WO2022235238A2

WO2022235238A2 - Anti-inflammatory, anti-allergic, anti-bacterial, anti-aging and anti-oxidant effective multifunctional and nanotechnological gel content and production method for the facial contour

Info

Publication number: WO2022235238A2
Application number: PCT/TR2022/050370
Authority: WO
Inventors: Şeyda ATABAY
Original assignee: Dr. Şeyda Atabay Sağlik Ve Kozmeti̇k Ürünleri̇ A.Ş.
Priority date: 2021-05-04
Filing date: 2022-04-26
Publication date: 2022-11-10
Also published as: WO2022235238A3; TR202107577A2

Abstract

A gel formulation for the facial area with soothing, blackhead and acne removal, anti-oxidant, anti-aging and antibacterial effects has been developed with the present invention with its anti-inflammation-like effect without making oily and acne-prone skins wherein the combination of hemp oil, grape seed oil and rosehip oil has been formulated as nanoparticles and is used together with this mixture. The present invention relates to a nanotechnological, gel-based cosmetic formulation that contains solid lipid nanoparticles (SLN) obtained with oils similar to the fat structures existing in our body.

Description

ANTI-INFLAMMATORY, ANTI-ALLERGIC, ANTI-BACTERIAL, ANTI-AGING AND ANTI-OXIDANT EFFECTIVE MULTIFUNCTIONAL AND NANOTECHNOLOGICAL GEL CONTENT AND PRODUCTION METHOD

FOR THE FACIAL CONTOUR

Technological Field:

The present invention relates to an anti-inflammatory, anti-allergic, anti bacterial, anti-aging and anti-oxidant effective multifunctional and nanotechnological gel content and production method for the facial contour.

A gel formulation for the facial area with soothing, blackhead and acne removal, anti-oxidant, anti-aging and antibacterial effects has been developed with its anti-inflammation-like effect without making oily and acne-prone skins wherein the combination of hemp oil, grape seed oil and rosehip oil has been formulated as nanoparticles and is used together with this mixture.

In particular, the present invention relates to a nanotechnological, gel-based cosmetic formulation that contains solid lipid nanoparticles (SLN) obtained with oils similar to the fat structures existing in our body, which are particularly effective in changing the appearance of wrinkles around the face.

State of the Art:

Cosmetics are defined as all preparations or substances which are prepared to be applied to different external parts of the human body such as the epidermis, nails, hair, hair, lips and external genitalia, teeth and oral mucosa, whose sole or primary purpose is to clean, scent, change the appearance and/or correct and/or protect or keep these parts in good condition. For this reason, cosmetic products are products that must be designed safe and risk-free. The primary function of the product must comply with the definition of cosmetics.

Substances serve for anti-aging and blemishes should be pharmacologically appropriate, should show their effect in 2-3 months, their possibility of side effects should be low, and they should be able to remove unwanted blemishes permanently. In order to increase the effect by adding, combinations of these substances are used in most of the formulations. In particular, it is aimed to reduce the side effects and increase the effectiveness by choosing low concentrations of substances that act by different mechanisms. Skin peeling products such as trichloroacetic acid are used to remove melanin-containing skin surfaces with a peeling effect. However, even if acidic peels are used for facial skin, the possibility of side effects is medium-high. The face is one of the most important parts of a person's physical appearance. The first interaction with the social environment takes place over the face, people try to recognize and estimate each other by looking at their faces. For this reason, people try to take good care of their faces and make an effort to prevent possible skin problems. The present invention of this description discloses a gel formulation for the facial area with soothing, blackhead and acne removal, anti-oxidant, anti-aging and antibacterial effects with its anti- inflammation-like effect.

Wrinkles and sagging are seen on the skin together with advancing age Studies show that 80-90% of aging-related skin problems are caused by environmental damage. Sun rays are the most effective environmental factor causing skin aging and cause blemish formation on the skin. The products sold in the market are designed through a single mechanism such as anti-aging, anti-wrinkle, sunscreen, blemish remover and so on so as to solve this problem. A person who wants to use anti-aging purchases a different product and a person who wants to get anti-wrinkle support purchases another different product. However, since it is not possible to use all of these products at the same time, the needs of the skin cannot be fully met; it is observed that it is costly for the user since more than one product has to be purchased. A facial cream is disclosed in the patent document numbered 2020/14776 found in the literature research. Said face cream contains jojoba and panthenol, and these ingredients are not included in the invention subject to the description.

A facial cream containing cannabis leaf is disclosed in the Chinese patent document numbered CN111184663A found in the literature research. However, in said invention in addition to hemp oil, rosehip and grape seed oil are also present, and the ingredients are formulated as nano-particular.

As a result, there is a need for a new gel content and production method to be used for the facial contour, in which the state of the art is overcome and its disadvantages are eliminated.

Aim of the Invention:

The invention is a new gel content and production method which exceeds the state of the art and eliminates the disadvantages and has some additional features.

It is aimed to produce a product prototype with anti-aging effect by balancing the color change in the skin and stimulating the stimulation of collagen synthesis with the present invention A nanotechnological, gel-based cosmetic formulation that contains solid lipid nanoparticles obtained with oils similar to the fat structures existing in our body, which are particularly effective in changing the appearance of wrinkles around the face is formed. The main aim of the invention, which is the subject of the description, is to design an effective cosmetic product that will help reduce wrinkles in the facial area and structural restoration of the skin. It is aimed to reveal an effective cosmetic product for the facial region within the scope of the present invention that can be used by even sensitive skin individuals, minimizes the appearance of fine wrinkles, helps to open deep wrinkles, has a sunscreen effect with solid lipid nanoparticles, and also has anti-aging, anti-inflammatory and antioxidant effects by balancing the skin color. The product subject to the invention can be used easily even by people with sensitive skin and skin prone to acne.

The aim of the invention is to reveal a multifunctional and nanotechnological gel content with anti-aging effect, which is obtained with oils similar to the fat structures in our body, especially cannabis oil, that will minimize the appearance of fine wrinkles in the facial area, helps to open deep wrinkles, has a sunscreen effect, balances the skin color, and has anti-aging effects.

Another aim of the invention is to reveal a gel content in which possible side effects are minimized with the use of low amount of preservatives. Another aim of the invention is to have a hydrophilic gel-based gel content of the developed formulation, which does not give an oily feeling.

Multifunctional gel content has been revealed by the use of solid lipid nanoparticles and natural herbal oils in the present invention. These functions are listed below.

• It has been determined that solid lipid nanoparticles create a pigment effect due to their white color.

• Solid lipid nanoparticles act as physical protectors due to their crystalline structure. • The product that will be formed with the formula developed by using this feature, has sunscreen feature without using physical and chemical preservatives. Description of the Invention:

In this detailed description, the inventive face gel and production method is described by means of examples only for clarifying the subject matter such that no limiting effect is created. In the present invention, an anti-inflammatory, anti allergic, anti-bacterial, anti-aging and anti-oxidant effective multifunctional and nanotechnological gel content and production method for the facial contour is described.

The present invention is a facial gel containing effective amounts of cannabis oil, grape seed oil and rosehip oil. Additionally, it contains distilled water, carbomer, triethanolamine, Peg-8, Compritol® 888, hyaluronic acid, vitamin C, Gransome Heptapeptide-7, Eukly 9010 and Sensiva® PA 40.

Cannabis oil used in the invention;

• is a fighter against cancer

• reduces the risk of Alzheimer's and Parkinson's.

• reduces autoimmunity and inflammation.

• reduces pain.

• is effective in psoriasis.

• is protective against bacteria.

• supports heart health.

• provides the regulation of diabetes.

• helps in the treatment of asthma.

Hemp oil, also called CBD oil, is an oil obtained by separating CBD from hemp extract by various methods and mixing it with oils such as coconut oil, grape seed oil, rosehip oil, olive oil or hemp seed oil, and is used in many sectors, mostly in the medical industry.

In order to use hemp oil, it must be used with an active base substance, that is, it must be dissolved in oil. Rosehip oil and grape seed oil are used in the invention so as to achieve this. If hemp oil is used together with these oils, it becomes more homogenized and its effectiveness increases. As noted in the following section, said two oils have anti-inflammatory properties and support hemp oil in this respect as well. In other words, they both ensure the condensation of the oil and increase the effectiveness of the oil due to the substances therein. In current applications, it has been observed that hemp oil is used with olive oil or different oils.

Hemp oil delays aging and prevents early signs of aging with the help of the linoleic acid in its content. It does not leave an oily effect on the skin after application. It balances the pH of the skin and reduces the UV effect. It helps to restore the microfilm layer of the skin and thus increases the skin's resistance to environmental negative effects. It increases skin elasticity and flexibility. The major advantage of hemp oil is that it is hypoallergenic. Therefore, it is suitable for sensitive and eczematic skin. It prevents irritation and redness. Hemp oils are helpful in acne, atopic eczema and psoriasis. It not only improves the condition of the skin, but also relieves mild itching.

Rosehip oil which is another ingredient used in the invention is used to prevent or improve fine lines and wrinkles. It is an effective moisturizer for dry skin. It helps to prevent or reduce cracks. It gives a natural shine to the skin. It balances skin tone by minimizing pores and blemishes. It is the only fruit in the world that contains natural Retinoic Acid. It contains high levels of vitamin A (retinol) and B1, B2, E, K, Sodium and Calcium It has anti-septic properties. It is antioxidant. It is good for redness, sensitivity and flaking problems. It provides the disappearance of scars caused by eczema and acne. It reduces the effect of the sun on the skin.

The grape seed oil used in the invention has skin penetration, so it does not cause an oily feeling on the skin after application. Grape seed oil strengthens cell membranes and improves the overall quality of the skin with its linoleic acid content. As a moisturizer, it nourishes the skin and adds a shiny touch to the skin. Grape seed oil is one of the essential oils used in aromatherapy, as it is a light and thin oil. It slows down the formation of wrinkles and prevents sagging. Its application as a massage oil helps in reducing varicose, rheumatism and joint pain.

Grape seed oil prevents clogging of pores and prevents formation of more acne with its high antioxidant properties. It not only prevents the formation of acne, but also helps to treat existing acne with its anti-inflammatory properties. It removes under-eye and skin wrinkles and prevents skin sagging. It removes under-eye and skin wrinkles and prevents skin sagging.

Vitamin C used in the invention provides a bright and tight skin appearance, supports collagen production, reduces the appearance of fine lines and skin sagging, and acts as a real antioxidant by eliminating the pigmentation problem. Ascorbic acid is an important cofactor of propyl hydroxylase and lysyl hydroxylase enzymes required for collagen formation in the skin. This hydroxylation process is important for the collagen to function in the skin. As a result of contact with UV, free oxygen radicals are formed in the skin and ascorbic acid accumulations in the skin are discharged. Topical ascorbic acid acts as a free radical scavenger and stimulates collagen synthesis.

Hyaluronic acid used in the invention provides a more tense and smooth appearance to the skin by increasing the moisture content and creates an artificial lipid mantle by forming a thin film layer on the skin surface. Thus, it protects the skin against external factors and provides a natural shine. Hyaluronic acid shows high molecular weight hydrophilic forming properties. It is effective in regulating and strengthening dermal collagen.

The gransome heptapeptide-7 used in the invention is a patented peptide sequence prepared in phospholipid mini-vesicles. The active peptide is produced from a naturally occurring wound-healing protein with EGF-like activity. This delivery mechanism provides enhanced population and long-term bioavailability of active peptides, which offers the best opportunity for visible improvements in the skin. Gransome Heptapeptide-7 is an ideal compound to combat the visible manifestations of crepey skin and other undesirable changes in the skin where extracellular matrix remodeling is required for significant improvements.

Carbopol 974 which is used in the invention is a white, fluffy, acidic and hygroscopic high molecular weight synthetic polymer with a slight characteristic odor. Carbomers are used as gelling agents in concentrations between 0.5 and 2%. The pH of 0.5-1% dispersion is between 2.5-3.5. It is soluble in water and after neutralization in ethanol and glycerine. When carbomers are dispersed in water, a low viscosity colloidal solution is formed. Viscosity increases when an alkaline substance such as trolamine (triethanolamine) is added. The carbomer can be quickly scattered into the water being mixed so as to accelerate dispersion initially; during this time, attention should be paid to the formation of pellets. Efforts should be made to minimize the formation of air bubbles in the gel. Maximum viscosity is usually achieved between pH 6-11. Carbomer gels should be protected from light and contain antimicrobial preservatives.

Compritol 888 (solid lipid nanoparticles) used in the invention which are solid lipid nanoparticles are new drug delivery systems on which studies have been focused in recent years. Studies on dermatological and cosmetic applications have always been at the forefront. It is aimed to increase the penetration and absorption of the active substance trapped in solid lipid nanoparticles through the skin, to reduce its penetration through the skin, to ensure that it only acts on the skin surface for a longer time, and to reduce the irritation potential of substances that cause irritation on the skin. Solid lipid nanoparticles began to be developed in the early 1990s as alternative carrier systems to emulsions, liposomes and polymeric particulate systems. The hyaluronic acid used in the present invention is not sodium hyaluronate, which can show the effect of hyaluronic acid used in the market. Hyaluronic acid is widely used in all kinds of ophthalmic surgery, such as biochemical medicine, crystal implantation, corneal transplantation and anti-glaucoma surgery, whose main function is high clinical value, when used in a cosmetic product, has a unique skin protection effect and can keep the skin moist and smooth, is a raw material that can restore delicate, soft, elastic, anti-wrinkle, beauty care and skin physiology function. On the other hand, sodium hyaluronate is a substance that is widely used in the low-cost cosmetic industry, shows the effect of hyaluronic acid with its moisturizing feature.

Studies have shown that the use of low molecular weight hyaluronic acid in cosmetic formulations is successful in preventing signs of skin aging and line formation. The values given for this are 50-130 and 300 kDA. The hyaluronic acid used in our formulation is 300kDA.

The contribution of solid lipid nanoparticles in the developed formulation can be expressed as follows;

• They protect components with stability problems against chemical degradation.

• They provide controlled release of cosmetic active ingredients depending on the type and size of the nanoparticle produced. • They can be used as carriers for chemical UV filters. Thus, they allow to increase the UV blocking effect and reduce the concentration of sunscreen in the formulation.

• Solid lipid nanoparticles have UV blocking properties. They act as physical sun filters by effectively reflecting UV light due to their particulate properties.

In the preferred embodiment of the invention, the given ingredients are used in the ratios given below.

Accordingly, 80-85% distilled water, 0.2-0.5% carbomer, 0.2-0.5% triethanolamine, 1-5% rosehip oil, 1-5% hemp oil, 1-5% grape seed oil, 6-12% Peg -8, 0.1-1% Compritol® 888, 0.08-0.5% hyaluronic acid, 0.08-0.5% vitamin C, 0.01-0.5% Gransome Heptapeptide-7, 0.01-0.5% Eukly 9010, 0.01-0.5% Sensiva® PA 40 by mass are found in the preferred embodiment of the present invention. In addition, it optionally contains a microbial preservative in the range of 0.01-0.5%, as well as a chelating agent in the range of 0.01-0.015%, it does not contain any fragrances. The content ratios of the preferred embodiment of the present invention can optionally be expanded. Accordingly, 70-95%, more preferably 80-85% distilled water, preferably 0.1-1% more preferably 0.2-0.5% carbomer, preferably 0.1-1% more preferably 0.2-0.5% triethanolamine, preferably 0.1-10% more preferably 1-5% rosehip oil, preferably 0.1-10% more preferably 1-5% hemp oil, preferably 0.1-10% more preferably 1-5% grape seed oil, preferably 2-20% more preferably 6-12% Peg-8, preferably 0.05-2% more preferably 0.1-1% Compritol® 888, preferably 0.02-1% more preferably 0.08-0.5% hyaluronic acid, preferably 0.02-1% more preferably 0.08-0.5% vitamin C, preferably 0.005-1% more preferably 0.01-0.5% Gransome Heptapeptide-7, preferably 0.005-1% more preferably 0.01-0.5% Eukly 9010, preferably 0.005-1% more preferably 0.01-0.5% Sensiva® PA 40 by mass are found in the preferred embodiment of the present invention. In addition, it optionally contains a microbial preservative, preferably in the range of 0.005-1%, more preferably 0.01-0.5%, as well as a chelating agent in the range of 0.005-1.5%, more preferably 0.01-0.015%, it does not contain any fragrance substances. The present invention may contain effective amounts of tween 80 (polysorbate 80).

In another preferred embodiment of the present invention, effective amounts of hemp oil, grape seed oil and rosehip oil are prepared by blending them with various additional ingredients in an effective amount of Compritol® 888 solid lipid nanoparticles carrier system. Accordingly, preferably 0.1-10% more preferably 1-5% rosehip oil, preferably 0.1-10% more preferably 1-5% hemp oil, preferably 0.1-10% more preferably 1-5% grape seed oil and preferably 0.05-2 more preferably 0.1-1% Compritol® 888 is used in the present invention. Furthermore, it contains preferably 70-95%, more preferably 80-85% by mass of distilled water, preferably 0.1-1% more preferably 0.2-0.5% carbomer, preferably 0.1-1%more preferably 0.2-0.5% triethanolamine, preferably 2-20% more preferably 6-12% Peg-8, preferably 0.02-1% more preferably 0.08-0.5% hyaluronic acid, preferably 0.02-1% more preferably 0.08-0.5% vitamin C, preferably 0.005-1% more preferably 0.01-0.5% Gransome Heptapeptide-7, preferably 0.005-1% more preferably 0.01-0.5% Eukly 9010, preferably 0.005- 1% more preferably 0.01-0.5% Sensiva® PA 40, preferably 0.005-1% more preferably a microbial preservative in the range of 0.01-0.5%, also a chelating agent in the range of 0.005-1.5% more preferably 0.01-0.015%, it does not contain any fragrance ingredient. The production method for the present invention is described below.

• 0,40% prepared carbopol is kept at +40 °C for 1 night and after the carbopol molecules are fully swelled the next day, it is neutralized with 0.20% triethylamine to obtain phase A.

• Tween 80 is added to the heated water and mixed at 24000 rpm, Compritol® 888, weighed in the desired amount, is added to this mixture, mixing process with ultra sonox continues, after homogenization, the solid lipid nanoparticles (SLN) obtained are kept at +4 °C for 1 night and phase B is obtained.

• It is dissolved in distilled water by mixing thoroughly and phase C is obtained so as to obtain a solution gransome heptapeptide-7, hyaluronic acid, vitamin C;

• A mixture of rosehip oil, grape seed oil and hemp oil is dissolved in PEG- 8 and phase D is obtained.

• Phase C is added to the A phase gradually, after a homogeneous mixture is achieved, the B phase and D phase are added to the A+C phase mixture, respectively, in the same process so as to ensure a homogeneous mixture.

• The final product is obtained by adding a preservative to the final mixture.

• The final product is stored in the refrigerator at +4-8 degrees.

Instructions for applying the formulation

When the resulting gel-based face cream is applied twice a day, in the morning and evening, in the size of six lentils, within 7 days, it is expected to balance the color around the face, decrease in bruises, moisturize, and open wrinkles.

The natural oils used in the invention will be additive-free oils obtained with 95% efficiency from the seed or leaf with a purity close to 100%. Oil obtained in this way will have a higher penetration through the skin and a more effective formulation. In many products used in the market, the use of adulterant oil or the use of lower quality natural oils is preferred. Therefore, other products on the market are in the form of oily creams and cause skin to be oily. The present invention, which will be prepared on a gel basis and will contain natural herbal ingredients, is anti-allergic and will moisturize the skin without making it oily. Among the anti-aging active ingredients the following can be listed; moisturizers and plumpers, cell regenerative and repairers, antioxidants, substances that provide repair in the dermis, and those that increase skin elasticity by stimulating collagen synthesis. Some of the active ingredients may have more than one effect. Some of the active ingredients may have more than one effect. These are antioxidant substances and cell regulating substances.

Sun filters, which are anti-aging components, are divided into two as chemical and physical effects. Chemical sun filters take the energy of the UV light coming to the skin surface and convert it into heat energy, they must not be absorbed and remain on the skin surface so as to be effective.

Physically effective sun filters are compounds that act by reflecting the barrier properties and by scattering the rays coming to the skin due to their structure and they can have an opaque or transparent appearance on the skin surface due to their size. Solid lipid nanoparticles act as physical protectors due to their crystalline structure. The product that will be formed with the formula developed by using this feature, has sunscreen feature without using physical and chemical preservatives. An effective cosmetic product that will help reduce wrinkles in the facial area and structural restoration of the skin will be obtained with the present invention.

Claims

1- An anti-inflammatory, anti-allergic, anti-bacterial, anti-aging and anti-oxidant effective multifunctional and nanotechnological gel content, characterized in that, it contains the following;

• preferably 70-95%, more preferably 80-85% by mass distilled water,

• preferably 0.1-1%, more preferably 0.2-0.5% triethanolamine,

• preferably 0.1-1%, more preferably 0.2-0.5%carbomer,

• preferably 0.1 -10% more preferably 1 -5% rosehip oil,

• preferably 0.1-10% more preferably 1-5% hemp oil,

• preferably 0.1 -10% more preferably 1 -5% grape seed oil,

• preferably 2-20% more preferably 6-12% Peg-8,

• preferably 0.05-2% more preferably 0.1-1% Compritol® 888,

• preferably 0.02-1 %, more preferably 0.08-0.5% hyaluronic acid,

• preferably 0.02-1 % more preferably 0.08-0.5% vitamin C,

• preferably 0.005-1% more preferably 0.01-0.5% Gransome Heptapeptide-7,

• preferably 0.005-1 % more preferably 0.01 -0.5% Eukly 9010,

• preferably 0.005-1 %, more preferably 0.01 -0.5% Sensiva® PA 40. 2- A cosmetic gel content according to claim 1, characterized in that; it contains preferably 0.005-1%, more preferably 0.01-0.5% microbial preservative.

3- A cosmetic gel content according to claim 1, characterized in that; it contains preferably 0.005-1.5%, more preferably 0.01-0.015% of a chelating agent, it does not contain any fragrance substance. 4- A cosmetic gel content according to claim 1, characterized in that; it does not contain any fragrance substance.

5- Another embodiment of an anti-inflammatory, anti-allergic, anti-bacterial, anti- aging and anti-oxidant effective multifunctional and nanotechnological gel content for the facial region, characterized in that, it contains the following;

• preferably 0.1 -10% more preferably 1 -5% rosehip oil,

• preferably 0.1-10% more preferably 1-5% hemp oil,

• preferably 0.1 -10% more preferably 1 -5% grape seed oil,

• preferably 0.05-2% more preferably 0.1-1% Compritol® 888.

6- A cosmetic gel content according to claim 5, characterized in that; it contains preferably 70-95%, more preferably 80-85% distilled water by mass. 7- A cosmetic gel content according to claim 5 or claim 6, characterized in that; it contains preferably 0.1-1%, more preferably 0.2-0.5% carbomer.

8- A cosmetic gel content according to any of the claims 5 to 7, characterized in that; it contains preferably 0.1-1%, more preferably 0.2-0.5% triethanolamine.

9- A cosmetic gel content according to any of the claims 5 to 8, characterized in that; it contains preferably 2-20%, more preferably 6-12% Peg-8. 10- A cosmetic gel content according to any of the claims 5 to 9, characterized in that; it contains preferably 0.02-1%, more preferably 0.08-0.5% hyaluronic acid. 11 A cosmetic gel content according to any of the claims 5 to 10, characterized in that; it contains preferably 0.02-1%, more preferably 0.08- 0.5% Vitamin C. 12- A cosmetic gel content according to any of the claims 5 to 11, characterized in that; it contains preferably 0.005-1% more preferably 0.01- 0.5% Gransome Heptapeptide-7, preferably 0.005-1% more preferably 0.01- 0.5% Eukly 9010, preferably 0.005-1% more preferably 0.01-0.5% Sensiva® PA 40, preferably 0.005-1% more preferably a microbial preservative in the range of 0.01-0.5%, also a chelating agent in the range of 0.005-1.5% more preferably 0.01-0.015%, it does not contain any fragrance ingredient.

13 A cosmetic gel content according to any of the claims 5 to 12, characterized in that; it contains preferably 0.005-1%, more preferably 0.01- 0.5% Eukly 9010.

14 A cosmetic gel content according to any of the claims 5 to 13, characterized in that; it contains preferably 0.005-1%, more preferably 0.01- 0.5% Sensiva® PA 40.

15 A cosmetic gel content according to any of the claims 5 to 14, characterized in that; it contains preferably 0.005-1%, more preferably 0.01- 0.5% microbial preservative. 16 A cosmetic gel content according to any of the claims 5 to 15, characterized in that; it contains preferably 0.005-1.5%, more preferably 0.01- 0.015% chelating agent. 17 A cosmetic gel content according to any of the claims 5 to 16, characterized in that; it does not contain any fragrance substance.

18 An anti-inflammatory, anti-allergic, anti-bacterial, anti-aging and anti-oxidant effective multifunctional and nanotechnological gel content for the facial region, characterized by the preparation of effective amounts of hemp oil, grape seed oil and rosehip oil in an effective amount of Compritol® 888 solid lipid nanoparticles carrier system by blending with various additional ingredients. 19 Production method for an anti-inflammatory, anti-allergic, anti-bacterial, anti aging and anti-oxidant effective multifunctional and nanotechnological gel content for the facial region, characterized in that, it contains the following process steps;

• keeping 0,40% prepared carbopol at +40 °C for 1 night and after the carbopol molecules are fully swelled the next day, obtaining phase A by neutralizing the same with 0.20% triethylamine,

• adding Tween 80 to the heated water and mixing at 24000 rpm and adding Compritol® 888 weighed in the desired amount to this mixture and continuing the mixing process with ultra sonox and obtaining the B phase by keeping the solid lipid nanoparticles (SLN) obtained after homogenization, at +4 °C for 1 night,

• dissolving gransome heptapeptide-7, hyaluronic acid , vitamin C in distilled water by mixing thoroughly so as to obtain a solution and obtaining phase C;

• dissolving a mixture of rosehip oil, grape seed oil and hemp oil in PEG-8 and obtaining phase D,

• gradually adding phase C to phase A, respectively, • after obtaining a homogeneous mixture, adding the B phase and D phase to the A+C phase mixture in the same process, respectively so as to ensure a homogeneous mixture,

• obtaining the final product by adding preservative to the final mixture, · storing the final product in the refrigerator at +4-8 degrees.