Hypertension Diseases 0.000 description 3
- 206010022489 Insulin Resistance Diseases 0.000 description 3
- 239000004367 Lipase Substances 0.000 description 3
- 102000004882 Lipase Human genes 0.000 description 3
- 108090001060 Lipase Proteins 0.000 description 3
- 102000002274 Matrix Metalloproteinases Human genes 0.000 description 3
- 108010000684 Matrix Metalloproteinases Proteins 0.000 description 3
- 208000001145 Metabolic Syndrome Diseases 0.000 description 3
- 206010027476 Metastases Diseases 0.000 description 3
- ACFIXJIJDZMPPO-NNYOXOHSSA-N NADPH Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](OP(O)(O)=O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 ACFIXJIJDZMPPO-NNYOXOHSSA-N 0.000 description 3
- 208000002193 Pain Diseases 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 3
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 3
- 206010039792 Seborrhoea Diseases 0.000 description 3
- 102100038803 Somatotropin Human genes 0.000 description 3
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 description 3
- 238000009825 accumulation Methods 0.000 description 3
- 229960001138 acetylsalicylic acid Drugs 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- PYMYPHUHKUWMLA-LMVFSUKVSA-N aldehydo-D-ribose Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 3
- 208000026935 allergic disease Diseases 0.000 description 3
- 235000001014 amino acid Nutrition 0.000 description 3
- 229940024606 amino acid Drugs 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 229940030486 androgens Drugs 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 238000009835 boiling Methods 0.000 description 3
- 210000000988 bone and bone Anatomy 0.000 description 3
- 239000007853 buffer solution Substances 0.000 description 3
- 235000019437 butane-1,3-diol Nutrition 0.000 description 3
- 238000011088 calibration curve Methods 0.000 description 3
- 150000001720 carbohydrates Chemical class 0.000 description 3
- 235000014633 carbohydrates Nutrition 0.000 description 3
- 210000003169 central nervous system Anatomy 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000003240 coconut oil Substances 0.000 description 3
- 235000019864 coconut oil Nutrition 0.000 description 3
- 238000004440 column chromatography Methods 0.000 description 3
- 239000012141 concentrate Substances 0.000 description 3
- 235000009508 confectionery Nutrition 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 235000015872 dietary supplement Nutrition 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 210000001339 epidermal cell Anatomy 0.000 description 3
- 239000003925 fat Substances 0.000 description 3
- 235000019197 fats Nutrition 0.000 description 3
- 230000037406 food intake Effects 0.000 description 3
- 239000000122 growth hormone Substances 0.000 description 3
- 230000031774 hair cycle Effects 0.000 description 3
- 229910001385 heavy metal Inorganic materials 0.000 description 3
- 206010021198 ichthyosis Diseases 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 230000028709 inflammatory response Effects 0.000 description 3
- 210000002510 keratinocyte Anatomy 0.000 description 3
- 235000019421 lipase Nutrition 0.000 description 3
- 230000003908 liver function Effects 0.000 description 3
- 239000006210 lotion Substances 0.000 description 3
- 239000002932 luster Substances 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- 230000009401 metastasis Effects 0.000 description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
- 239000011259 mixed solution Substances 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 230000036407 pain Effects 0.000 description 3
- 239000008363 phosphate buffer Substances 0.000 description 3
- 230000019612 pigmentation Effects 0.000 description 3
- 239000002798 polar solvent Substances 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- 108020003175 receptors Proteins 0.000 description 3
- 208000008742 seborrheic dermatitis Diseases 0.000 description 3
- 230000008591 skin barrier function Effects 0.000 description 3
- 208000019116 sleep disease Diseases 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 3
- 230000000638 stimulation Effects 0.000 description 3
- 210000000434 stratum corneum Anatomy 0.000 description 3
- 230000035882 stress Effects 0.000 description 3
- 150000005846 sugar alcohols Polymers 0.000 description 3
- 150000008163 sugars Chemical group 0.000 description 3
- 229960000278 theophylline Drugs 0.000 description 3
- 238000009281 ultraviolet germicidal irradiation Methods 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 2
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 2
- MSWZFWKMSRAUBD-GASJEMHNSA-N 2-amino-2-deoxy-D-galactopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@H](O)[C@@H]1O MSWZFWKMSRAUBD-GASJEMHNSA-N 0.000 description 2
- KIUMMUBSPKGMOY-UHFFFAOYSA-N 3,3'-Dithiobis(6-nitrobenzoic acid) Chemical compound C1=C([N+]([O-])=O)C(C(=O)O)=CC(SSC=2C=C(C(=CC=2)[N+]([O-])=O)C(O)=O)=C1 KIUMMUBSPKGMOY-UHFFFAOYSA-N 0.000 description 2
- 108010089063 4-hydroxybenzoate decarboxylase Proteins 0.000 description 2
- 208000030507 AIDS Diseases 0.000 description 2
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 description 2
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 description 2
- 208000024827 Alzheimer disease Diseases 0.000 description 2
- 108010063290 Aquaporins Proteins 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 208000023275 Autoimmune disease Diseases 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 206010004146 Basal cell carcinoma Diseases 0.000 description 2
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 2
- 206010006187 Breast cancer Diseases 0.000 description 2
- 208000026310 Breast neoplasm Diseases 0.000 description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical group ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 206010008909 Chronic Hepatitis Diseases 0.000 description 2
- 208000032170 Congenital Abnormalities Diseases 0.000 description 2
- 201000004624 Dermatitis Diseases 0.000 description 2
- 239000004375 Dextrin Substances 0.000 description 2
- 229920001353 Dextrin Polymers 0.000 description 2
- 208000007342 Diabetic Nephropathies Diseases 0.000 description 2
- 208000032131 Diabetic Neuropathies Diseases 0.000 description 2
- 238000011891 EIA kit Methods 0.000 description 2
- 206010014989 Epidermolysis bullosa Diseases 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 206010064503 Excessive skin Diseases 0.000 description 2
- 101710198884 GATA-type zinc finger protein 1 Proteins 0.000 description 2
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 description 2
- 108010053070 Glutathione Disulfide Proteins 0.000 description 2
- 108010063907 Glutathione Reductase Proteins 0.000 description 2
- 102100036442 Glutathione reductase, mitochondrial Human genes 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 description 2
- 208000031886 HIV Infections Diseases 0.000 description 2
- 208000037357 HIV infectious disease Diseases 0.000 description 2
- 206010020112 Hirsutism Diseases 0.000 description 2
- 206010023126 Jaundice Diseases 0.000 description 2
- 108010076876 Keratins Proteins 0.000 description 2
- 102000011782 Keratins Human genes 0.000 description 2
- 208000003947 Knee Osteoarthritis Diseases 0.000 description 2
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 description 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 2
- 240000008415 Lactuca sativa Species 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 208000012902 Nervous system disease Diseases 0.000 description 2
- 208000025966 Neurological disease Diseases 0.000 description 2
- 229920001214 Polysorbate 60 Polymers 0.000 description 2
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 description 2
- 102100040918 Pro-glucagon Human genes 0.000 description 2
- 102100038277 Prostaglandin G/H synthase 1 Human genes 0.000 description 2
- 108050003243 Prostaglandin G/H synthase 1 Proteins 0.000 description 2
- 208000004403 Prostatic Hyperplasia Diseases 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 208000008765 Sciatica Diseases 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 229920002385 Sodium hyaluronate Polymers 0.000 description 2
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 description 2
- 208000007107 Stomach Ulcer Diseases 0.000 description 2
- 206010042971 T-cell lymphoma Diseases 0.000 description 2
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 description 2
- 244000299461 Theobroma cacao Species 0.000 description 2
- 208000024770 Thyroid neoplasm Diseases 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 238000011481 absorbance measurement Methods 0.000 description 2
- 239000012190 activator Substances 0.000 description 2
- 231100000354 acute hepatitis Toxicity 0.000 description 2
- 210000001789 adipocyte Anatomy 0.000 description 2
- 206010064930 age-related macular degeneration Diseases 0.000 description 2
- 235000004279 alanine Nutrition 0.000 description 2
- 208000004631 alopecia areata Diseases 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- 230000003796 beauty Effects 0.000 description 2
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 2
- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 description 2
- 239000001110 calcium chloride Substances 0.000 description 2
- 229910001628 calcium chloride Inorganic materials 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 230000009400 cancer invasion Effects 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 239000012159 carrier gas Substances 0.000 description 2
- 230000003778 catagen phase Effects 0.000 description 2
- 229940119217 chamomile extract Drugs 0.000 description 2
- 235000020221 chamomile extract Nutrition 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 235000015218 chewing gum Nutrition 0.000 description 2
- 229940112822 chewing gum Drugs 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 208000019425 cirrhosis of liver Diseases 0.000 description 2
- 239000012228 culture supernatant Substances 0.000 description 2
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 2
- 230000007850 degeneration Effects 0.000 description 2
- 238000005238 degreasing Methods 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 235000019425 dextrin Nutrition 0.000 description 2
- 208000033679 diabetic kidney disease Diseases 0.000 description 2
- RXKJFZQQPQGTFL-UHFFFAOYSA-N dihydroxyacetone Chemical compound OCC(=O)CO RXKJFZQQPQGTFL-UHFFFAOYSA-N 0.000 description 2
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 230000035622 drinking Effects 0.000 description 2
- 210000002889 endothelial cell Anatomy 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 230000005284 excitation Effects 0.000 description 2
- 230000029142 excretion Effects 0.000 description 2
- 208000010706 fatty liver disease Diseases 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000013355 food flavoring agent Nutrition 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- YPZRWBKMTBYPTK-BJDJZHNGSA-N glutathione disulfide Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@H](C(=O)NCC(O)=O)CSSC[C@@H](C(=O)NCC(O)=O)NC(=O)CC[C@H](N)C(O)=O YPZRWBKMTBYPTK-BJDJZHNGSA-N 0.000 description 2
- 229940075507 glyceryl monostearate Drugs 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 208000024963 hair loss Diseases 0.000 description 2
- 230000003676 hair loss Effects 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 210000003630 histaminocyte Anatomy 0.000 description 2
- 230000013632 homeostatic process Effects 0.000 description 2
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 description 2
- 229920002674 hyaluronan Polymers 0.000 description 2
- 229960003160 hyaluronic acid Drugs 0.000 description 2
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 description 2
- MGXWVYUBJRZYPE-YUGYIWNOSA-N incretin Chemical class C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)[C@@H](C)O)[C@@H](C)CC)C1=CC=C(O)C=C1 MGXWVYUBJRZYPE-YUGYIWNOSA-N 0.000 description 2
- 230000008595 infiltration Effects 0.000 description 2
- 238000001764 infiltration Methods 0.000 description 2
- 230000003914 insulin secretion Effects 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 230000003834 intracellular effect Effects 0.000 description 2
- 238000005342 ion exchange Methods 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 210000003041 ligament Anatomy 0.000 description 2
- 230000005976 liver dysfunction Effects 0.000 description 2
- 244000144972 livestock Species 0.000 description 2
- 208000002780 macular degeneration Diseases 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 210000004379 membrane Anatomy 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 2
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 2
- 230000004770 neurodegeneration Effects 0.000 description 2
- 208000015122 neurodegenerative disease Diseases 0.000 description 2
- PGSADBUBUOPOJS-UHFFFAOYSA-N neutral red Chemical compound Cl.C1=C(C)C(N)=CC2=NC3=CC(N(C)C)=CC=C3N=C21 PGSADBUBUOPOJS-UHFFFAOYSA-N 0.000 description 2
- 235000012149 noodles Nutrition 0.000 description 2
- 238000010899 nucleation Methods 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 235000014593 oils and fats Nutrition 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- YPZRWBKMTBYPTK-UHFFFAOYSA-N oxidized gamma-L-glutamyl-L-cysteinylglycine Natural products OC(=O)C(N)CCC(=O)NC(C(=O)NCC(O)=O)CSSCC(C(=O)NCC(O)=O)NC(=O)CCC(N)C(O)=O YPZRWBKMTBYPTK-UHFFFAOYSA-N 0.000 description 2
- 229940094443 oxytocics prostaglandins Drugs 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 208000028169 periodontal disease Diseases 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 2
- 150000003180 prostaglandins Chemical class 0.000 description 2
- 238000003753 real-time PCR Methods 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 238000007665 sagging Methods 0.000 description 2
- 235000012045 salad Nutrition 0.000 description 2
- 235000015067 sauces Nutrition 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 239000002453 shampoo Substances 0.000 description 2
- 239000000741 silica gel Substances 0.000 description 2
- 229910002027 silica gel Inorganic materials 0.000 description 2
- 210000001626 skin fibroblast Anatomy 0.000 description 2
- 230000004215 skin function Effects 0.000 description 2
- 229940010747 sodium hyaluronate Drugs 0.000 description 2
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 2
- 229950004959 sorbitan oleate Drugs 0.000 description 2
- 229940032094 squalane Drugs 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- 230000003797 telogen phase Effects 0.000 description 2
- 210000002435 tendon Anatomy 0.000 description 2
- 201000002510 thyroid cancer Diseases 0.000 description 2
- 230000001256 tonic effect Effects 0.000 description 2
- 230000009261 transgenic effect Effects 0.000 description 2
- 208000002271 trichotillomania Diseases 0.000 description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 2
- 210000003556 vascular endothelial cell Anatomy 0.000 description 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
- WEAKOQKTQAUHGL-WCEVMLKJSA-N (2r)-2-[[(2s)-5-amino-2-[[2-[[(2s)-2-[[(2s,3s)-2-[[2-[[(2s)-5-amino-2-[[(2s)-1-(2,4-dinitrophenyl)pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]acetyl]amino]-3-methylpentanoyl]amino]propanoyl]amino]acetyl]amino]-5-oxopentanoyl]amino]-5-(diaminomethyl Chemical compound NC(=N)NCCC[C@H](C(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O WEAKOQKTQAUHGL-WCEVMLKJSA-N 0.000 description 1
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 description 1
- FRWNAQDBODEVAL-VMPITWQZSA-N (5e)-5-[(4-nitrophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one Chemical compound C1=CC([N+](=O)[O-])=CC=C1\C=C\1C(=O)NC(=S)S/1 FRWNAQDBODEVAL-VMPITWQZSA-N 0.000 description 1
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- ZDSCFBCGDDCJFZ-UHFFFAOYSA-N 2-(methylamino)ethanesulfonic acid;sodium Chemical compound [Na].CNCCS(O)(=O)=O ZDSCFBCGDDCJFZ-UHFFFAOYSA-N 0.000 description 1
- QNMKGMUGYVWVFQ-UHFFFAOYSA-N 2alpha-Hydroxyursolic acid Natural products CC12CC(O)C(O)C(C)(C)C1CCC1(C)C2CC=C2C3C(C)C(C)(C)CCC3(C(O)=O)CCC21C QNMKGMUGYVWVFQ-UHFFFAOYSA-N 0.000 description 1
- IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 description 1
- 102100023987 Aquaporin-12A Human genes 0.000 description 1
- 240000005528 Arctium lappa Species 0.000 description 1
- 235000003130 Arctium lappa Nutrition 0.000 description 1
- 235000008078 Arctium minus Nutrition 0.000 description 1
- 235000003261 Artemisia vulgaris Nutrition 0.000 description 1
- 240000006891 Artemisia vulgaris Species 0.000 description 1
- 208000036487 Arthropathies Diseases 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- 235000010082 Averrhoa carambola Nutrition 0.000 description 1
- 240000006063 Averrhoa carambola Species 0.000 description 1
- 210000002237 B-cell of pancreatic islet Anatomy 0.000 description 1
- 206010004385 Benign neoplasm of prostate Diseases 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 101150071146 COX2 gene Proteins 0.000 description 1
- 101100114534 Caenorhabditis elegans ctc-2 gene Proteins 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- 108010066551 Cholestenone 5 alpha-Reductase Proteins 0.000 description 1
- 240000007154 Coffea arabica Species 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 235000003363 Cornus mas Nutrition 0.000 description 1
- 240000006766 Cornus mas Species 0.000 description 1
- 241000699800 Cricetinae Species 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 206010061619 Deformity Diseases 0.000 description 1
- 206010012689 Diabetic retinopathy Diseases 0.000 description 1
- 102000003779 Dipeptidyl-peptidases and tripeptidyl-peptidases Human genes 0.000 description 1
- 108090000194 Dipeptidyl-peptidases and tripeptidyl-peptidases Proteins 0.000 description 1
- AHMIDUVKSGCHAU-UHFFFAOYSA-N Dopaquinone Natural products OC(=O)C(N)CC1=CC(=O)C(=O)C=C1 AHMIDUVKSGCHAU-UHFFFAOYSA-N 0.000 description 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
- 239000004278 EU approved seasoning Substances 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 235000009419 Fagopyrum esculentum Nutrition 0.000 description 1
- 240000008620 Fagopyrum esculentum Species 0.000 description 1
- 208000004930 Fatty Liver Diseases 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 102000013382 Gelatinases Human genes 0.000 description 1
- 108010026132 Gelatinases Proteins 0.000 description 1
- 239000009429 Ginkgo biloba extract Substances 0.000 description 1
- 102000051325 Glucagon Human genes 0.000 description 1
- 108060003199 Glucagon Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 206010056438 Growth hormone deficiency Diseases 0.000 description 1
- 206010019133 Hangover Diseases 0.000 description 1
- 241000193159 Hathewaya histolytica Species 0.000 description 1
- 206010019708 Hepatic steatosis Diseases 0.000 description 1
- 101000757607 Homo sapiens Aquaporin-12A Proteins 0.000 description 1
- 101000908391 Homo sapiens Dipeptidyl peptidase 4 Proteins 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 208000004454 Hyperalgesia Diseases 0.000 description 1
- 208000035154 Hyperesthesia Diseases 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 206010020710 Hyperphagia Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 208000026350 Inborn Genetic disease Diseases 0.000 description 1
- 244000017020 Ipomoea batatas Species 0.000 description 1
- 235000002678 Ipomoea batatas Nutrition 0.000 description 1
- 208000012659 Joint disease Diseases 0.000 description 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- AHMIDUVKSGCHAU-LURJTMIESA-N L-dopaquinone Chemical compound [O-]C(=O)[C@@H]([NH3+])CC1=CC(=O)C(=O)C=C1 AHMIDUVKSGCHAU-LURJTMIESA-N 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
- 240000001929 Lactobacillus brevis Species 0.000 description 1
- 235000013957 Lactobacillus brevis Nutrition 0.000 description 1
- 240000006024 Lactobacillus plantarum Species 0.000 description 1
- 235000013965 Lactobacillus plantarum Nutrition 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- 102100023487 Lens fiber major intrinsic protein Human genes 0.000 description 1
- FURUXTVZLHCCNA-UHFFFAOYSA-N Liquiritigenin Natural products C1=CC(O)=CC=C1C1OC2=CC(O)=CC=C2C(=O)C1 FURUXTVZLHCCNA-UHFFFAOYSA-N 0.000 description 1
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 1
- 238000000134 MTT assay Methods 0.000 description 1
- 231100000002 MTT assay Toxicity 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 102000005741 Metalloproteases Human genes 0.000 description 1
- 108010006035 Metalloproteases Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 108090000189 Neuropeptides Proteins 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 235000011203 Origanum Nutrition 0.000 description 1
- 240000000783 Origanum majorana Species 0.000 description 1
- 229940123973 Oxygen scavenger Drugs 0.000 description 1
- MCPFEAJYKIXPQF-UHFFFAOYSA-N PM-2004-70-458-4 Natural products CC1OC(C2O)OC3C(O)C(O)COC3OC(=O)C3(CCC4(C)C5(C)CCC6C7(CO)C)CCC(C)(C)CC3C4=CCC5C6(C)CC(O)C7OC3OC(CO)C(O)C(O)C3OC(C(C3O)O)OCC3OC(=O)CC(C)(O)CC(=O)OC1C2OC1OCC(O)C(O)C1O MCPFEAJYKIXPQF-UHFFFAOYSA-N 0.000 description 1
- 101150000187 PTGS2 gene Proteins 0.000 description 1
- 241000191996 Pediococcus pentosaceus Species 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 235000004347 Perilla Nutrition 0.000 description 1
- 244000124853 Perilla frutescens Species 0.000 description 1
- 108010001441 Phosphopeptides Proteins 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 206010062519 Poor quality sleep Diseases 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- 102000004005 Prostaglandin-endoperoxide synthases Human genes 0.000 description 1
- 108090000459 Prostaglandin-endoperoxide synthases Proteins 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 208000017442 Retinal disease Diseases 0.000 description 1
- 206010038923 Retinopathy Diseases 0.000 description 1
- 241000124033 Salix Species 0.000 description 1
- 241000133134 Saussurea Species 0.000 description 1
- 239000002262 Schiff base Substances 0.000 description 1
- 150000004753 Schiff bases Chemical class 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- 102000012479 Serine Proteases Human genes 0.000 description 1
- 108010022999 Serine Proteases Proteins 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 240000003768 Solanum lycopersicum Species 0.000 description 1
- 108010073771 Soybean Proteins Proteins 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 230000006044 T cell activation Effects 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 235000005764 Theobroma cacao ssp. cacao Nutrition 0.000 description 1
- 235000005767 Theobroma cacao ssp. sphaerocarpum Nutrition 0.000 description 1
- 235000005158 Thymus praecox ssp. arcticus Nutrition 0.000 description 1
- 235000004054 Thymus serpyllum Nutrition 0.000 description 1
- 240000006001 Thymus serpyllum Species 0.000 description 1
- 206010052779 Transplant rejections Diseases 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- MCPFEAJYKIXPQF-DXZAWUHFSA-N Tubeimoside I Chemical compound O([C@@H]1[C@H]2OC(=O)C[C@@](C)(O)CC(=O)O[C@H]3CO[C@H]([C@@H]([C@H]3O)O)O[C@@H]3[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]3O[C@H]3[C@@H](O)C[C@]4(C)[C@H]5CC=C6[C@@H]7CC(C)(C)CC[C@@]7(CC[C@@]6(C)[C@]5(C)CC[C@H]4[C@@]3(CO)C)C(=O)O[C@@H]3OC[C@H](O)[C@H](O)[C@H]3O[C@@H]([C@@H]1O)O[C@H]2C)[C@@H]1OC[C@@H](O)[C@H](O)[C@H]1O MCPFEAJYKIXPQF-DXZAWUHFSA-N 0.000 description 1
- MCPFEAJYKIXPQF-ILYISTIZSA-N Tubeimoside I Natural products O([C@@H]1[C@@H](O)[C@H](O)[C@H](O)CO1)[C@H]1[C@@H](O)[C@H]2O[C@@H](C)[C@@H]1OC(=O)C[C@@](O)(C)CC(=O)O[C@@H]1[C@H](O)[C@H](O)[C@H](O[C@H]3[C@@H](O)[C@H](O)[C@H](CO)O[C@@H]3O[C@H]3[C@@H](O)C[C@@]4(C)[C@@H]5[C@](C)([C@@]6(C)C([C@H]7[C@@](C(=O)O[C@@H]8OC[C@H](O)[C@H](O)[C@H]8O2)(CC6)CCC(C)(C)C7)=CC5)CC[C@H]4[C@@]3(CO)C)OC1 MCPFEAJYKIXPQF-ILYISTIZSA-N 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 241000219995 Wisteria Species 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009692 acute damage Effects 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- TUFYVOCKVJOUIR-UHFFFAOYSA-N alpha-Thujaplicin Natural products CC(C)C=1C=CC=CC(=O)C=1O TUFYVOCKVJOUIR-UHFFFAOYSA-N 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 229960003473 androstanolone Drugs 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000000043 antiallergic agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 108010018755 aquaporin 0 Proteins 0.000 description 1
- 229960000271 arbutin Drugs 0.000 description 1
- 239000003212 astringent agent Substances 0.000 description 1
- 239000005441 aurora Substances 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 235000015173 baked goods and baking mixes Nutrition 0.000 description 1
- 210000003651 basophil Anatomy 0.000 description 1
- 229960003237 betaine Drugs 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 235000015895 biscuits Nutrition 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 239000011449 brick Substances 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 235000001046 cacaotero Nutrition 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 229940008396 carrot extract Drugs 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 230000021164 cell adhesion Effects 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000003833 cell viability Effects 0.000 description 1
- 230000036755 cellular response Effects 0.000 description 1
- 239000007765 cera alba Substances 0.000 description 1
- 150000001783 ceramides Chemical class 0.000 description 1
- 235000019219 chocolate Nutrition 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 230000009693 chronic damage Effects 0.000 description 1
- 235000016213 coffee Nutrition 0.000 description 1
- 235000013353 coffee beverage Nutrition 0.000 description 1
- 108010006161 conchiolin Proteins 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 210000004087 cornea Anatomy 0.000 description 1
- 210000000736 corneocyte Anatomy 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 235000015140 cultured milk Nutrition 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 235000011850 desserts Nutrition 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 108010067755 dinitrophenyl-bovine serum albumin Proteins 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 235000021186 dishes Nutrition 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 239000010459 dolomite Substances 0.000 description 1
- 229910000514 dolomite Inorganic materials 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- SFNALCNOMXIBKG-UHFFFAOYSA-N ethylene glycol monododecyl ether Chemical compound CCCCCCCCCCCCOCCO SFNALCNOMXIBKG-UHFFFAOYSA-N 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000004299 exfoliation Methods 0.000 description 1
- 210000001723 extracellular space Anatomy 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 102000034240 fibrous proteins Human genes 0.000 description 1
- 108091005899 fibrous proteins Proteins 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 235000011194 food seasoning agent Nutrition 0.000 description 1
- 239000013505 freshwater Substances 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 230000009760 functional impairment Effects 0.000 description 1
- 230000027119 gastric acid secretion Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 230000030136 gastric emptying Effects 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 208000016361 genetic disease Diseases 0.000 description 1
- 229940068052 ginkgo biloba extract Drugs 0.000 description 1
- 235000020686 ginkgo biloba extract Nutrition 0.000 description 1
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 description 1
- 229960004666 glucagon Drugs 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 108091005996 glycated proteins Proteins 0.000 description 1
- 208000035474 group of disease Diseases 0.000 description 1
- 239000007952 growth promoter Substances 0.000 description 1
- 230000003700 hair damage Effects 0.000 description 1
- 230000003660 hair regeneration Effects 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 229940014041 hyaluronate Drugs 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- ARRNBPCNZJXHRJ-UHFFFAOYSA-M hydron;tetrabutylazanium;phosphate Chemical compound OP(O)([O-])=O.CCCC[N+](CCCC)(CCCC)CCCC ARRNBPCNZJXHRJ-UHFFFAOYSA-M 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 210000003016 hypothalamus Anatomy 0.000 description 1
- 235000015243 ice cream Nutrition 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 230000004957 immunoregulator effect Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 210000004969 inflammatory cell Anatomy 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 235000008446 instant noodles Nutrition 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 230000016507 interphase Effects 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
- 229960000310 isoleucine Drugs 0.000 description 1
- JBQATDIMBVLPRB-UHFFFAOYSA-N isoliquiritigenin Natural products OC1=CC(O)=CC=C1C1OC2=CC(O)=CC=C2C(=O)C1 JBQATDIMBVLPRB-UHFFFAOYSA-N 0.000 description 1
- NFIDBGJMFKNGGQ-UHFFFAOYSA-N isopropylmethylphenol Natural products CC(C)CC1=CC=CC=C1O NFIDBGJMFKNGGQ-UHFFFAOYSA-N 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- 208000008106 junctional epidermolysis bullosa Diseases 0.000 description 1
- 230000003780 keratinization Effects 0.000 description 1
- 229940072205 lactobacillus plantarum Drugs 0.000 description 1
- 108010057670 laminin 1 Proteins 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 229940069445 licorice extract Drugs 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 230000004130 lipolysis Effects 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- FURUXTVZLHCCNA-AWEZNQCLSA-N liquiritigenin Chemical compound C1=CC(O)=CC=C1[C@H]1OC2=CC(O)=CC=C2C(=O)C1 FURUXTVZLHCCNA-AWEZNQCLSA-N 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 239000000845 maltitol Substances 0.000 description 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
- 235000010449 maltitol Nutrition 0.000 description 1
- 229940035436 maltitol Drugs 0.000 description 1
- 239000003264 margarine Substances 0.000 description 1
- 235000013310 margarine Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000008268 mayonnaise Substances 0.000 description 1
- 235000010746 mayonnaise Nutrition 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 239000012454 non-polar solvent Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 210000004798 organs belonging to the digestive system Anatomy 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 210000002488 outer root sheath cell Anatomy 0.000 description 1
- 235000020830 overeating Nutrition 0.000 description 1
- 238000012261 overproduction Methods 0.000 description 1
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 description 1
- MNBKLUUYKPBKDU-BBECNAHFSA-N palmitoyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCCCCCCCCCCCCCC)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MNBKLUUYKPBKDU-BBECNAHFSA-N 0.000 description 1
- 210000002571 pancreatic alpha cell Anatomy 0.000 description 1
- 230000001936 parietal effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 235000021110 pickles Nutrition 0.000 description 1
- 210000004694 pigment cell Anatomy 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 206010036067 polydipsia Diseases 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 239000002599 prostaglandin synthase inhibitor Substances 0.000 description 1
- 208000023958 prostate neoplasm Diseases 0.000 description 1
- 235000019833 protease Nutrition 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 235000021067 refined food Nutrition 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 235000013580 sausages Nutrition 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 235000012046 side dish Nutrition 0.000 description 1
- 238000010898 silica gel chromatography Methods 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 230000037380 skin damage Effects 0.000 description 1
- 230000036620 skin dryness Effects 0.000 description 1
- 230000037394 skin elasticity Effects 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 235000011888 snacks Nutrition 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229940037001 sodium edetate Drugs 0.000 description 1
- GSZUGBAEBARHAW-UHFFFAOYSA-N sophoraflavone B Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(C=2OC3=CC(O)=CC=C3C(=O)C=2)C=C1 GSZUGBAEBARHAW-UHFFFAOYSA-N 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 235000019710 soybean protein Nutrition 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- WNIFXKPDILJURQ-UHFFFAOYSA-N stearyl glycyrrhizinate Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C)CCC(C(=O)OCCCCCCCCCCCCCCCCCC)(C)CC5C4=CC(=O)C3C21C WNIFXKPDILJURQ-UHFFFAOYSA-N 0.000 description 1
- 231100000240 steatosis hepatitis Toxicity 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000003270 steroid hormone Substances 0.000 description 1
- 235000013547 stew Nutrition 0.000 description 1
- 238000003883 substance clean up Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 230000008728 vascular permeability Effects 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000002349 well water Substances 0.000 description 1
- 235000020681 well water Nutrition 0.000 description 1
- 239000008256 whipped cream Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 238000004383 yellowing Methods 0.000 description 1
- 229930007845 β-thujaplicin Natural products 0.000 description 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Cosmetics (AREA)
- Non-Alcoholic Beverages (AREA)
Description
本実施形態の抗老化剤、美白剤、育毛剤、抗男性ホルモン剤、抗炎症剤、抗肥満剤、サイクリックAMPホスホジエステラーゼ活性阻害剤、グルタチオン低下抑制剤およびジペプチジルペプチダーゼIV活性阻害剤は、4-ビニルカテコールを有効成分とするものである。また、本実施形態の皮膚化粧料、頭髪化粧料および飲食品は、4-ビニルカテコールが配合されるものである。
以上のようにして得られる4-ビニルカテコールは、優れた抗老化作用、美白作用、育毛作用、抗男性ホルモン作用、抗炎症作用、抗肥満作用、サイクリックAMP(cAMP)ホスホジエステラーゼ活性阻害作用、グルタチオン低下抑制作用およびジペプチジルペプチダーゼIV(DPPIV)活性阻害作用を有しているため、抗老化剤、美白剤、育毛剤、抗男性ホルモン剤、抗炎症剤、抗肥満剤、cAMPホスホジエステラーゼ活性阻害剤、グルタチオン低下抑制剤およびDPPIV活性阻害剤の有効成分として用いることができる。本実施形態の抗老化剤、美白剤、育毛剤、抗男性ホルモン剤、抗炎症剤、抗肥満剤、cAMPホスホジエステラーゼ活性阻害剤、グルタチオン低下抑制剤およびDPPIV活性阻害剤は、医薬品、医薬部外品、化粧品等の幅広い用途に使用することができる。
4-ビニルカテコールは、優れた抗老化作用、美白作用、育毛作用、抗男性ホルモン作用、抗炎症作用、抗肥満作用、cAMPホスホジエステラーゼ活性阻害作用、グルタチオン低下抑制作用およびDPPIV活性阻害作用を有しているため、皮膚化粧料または頭髪化粧料に配合するのに好適である。この場合、4-ビニルカテコールまたは4-ビニルカテコールを含有する組成物をそのまま配合してもよいし、4-ビニルカテコールまたは4-ビニルカテコールを含有する組成物から製剤化した抗老化剤、美白剤、育毛剤、抗男性ホルモン剤、抗炎症剤、抗肥満剤、cAMPホスホジエステラーゼ活性阻害剤、グルタチオン低下抑制剤またはDPPIV活性阻害剤を配合してもよい。
4-ビニルカテコールは、優れた抗老化作用、美白作用、育毛作用、抗男性ホルモン作用、抗炎症作用、抗肥満作用、cAMPホスホジエステラーゼ活性阻害作用、グルタチオン低下抑制作用およびDPPIV活性阻害作用を有しているため、飲食品に配合するのに好適である。この場合、4-ビニルカテコールをそのまま配合してもよいし、4-ビニルカテコールから製剤化した抗老化剤、美白剤、育毛剤、抗男性ホルモン剤、抗炎症剤、抗肥満剤、cAMPホスホジエステラーゼ活性阻害剤、グルタチオン低下抑制剤またはDPPIV活性阻害剤を配合してもよい。
4-ビニルカテコール(試料1)について、以下のようにしてグルタチオン産生促進作用を試験した。
式中の各項はそれぞれ以下を表す。
A:試料無添加における総タンパク量当たりのグルタチオン量
B:被験試料添加における総タンパク量当たりのグルタチオン量
結果を表1に示す。
4-ビニルカテコール(試料1)について、以下のようにしてラミニン5産生促進作用を試験した。
式中の各項はそれぞれ以下を表す。
A:被験試料添加でのラミニン5量
B:試料無添加でのラミニン5量
結果を表2に示す。
4-ビニルカテコール(試料1)について、以下のようにしてMMP-1活性阻害作用を試験した。
式中の各項はそれぞれ以下を表す。
A:試料無添加・酵素添加での波長320nmにおける吸光度
B:試料無添加・酵素無添加での波長320nmにおける吸光度
C:被験試料添加・酵素添加での波長320nmにおける吸光度
D:被験試料添加・酵素無添加での波長320nmにおける吸光度
結果を表3に示す。
4-ビニルカテコール(試料1)について、以下のようにして最終糖化生成物(AGEs)の分解促進作用を試験した。
式中の各項はそれぞれ以下を表す。
A:陰性対照での波長405nmにおける吸光度
B:試料無添加(陽性対照)での波長405nmにおける吸光度
C:被験試料添加での波長405nmにおける吸光度
結果を表4に示す。
4-ビニルカテコール(試料1)について、以下のようにして最終糖化生成物(AGEs)の形成抑制作用を試験した。
式中の各項はそれぞれ以下を表す。
A:陰性対照での波長405nmにおける吸光度
B:試料無添加(陽性対照)での波長405nmにおける吸光度
C:被験試料添加での波長405nmにおける吸光度
結果を表5に示す。
4-ビニルカテコール(試料1)について、以下のようにしてI型コラーゲン産生促進作用を試験した。
式中の各項はそれぞれ以下を表す。
A:被験試料添加でのI型コラーゲン量
B:試料無添加でのI型コラーゲン量
結果を表6に示す。
MMP-2は、特開2007-217352号公報に記載の方法により調製したものを用いた。すなわち、MMP-2タンパク質を、C末端にヒスチジン6残基を持つ組換え体proMMPタンパク質として大腸菌遺伝子発現系を用い大量発現させ、Ni-NTA樹脂を用いた精製およびリフォールディングを行った後、活性型へ移行させた。これを酵素標品とし、適宜希釈し酵素溶液を調製した。
得られた酵素溶液を用い、4-ビニルカテコール(試料1)について、以下のようにしてMMP-2活性阻害作用を試験した。
式中の各項はそれぞれ以下を表す。
A:試料無添加・基質添加120分後での波長420nmにおける蛍光強度
B:試料無添加・基質添加直後での波長420nmにおける蛍光強度
C:被験試料添加・基質添加120分後での波長420nmにおける蛍光強度
D:被験試料添加・基質添加直後での波長420nmにおける蛍光強度
結果を表7に示す。
4-ビニルカテコール(試料1)について、以下のようにしてSPTmRNA発現促進作用を試験した。
式中の各項はそれぞれ以下を表す。
A:被験試料添加での補正値
B:試料無添加での補正値
結果を表8に示す。
4-ビニルカテコール(試料1)について、以下のようにしてAQP3mRNA発現促進作用を試験した。
式中の各項はそれぞれ以下を表す。
A:被験試料添加での補正値
B:試料無添加での補正値
結果を表9に示す。
4-ビニルカテコール(試料1)について、以下のようにしてチロシナーゼ活性阻害作用を試験した。
式中の各項はそれぞれ以下を表す。
St:被験試料添加・酵素添加での波長475nmにおける吸光度
Sb:被験試料添加・酵素無添加での波長475nmにおける吸光度
Ct:試料無添加・酵素添加での波長475nmにおける吸光度
Cb:試料無添加・酵素無添加での波長475nmにおける吸光度
結果を表10に示す。
4-ビニルカテコール(試料1)について、以下のようにしてB16メラノーマ細胞に対するメラニン産生抑制作用を試験した。
式中の各項はそれぞれ以下を表す。
A:試料無添加におけるメラニン量
B:被験試料添加におけるメラニン量
C:試料無添加での波長540nmにおける吸光度
D:被験試料添加での波長540nmにおける吸光度
結果を表11に示す。
4-ビニルカテコール(試料1)について、以下のようにしてテストステロン5α-レダクターゼ阻害作用を試験した。
使用装置:Shimadzu GC-2010(島津製作所社製)
カラム:DB-1701(内径:0.53mm,長さ:30m,膜厚:1.0μm)(J&W Scientific社製)
カラム温度:240℃
注入口温度:300℃
検出器:FID
試料注入量:1μL
スプリット比:1:2
キャリアガス:窒素ガス
キャリアガス流速:3mL/min
3α-アンドロスタンジオール、5α-DHTおよびテストステロンの標準品を塩化メチレンに溶解し、当該溶液をガスクロマトグラフィー分析に供し、これらの化合物の濃度(μg/mL)およびピーク面積から、ピーク面積と化合物の濃度との対応関係を予め求めておいた。そして、テストステロンとS-9との反応後の3α-アンドロスタンジオール、5α-DHTおよびテストステロンのそれぞれのピーク面積あたりの濃度を、予め求めておいた対応関係を利用して、下記式(1)に基づいて求めた。
式中の各項はそれぞれ以下を表す。
A:3α-アンドロスタンジオール、5α-DHTまたはテストステロンの濃度
B:3α-アンドロスタンジオール、5α-DHTまたはテストステロンのピーク面積
C:標準品の濃度
D:標準品のピーク面積
式中の各項はそれぞれ以下を表す。
E:3α-アンドロスタンジオールの濃度(μg/mL)
F:5α-DHTの濃度(μg/mL)
G:テストステロンの濃度(μg/mL)
テストステロン5α-レダクターゼ阻害率(%)=(1-H/I)×100・・・(3)
式中の各項はそれぞれ以下を表す。
H:被検試料添加での変換率
I:試料無添加での変換率
結果を表12に示す。
4-ビニルカテコール(試料1)について、以下のようにして毛乳頭細胞増殖促進作用を試験した。
式中の各項はそれぞれ以下を表す。
A:被験試料添加でのブルーホルマザン生成量
B:試料無添加でのブルーホルマザン生成量
結果を表13に示す。
0.1mol/L酢酸緩衝液(pH3.5)に溶解した被験試料(試料1,試料濃度は下記表14を参照)0.2mLに、ヒアルロニダーゼ溶液(SIGMA社製,Type IV-S,from bovine testes,400 NF units/mL)0.1mLを加え、37℃で20分間静置した。さらに、活性化剤として2.5mmol/L塩化カルシウム0.2mLを加え、37℃で20分間静置した。これに0.8mg/mLヒアルロン酸ナトリウム溶液(from rooster comb)0.5mLを加え、37℃で40分間反応した。その後、0.4mol/L水酸化ナトリウム0.2mLを加えて反応を止め冷却した後、各反応溶液にホウ酸溶液0.2mLを加え、3分間煮沸した。氷冷後、p-DABA試薬6mLを加え、37℃で20分間反応した。その後、波長585nmにおける吸光度を測定した。
ヒアルロニダーゼ活性阻害率(%)={1-(St-Sb)/(Ct-Cb)}×100
式中の各項はそれぞれ以下を表す。
St:被験試料添加・酵素添加での波長585nmにおける吸光度
Sb:被験試料添加・酵素無添加での波長585nmにおける吸光度
Ct:試料無添加・酵素添加での波長585nmにおける吸光度
Cb:試料無添加・酵素無添加での波長585nmにおける吸光度
結果を表14に示す。
4-ビニルカテコール(試料1)について、以下のようにしてヘキソサミニダーゼ遊離抑制作用を試験した。
式中の各項はそれぞれ以下を表す。
A:試料無添加での補正値
B:被験試料添加での補正値
C:被験試料添加・p-NAG無添加での補正値
結果を表15に示す。
マウスマクロファージ細胞(RAW264.7)を、10%FBS含有ダルベッコMEM培地を用いて培養した後、セルスクレーパーにより細胞を回収した。回収した細胞を2.0×105 cells/mLの濃度になるように10%FBS含有ダルベッコMEM培地で希釈した後、96ウェルプレートに1ウェル当たり100μLずつ播種し、18時間培養した。
式中の各項はそれぞれ以下を表す。
A:被験試料添加・LPS刺激でのプロスタグランジンE2 量
B:試料無添加・LPS刺激でのプロスタグランジンE2 量
C:試料無添加・LPS無刺激でのプロスタグランジンE2 量
結果を表16に示す。
正常ヒト新生児表皮角化細胞(NHEK)を、正常ヒト表皮角化細胞用増殖培地(KGM)を用いて培養した後、トリプシン処理により細胞を回収した。回収した細胞を12.5×104 cells/mLの細胞密度になるようKGM培地で希釈した後、コラーゲンコートした48ウェルプレートに1ウェル当たり200μLずつ播種し(2.5×104 cells/ウェル)、一晩培養した。細胞が定着したことを確認した後、hydrocortisone(ハイドロコルチゾン)を抜いたKGM培地200μLにて、24時間培養した。
式中の各項はそれぞれ以下を表す。
A:被験試料添加・紫外線照射でのプロスタグランジンE2 量
B:試料無添加・紫外線照射でのプロスタグランジンE2 量
C:試料無添加・紫外線未照射でのプロスタグランジンE2 量
結果を表17に示す。
4-ビニルカテコール(試料1)について、以下のようにしてサイクリックAMPホスホジエステラーゼ活性阻害作用を試験した。
製品名:Chromatocorder 12(SYSTEM INSTRUMENTS社製)
固定相:Wakosil C18-ODS 5μm(和光純薬工業社製)
カラム長:250mm
移動相:1mmol/L TBAP in 25mmol/L KH2PO4 :CH3CN=90:10
移動相流速:1.0mL/min
検出:260nm
被験試料添加での標準品の分解率(D,%)=(1-B2/A)×100
cAMPホスホジエステラーゼ活性阻害率(%)=(1-D/C)×100
結果を表18に示す。
正常ヒト肝細胞を、10%FBS含有ダルベッコMEM培地を用いて培養した後、トリプシン処理により細胞を回収した。回収した細胞を10×104 cells/mLの細胞密度になるよう10%FBS含有ダルベッコMEM培地で希釈した後、48ウェルプレートに1ウェル当たり200μLずつ播種し、一晩培養した。
式中の各項はそれぞれ以下を表す。
Nt:ガラクトサミン塩酸塩非処理(非処理群)のにおける総タンパク量当たりのグルタチオン量
C :試料無添加・ガラクトサミン塩酸塩処理(処理群)における総タンパク量当たりのグルタチオン量
Sa:被験試料添加・ガラクトサミン塩酸塩処理における総タンパク量当たりのグルタチオン量
結果を表19に示す。
4-ビニルカテコール(試料1)について、以下のようにしてジペプチジルペプチダーゼIV(DPPIV)阻害作用を試験した。
式中の各項はそれぞれ以下を表す。
A:試料無添加・酵素添加での波長415nmにおける吸光度
B:試料無添加・酵素無添加での波長415nmにおける吸光度
C:被験試料添加・酵素添加での波長415nmにおける吸光度
D:被験試料添加・酵素無添加での波長415nmにおける吸光度
結果を表20に示す。
下記組成の乳液を常法により製造した。
4-ビニルカテコール 0.01g
ホホバオイル 4.00g
1,3-ブチレングリコール 3.00g
アルブチン 3.00g
ポリオキシエチレンセチルエーテル(20E.O.) 2.50g
オリーブオイル 2.00g
スクワラン 2.00g
セタノール 2.00g
モノステアリン酸グリセリル 2.00g
オレイン酸ポリオキシエチレンソルビタン(20E.O.) 2.00g
パラオキシ安息香酸メチル 0.15g
グリチルリチン酸ステアリル 0.10g
黄杞エキス 0.10g
グリチルリチン酸ジカリウム 0.10g
イチョウ葉エキス 0.10g
コンキオリン 0.10g
オウバクエキス 0.10g
カミツレエキス 0.10g
香料 0.05g
精製水 残部(全量を100gとする)
下記組成のクリームを常法により製造した。
4-ビニルカテコール 0.05g
クジンエキス 0.1g
オウゴンエキス 0.1g
流動パラフィン 5.0g
サラシミツロウ 4.0g
スクワラン 10.0g
セタノール 3.0g
ラノリン 2.0g
ステアリン酸 1.0g
オレイン酸ポリオキシエチレンソルビタン(20E.O.) 1.5g
モノステアリン酸グリセリル 3.0g
油溶性甘草エキス 0.1g
1,3-ブチレングリコール 6.0g
パラオキシ安息香酸メチル 1.5g
香料 0.1g
精製水 残部(全量を100gとする)
下記組成の美容液を常法により製造した。
4-ビニルカテコール 0.01g
カミツレエキス 0.1g
ニンジンエキス 0.1g
キサンタンガム 0.3g
ヒドロキシエチルセルロース 0.1g
カルボキシビニルポリマー 0.1g
1,3-ブチレングリコール 4.0g
グリチルリチン酸ジカリウム 0.1g
グリセリン 2.0g
水酸化カリウム 0.25g
香料 0.01g
防腐剤(パラオキシ安息香酸メチル) 0.15g
エタノール 2.0g
精製水 残部(全量を100gとする)
下記組成のヘアトニックを常法により製造した。
4-ビニルカテコール 0.4g
酢酸トコフェロール 適量
セファラチン 0.002g
イソプロピルメチルフェノール 0.1g
ヒアルロン酸ナトリウム 0.15g
グリセリン 15.0g
エタノール 15.0g
香料 適量
キレート剤(エデト酸ナトリウム) 適量
防腐剤(ヒノキチオール) 適量
可溶化剤(ポリオキシエチレンセチルエーテル) 適量
精製水 残部(全量を100gとする)
下記組成のシャンプーを常法により製造した。
4-ビニルカテコール 0.5g
マジョラム抽出物 1.0g
ウメ果実部抽出物 0.2g
ヤシ油脂肪酸メチルタウリンナトリウム 10.0g
ヤシ油脂肪酸アミドプロピルベタイン 10.0g
ポリオキシエチレンアルキルエーテル硫酸ナトリウム 20.0g
ヤシ油脂肪酸ジエタノールアミド 4.0g
プロピレングリコール 2.0g
香料 適量
精製水 残部(全量を100gとする)
常法により、以下の組成を有する錠剤を製造した。
4-ビニルカテコール 5.0mg
ドロマイト(カルシウム20%、マグネシウム10%含有) 83.4mg
カゼインホスホペプチド 16.7mg
ビタミンC 33.4mg
マルチトール 136.8mg
コラーゲン 12.7mg
ショ糖脂肪酸エステル 12.0mg
常法により、以下の組成を有する経口液状製剤を製造した。
<1アンプル(1本100mL)中の組成>
4-ビニルカテコール 0.3質量%
ソルビット 12.0質量%
安息香酸ナトリウム 0.1質量%
香料 1.0質量%
硫酸カルシウム 0.5質量%
精製水 残部(100質量%)
Claims (2)
- 4-ビニルカテコールを有効成分とすることを特徴とするグルタチオン低下抑制剤。
- 4-ビニルカテコールを配合した飲食品であって、
グルタチオン低下抑制用途に用いられることを特徴とする飲食品。
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2021184224A JP7351541B2 (ja) | 2014-10-21 | 2021-11-11 | 皮膚化粧料、頭髪化粧料および飲食品 |
JP2023144867A JP2023162426A (ja) | 2014-10-21 | 2023-09-06 | 皮膚化粧料、頭髪化粧料および飲食品 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2014214882A JP6666650B2 (ja) | 2014-10-21 | 2014-10-21 | 皮膚化粧料、頭髪化粧料および飲食品 |
JP2020002886A JP6981685B2 (ja) | 2014-10-21 | 2020-01-10 | 皮膚化粧料、頭髪化粧料および飲食品 |
JP2021184224A JP7351541B2 (ja) | 2014-10-21 | 2021-11-11 | 皮膚化粧料、頭髪化粧料および飲食品 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2020002886A Division JP6981685B2 (ja) | 2014-10-21 | 2020-01-10 | 皮膚化粧料、頭髪化粧料および飲食品 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2023144867A Division JP2023162426A (ja) | 2014-10-21 | 2023-09-06 | 皮膚化粧料、頭髪化粧料および飲食品 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2022017573A JP2022017573A (ja) | 2022-01-25 |
JP7351541B2 true JP7351541B2 (ja) | 2023-09-27 |
Family
ID=79170151
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2020002886A Active JP6981685B2 (ja) | 2014-10-21 | 2020-01-10 | 皮膚化粧料、頭髪化粧料および飲食品 |
JP2021184224A Active JP7351541B2 (ja) | 2014-10-21 | 2021-11-11 | 皮膚化粧料、頭髪化粧料および飲食品 |
JP2023144867A Pending JP2023162426A (ja) | 2014-10-21 | 2023-09-06 | 皮膚化粧料、頭髪化粧料および飲食品 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2020002886A Active JP6981685B2 (ja) | 2014-10-21 | 2020-01-10 | 皮膚化粧料、頭髪化粧料および飲食品 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2023144867A Pending JP2023162426A (ja) | 2014-10-21 | 2023-09-06 | 皮膚化粧料、頭髪化粧料および飲食品 |
Country Status (1)
Country | Link |
---|---|
JP (3) | JP6981685B2 (ja) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010501023A (ja) | 2006-08-18 | 2010-01-14 | サントル、ナショナール、ド、ラ、ルシェルシュ、シアンティフィク、(セーエヌエルエス) | チコリ酸および/またはその代謝産物の1つを含有する抗糖尿病組成物 |
JP2011518570A (ja) | 2008-04-30 | 2011-06-30 | ネステク ソシエテ アノニム | コーヒーのクロロゲン酸に由来する脱炭酸したフェノール酸を含む生成物、及びその使用 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9903216D0 (en) * | 1999-02-13 | 1999-04-07 | Zylepsis Ltd | Preservative compounds,compositions and methods of making and using the same |
-
2020
- 2020-01-10 JP JP2020002886A patent/JP6981685B2/ja active Active
-
2021
- 2021-11-11 JP JP2021184224A patent/JP7351541B2/ja active Active
-
2023
- 2023-09-06 JP JP2023144867A patent/JP2023162426A/ja active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010501023A (ja) | 2006-08-18 | 2010-01-14 | サントル、ナショナール、ド、ラ、ルシェルシュ、シアンティフィク、(セーエヌエルエス) | チコリ酸および/またはその代謝産物の1つを含有する抗糖尿病組成物 |
JP2011518570A (ja) | 2008-04-30 | 2011-06-30 | ネステク ソシエテ アノニム | コーヒーのクロロゲン酸に由来する脱炭酸したフェノール酸を含む生成物、及びその使用 |
Also Published As
Publication number | Publication date |
---|---|
JP2023162426A (ja) | 2023-11-08 |
JP6981685B2 (ja) | 2021-12-17 |
JP2022017573A (ja) | 2022-01-25 |
JP2020062046A (ja) | 2020-04-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP7390755B2 (ja) | 皮膚化粧料、頭髪化粧料および飲食品 | |
JP6670166B2 (ja) | 化粧料 | |
JP5863721B2 (ja) | 肥満解消剤、脂肪分解促進剤、サイクリックamp−ホスホジエステラーゼ活性阻害剤、及びラット副睾丸脂肪細胞の脂肪分解促進剤 | |
JP2009051790A (ja) | 抗酸化剤、抗老化剤、抗炎症剤、育毛剤、抗肥満剤、及び美白剤、並びに化粧料及び美容用飲食品 | |
JP6969067B2 (ja) | 抗炎症剤、抗老化剤および美白剤 | |
JP2023166625A (ja) | 皮膚化粧料、頭髪化粧料および飲食品 | |
JP6666650B2 (ja) | 皮膚化粧料、頭髪化粧料および飲食品 | |
JP5936925B2 (ja) | マトリックスメタロプロテアーゼ−2(MMP−2)活性阻害剤、マトリックスメタロプロテアーゼ−9(MMP−9)mRNA発現上昇抑制剤、表皮角化細胞増殖促進剤、アンドロゲンレセプター拮抗剤、毛乳頭細胞増殖促進剤、エンドセリン−1mRNA発現上昇抑制剤、及びSCFmRNA発現上昇抑制剤 | |
JP2012162487A (ja) | 美白剤、抗老化剤及び皮膚化粧料 | |
JP7351541B2 (ja) | 皮膚化粧料、頭髪化粧料および飲食品 | |
JP6709587B2 (ja) | 皮膚化粧料および頭髪化粧料 | |
JP6993627B2 (ja) | 皮膚化粧料、頭髪化粧料および飲食品 | |
JP7215761B2 (ja) | 経口組成物、皮膚化粧料および頭髪化粧料 | |
JP6993628B2 (ja) | 皮膚化粧料、頭髪化粧料および飲食品 | |
JP7253283B2 (ja) | 化粧料および飲食品組成物 | |
JP5419259B2 (ja) | 化粧料 | |
JP2023008540A (ja) | メタボリックシンドローム改善剤及びメタボリックシンドローム改善用組成物、肝機能向上剤及び肝機能向上用組成物、免疫賦活剤及び免疫賦活用組成物、抗炎症剤及び抗炎症用組成物、抗老化剤及び抗老化用組成物、美白剤及び美白用組成物、育毛剤及び育毛用組成物、並びに抗酸化剤及び抗酸化用組成物 | |
JP2010105949A (ja) | 皮膚化粧料及び飲食品 | |
JP2023008538A (ja) | 痛風改善剤及び痛風改善用組成物、肝機能向上剤及び肝機能向上用組成物、免疫賦活剤及び免疫賦活用組成物、抗老化剤及び抗老化用組成物、抗炎症剤及び抗炎症用組成物、育毛剤及び育毛用組成物、並びに抗酸化剤及び抗酸化用組成物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20211213 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20230124 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20230322 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20230525 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20230808 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20230907 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 7351541 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |