JP2015525207A5 - - Google Patents
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- Publication number
- JP2015525207A5 JP2015525207A5 JP2015513349A JP2015513349A JP2015525207A5 JP 2015525207 A5 JP2015525207 A5 JP 2015525207A5 JP 2015513349 A JP2015513349 A JP 2015513349A JP 2015513349 A JP2015513349 A JP 2015513349A JP 2015525207 A5 JP2015525207 A5 JP 2015525207A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- stem cells
- group
- pluripotent stem
- undifferentiated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 2,4-dioxo-5-fluoropyrimidin-1-ylcarbonyl Chemical group 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 11
- 210000004027 cell Anatomy 0.000 claims 10
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 230000002062 proliferating effect Effects 0.000 claims 4
- 239000003112 inhibitor Substances 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 2
- BLNVISNJTIRAHF-UHFFFAOYSA-N 4-chlorobenzamide Chemical compound NC(=O)C1=CC=C(Cl)C=C1 BLNVISNJTIRAHF-UHFFFAOYSA-N 0.000 claims 2
- 101710159293 Acyl-CoA desaturase 1 Proteins 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000002334 N-hydroxyacetimidoyl group Chemical group [H]C([H])([H])C([*])=NO[H] 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 231100000433 cytotoxic Toxicity 0.000 claims 2
- 230000001472 cytotoxic effect Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000005146 naphthylsulfonyl group Chemical group C1(=CC=CC2=CC=CC=C12)S(=O)(=O)* 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000035755 proliferation Effects 0.000 claims 2
- 230000035899 viability Effects 0.000 claims 2
- 102100028897 Stearoyl-CoA desaturase Human genes 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261650049P | 2012-05-22 | 2012-05-22 | |
| US61/650,049 | 2012-05-22 | ||
| US201261696387P | 2012-09-04 | 2012-09-04 | |
| US61/696,387 | 2012-09-04 | ||
| PCT/IL2013/050441 WO2013175474A2 (en) | 2012-05-22 | 2013-05-22 | Selective inhibitors of undifferentiated cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015525207A JP2015525207A (ja) | 2015-09-03 |
| JP2015525207A5 true JP2015525207A5 (https=) | 2016-07-07 |
| JP6293127B2 JP6293127B2 (ja) | 2018-03-14 |
Family
ID=48746093
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015513349A Expired - Fee Related JP6293127B2 (ja) | 2012-05-22 | 2013-05-22 | 未分化細胞の選択的阻害剤 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US9456998B2 (https=) |
| EP (1) | EP2852387A2 (https=) |
| JP (1) | JP6293127B2 (https=) |
| KR (1) | KR20150013777A (https=) |
| CN (1) | CN104768549A (https=) |
| BR (1) | BR112014029365A2 (https=) |
| CA (1) | CA2873817A1 (https=) |
| MX (1) | MX2014014174A (https=) |
| RU (1) | RU2014149559A (https=) |
| WO (1) | WO2013175474A2 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2014014174A (es) | 2012-05-22 | 2015-07-06 | Hoffmann La Roche | Inhibidores selectivos de celulas no diferenciadas. |
| CN103755618A (zh) * | 2013-12-19 | 2014-04-30 | 南京农业大学 | 一种含n-取代苯肼的吡咯烷-2,4-二酮类化合物、制备方法及应用 |
| EP3097186B1 (en) | 2014-01-21 | 2019-05-08 | The Medical College of Wisconsin, Inc. | Methods for selective inhibition of pluripotent stem cells |
| US20180042925A1 (en) * | 2015-03-04 | 2018-02-15 | Children's Hospital Medical Center | Methods for treating cancer |
| US10905665B2 (en) | 2015-06-24 | 2021-02-02 | Duke University | Chemical modulators of signaling pathways and therapeutic use |
| WO2018117127A1 (ja) | 2016-12-20 | 2018-06-28 | 大日本住友製薬株式会社 | 未分化ｉＰＳ細胞の除去剤 |
| EP3566055B1 (en) | 2017-01-06 | 2025-03-12 | Janssen Pharmaceutica NV | Scd inhibitor for the treatment of neurological disorders |
| WO2018226797A1 (en) * | 2017-06-07 | 2018-12-13 | Academia Sinica | Method for removing undifferentiated pluripotent stem cells |
| EP3480296A1 (en) | 2017-11-06 | 2019-05-08 | Universität zu Köln | Diamines for use in the elimination of pluripotent stem cells |
| WO2019183587A1 (en) | 2018-03-23 | 2019-09-26 | Yumanity Therapeutics, Inc. | Compounds and uses thereof |
| CN109402121A (zh) * | 2018-12-11 | 2019-03-01 | 宁夏医科大学总医院 | 一种环状RNA hsa_circSCD_004及其特异性扩增引物和应用 |
| WO2020154571A1 (en) | 2019-01-24 | 2020-07-30 | Yumanity Therapeutics, Inc. | Compounds and uses thereof |
| EA202192047A1 (ru) | 2019-11-13 | 2021-12-08 | Юманити Терапьютикс, Инк. | Соединения и их применение |
| CN119548487B (zh) * | 2024-12-05 | 2025-11-14 | 浙江工业大学 | 5-(十四烷氧基)-2-糠酸在制备抑制破骨细胞分化和功能的药物中的应用 |
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| MXPA06001202A (es) | 2003-07-29 | 2006-08-31 | Xenon Pharmaceuticals Inc | Derivados piridilo y su uso como agentes terapeuticos. |
| CA2533900A1 (en) | 2003-07-30 | 2005-02-10 | Xenon Pharmaceuticals Inc. | Pyridyl derivatives and their use as therapeutic agents |
| CA2533897A1 (en) | 2003-07-30 | 2005-02-10 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives and their use as therapeutic agents |
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| ATE537830T1 (de) | 2004-07-06 | 2012-01-15 | Xenon Pharmaceuticals Inc | Nicotinamid derivate und ihre verwendung als therapeutika |
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| AU2005286647A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
| CN101084211A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 杂环衍生物及其作为治疗剂的用途 |
| BRPI0515482A (pt) | 2004-09-20 | 2008-07-22 | Xenon Pharmaceuticals Inc | derivados heterocìclicos e seus usos como agentes terapêuticos |
| AU2005286790A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Bicyclic heterocyclic derivatives and their use as inhibitors of stearoyl-CoA-desaturase (SCD) |
| GT200600046A (es) | 2005-02-09 | 2006-09-25 | Terapia de combinacion | |
| GB0508472D0 (en) | 2005-04-26 | 2005-06-01 | Glaxo Group Ltd | Compounds |
| WO2007046868A2 (en) | 2005-05-19 | 2007-04-26 | Xenon Pharmaceuticals Inc. | Thiazolidine derivatives and their uses as therapeutic agents |
| WO2007044085A2 (en) | 2005-05-19 | 2007-04-19 | Xenon Pharmaceuticals Inc. | Heteroaryl compounds and their uses as therapeutic agents |
| WO2007046867A2 (en) | 2005-05-19 | 2007-04-26 | Xenon Pharmaceuticals Inc. | Piperidine derivatives and their uses as therapeutic agents |
| WO2006125181A2 (en) | 2005-05-19 | 2006-11-23 | Xenon Pharmaceuticals Inc. | Piperidine derivatives and their use as stearoyl-coa desaturase modulators |
| WO2006125194A2 (en) | 2005-05-19 | 2006-11-23 | Xenon Pharmaceuticals Inc. | Piperazine derivatives and their uses as therapeutic agents |
| WO2006125179A1 (en) | 2005-05-19 | 2006-11-23 | Xenon Pharmaceuticals Inc. | Tricyclic compounds and their uses as therapeutic agents |
| WO2006125178A2 (en) | 2005-05-19 | 2006-11-23 | Xenon Pharmaceuticals Inc. | Tricyclic pyridazine compounds and their uses as therapeutic agents |
| WO2007050124A1 (en) | 2005-05-19 | 2007-05-03 | Xenon Pharmaceuticals Inc. | Fused piperidine derivatives and their uses as therapeutic agents |
| WO2006125180A1 (en) | 2005-05-19 | 2006-11-23 | Xenon Pharmaceuticals Inc. | Piperazine derivatives and their uses as therapeutic agents |
| CA2618646A1 (en) | 2005-06-03 | 2007-11-15 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
| CA2610196A1 (en) | 2005-06-09 | 2006-12-14 | Merck Frosst Canada Ltd. | Azacyclohexane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
| US20090118296A1 (en) | 2005-07-20 | 2009-05-07 | Merck Frosst Canada Ltd. | Heteroaromatic Compounds As Inhibitors Of Stearoyl-Coenzyme A Delta-9 Desaturase |
| AU2006315025A1 (en) | 2005-11-15 | 2007-05-24 | Merck Frosst Canada Ltd. | Azacyclohexane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
| EP1966183A4 (en) | 2005-12-20 | 2010-12-29 | Merck Frosst Canada Ltd | HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A-DELTA-9-DESATURASE |
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| WO2008003753A1 (en) | 2006-07-07 | 2008-01-10 | Biovitrum Ab (Publ) | Pyrazolo [1,5-a] pyrimidine analogs for use as inhibitors of stearoyl-coa desaturase (scd) activity |
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| MX2009001634A (es) | 2006-08-15 | 2009-02-25 | Novartis Ag | Compuestos heterociclicos adecuados para el tratamiento de enfermedades relacionadas con el nivel elevado de lipidos. |
| MX2009002019A (es) | 2006-08-24 | 2009-03-09 | Novartis Ag | Derivados de 2-(pirazin-2-il)-tiazol y 2-(1h-pirazol-3-il)-tiazol asi como compuestos relacionados como inhibidores de la estearoil-coa-desaturasa (scd) para el tratamiento de trastornos metabolicos, cardiovasculares, y otros. |
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| CA2662574A1 (en) | 2006-09-22 | 2008-03-27 | Novartis Ag | Heterocyclic organic compounds |
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| CA2664849A1 (en) | 2006-10-20 | 2008-04-24 | Merck Frosst Canada Ltd. | Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
| WO2008056687A1 (en) | 2006-11-09 | 2008-05-15 | Daiichi Sankyo Company, Limited | Novel spiropiperidine derivative |
| WO2008062276A2 (en) | 2006-11-20 | 2008-05-29 | Glenmark Pharmaceuticals S.A. | Acetylene derivatives as stearoyl coa desaturase inhibitors |
| TW200826936A (en) | 2006-12-01 | 2008-07-01 | Merck Frosst Canada Ltd | Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
| WO2008074835A1 (en) | 2006-12-20 | 2008-06-26 | Novartis Ag | 2-substituted 5-membered heterocycles as scd inhibitors |
| GB0625654D0 (en) | 2006-12-21 | 2007-01-31 | Smithkline Beecham Corp | Compounds |
| GB0625594D0 (en) | 2006-12-21 | 2007-01-31 | Smithkline Beecham Corp | Compounds |
| AR064965A1 (es) | 2007-01-26 | 2009-05-06 | Merck Frosst Canada Inc | Derivados de azacicloalcanos como inhibidores de estearoil - coenzima a delta -9 desaturasa |
| US8575167B2 (en) | 2007-02-06 | 2013-11-05 | Takeda Pharmaceutical Company Limited | Spiro compounds having stearoyl-CoA desaturase action |
| WO2009070533A1 (en) * | 2007-11-29 | 2009-06-04 | Complegen, Inc. | Methods of inhibiting steroyl coa desaturase |
| WO2010144059A2 (en) * | 2009-06-12 | 2010-12-16 | Nanyang Polytechnic | Novel uses |
| WO2011030329A1 (en) * | 2009-09-10 | 2011-03-17 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Method of treating tumors |
| MX2014014174A (es) | 2012-05-22 | 2015-07-06 | Hoffmann La Roche | Inhibidores selectivos de celulas no diferenciadas. |
-
2013
- 2013-05-22 MX MX2014014174A patent/MX2014014174A/es unknown
- 2013-05-22 BR BR112014029365A patent/BR112014029365A2/pt not_active IP Right Cessation
- 2013-05-22 CA CA2873817A patent/CA2873817A1/en not_active Abandoned
- 2013-05-22 JP JP2015513349A patent/JP6293127B2/ja not_active Expired - Fee Related
- 2013-05-22 EP EP13733462.9A patent/EP2852387A2/en not_active Withdrawn
- 2013-05-22 KR KR1020147035024A patent/KR20150013777A/ko not_active Withdrawn
- 2013-05-22 WO PCT/IL2013/050441 patent/WO2013175474A2/en not_active Ceased
- 2013-05-22 US US14/402,467 patent/US9456998B2/en not_active Expired - Fee Related
- 2013-05-22 CN CN201380038889.6A patent/CN104768549A/zh active Pending
- 2013-05-22 RU RU2014149559A patent/RU2014149559A/ru not_active Application Discontinuation
-
2016
- 2016-09-08 US US15/259,119 patent/US20170027890A1/en not_active Abandoned
-
2018
- 2018-02-01 US US15/885,872 patent/US20180153830A1/en not_active Abandoned
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