JP6251396B2 - 薬物送達システム - Google Patents

薬物送達システム Download PDF

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Publication number
JP6251396B2
JP6251396B2 JP2016538065A JP2016538065A JP6251396B2 JP 6251396 B2 JP6251396 B2 JP 6251396B2 JP 2016538065 A JP2016538065 A JP 2016538065A JP 2016538065 A JP2016538065 A JP 2016538065A JP 6251396 B2 JP6251396 B2 JP 6251396B2
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Japan
Prior art keywords
vinyl acetate
delivery system
drug delivery
release
ethylene
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JP2016538065A
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Japanese (ja)
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JP2016539991A (ja
Inventor
フエルフーフエン，ヴイリー・イエー・ハー
デ・フラーフ，ヴアウテル
Original Assignee
メルク・シャープ・エンド・ドーム・ベー・フェー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2016538065A 2013-12-11 2014-12-08 薬物送達システム Active JP6251396B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361914500P 2013-12-11 2013-12-11
EP13196737 2013-12-11
US61/914,500 2013-12-11
EP13196737.4 2013-12-12
PCT/EP2014/076823 WO2015086491A1 (en) 2013-12-11 2014-12-08 Drug delivery system.

Publications (2)

Publication Number Publication Date
JP2016539991A JP2016539991A (ja) 2016-12-22
JP6251396B2 true JP6251396B2 (ja) 2017-12-20

Family

ID=49759119

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016538065A Active JP6251396B2 (ja) 2013-12-11 2014-12-08 薬物送達システム

Country Status (23)

Country Link
US (1) US10413504B2 (https=)
EP (1) EP3079660B1 (https=)
JP (1) JP6251396B2 (https=)
KR (1) KR101808977B1 (https=)
CN (1) CN105979930B (https=)
AP (1) AP2016009223A0 (https=)
AU (1) AU2014363724B2 (https=)
BR (1) BR112016013325B1 (https=)
CA (1) CA2931559C (https=)
CR (1) CR20160261A (https=)
DO (1) DOP2016000132A (https=)
EA (1) EA031802B1 (https=)
HK (1) HK1224208A1 (https=)
IL (1) IL245544A0 (https=)
MA (1) MA39059A1 (https=)
MD (1) MD20160079A2 (https=)
MX (1) MX2016007681A (https=)
PE (1) PE20160680A1 (https=)
PH (1) PH12016501083A1 (https=)
SG (1) SG11201604660VA (https=)
SV (1) SV2016005214A (https=)
TW (1) TW201607563A (https=)
WO (1) WO2015086491A1 (https=)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10413504B2 (en) 2013-12-11 2019-09-17 Merck Sharp & Dohme Corp. Intravaginal ring drug delivery system
WO2015086489A1 (en) 2013-12-11 2015-06-18 Merck Sharp & Dohme B.V. Drug delivery system for delivery of anti-virals
WO2015094759A1 (en) 2013-12-19 2015-06-25 The Procter & Gamble Company Shaping keratin fibres using an active agent comprising at least two functional groups selected from: -c(oh)- and -c(=o)oh
EP3082735B1 (en) 2013-12-19 2018-05-02 The Procter and Gamble Company Shaping keratin fibres using oxoethanoic acid and/or derivatives thereof
MX361100B (es) 2013-12-19 2018-11-27 Procter & Gamble Modelado de fibras de queratina mediante el uso de un azucar.
MX376963B (es) 2013-12-19 2025-03-07 Procter & Gamble Modelado de fibras de queratina mediante el uso de éster de carbonato.
CN105828786B (zh) 2013-12-19 2020-07-07 宝洁公司 使用包含选自-c(＝o)-、-c(＝o)-h和-c(＝o)-o-的官能团的an活性剂使角蛋白纤维成形
EP3082750A1 (en) 2013-12-19 2016-10-26 The Procter & Gamble Company Shaping keratin fibres using a reducing composition and a fixing composition
MX357743B (es) 2013-12-19 2018-07-23 Procter & Gamble Formacion de fibras de queratina con 2-hidroxipropano-1,2,3-acido tricarboxilico y/o 1,2,3,4-acido butanetetracarboxilico.
EP3017809A1 (en) * 2014-11-07 2016-05-11 Ferring B.V. Drug-device unit containing quinagolide
EP3297731A1 (en) 2014-12-19 2018-03-28 The Procter and Gamble Company Shaping keratin fibres using arabinose and ethylene carbonate
EP3297730A1 (en) 2014-12-19 2018-03-28 The Procter and Gamble Company Method of shaping keratin fibres
US10945931B2 (en) 2015-06-18 2021-03-16 The Procter And Gamble Company Shaping keratin fibres using dialdehyde compounds
US20180228942A1 (en) * 2015-08-11 2018-08-16 Ptt Holding Aps A delivery device
EP3395335A1 (en) * 2017-04-24 2018-10-31 Kern Pharma, S.L. Vaginal ring for the simultaneous release of two active ingredients
DE102017113166A1 (de) * 2017-06-14 2018-12-20 Amw Gmbh Depotform zur Abgabe eines Östrogen-Wirkstoffs
EP3803866A4 (en) 2018-05-24 2022-03-16 Nureva Inc. METHOD, APPARATUS, AND COMPUTER READABLE MATERIALS FOR MANAGING SEMI-CONSTANT (PERSISTENT) SOUND SOURCES IN MICROPHONE CATCH/HOME AREAS
MX2020012459A (es) 2018-05-24 2021-04-28 Celanese Eva Performance Polymers Llc Dispositivo implantable para liberacion sostenida de un compuesto de farmaco macromolecular.
KR20260007295A (ko) 2018-05-24 2026-01-13 셀라니즈 이브이에이 퍼포먼스 폴리머스 엘엘씨 거대 분자 약물 화합물의 지속적인 방출을 위한 이식가능 장치
US10918649B2 (en) 2019-06-21 2021-02-16 The Population Council, Inc. System for providing birth control
BR112023022439A2 (pt) 2021-04-26 2023-12-26 Celanese Eva Performance Polymers Llc Dispositivo implantável para liberação sustentada de um composto de fármaco macromolecular
EP4215180A1 (en) * 2022-01-21 2023-07-26 Sever Pharma Solutions A drug delivery system
EP4465939A4 (en) * 2022-01-21 2026-01-07 The Population Council Inc Intravaginal Combination Therapy Rings
WO2024115763A1 (en) 2022-12-02 2024-06-06 Vari Bioscience Gmbh Estriol vaginal ring

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3545439A (en) 1968-01-04 1970-12-08 Upjohn Co Medicated devices and methods
US3854480A (en) 1969-04-01 1974-12-17 Alza Corp Drug-delivery system
US3995634A (en) 1975-12-02 1976-12-07 The Procter & Gamble Company Vaginal cavity dispensing means and method
US3995633A (en) 1975-12-02 1976-12-07 The Procter & Gamble Company Vaginal Medicament dispensing device
US4237885A (en) 1978-10-23 1980-12-09 Alza Corporation Delivery system with mated members for storing and releasing a plurality of beneficial agents
US4292965A (en) 1978-12-29 1981-10-06 The Population Council, Inc. Intravaginal ring
DE3040978A1 (de) 1980-10-28 1982-05-27 Schering Ag, 1000 Berlin Und 4619 Bergkamen Vaginalring
US4629449A (en) 1982-07-29 1986-12-16 Alza Corporation Vaginal dispenser for dispensing beneficial hormone
EP0162492B1 (en) 1984-04-11 1989-08-02 Thiemann Arzneimittel GmbH Dosage units for controlled release of active material
US4596576A (en) 1984-10-12 1986-06-24 Akzo N.V. Release system for two or more active substances
US4816258A (en) 1987-02-26 1989-03-28 Alza Corporation Transdermal contraceptive formulations
EP0303306B1 (en) 1987-08-08 1993-03-10 Akzo N.V. Contraceptive implant
AU3432689A (en) 1988-03-24 1989-10-16 Bukh Meditec A/S Controlled release composition
US5766632A (en) 1993-10-01 1998-06-16 Legere Pharmaceuticals, Ltd. Method of using lectins for contraception
JP3720386B2 (ja) 1993-12-27 2005-11-24 住友製薬株式会社 薬物放出制御製剤
WO1997002015A1 (en) 1995-07-04 1997-01-23 Akzo Nobel N.V. Ring-shaped devices
US5972372A (en) 1996-07-31 1999-10-26 The Population Council, Inc. Intravaginal rings with insertable drug-containing core
FR2754179B1 (fr) 1996-10-08 1998-12-24 Theramex Nouvelle composition hormononale et son utilisation
IL123813A0 (en) 1997-04-11 1998-10-30 Akzo Nobel Nv Drug delivery system for two or more active substances
ATE246638T1 (de) 1997-12-12 2003-08-15 Akzo Nobel Nv Verpackung für einen vaginalring
PL341209A1 (en) 1997-12-18 2001-03-26 Lilly Co Eli Crystalline teriparatide
US6579533B1 (en) 1999-11-30 2003-06-17 Bioasborbable Concepts, Ltd. Bioabsorbable drug delivery system for local treatment and prevention of infections
WO2002076426A2 (en) 2001-03-27 2002-10-03 Galen (Chemicals) Limited Intravaginal drug delivery devices for the administration of an antimicrobial agent
WO2003000156A1 (en) 2001-06-22 2003-01-03 Southern Biosystems, Inc. Zero-order prolonged release coaxial implants
AU2002313517B2 (en) 2001-08-31 2007-09-06 Bayer Schering Pharma Oy Drug delivery system
NZ532096A (en) 2001-09-28 2006-10-27 Mcneil Ppc Inc Dosage forms having an inner core and outer shell with different shapes
CN1242819C (zh) 2002-06-07 2006-02-22 上海市计划生育科学研究所 一种新型阴道环及制备方法
US6992219B2 (en) 2002-08-09 2006-01-31 Cephalon France Modafinil polymorphic forms
TWI336627B (en) * 2003-05-23 2011-02-01 Organon Nv Drug delivery system,and use and manufacturing method thereof
CA2531640C (en) 2003-07-10 2013-06-18 Galen (Chemicals) Limited Intravaginal drug delivery devices
PL1670440T3 (pl) * 2003-09-29 2014-11-28 Novo Nordisk Healthcare Ag Preparaty HRT
WO2005089723A1 (en) * 2004-03-24 2005-09-29 N.V. Organon Drug delivery system based on polyethylene vinylacetate copolymers
KR20060046263A (ko) * 2004-08-04 2006-05-17 도쿄파츠고교 가부시키가이샤 편평형 진동모터를 내장시킨 전자음향변환기
TW200727920A (en) 2005-06-21 2007-08-01 Organon Nv New regimens for oral monophasic contraceptives
NZ577014A (en) 2006-11-20 2011-07-29 Organon Nv Helically-shaped drug delivery system
US10258571B2 (en) 2007-02-12 2019-04-16 Particle Sciences, Inc. Delivery devices containing encapsulated and/or practice-bound active pharmaceutical ingredients
PE20081895A1 (es) 2007-03-26 2009-01-26 Theramex Regimen anticonceptivo oral
DK2207529T3 (en) 2007-09-07 2015-03-09 Mati Therapeutics Inc PHARMACEUTICAL cores for the sustained release of therapeutic agents
TW200930343A (en) 2007-09-21 2009-07-16 Organon Nv Drug delivery system
TW200927141A (en) 2007-11-22 2009-07-01 Bayer Schering Pharma Oy Vaginal delivery system
CN102497855B (zh) 2009-07-21 2013-12-25 人口委员会股份有限公司 多层梯度的阴道环
EP2468750A1 (en) 2010-12-13 2012-06-27 Chemo Ibérica, S.A. Polymorphic forms of asenapine maleate and processes for their preparation
TW201332585A (zh) 2012-02-14 2013-08-16 Chemo Res S L 核鞘藥物遞送裝置
US10413504B2 (en) 2013-12-11 2019-09-17 Merck Sharp & Dohme Corp. Intravaginal ring drug delivery system

Also Published As

Publication number Publication date
EP3079660B1 (en) 2021-03-03
AU2014363724A1 (en) 2016-05-26
PH12016501083A1 (en) 2016-07-25
SV2016005214A (es) 2016-11-21
CN105979930B (zh) 2019-11-19
US10413504B2 (en) 2019-09-17
HK1224208A1 (zh) 2017-08-18
PE20160680A1 (es) 2016-07-31
US20150157561A1 (en) 2015-06-11
DOP2016000132A (es) 2016-07-31
CA2931559A1 (en) 2015-06-18
BR112016013325B1 (pt) 2022-11-29
AU2014363724B2 (en) 2017-02-23
SG11201604660VA (en) 2016-07-28
MX2016007681A (es) 2016-10-14
EA201691193A1 (ru) 2016-09-30
WO2015086491A1 (en) 2015-06-18
IL245544A0 (en) 2016-06-30
EA031802B1 (ru) 2019-02-28
EP3079660A1 (en) 2016-10-19
JP2016539991A (ja) 2016-12-22
CN105979930A (zh) 2016-09-28
CR20160261A (es) 2016-08-16
BR112016013325A2 (https=) 2017-08-08
MD20160079A2 (ro) 2016-10-31
TW201607563A (zh) 2016-03-01
KR101808977B1 (ko) 2017-12-13
AP2016009223A0 (en) 2016-05-31
KR20160095110A (ko) 2016-08-10
MA39059A1 (fr) 2018-08-31
CA2931559C (en) 2018-03-13

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