JP6334395B2 - 侵食細胞の選択的排除 - Google Patents

侵食細胞の選択的排除 Download PDF

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Publication number
JP6334395B2
JP6334395B2 JP2014515224A JP2014515224A JP6334395B2 JP 6334395 B2 JP6334395 B2 JP 6334395B2 JP 2014515224 A JP2014515224 A JP 2014515224A JP 2014515224 A JP2014515224 A JP 2014515224A JP 6334395 B2 JP6334395 B2 JP 6334395B2
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antibody
nkg2a
cells
amino acid
acid residues
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Japanese (ja)
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JP2014519522A5 (enExample
JP2014519522A (ja
Inventor
カレ・ゼーダーシュトレーム
エリザベス・ダグラス・ガルスガード
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Novo Nordisk AS
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Novo Nordisk AS
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2014515224A 2011-06-17 2012-06-18 侵食細胞の選択的排除 Active JP6334395B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP11170402.9 2011-06-17
EP11170402 2011-06-17
US201161501533P 2011-06-27 2011-06-27
US61/501,533 2011-06-27
PCT/EP2012/061583 WO2012172102A1 (en) 2011-06-17 2012-06-18 Selective elimination of erosive cells

Publications (3)

Publication Number Publication Date
JP2014519522A JP2014519522A (ja) 2014-08-14
JP2014519522A5 JP2014519522A5 (enExample) 2015-08-06
JP6334395B2 true JP6334395B2 (ja) 2018-05-30

Family

ID=44904625

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014515224A Active JP6334395B2 (ja) 2011-06-17 2012-06-18 侵食細胞の選択的排除

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Country Link
US (4) US9512228B2 (enExample)
EP (1) EP2721068B1 (enExample)
JP (1) JP6334395B2 (enExample)
KR (1) KR102047248B1 (enExample)
CN (1) CN103635487B (enExample)
AU (1) AU2012268939B2 (enExample)
BR (1) BR112013032217B1 (enExample)
CA (1) CA2838220C (enExample)
MX (1) MX342131B (enExample)
RU (1) RU2617056C2 (enExample)
WO (1) WO2012172102A1 (enExample)

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EP3026063A1 (en) 2004-12-28 2016-06-01 Innate Pharma S.A. Monoclonal antibodies against nkg2a
WO2011104381A2 (en) 2010-02-26 2011-09-01 Novo Nordisk A/S Stable antibody containing compositions
CN103635487B (zh) 2011-06-17 2016-10-12 诺沃—诺迪斯克有限公司 选择性消除侵蚀性细胞
SG11201701387SA (en) 2014-09-16 2017-03-30 Innate Pharma Treatment regimens using anti-nkg2a antibodies
EP4368205A1 (en) 2014-09-16 2024-05-15 Innate Pharma Neutralization of inhibitory pathways in lymphocytes
WO2016062851A1 (en) * 2014-10-23 2016-04-28 Innate Pharma Treatment of cancers using anti-nkg2a agents
SI3405495T1 (sl) 2016-01-21 2021-08-31 Innate Pharma Nevtralizacija inhibitornih poti v limfocitih
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WO2019175182A1 (en) 2018-03-13 2019-09-19 Innate Pharma Treatment of head and neck cancer
EP3793607A1 (en) 2018-05-15 2021-03-24 MedImmune Limited Treatment of cancer
WO2020205440A1 (en) * 2019-03-29 2020-10-08 Dren Bio, Inc. Methods of reducing large granular lymphocyte and natural killer cell levels
CA3181963A1 (en) * 2020-05-04 2021-11-11 Immunorizon Ltd. Precursor tri-specific antibody constructs and methods of use thereof
EP4221752A4 (en) 2020-09-30 2024-12-04 Dren Bio, Inc. ANTI-CD94 ANTIBODIES AND METHODS OF USE THEREOF
CN114524876B (zh) * 2020-11-23 2025-12-05 南京北恒生物科技有限公司 靶向nkg2a的抗体及其用途

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Also Published As

Publication number Publication date
BR112013032217B1 (pt) 2021-01-19
WO2012172102A1 (en) 2012-12-20
US20230416374A1 (en) 2023-12-28
AU2012268939B2 (en) 2017-05-04
RU2617056C2 (ru) 2017-04-19
KR102047248B1 (ko) 2019-11-21
KR20140037918A (ko) 2014-03-27
US20170073417A1 (en) 2017-03-16
EP2721068B1 (en) 2018-12-05
CA2838220C (en) 2020-07-21
CA2838220A1 (en) 2012-12-20
RU2013158625A (ru) 2015-07-27
CN103635487B (zh) 2016-10-12
JP2014519522A (ja) 2014-08-14
CN103635487A (zh) 2014-03-12
MX342131B (es) 2016-09-14
US11697687B2 (en) 2023-07-11
US20140161802A1 (en) 2014-06-12
BR112013032217A2 (pt) 2016-11-22
EP2721068A1 (en) 2014-04-23
US9512228B2 (en) 2016-12-06
US20200109206A1 (en) 2020-04-09
MX2013014203A (es) 2014-01-20

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