JP6334529B2 - イサブコナゾールまたはラブコナゾールの製造方法 - Google Patents
イサブコナゾールまたはラブコナゾールの製造方法 Download PDFInfo
- Publication number
- JP6334529B2 JP6334529B2 JP2015525826A JP2015525826A JP6334529B2 JP 6334529 B2 JP6334529 B2 JP 6334529B2 JP 2015525826 A JP2015525826 A JP 2015525826A JP 2015525826 A JP2015525826 A JP 2015525826A JP 6334529 B2 JP6334529 B2 JP 6334529B2
- Authority
- JP
- Japan
- Prior art keywords
- ester
- formula
- solvent
- amino acid
- iii
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 *c(cc1C(C[n]2ncnc2)=O)c(*)cc1F Chemical compound *c(cc1C(C[n]2ncnc2)=O)c(*)cc1F 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12179540.5 | 2012-08-07 | ||
| EP12179540 | 2012-08-07 | ||
| PCT/EP2013/066071 WO2014023623A1 (en) | 2012-08-07 | 2013-07-31 | Process for the manufacture of isavuconazole or ravuconazole |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015527345A JP2015527345A (ja) | 2015-09-17 |
| JP2015527345A5 JP2015527345A5 (enExample) | 2016-09-15 |
| JP6334529B2 true JP6334529B2 (ja) | 2018-05-30 |
Family
ID=48979725
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015525826A Active JP6334529B2 (ja) | 2012-08-07 | 2013-07-31 | イサブコナゾールまたはラブコナゾールの製造方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US9783508B2 (enExample) |
| EP (1) | EP2882723B1 (enExample) |
| JP (1) | JP6334529B2 (enExample) |
| KR (1) | KR102129150B1 (enExample) |
| CN (1) | CN104507917B (enExample) |
| BR (1) | BR112015002526B1 (enExample) |
| CA (1) | CA2878361C (enExample) |
| ES (1) | ES2616412T3 (enExample) |
| HR (1) | HRP20170171T1 (enExample) |
| HU (1) | HUE031679T2 (enExample) |
| MX (1) | MX360783B (enExample) |
| PL (1) | PL2882723T3 (enExample) |
| PT (1) | PT2882723T (enExample) |
| SI (1) | SI2882723T1 (enExample) |
| WO (1) | WO2014023623A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105801500B (zh) * | 2014-12-31 | 2018-08-24 | 四川科伦药物研究院有限公司 | 拆分艾沙康唑中间化合物消旋体的方法 |
| CN106317044A (zh) * | 2015-06-30 | 2017-01-11 | 刘玫君 | 一种制造艾沙康唑或雷夫康唑的方法 |
| CN104961695A (zh) * | 2015-07-27 | 2015-10-07 | 成都塞恩斯医药科技有限公司 | 一种艾沙康唑和雷夫康唑中间体的制备方法 |
| CN106467534B (zh) * | 2015-08-17 | 2019-10-11 | 江苏奥赛康药业有限公司 | 一种硫酸艾沙康唑鎓化合物及其药物组合物 |
| CN105907832B (zh) * | 2015-12-02 | 2019-07-12 | 成都师范学院 | 一种酶法拆分艾沙康唑中间体的方法 |
| CN108452848B (zh) * | 2016-02-24 | 2020-12-11 | 上海兰立生物科技有限公司 | 一种催化剂 |
| WO2018200214A2 (en) * | 2017-04-27 | 2018-11-01 | Codexis, Inc. | Ketoreductase polypeptides and polynucleotides |
| WO2021245590A1 (en) * | 2020-06-04 | 2021-12-09 | Metrochem Api Private Limited | An improved process for the preparation of triazole derivatives |
| CN111574444A (zh) * | 2020-07-07 | 2020-08-25 | 安徽贝克生物制药有限公司 | 一种贝达喹啉的制备方法 |
| CN116478103B (zh) * | 2023-03-24 | 2025-07-25 | 四川澄华生物科技有限公司 | 一种拆分艾沙康唑中间体4的方法 |
| CN119661453B (zh) * | 2025-02-17 | 2025-04-22 | 四川澄华生物科技有限公司 | 一种制备艾沙康唑的主链中间体的方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8510195D0 (en) * | 1985-04-22 | 1985-05-30 | Ici Plc | Heterocyclic compounds |
| US5134152A (en) | 1989-12-07 | 1992-07-28 | Sankyo Company, Limited | Oxetane derivatives and their use as anti-fungal or fungicidal agents |
| JP2887523B2 (ja) * | 1990-11-30 | 1999-04-26 | 富山化学工業株式会社 | 新規なトリアゾール誘導体およびその塩 |
| GB9107055D0 (en) * | 1991-04-04 | 1991-05-22 | Pfizer Ltd | Triazole antifungal agents |
| JP4208269B2 (ja) * | 1996-10-01 | 2009-01-14 | 東芝ソリューション株式会社 | 異種物混入検査方法及びそのシステム |
| AU7937998A (en) | 1997-07-08 | 1999-02-08 | Sankyo Company Limited | Antifungal triazole compounds |
| WO1999045008A1 (en) | 1998-03-06 | 1999-09-10 | F. Hoffmann-La Roche Ag | 3-[4-(4-cyanophenyl)thiazol-2-y)]-1-(1h-1,2,4-triazol-1-yl)-butan-2-ol derivatives having antifungal activity |
| MXPA03010914A (es) | 2001-06-26 | 2004-02-17 | Basilea Pharmaceutica Ag | DERIVADOS DE HALOFENILO INTERMEDIARIOS Y SU USO EN UN PROCESO PARA LA PREPARACIoN DE DERIVADOS DE AZOL. |
| WO2007062542A2 (en) | 2005-12-01 | 2007-06-07 | Basilea Pharmaceutica Ag | Process for the manufacture of epoxybutanol intermediates |
| GB0712972D0 (en) | 2007-07-04 | 2007-08-15 | Glaxosmithkline Consumer Healt | Formulation |
| ES2652559T3 (es) | 2007-07-04 | 2018-02-05 | Dpx Holdings B.V. | Preparación de una esterasa |
| CN102344457B (zh) | 2007-09-12 | 2015-07-22 | 杏林制药株式会社 | 作为 gsk-3 抑制剂的螺环状氨基喹诺酮 |
| EP2289868B1 (en) | 2008-06-25 | 2014-08-13 | Daiichi Sankyo Company, Limited | Carboxylic acid compound |
| SI2298747T1 (sl) * | 2008-07-03 | 2017-08-31 | Astellas Pharma Inc. | Derivat triazola ali njegova sol |
| US8921080B2 (en) | 2009-04-24 | 2014-12-30 | Dsm Ip Assets B.V. | Pig liver esterases |
| US8207352B2 (en) * | 2009-10-08 | 2012-06-26 | Drug Process Licensing Associates LLC | Process for the manufacture of enantiomerically pure antifungal azoles as ravuconazole and isavuconazole |
| WO2011145669A1 (ja) * | 2010-05-19 | 2011-11-24 | 大日本住友製薬株式会社 | アミド誘導体 |
-
2013
- 2013-07-31 MX MX2015000744A patent/MX360783B/es active IP Right Grant
- 2013-07-31 WO PCT/EP2013/066071 patent/WO2014023623A1/en not_active Ceased
- 2013-07-31 HR HRP20170171TT patent/HRP20170171T1/hr unknown
- 2013-07-31 JP JP2015525826A patent/JP6334529B2/ja active Active
- 2013-07-31 EP EP13747999.4A patent/EP2882723B1/en active Active
- 2013-07-31 US US14/419,153 patent/US9783508B2/en active Active
- 2013-07-31 KR KR1020157001779A patent/KR102129150B1/ko active Active
- 2013-07-31 CN CN201380038886.2A patent/CN104507917B/zh active Active
- 2013-07-31 ES ES13747999.4T patent/ES2616412T3/es active Active
- 2013-07-31 SI SI201330513A patent/SI2882723T1/sl unknown
- 2013-07-31 HU HUE13747999A patent/HUE031679T2/en unknown
- 2013-07-31 PL PL13747999T patent/PL2882723T3/pl unknown
- 2013-07-31 PT PT137479994T patent/PT2882723T/pt unknown
- 2013-07-31 CA CA2878361A patent/CA2878361C/en active Active
- 2013-07-31 BR BR112015002526-9A patent/BR112015002526B1/pt active IP Right Grant
-
2017
- 2017-09-11 US US15/700,647 patent/US10590092B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| KR20150037875A (ko) | 2015-04-08 |
| CA2878361A1 (en) | 2014-02-13 |
| CN104507917A (zh) | 2015-04-08 |
| PT2882723T (pt) | 2017-02-23 |
| EP2882723A1 (en) | 2015-06-17 |
| WO2014023623A1 (en) | 2014-02-13 |
| KR102129150B1 (ko) | 2020-07-02 |
| CN104507917B (zh) | 2017-10-17 |
| ES2616412T3 (es) | 2017-06-13 |
| US20150239852A1 (en) | 2015-08-27 |
| US9783508B2 (en) | 2017-10-10 |
| BR112015002526A2 (pt) | 2018-06-12 |
| MX2015000744A (es) | 2015-04-14 |
| US20190077771A1 (en) | 2019-03-14 |
| EP2882723B1 (en) | 2016-11-16 |
| MX360783B (es) | 2018-11-16 |
| JP2015527345A (ja) | 2015-09-17 |
| BR112015002526B1 (pt) | 2022-09-06 |
| CA2878361C (en) | 2020-09-22 |
| PL2882723T3 (pl) | 2017-05-31 |
| HRP20170171T1 (hr) | 2017-04-07 |
| SI2882723T1 (sl) | 2017-04-26 |
| HUE031679T2 (en) | 2017-07-28 |
| US10590092B2 (en) | 2020-03-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6334529B2 (ja) | イサブコナゾールまたはラブコナゾールの製造方法 | |
| US9061991B2 (en) | Method for producing 1-amino-1-alkoxycarbonyl-2-vinylcyclopropane | |
| KR100887777B1 (ko) | 지방족 디니트릴의 시아노 카르복실산으로의 입체선택적생물전환 | |
| CA2449836C (fr) | Preparation stereoselective de l-acides amines cycliques | |
| JP6039710B2 (ja) | Ｌ−アミノ酸の製造方法 | |
| CN103228640A (zh) | 奈必洛尔的制备过程 | |
| US7232925B2 (en) | Process for producing (4E)-5-chloro-2-isopropyl-4-pentenoate and optically active form thereof | |
| JP3140549B2 (ja) | α−置換カルボン酸の光学異性体の分離法 | |
| KR101565439B1 (ko) | 시타글립틴의 합성을 위한 전구체인 베타아미노산을 포함한 다양한 광학활성 베타아미노산의 효소적 생산 방법 | |
| US20210087592A1 (en) | Enzymatic processes for the preparation of (±)-2-(difluoromethyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acid and (±)-2-(vinyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acid | |
| CN111918969B (zh) | 新型水解酶和利用该酶的(1s,2s)-1-烷氧基羰基-2-乙烯基环丙烷羧酸的制造方法 | |
| JP5329973B2 (ja) | リパーゼ触媒を用いるエナンチオ選択的アシル化とその後の硫酸による沈殿によって、ラセミ体の４−（１−アミノエチル）安息香酸メチルエステルから（ｒ）−および（ｓ）−４−（１−アンモニウムエチル）安息香酸メチルエステル硫酸塩を調製する方法 | |
| JP2006115726A (ja) | 可溶化による光学活性β−ヒドロキシアミノ酸の製造方法 | |
| JP2015139426A (ja) | 新規β−アミノ酸の製造方法 | |
| JP2003219896A (ja) | Ｌ−アリールグリシンの製造方法及び分解方法 | |
| JP2012193135A (ja) | アミノ酸の製造方法 | |
| JP2012102032A (ja) | 光学活性１，１，１−トリフルオロ−２−プロパノールの精製方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20150313 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20160727 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20160727 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20170420 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20170425 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20170714 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20170921 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20171025 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20180109 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20180322 |
|
| A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20180328 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20180417 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20180426 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6334529 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |