JP6336389B2 - Ａｔｐ結合部位に変異を有するエンドスタチン変異体 - Google Patents
Ａｔｐ結合部位に変異を有するエンドスタチン変異体 Download PDFInfo
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110280441.8 | 2011-09-09 | ||
| CN201110280441 | 2011-09-09 | ||
| PCT/CN2012/081210 WO2013034116A1 (fr) | 2011-09-09 | 2012-09-10 | Mutant de myostatine endothéliale vasculaire qui est muté au niveau de sites de liaison à l'atp |
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| Publication Number | Publication Date |
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| JP2014531897A JP2014531897A (ja) | 2014-12-04 |
| JP2014531897A5 JP2014531897A5 (fr) | 2015-11-05 |
| JP6336389B2 true JP6336389B2 (ja) | 2018-06-06 |
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| JP2014528847A Active JP6336389B2 (ja) | 2011-09-09 | 2012-09-10 | Ａｔｐ結合部位に変異を有するエンドスタチン変異体 |
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| Country | Link |
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| US (1) | US10647968B2 (fr) |
| EP (1) | EP2754718B1 (fr) |
| JP (1) | JP6336389B2 (fr) |
| CN (2) | CN108291248B (fr) |
| AU (1) | AU2012306826B2 (fr) |
| CA (1) | CA2848118C (fr) |
| HK (1) | HK1251864A1 (fr) |
| IL (1) | IL231419A0 (fr) |
| RU (1) | RU2014113924A (fr) |
| WO (1) | WO2013034116A1 (fr) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104926933B (zh) * | 2014-03-19 | 2018-09-07 | 北京仁和天通生物科技有限公司 | Endostatin突变体、Endostatin突变体与聚乙二醇的交联物以及它们的应用 |
| AU2015342324B2 (en) * | 2014-11-03 | 2021-08-19 | Beijing Protgen Ltd. | Drug for inhibiting adipose cell differentiation and insulin resistance |
| JP6896636B2 (ja) * | 2015-02-13 | 2021-06-30 | 清華大学Ｔｓｉｎｇｈｕａ Ｕｎｉｖｅｒｓｉｔｙ | 組換えタンパク質薬の分子設計 |
| CN106674352B (zh) * | 2015-11-10 | 2020-05-15 | 孙嘉琳 | 抗肿瘤蛋白内皮抑素的衍生物及应用 |
| CN109963597B (zh) * | 2016-11-10 | 2022-08-26 | 北京普罗吉生物科技发展有限公司 | 聚乙二醇化血管内皮抑制素类似物及其应用 |
| JP7492687B2 (ja) * | 2017-07-30 | 2024-05-30 | 清華大学 | Ｄｎａ－ｐｋｃｓを阻害するための薬物治療 |
| CN114645025B (zh) * | 2022-04-13 | 2023-12-22 | 南开大学 | 一种人源atp合成酶的纯化方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2313705A1 (fr) * | 1997-12-08 | 1999-06-17 | Beth Israel Deaconess Medical Center | Restine et ses methodes d'utilisation |
| WO2000067771A1 (fr) * | 1999-05-06 | 2000-11-16 | The Burnham Institute | Peptides d'endostatine anti-angiogenique, variantes d'endostatine et procedes d'utilisation |
| CN1237072C (zh) | 2000-05-22 | 2006-01-18 | 烟台荣昌生物工程有限公司 | 生产内皮抑制素的方法 |
| JP4511108B2 (ja) | 2002-05-31 | 2010-07-28 | オンコリクス インコーポレイテッド | ヒトプロラクチン拮抗剤−血管新生阻害剤融合蛋白質 |
| CN100475270C (zh) * | 2006-01-20 | 2009-04-08 | 清华大学 | 一种治疗肿瘤的药物及其应用 |
| CN101143894A (zh) * | 2007-06-22 | 2008-03-19 | 中国药科大学 | 高效抑制血管生成多肽及其物理化学修饰方法和应用 |
| EP2270055A4 (fr) | 2008-04-04 | 2011-06-29 | Procell Therapeutics Inc | Protéine recombinante d'endostatine à cellules perméables |
| CN101256139A (zh) | 2008-04-18 | 2008-09-03 | 山东先声麦得津生物制药有限公司 | 一种血管内皮抑制素生物活性的检测方法 |
| CN101890155B (zh) * | 2010-05-25 | 2012-07-25 | 江苏先声药物研究有限公司 | 一种药物组合物及其应用 |
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2012
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- 2012-09-10 WO PCT/CN2012/081210 patent/WO2013034116A1/fr active Application Filing
- 2012-09-10 CN CN201280078261.4A patent/CN108291248B/zh active Active
- 2012-09-10 CN CN202410186085.0A patent/CN117987505A/zh active Pending
- 2012-09-10 EP EP12830317.9A patent/EP2754718B1/fr active Active
- 2012-09-10 CA CA2848118A patent/CA2848118C/fr active Active
- 2012-09-10 AU AU2012306826A patent/AU2012306826B2/en active Active
- 2012-09-10 JP JP2014528847A patent/JP6336389B2/ja active Active
- 2012-09-10 RU RU2014113924/10A patent/RU2014113924A/ru not_active Application Discontinuation
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2014
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2018
- 2018-08-23 HK HK18110856.2A patent/HK1251864A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN117987505A (zh) | 2024-05-07 |
| CA2848118A1 (fr) | 2013-03-14 |
| EP2754718B1 (fr) | 2017-12-13 |
| HK1251864A1 (zh) | 2019-04-26 |
| US10647968B2 (en) | 2020-05-12 |
| RU2014113924A (ru) | 2015-10-20 |
| AU2012306826A1 (en) | 2014-04-03 |
| AU2012306826B2 (en) | 2018-01-04 |
| CA2848118C (fr) | 2023-09-05 |
| JP2014531897A (ja) | 2014-12-04 |
| US20140308263A1 (en) | 2014-10-16 |
| WO2013034116A1 (fr) | 2013-03-14 |
| EP2754718A1 (fr) | 2014-07-16 |
| CN108291248B (zh) | 2024-03-08 |
| US20150197733A9 (en) | 2015-07-16 |
| IL231419A0 (en) | 2014-04-30 |
| EP2754718A4 (fr) | 2015-04-22 |
| CN108291248A (zh) | 2018-07-17 |
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