JP6280869B2 - 工業的な医薬用途に適合する拡張可能なレンチウイルスベクター製造システム - Google Patents

工業的な医薬用途に適合する拡張可能なレンチウイルスベクター製造システム Download PDF

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JP6280869B2
JP6280869B2 JP2014542880A JP2014542880A JP6280869B2 JP 6280869 B2 JP6280869 B2 JP 6280869B2 JP 2014542880 A JP2014542880 A JP 2014542880A JP 2014542880 A JP2014542880 A JP 2014542880A JP 6280869 B2 JP6280869 B2 JP 6280869B2
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plasmid
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lentiviral
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JP2014533516A (ja
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ニコラ・マルソー
メディ・ギャスミ
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ジェネトン
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/02—Recovery or purification
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/10051—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16051—Methods of production or purification of viral material

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  • Life Sciences & Earth Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
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  • General Engineering & Computer Science (AREA)
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  • Biochemistry (AREA)
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  • Virology (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2014542880A 2011-11-24 2012-11-26 工業的な医薬用途に適合する拡張可能なレンチウイルスベクター製造システム Expired - Fee Related JP6280869B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161563566P 2011-11-24 2011-11-24
EP11306551 2011-11-24
US61/563,566 2011-11-24
EP11306551.0 2011-11-24
PCT/EP2012/073645 WO2013076309A1 (en) 2011-11-24 2012-11-26 Scalable lentiviral vector production system compatible with industrial pharmaceutical applications

Related Child Applications (1)

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JP2017195148A Division JP2018046828A (ja) 2011-11-24 2017-10-05 工業的な医薬用途に適合する拡張可能なレンチウイルスベクター製造システム

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JP2014533516A JP2014533516A (ja) 2014-12-15
JP6280869B2 true JP6280869B2 (ja) 2018-02-14

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JP2014542880A Expired - Fee Related JP6280869B2 (ja) 2011-11-24 2012-11-26 工業的な医薬用途に適合する拡張可能なレンチウイルスベクター製造システム
JP2017195148A Pending JP2018046828A (ja) 2011-11-24 2017-10-05 工業的な医薬用途に適合する拡張可能なレンチウイルスベクター製造システム

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JP2017195148A Pending JP2018046828A (ja) 2011-11-24 2017-10-05 工業的な医薬用途に適合する拡張可能なレンチウイルスベクター製造システム

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US (3) US20140315294A1 (en22)
EP (2) EP2782997B1 (en22)
JP (2) JP6280869B2 (en22)
CN (2) CN109097398A (en22)
AU (1) AU2012342355B2 (en22)
BR (1) BR112014012600A2 (en22)
CA (1) CA2856455C (en22)
CY (1) CY1120103T1 (en22)
DK (1) DK2782997T3 (en22)
ES (1) ES2663815T3 (en22)
HR (1) HRP20180424T1 (en22)
HU (1) HUE036742T2 (en22)
LT (1) LT2782997T (en22)
PL (1) PL2782997T3 (en22)
PT (1) PT2782997T (en22)
RS (1) RS57066B1 (en22)
SG (1) SG11201402584RA (en22)
SI (1) SI2782997T1 (en22)
SM (1) SMT201800174T1 (en22)
WO (1) WO2013076309A1 (en22)

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JP2018046828A (ja) * 2011-11-24 2018-03-29 ジェネトン 工業的な医薬用途に適合する拡張可能なレンチウイルスベクター製造システム

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WO2015097650A1 (en) * 2013-12-23 2015-07-02 Theravectys Lyophilized lentiviral vector particles, compositions and methods
GB201417042D0 (en) * 2014-09-29 2014-11-12 Fkd Therapies Oy Method
EP4316500A3 (en) 2015-05-13 2024-04-10 CSL Behring Gene Therapy, Inc. Bio-production of lentiviral vectors
CN105483092A (zh) * 2015-10-10 2016-04-13 和元生物技术（上海）股份有限公司 一种中试化生产重组腺相关病毒的新技术
SG11201806976UA (en) 2016-02-23 2018-09-27 Immune Design Corp Multigenome retroviral vector preparations and methods and systems for producing and using same
CN109071594A (zh) * 2016-04-14 2018-12-21 崔泽尔有限公司 具有恒流泵/管道系统的固定床生物反应器
CN116144500A (zh) 2016-04-14 2023-05-23 崔泽尔有限公司 具有恒流泵/管道系统的固定床生物反应器
WO2018064584A1 (en) * 2016-09-30 2018-04-05 Life Technologies Corporation Serum-free suspension system for lentiviral production
CN106867877A (zh) * 2017-02-15 2017-06-20 昆明医科大学第二附属医院 一种密闭式慢病毒载体培养装置和培养方法
US11674115B2 (en) 2017-10-31 2023-06-13 Global Life Sciences Solutions Usa Llc Flexible bag
CN111727251B (zh) 2017-11-21 2024-09-20 克里斯珀医疗股份公司 用于治疗常染色体显性色素性视网膜炎的材料和方法
CA3084632A1 (en) 2017-12-21 2019-06-27 Crispr Therapeutics Ag Materials and methods for treatment of usher syndrome type 2a
WO2019123430A1 (en) 2017-12-21 2019-06-27 Casebia Therapeutics Llp Materials and methods for treatment of usher syndrome type 2a and/or non-syndromic autosomal recessive retinitis pigmentosa (arrp)
CN110317832B (zh) 2018-03-28 2022-07-05 西比曼生物科技（香港）有限公司 Gmp级规模化制备重组慢病毒载体的纯化制剂的方法
CN110317791A (zh) * 2018-03-29 2019-10-11 西比曼生物科技（香港）有限公司 Gmp级无血清悬浮细胞大规模生产慢病毒的方法
CN108866013B (zh) * 2018-08-06 2021-03-23 武汉赛科成科技有限公司 一种大规模生产慢病毒的方法
EP3854879A4 (en) * 2018-09-20 2022-06-22 National University Corporation Tokyo Medical and Dental University METHOD OF INCREASING THE PRODUCTION OF LENTIVIRUS VECTORS
CN109401969B (zh) * 2018-12-13 2024-02-02 珠海西格膜生物技术有限公司 一种细胞工厂的管道连接系统及其使用方法
JP7333930B2 (ja) * 2019-01-07 2023-08-28 独立行政法人国立高等専門学校機構 ミミズ細胞の保存方法及びミミズ培養細胞の形質転換方法
JP2022551219A (ja) 2019-08-23 2022-12-08 ロンザ ウォーカーズヴィル，インコーポレーテッド レンチウイルスベクターの製造方法および構築物
CN113122501B (zh) * 2019-12-30 2023-06-16 重庆精准生物技术有限公司 适合大规模临床级病毒载体制备的培养基及其应用
JP2023526348A (ja) * 2020-05-15 2023-06-21 アイヴェックスソル インコーポレイテッド 細胞療法及び遺伝子療法のための安定したウイルスベクター産生細胞を産生するための組成物及び方法
US20230220417A1 (en) * 2020-05-26 2023-07-13 Expression Therapeutics, Llc Lentiviral System
KR20230126214A (ko) * 2020-12-29 2023-08-29 지앙수 젠스크립트 프로바이오 바이오테크 컴퍼니 리미티드 고분산성 hek293t 세포주 및 이의 스크리닝 방법
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Publication number Priority date Publication date Assignee Title
JP2018046828A (ja) * 2011-11-24 2018-03-29 ジェネトン 工業的な医薬用途に適合する拡張可能なレンチウイルスベクター製造システム

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ES2663815T3 (es) 2018-04-17
CN104136605B (zh) 2018-08-14
EP2782997A1 (en) 2014-10-01
CN109097398A (zh) 2018-12-28
EP3327119A1 (en) 2018-05-30
CA2856455C (en) 2022-08-23
SG11201402584RA (en) 2014-06-27
JP2018046828A (ja) 2018-03-29
SI2782997T1 (en) 2018-04-30
DK2782997T3 (en) 2018-04-16
PL2782997T3 (pl) 2018-06-29
WO2013076309A1 (en) 2013-05-30
RS57066B1 (sr) 2018-06-29
LT2782997T (lt) 2018-05-25
HRP20180424T1 (hr) 2018-06-29
CA2856455A1 (en) 2013-05-30
JP2014533516A (ja) 2014-12-15
US20220235371A1 (en) 2022-07-28
AU2012342355A1 (en) 2014-07-17
US20190211360A1 (en) 2019-07-11
EP2782997B1 (en) 2018-01-10
BR112014012600A2 (pt) 2017-06-06
CN104136605A (zh) 2014-11-05
SMT201800174T1 (it) 2018-07-17
AU2012342355B2 (en) 2017-10-12
PT2782997T (pt) 2018-04-09
US20140315294A1 (en) 2014-10-23
CY1120103T1 (el) 2018-12-12
HUE036742T2 (hu) 2018-07-30

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