CN109097398A - 与工业制药应用相容的可放大的慢病毒载体生产系统 - Google Patents
与工业制药应用相容的可放大的慢病毒载体生产系统 Download PDFInfo
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| CN201280058157.9A CN104136605B (zh) | 2011-11-24 | 2012-11-26 | 与工业制药应用相容的可放大的慢病毒载体生产系统 |
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| EP2782997B1 (en) | 2011-11-24 | 2018-01-10 | Genethon | Scalable lentiviral vector production system compatible with industrial pharmaceutical applications |
| FR3010720B1 (fr) * | 2013-09-16 | 2017-08-11 | Genethon | Procede de production de virus enveloppes |
| FR3014901B1 (fr) | 2013-12-17 | 2017-06-09 | Genethon | Procede de purification de virus ou vecteurs viraux enveloppes |
| WO2015097650A1 (en) * | 2013-12-23 | 2015-07-02 | Theravectys | Lyophilized lentiviral vector particles, compositions and methods |
| GB201417042D0 (en) * | 2014-09-29 | 2014-11-12 | Fkd Therapies Oy | Method |
| EP4316500A3 (en) | 2015-05-13 | 2024-04-10 | CSL Behring Gene Therapy, Inc. | Bio-production of lentiviral vectors |
| CN105483092A (zh) * | 2015-10-10 | 2016-04-13 | 和元生物技术（上海）股份有限公司 | 一种中试化生产重组腺相关病毒的新技术 |
| SG11201806976UA (en) | 2016-02-23 | 2018-09-27 | Immune Design Corp | Multigenome retroviral vector preparations and methods and systems for producing and using same |
| CN109071594A (zh) * | 2016-04-14 | 2018-12-21 | 崔泽尔有限公司 | 具有恒流泵/管道系统的固定床生物反应器 |
| CN116144500A (zh) | 2016-04-14 | 2023-05-23 | 崔泽尔有限公司 | 具有恒流泵/管道系统的固定床生物反应器 |
| WO2018064584A1 (en) * | 2016-09-30 | 2018-04-05 | Life Technologies Corporation | Serum-free suspension system for lentiviral production |
| CN106867877A (zh) * | 2017-02-15 | 2017-06-20 | 昆明医科大学第二附属医院 | 一种密闭式慢病毒载体培养装置和培养方法 |
| US11674115B2 (en) | 2017-10-31 | 2023-06-13 | Global Life Sciences Solutions Usa Llc | Flexible bag |
| CN111727251B (zh) | 2017-11-21 | 2024-09-20 | 克里斯珀医疗股份公司 | 用于治疗常染色体显性色素性视网膜炎的材料和方法 |
| CA3084632A1 (en) | 2017-12-21 | 2019-06-27 | Crispr Therapeutics Ag | Materials and methods for treatment of usher syndrome type 2a |
| WO2019123430A1 (en) | 2017-12-21 | 2019-06-27 | Casebia Therapeutics Llp | Materials and methods for treatment of usher syndrome type 2a and/or non-syndromic autosomal recessive retinitis pigmentosa (arrp) |
| CN110317832B (zh) | 2018-03-28 | 2022-07-05 | 西比曼生物科技（香港）有限公司 | Gmp级规模化制备重组慢病毒载体的纯化制剂的方法 |
| CN110317791A (zh) * | 2018-03-29 | 2019-10-11 | 西比曼生物科技（香港）有限公司 | Gmp级无血清悬浮细胞大规模生产慢病毒的方法 |
| CN108866013B (zh) * | 2018-08-06 | 2021-03-23 | 武汉赛科成科技有限公司 | 一种大规模生产慢病毒的方法 |
| EP3854879A4 (en) * | 2018-09-20 | 2022-06-22 | National University Corporation Tokyo Medical and Dental University | METHOD OF INCREASING THE PRODUCTION OF LENTIVIRUS VECTORS |
| CN109401969B (zh) * | 2018-12-13 | 2024-02-02 | 珠海西格膜生物技术有限公司 | 一种细胞工厂的管道连接系统及其使用方法 |
| JP7333930B2 (ja) * | 2019-01-07 | 2023-08-28 | 独立行政法人国立高等専門学校機構 | ミミズ細胞の保存方法及びミミズ培養細胞の形質転換方法 |
| JP2022551219A (ja) | 2019-08-23 | 2022-12-08 | ロンザ ウォーカーズヴィル，インコーポレーテッド | レンチウイルスベクターの製造方法および構築物 |
| CN113122501B (zh) * | 2019-12-30 | 2023-06-16 | 重庆精准生物技术有限公司 | 适合大规模临床级病毒载体制备的培养基及其应用 |
| JP2023526348A (ja) * | 2020-05-15 | 2023-06-21 | アイヴェックスソル インコーポレイテッド | 細胞療法及び遺伝子療法のための安定したウイルスベクター産生細胞を産生するための組成物及び方法 |
| US20230220417A1 (en) * | 2020-05-26 | 2023-07-13 | Expression Therapeutics, Llc | Lentiviral System |
| KR20230126214A (ko) * | 2020-12-29 | 2023-08-29 | 지앙수 젠스크립트 프로바이오 바이오테크 컴퍼니 리미티드 | 고분산성 hek293t 세포주 및 이의 스크리닝 방법 |
| GB202100688D0 (en) * | 2021-01-19 | 2021-03-03 | Autolus Ltd | Process |
| US20240425880A1 (en) * | 2021-10-12 | 2024-12-26 | Jiangsu Genscript Probio Biotech Co., Ltd. | Hek293 cell line adapted to serum-free suspension culture and use thereof |
| CA3231011A1 (en) * | 2021-10-19 | 2023-04-27 | Amgen Inc. | Composition and methods for recombinant lentiviral production |
| EP4508198A1 (en) * | 2022-04-11 | 2025-02-19 | Adverum Biotechnologies, Inc. | Optimization of hek293 suspension platform for improved raav titers |
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| FR2722506B1 (fr) | 1994-07-13 | 1996-08-14 | Rhone Poulenc Rorer Sa | Composition contenant des acides nucleiques, preparation et utilisations |
| US6210922B1 (en) | 1998-11-30 | 2001-04-03 | National Research Council Of Canada | Serum free production of recombinant proteins and adenoviral vectors |
| US20030096414A1 (en) | 2001-03-27 | 2003-05-22 | Invitrogen Corporation | Culture medium for cell growth and transfection |
| AU2002348151A1 (en) | 2001-11-05 | 2003-05-19 | Genvec, Inc. | Viral vector production methods and compositions |
| GB0702695D0 (en) * | 2007-02-12 | 2007-03-21 | Ark Therapeutics Ltd | Production of vectors |
| EP2307551B1 (en) | 2008-06-18 | 2016-12-14 | Oxford BioMedica (UK) Limited | Purification of retroviral vectors |
| US20110008894A1 (en) | 2009-07-07 | 2011-01-13 | Cayla | Lyophilized plasmid/dna transfection reagent carrier complex |
| US8580554B2 (en) | 2009-07-31 | 2013-11-12 | Baxter International Inc. | Method of producing a polypeptide or virus of interest in a continuous cell culture |
| CA2823639A1 (en) | 2011-01-05 | 2012-07-12 | Expression Therapeutics, Llc | High yield suspension cell line, system, and method for making same |
| EP2782997B1 (en) | 2011-11-24 | 2018-01-10 | Genethon | Scalable lentiviral vector production system compatible with industrial pharmaceutical applications |
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- 2012-11-26 CN CN201810811238.0A patent/CN109097398A/zh active Pending
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- 2012-11-26 EP EP17210574.4A patent/EP3327119A1/en not_active Withdrawn
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| WO2011097447A2 (en) * | 2010-02-04 | 2011-08-11 | Neurologix, Inc. | Production of recombinant virus |
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Also Published As
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| ES2663815T3 (es) | 2018-04-17 |
| CN104136605B (zh) | 2018-08-14 |
| EP2782997A1 (en) | 2014-10-01 |
| EP3327119A1 (en) | 2018-05-30 |
| CA2856455C (en) | 2022-08-23 |
| SG11201402584RA (en) | 2014-06-27 |
| JP2018046828A (ja) | 2018-03-29 |
| SI2782997T1 (en) | 2018-04-30 |
| DK2782997T3 (en) | 2018-04-16 |
| JP6280869B2 (ja) | 2018-02-14 |
| PL2782997T3 (pl) | 2018-06-29 |
| WO2013076309A1 (en) | 2013-05-30 |
| RS57066B1 (sr) | 2018-06-29 |
| LT2782997T (lt) | 2018-05-25 |
| HRP20180424T1 (hr) | 2018-06-29 |
| CA2856455A1 (en) | 2013-05-30 |
| JP2014533516A (ja) | 2014-12-15 |
| US20220235371A1 (en) | 2022-07-28 |
| AU2012342355A1 (en) | 2014-07-17 |
| US20190211360A1 (en) | 2019-07-11 |
| EP2782997B1 (en) | 2018-01-10 |
| BR112014012600A2 (pt) | 2017-06-06 |
| CN104136605A (zh) | 2014-11-05 |
| SMT201800174T1 (it) | 2018-07-17 |
| AU2012342355B2 (en) | 2017-10-12 |
| PT2782997T (pt) | 2018-04-09 |
| US20140315294A1 (en) | 2014-10-23 |
| CY1120103T1 (el) | 2018-12-12 |
| HUE036742T2 (hu) | 2018-07-30 |
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