JP6196016B2 - グルカン酸の細胞での産生 - Google Patents

グルカン酸の細胞での産生 Download PDF

Info

Publication number
JP6196016B2
JP6196016B2 JP2011502991A JP2011502991A JP6196016B2 JP 6196016 B2 JP6196016 B2 JP 6196016B2 JP 2011502991 A JP2011502991 A JP 2011502991A JP 2011502991 A JP2011502991 A JP 2011502991A JP 6196016 B2 JP6196016 B2 JP 6196016B2
Authority
JP
Japan
Prior art keywords
cell
acid
myo
gene
inositol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2011502991A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011516063A5 (enExample
JP2011516063A (ja
Inventor
ムン，テ，ソク
ユン，サン−ファル
ジョーンズ プレイサー，クリスタラ，ラネット
ジョーンズ プレイサー，クリスタラ，ラネット
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Publication of JP2011516063A publication Critical patent/JP2011516063A/ja
Publication of JP2011516063A5 publication Critical patent/JP2011516063A5/ja
Application granted granted Critical
Publication of JP6196016B2 publication Critical patent/JP6196016B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/58—Aldonic, ketoaldonic or saccharic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8245—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified carbohydrate or sugar alcohol metabolism, e.g. starch biosynthesis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0069—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/02—Monosaccharides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01203—Uronate dehydrogenase (1.1.1.203)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y113/00—Oxidoreductases acting on single donors with incorporation of molecular oxygen (oxygenases) (1.13)
    • C12Y113/99—Miscellaneous (1.13.99)
    • C12Y113/99001—Inositol oxygenase (1.13.99.1), i.e. myo-inositol oxygenase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y505/00—Intramolecular lyases (5.5)
    • C12Y505/01—Intramolecular lyases (5.5.1)
    • C12Y505/01004—Inositol-3-phosphate synthase (5.5.1.4)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
JP2011502991A 2008-04-04 2009-04-03 グルカン酸の細胞での産生 Active JP6196016B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4250208P 2008-04-04 2008-04-04
US61/042,502 2008-04-04
PCT/US2009/002111 WO2009145838A2 (en) 2008-04-04 2009-04-03 Cellular production of glucaric acid

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016190435A Division JP2017018140A (ja) 2008-04-04 2016-09-28 グルカン酸の細胞での産生

Publications (3)

Publication Number Publication Date
JP2011516063A JP2011516063A (ja) 2011-05-26
JP2011516063A5 JP2011516063A5 (enExample) 2013-06-13
JP6196016B2 true JP6196016B2 (ja) 2017-09-13

Family

ID=41377836

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2011502991A Active JP6196016B2 (ja) 2008-04-04 2009-04-03 グルカン酸の細胞での産生
JP2016190435A Pending JP2017018140A (ja) 2008-04-04 2016-09-28 グルカン酸の細胞での産生

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2016190435A Pending JP2017018140A (ja) 2008-04-04 2016-09-28 グルカン酸の細胞での産生

Country Status (8)

Country Link
US (2) US8835147B2 (enExample)
EP (1) EP2274417B1 (enExample)
JP (2) JP6196016B2 (enExample)
KR (1) KR101625443B1 (enExample)
CN (1) CN102066552B (enExample)
CA (1) CA2720526C (enExample)
DK (1) DK2274417T3 (enExample)
WO (1) WO2009145838A2 (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI20086236A0 (fi) * 2008-12-23 2008-12-23 Valtion Teknillinen Heksuronihapon konversio heksarihapoksi
KR101740848B1 (ko) 2011-11-14 2017-05-26 아사히 가세이 케미칼즈 가부시키가이샤 미오이노시톨 및 미오이노시톨 유도체의 제조 방법
EP2818552B1 (en) * 2012-02-24 2017-12-27 Asahi Kasei Kabushiki Kaisha Method for producing glucaric acid
US9803209B2 (en) 2012-05-18 2017-10-31 Novozymes A/S Bacterial mutants with improved transformation efficiency
CN105026548B (zh) * 2012-06-04 2019-06-18 盐水港精糖株式会社 D-葡萄糖二酸生产菌及d-葡萄糖二酸的制造方法
BR112015006255A2 (pt) * 2012-09-21 2017-08-22 Synthetic Genomics Inc Métodos para a produção de produtos químicos e derivados dos mesmos
US9528133B2 (en) 2012-09-21 2016-12-27 Synthetic Genomics, Inc. Compositions and methods for producing chemicals and derivatives thereof
CN106414753A (zh) * 2014-03-21 2017-02-15 合成基因组股份有限公司 用于生产化学品及其衍生物的组合物和方法
US20170130210A1 (en) * 2014-06-09 2017-05-11 Massachusetts Institute Of Technology Dynamic knockdown of central metabolism for redirecting glucose-6-phosphate fluxes
CN104312934A (zh) * 2014-10-22 2015-01-28 江南大学 一种构建重组酵母生物合成葡萄糖醛酸的方法
CN104312935B (zh) * 2014-10-22 2018-07-06 江南大学 一种构建重组酵母发酵生产葡萄糖二酸的方法
EP3480305A4 (en) 2016-06-30 2020-01-22 Cj Cheiljedang Corporation METHOD FOR THE ENZYMATIC PRODUCTION OF HIGHLY CONCENTRATED MYO-INOSITOL
CN106148292B (zh) * 2016-07-06 2019-05-17 江南大学 一种肌醇加氧酶突变体及其应用
EP3519567A4 (en) * 2016-10-03 2020-06-03 The Regents of The University of California MANIPULATED MICROORGANISMS FOR THE PRODUCTION OF CHEMICAL BASIC MATERIALS AND CELL BIOMASS
FR3067350B1 (fr) 2017-06-12 2020-12-11 Seprosys Procede d'obtention d'une solution d'acide glucarique libre et solution obtenue
HUE061086T2 (hu) 2017-06-22 2023-05-28 Archer Daniels Midland Co Eljárás furándikarbonsav-észterek elõállítására
CN107365806B (zh) * 2017-08-02 2020-04-03 南京师范大学 一种葡萄糖二酸的制备方法及其制备中的糖醛酸脱氢酶-nadh氧化酶和应用
CA3138481A1 (en) * 2019-05-17 2020-11-26 The Governing Council Of The University Of Toronto Enzymatic production of glucaric acid from glucuronic acid
CN110846436B (zh) * 2019-12-25 2021-09-28 江南大学 一种快速鉴别Ale和Lager型啤酒酵母的方法
CN111019852B (zh) * 2019-12-31 2021-11-23 江南大学 一种提高酿酒酵母工程菌株合成葡萄糖二酸效率的方法
CN110951794B (zh) * 2019-12-31 2022-03-25 江南大学 一种提高酿酒酵母工程菌生产葡萄糖二酸的发酵方法
KR102649855B1 (ko) * 2020-09-15 2024-03-22 경북대학교 산학협력단 갈락투론산을 발효하여 뮤식산을 생산하는 신규 효모 균주
WO2022204246A1 (en) * 2021-03-26 2022-09-29 Archer-Daniels-Midland Company Thermostable d-glucarate dehydratase that is resistant to inhibition by tartrate sequence submission
KR102626750B1 (ko) * 2021-12-27 2024-01-19 한국프라임제약주식회사 키로이노시톨 생성능이 우수한 락티카제이 바실러스 카제이 WiKim0135 균주 및 이의 혈당강하 용도
CN115820761A (zh) * 2022-11-28 2023-03-21 南京工业大学 一种生物法催化合成d-葡萄糖醛酸的方法
WO2024217529A1 (zh) * 2023-04-21 2024-10-24 西湖大学 一种新型的葡萄糖二酸生物合成路径及发酵生产葡萄糖二酸的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5859205A (en) 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
DE19604798A1 (de) * 1996-02-09 1997-08-14 Herbstreith & Fox Kg Pektin Fa Herstellung von L-Ascorbinsäure
JP2004536577A (ja) 2001-03-19 2004-12-09 カーギル，インコーポレーテッド ミオイノシトールオキシゲナーゼ

Also Published As

Publication number Publication date
EP2274417A2 (en) 2011-01-19
CN102066552A (zh) 2011-05-18
KR20110027652A (ko) 2011-03-16
CN102066552B (zh) 2014-03-12
KR101625443B1 (ko) 2016-05-30
CA2720526A1 (en) 2009-12-03
EP2274417A4 (en) 2012-05-02
EP2274417B1 (en) 2013-07-24
BRPI0911171A2 (pt) 2015-08-04
US20150093794A1 (en) 2015-04-02
US20110124065A1 (en) 2011-05-26
JP2011516063A (ja) 2011-05-26
CA2720526C (en) 2017-11-28
US8835147B2 (en) 2014-09-16
DK2274417T3 (da) 2013-10-28
WO2009145838A3 (en) 2010-02-18
JP2017018140A (ja) 2017-01-26
WO2009145838A2 (en) 2009-12-03

Similar Documents

Publication Publication Date Title
JP6196016B2 (ja) グルカン酸の細胞での産生
CN107690482B (zh) 用于2,4-二羟基丁酸的优化生产的经修饰的微生物
JP4532116B2 (ja) アラニン２，３−アミノムターゼ
CN101528918B (zh) 生产3-羟基丙酸的β-丙氨酸/α-酮戊二酸氨基转移酶
CN107771214B (zh) 用于具有增加的2,4-二羟基丁酸外排物的优化的2,4-二羟基丁酸产生的修饰的微生物
KR102621632B1 (ko) Ｎａｄｐｈ 의존성 아세톨 리덕타제 및 개선된 ｎａｄｐｈ 공급에 기반한 １,２-프로판디올의 생산을 위한 신규한 미생물 및 방법
US20110294178A1 (en) Method for the preparation of diols
KR20110046560A (ko) 2-히드록시-이소부티레이트 (2-ｈｉｂａ)의 효소적 생산
EP2411502A1 (en) Method for producting high amount of glycolic acid by fermentation
KR20170025315A (ko) 3-hp를 생산할 수 있는 재조합 효모 및 이를 이용한 3-hp의 제조방법
Watanabe et al. A novel α-ketoglutaric semialdehyde dehydrogenase: evolutionary insight into an alternative pathway of bacterial L-arabinose metabolism
JP2017534268A (ja) 有用産物の生産のための改変微生物および方法
KR20190097250A (ko) 신규한 효소를 사용한 메틸글리옥살의 히드록시아세톤으로의 전환 및 그의 적용
KR102149044B1 (ko) 2-히드록시 감마 부티로락톤 또는 2,4-디히드록시-부티레이트 의 제조 방법
BRPI0911171B1 (pt) Microrganismo transgênico e método para produzir ácido glicárico
CN115232800A (zh) 一种298位突变的醛酮还原酶突变体及其应用
CN117730147A (zh) 苯丙素类化合物的生物合成
CN115161299A (zh) 一种158位突变的醛酮还原酶突变体及其应用
Sakakibara et al. Isolation of an operon involved in xylitol metabolism from a xylitol-utilizing Pantoea ananatis mutant
WO2012081084A1 (ja) 新規微生物、ならびにそれを用いる２，３－ジヒドロキシ安息香酸およびサリチル酸の製造法

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120330

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20120330

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130401

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130910

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20131210

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20131217

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20140110

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140120

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20140207

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140217

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140310

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20141007

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150209

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20150219

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20150212

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20150422

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20150703

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20160622

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20160728

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20160826

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160928

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20170322

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20170424

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20170522

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170622

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20170817

R150 Certificate of patent or registration of utility model

Ref document number: 6196016

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250