JP6293127B2 - 未分化細胞の選択的阻害剤 - Google Patents

未分化細胞の選択的阻害剤 Download PDF

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JP6293127B2
JP6293127B2 JP2015513349A JP2015513349A JP6293127B2 JP 6293127 B2 JP6293127 B2 JP 6293127B2 JP 2015513349 A JP2015513349 A JP 2015513349A JP 2015513349 A JP2015513349 A JP 2015513349A JP 6293127 B2 JP6293127 B2 JP 6293127B2
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cells
plurisin
undifferentiated
cell
cancer
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JP2015525207A5 (https=
JP2015525207A (ja
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ウリ ベン−デイヴィッド，
ウリ ベン−デイヴィッド，
ニッシム ベンヴェニスティ，
ニッシム ベンヴェニスティ，
パヤル アロラ，
パヤル アロラ，
チン−フェン ガン，
チン−フェン ガン，
ラルフ ジェー． ガリッパ，
ラルフ ジェー． ガリッパ，
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • A61K31/13—Amines
    • A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
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    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
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    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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JP2015513349A 2012-05-22 2013-05-22 未分化細胞の選択的阻害剤 Expired - Fee Related JP6293127B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261650049P 2012-05-22 2012-05-22
US61/650,049 2012-05-22
US201261696387P 2012-09-04 2012-09-04
US61/696,387 2012-09-04
PCT/IL2013/050441 WO2013175474A2 (en) 2012-05-22 2013-05-22 Selective inhibitors of undifferentiated cells

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JP2015525207A JP2015525207A (ja) 2015-09-03
JP2015525207A5 JP2015525207A5 (https=) 2016-07-07
JP6293127B2 true JP6293127B2 (ja) 2018-03-14

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US (3) US9456998B2 (https=)
EP (1) EP2852387A2 (https=)
JP (1) JP6293127B2 (https=)
KR (1) KR20150013777A (https=)
CN (1) CN104768549A (https=)
BR (1) BR112014029365A2 (https=)
CA (1) CA2873817A1 (https=)
MX (1) MX2014014174A (https=)
RU (1) RU2014149559A (https=)
WO (1) WO2013175474A2 (https=)

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MX2014014174A (es) 2012-05-22 2015-07-06 Hoffmann La Roche Inhibidores selectivos de celulas no diferenciadas.
CN103755618A (zh) * 2013-12-19 2014-04-30 南京农业大学 一种含n-取代苯肼的吡咯烷-2,4-二酮类化合物、制备方法及应用
EP3097186B1 (en) 2014-01-21 2019-05-08 The Medical College of Wisconsin, Inc. Methods for selective inhibition of pluripotent stem cells
US20180042925A1 (en) * 2015-03-04 2018-02-15 Children's Hospital Medical Center Methods for treating cancer
US10905665B2 (en) 2015-06-24 2021-02-02 Duke University Chemical modulators of signaling pathways and therapeutic use
WO2018117127A1 (ja) 2016-12-20 2018-06-28 大日本住友製薬株式会社 未分化ｉＰＳ細胞の除去剤
EP3566055B1 (en) 2017-01-06 2025-03-12 Janssen Pharmaceutica NV Scd inhibitor for the treatment of neurological disorders
WO2018226797A1 (en) * 2017-06-07 2018-12-13 Academia Sinica Method for removing undifferentiated pluripotent stem cells
EP3480296A1 (en) 2017-11-06 2019-05-08 Universität zu Köln Diamines for use in the elimination of pluripotent stem cells
WO2019183587A1 (en) 2018-03-23 2019-09-26 Yumanity Therapeutics, Inc. Compounds and uses thereof
CN109402121A (zh) * 2018-12-11 2019-03-01 宁夏医科大学总医院 一种环状RNA hsa_circSCD_004及其特异性扩增引物和应用
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WO2013175474A3 (en) 2014-01-16
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CA2873817A1 (en) 2013-11-28
MX2014014174A (es) 2015-07-06
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WO2013175474A9 (en) 2014-03-13
KR20150013777A (ko) 2015-02-05
CN104768549A (zh) 2015-07-08
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