JP6267653B2 - コロイド銀とデオキシリボ核酸との相乗的組み合わせに基づく皮膚化粧用組成物 - Google Patents
コロイド銀とデオキシリボ核酸との相乗的組み合わせに基づく皮膚化粧用組成物 Download PDFInfo
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- JP6267653B2 JP6267653B2 JP2014551617A JP2014551617A JP6267653B2 JP 6267653 B2 JP6267653 B2 JP 6267653B2 JP 2014551617 A JP2014551617 A JP 2014551617A JP 2014551617 A JP2014551617 A JP 2014551617A JP 6267653 B2 JP6267653 B2 JP 6267653B2
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Classifications
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Landscapes
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- Biochemistry (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Description
<生理学的老化>
遺伝子的要因、ライフスタイル、全身の状態などの多くの現象が関与し、これら全てに加齢も加わり、外皮の身体的構造及び機能を変化させる。第1の指標の兆候は、約30歳で生じ、真皮乳頭層の弾性繊維に影響を与える。第2段階は、50歳頃生じ、真皮深層のコラーゲン線維に関する。
太陽は、しわを悪化させ、皮膚の色素沈着スポットの兆候を生じる。太陽光線に慢性的に晒した皮膚領域(例えば、顔)は、顕微鏡実験によると、紫外線に起因する変性及びフリーラジカルの形成を示す。この日光性弾性線維症は、弾性線維が不規則で、共に凝集する真皮の中央部分に影響を与える。線維の塊が、弾性の損失及びしわの形成の原因となるコラーゲンの束を変える。
皮膚化粧用組成物は、本発明の請求項1に定義され、そのような組成物の化粧品としての使用は、本発明の請求項12に定義される。
市場には、コロイド銀または銀コロイドと呼ばれる4つの異なる生成物があることが注目される。
コロイド銀は、抗ラジカル作用を有する。BECKER博士は、1985年に、銀イオンが組織を再生することに関するメカニズムを研究した。銀イオンは、組織再生を左右する幹細胞を産するため生体細胞と共に複合体を形成する。
新たな微生物試験により、コロイド銀の病原微生物に対する効能が示されている。1988年のUCLAによる研究は、コロイド銀が化膿性連鎖球菌、黄色ブドウ球菌に対する抗菌作用を有すると結論付けている。Helen BUCKLEY(フィラデルフィア州テンプル大学、1995年)は、様々な種類のカンジダ・アルビカンス及び様々なクリプトコッカスへの効能を有する非常に少量のコロイド銀を使用した。ローマの微生物研究所が行い、1992年12月の「Applied and Environmental Microbiology」に掲載された研究では、その殺菌能力を異なる形態の銀により変化させる試験が行われた。
Jason HENRYは、病原酵母(出芽酵母)に対するコロイド銀の作用を試験し、10ppmの用量での生成物の単回投与によって、24時間、酵母の増殖を停止させることができること、すなわち免疫システムが反応する時間を確保できることを報告した。
British Medical Journalは、コロイド銀が、抗炎症及び鎮痛活性も有することを報告している。
Natural Immunogenics社から市販される10ppmの用量のソベレインシルバーコロイド銀(Sovereign Silver colloidal silver)についてFDAに認可された研究所(Covance Laboratories Inc)で試験を行った。この毒性学に関する研究によって、該生成物の優れた耐性及び無毒性が確認された(2003年3月20日付の報告)。
デオキシリボ核酸(DNA)は、WATSONとCRIKの研究(ノーベル賞)により、生物学者にとって周知の分子である。
HP DNAは、優れた皮膚保湿剤である。細胞レベルにおいて、HP DNA分子が拡散すると、自身の10000倍以上の体積の水溶液と結合する。
HP DNA生体分子は、誘導体を生じない同様の活性を有する他の多くの基質と比較して、二重螺旋内へのOHラジカルの捕捉により、フリーラジカルの捕捉後、他の隣接構造を変質させやすい利点を有する。
HP DNAの活性は、角膜の傷に対する作用によって証明され、眼粘膜に対する優れた耐性がある(アイコンター(eye contour)製品での使用)。HP DNAの生物学的効果に加え、皮膚構造の保護の役割を強化する大きな物理的特性がある。1mmの厚さで、HP DNAの1%溶液は、細胞のDNAを損傷させる200〜300nmの低強度のUV線を完全に吸収する。
この生成物は脂肪分解効果を有し、本発明における製剤、より詳細には、良好な目の下のくまへの抗作用を有するアイコンター製剤として使用される。本発明の組成物は、0.1〜3%のカフェインを含有する。
本発明に係るコロイド銀及びHP DNAの組み合わせの相乗作用は、以下の指標で、in vitro及びin vivoにて実証されている。
脂質過酸化反応は、ラジカル経路により導かれる通常の状態の鎖反応である。膜脂質の酸化によって過酸化脂質が形成され、過酸化脂質は種々の断片へと分解される。分解された断片の一部は皮膚への毒性が高く肌荒れの原因ともなる。
・リノール酸エマルジョンの過酸化を、OHヒドロキシルラジカルにより誘発。
・相乗的効果(別の効果と比較して、54%〜215%の範囲で観察される保護による利益)。相乗作用は、より詳細には、0.3〜0.5%HP DNAを含有する65〜80mlの量の10ppmコロイド銀を用いて行われる。
UV線は、細胞代謝、特に、線維芽細胞の代謝を攪乱させる。
実施例1の製剤を抗しわ活性を評価する方法を使用して臨床的に試験した。接写撮影分析を伴う皮膚インプリント技術を使用した。30〜82歳の78名の女性で3ヶ月間行ったこの試験の結果が、以下の表においてしわ減少(%)として示される。
有効成分:70〜80mlの10ppmコロイド銀溶液
HP DNA:500mg
カフェイン:500mg
植物由来の天然賦形剤:
オーガニックスウィートアーモンドオイル:1〜5%
オーガニックアルガンオイル:1〜5%
オーガニックシアバター:1〜5%
オーガニックアロエベラオイル抽出物:1〜5%
セテアリルアルコール、セテアリルグルコシド:5〜10%
水素化植物性グリセリン:1〜5%
グリセリン:1〜5%
炭酸ジカプリリル:1〜5%
トリ(カプリル酸・カプリン酸)グリセリン:1〜5%
ステアロイルグルタミン酸ナトリウム:1%未満
トコフェロール酢酸:1%未満
キサンタンガム:1%未満
ECOCERT保存剤:1%未満
低アレルギー性香料:1%未満
有効成分:60〜80mlの10ppmコロイド銀溶液
HP DNA:900〜1000mg
ECOCERT保存剤:1%未満
低アレルギー性香料:1%未満
他の植物由来の天然賦形剤:最大100g
有効成分:65〜85mlの10ppmコロイド銀溶液
HP DNA:800mg
カフェイン:750mg
ECOCERT保存剤:1%未満
低アレルギー性香料:1%未満
他の植物由来の天然賦形剤:最大100g
有効成分:60〜80mlの10ppmコロイド銀溶液
HP DNA:350mg
ECOCERT保存剤:1%未満
低アレルギー性香料:1%未満
他の植物由来の天然賦形剤:最大100ml
有効成分:70〜80mlの10ppmコロイド銀溶液
HP DNA:250mg
ECOCERT保存剤:1%未満
低アレルギー性香料:1%未満
他の植物由来の天然賦形剤:最大100ml
有効成分:60〜80mlの10ppmコロイド銀溶液
HP DNA:1000〜1200mg
カフェイン:500〜800mg
ECOCERT保存剤:1%未満
低アレルギー性香料:1%未満
他の植物由来の天然賦形剤:最大100g
有効成分:2〜5mlの20ppmコロイド銀溶液
HP DNA:500〜900mg
ECOCERT保存剤:1%未満
低アレルギー性香料:1%未満
他の植物由来の天然賦形剤:最大100g
有効成分:70〜90mlの20ppmコロイド銀溶液
HP DNA:300〜500mg
カフェイン:300〜500mg
ECOCERT保存剤:1%未満
低アレルギー性香料:1%未満
他の植物由来の天然賦形剤:最大100ml
有効成分:1〜5mlの15ppmコロイド銀溶液
HP DNA:100〜200mg
ECOCERT保存剤:1%未満
低アレルギー性香料:1%未満
他の植物由来の天然賦形剤:最大100g
有効成分:60〜90mlの10ppmコロイド銀溶液
HP DNA:200〜500mg
ECOCERT保存剤:1%未満
低アレルギー性香料:1%未満
他の植物由来の天然賦形剤:最大100g
有効成分:70〜90mlの10ppmコロイド銀溶液
HP DNA:100〜200mg
ECOCERT保存剤:1%未満
低アレルギー性香料:1%未満
他の植物由来の天然賦形剤:最大100ml
有効成分:65〜85mlの10ppmコロイド銀溶液
HP DNA:500〜1000mg
ECOCERT保存剤:1%未満
低アレルギー性香料:1%未満
他の植物由来の天然賦形剤:最大100ml
有効成分:1〜3mlの10ppmコロイド銀溶液
HP DNA:100〜200mg
ECOCERT保存剤:1%未満
低アレルギー性香料:1%未満
他の植物由来の天然賦形剤:最大100ml
有効成分:65〜80mlの10ppmコロイド銀溶液
HP DNA:100〜1500mg
ECOCERT保存剤:1%未満
低アレルギー性香料:1%未満
他の植物由来の天然賦形剤:最大100g
有効成分:70〜80mlの15ppmコロイド銀溶液
HP DNA:500〜750mg
ECOCERT保存剤:1%未満
低アレルギー性香料:1%未満
有効成分:5〜10mlの20ppmコロイド銀溶液
HP DNA:300〜500mg
ECOCERT保存剤:1%未満
低アレルギー性香料:1%未満
他の植物由来の天然賦形剤:最大100g
有効成分:65〜80mlの10ppmコロイド銀溶液
HP DNA:300〜500mg
ECOCERT保存剤:1%未満
低アレルギー性香料:1%未満
他の植物由来の天然賦形剤:最大100g
有効成分:30〜50mlの5ppmコロイド銀溶液
HP DNA:100〜250mg
低アレルギー性香料:1%未満
エチルアルコール,95°:最大100ml
Claims (9)
- コロイド銀とデオキシリボ核酸との相乗的な組み合わせを有効成分として含有する皮膚化粧用組成物であって、
前記コロイド銀が、電気的コロイド銀の水溶液であり、
前記デオキシリボ核酸が、ナトリウム塩の形態の高重合デオキシリボ核酸(HP DNA)であることを特徴とする皮膚化粧用組成物。 - カフェインを含有することを特徴とする、請求項1に記載の組成物。
- 前記電気的コロイド銀は、80〜96%の銀イオンと、4〜20%の銀粒子とを含有することを特徴とする、請求項1に記載の組成物。
- 前記銀の粒子径が、0.0008〜0.04ミクロンであることを特徴とする、請求項3に記載の組成物。
- 前記コロイド銀の溶液は、5〜20ppmの銀を含有することを特徴とする、請求項1〜4のいずれか1項に記載の組成物。
- 前記コロイド銀の溶液は、10ppmの銀を含有することを特徴とする、請求項5に記載の組成物。
- 1〜90%のコロイド銀を含有することを特徴とする、請求項1〜6のいずれか1項に記載の組成物。
- 0.1〜5%のHP DNAを含有することを特徴とする、請求項1〜7のいずれか1項に記載の組成物。
- 0.1〜3%のカフェインを含有することを特徴とする、請求項1〜8のいずれか1項に記載の組成物。
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PCT/EP2013/050422 WO2013107687A2 (fr) | 2012-01-16 | 2013-01-10 | Compositions dermo-cosmétiques à base d'une association synergique d'argent colloïdal et d'acide désoxyribonucléique |
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BR112014017448B1 (pt) | 2019-06-25 |
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CN104053425B (zh) | 2016-10-05 |
JP2015503606A (ja) | 2015-02-02 |
ES2553055T3 (es) | 2015-12-03 |
EP2747739A2 (fr) | 2014-07-02 |
CN104053425A (zh) | 2014-09-17 |
RU2609867C1 (ru) | 2017-02-06 |
EP2747739B1 (fr) | 2015-09-02 |
US9486397B2 (en) | 2016-11-08 |
WO2013107687A2 (fr) | 2013-07-25 |
BR112014017448A2 (pt) | 2017-06-13 |
WO2013107687A3 (fr) | 2014-04-03 |
BR112014017448A8 (pt) | 2017-07-04 |
US20140356436A1 (en) | 2014-12-04 |
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