JP6324887B2 - 血清アルブミンに結合するタンパク質 - Google Patents

血清アルブミンに結合するタンパク質 Download PDF

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JP6324887B2
JP6324887B2 JP2014516279A JP2014516279A JP6324887B2 JP 6324887 B2 JP6324887 B2 JP 6324887B2 JP 2014516279 A JP2014516279 A JP 2014516279A JP 2014516279 A JP2014516279 A JP 2014516279A JP 6324887 B2 JP6324887 B2 JP 6324887B2
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seq
polypeptide
amino acid
nanobodies
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JP2014520129A (ja
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ドンブレヒト,ブルーノ
スホット,ピーテル
フェルフェルケン,セドリック・ヨーゼフ・ネオテレ
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アブリンクス エン.ヴェー.
アブリンクス エン.ヴェー.
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567Framework region [FR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2014516279A 2011-06-23 2012-06-14 血清アルブミンに結合するタンパク質 Active JP6324887B2 (ja)

Applications Claiming Priority (3)

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US201161500464P 2011-06-23 2011-06-23
US61/500,464 2011-06-23
PCT/EP2012/061304 WO2012175400A1 (en) 2011-06-23 2012-06-14 Serum albumin binding proteins

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JP2014520129A JP2014520129A (ja) 2014-08-21
JP6324887B2 true JP6324887B2 (ja) 2018-05-16

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JP2018076201A Active JP6843090B2 (ja) 2011-06-23 2018-04-11 血清アルブミンに結合するタンパク質
JP2021026177A Active JP7304375B2 (ja) 2011-06-23 2021-02-22 血清アルブミンに結合するタンパク質

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JP2021026177A Active JP7304375B2 (ja) 2011-06-23 2021-02-22 血清アルブミンに結合するタンパク質

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US (2) US9573992B2 (OSRAM)
EP (3) EP3466972A1 (OSRAM)
JP (3) JP6324887B2 (OSRAM)
CN (2) CN106046168A (OSRAM)
AU (1) AU2012271974B2 (OSRAM)
CA (1) CA2839779C (OSRAM)
CY (1) CY1122691T1 (OSRAM)
DK (1) DK2723771T3 (OSRAM)
ES (1) ES2759936T3 (OSRAM)
HR (2) HRP20192160T1 (OSRAM)
HU (1) HUE047238T2 (OSRAM)
IN (1) IN2014CN00414A (OSRAM)
LT (1) LT2723771T (OSRAM)
PL (1) PL2723771T3 (OSRAM)
PT (1) PT2723771T (OSRAM)
SI (1) SI2723771T1 (OSRAM)
WO (1) WO2012175400A1 (OSRAM)

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HRP20170535T4 (hr) 2022-08-19
AU2012271974A1 (en) 2013-12-12
ES2759936T3 (es) 2020-05-12
SI2723771T1 (sl) 2019-12-31
EP4218933A1 (en) 2023-08-02
JP2014520129A (ja) 2014-08-21
HRP20170535T1 (hr) 2017-06-16
IN2014CN00414A (OSRAM) 2015-04-03
US20170210789A1 (en) 2017-07-27
JP7304375B2 (ja) 2023-07-06
CY1122691T1 (el) 2021-03-12
HRP20192160T1 (hr) 2020-02-21
JP2018127478A (ja) 2018-08-16
EP2723771B1 (en) 2019-09-11
JP2021088585A (ja) 2021-06-10
CN103619878B (zh) 2016-10-26
PT2723771T (pt) 2019-12-11
WO2012175400A1 (en) 2012-12-27
LT2723771T (lt) 2019-12-10
CN103619878A (zh) 2014-03-05
CA2839779C (en) 2020-10-06
JP6843090B2 (ja) 2021-03-17
PL2723771T3 (pl) 2020-04-30
US9573992B2 (en) 2017-02-21
HUE047238T2 (hu) 2020-04-28
US20140228546A1 (en) 2014-08-14
DK2723771T3 (da) 2019-12-02
EP2723771A1 (en) 2014-04-30
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CN106046168A (zh) 2016-10-26
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